{"id":"https://openalex.org/W1985993090","doi":"https://doi.org/10.1038/nrg2507","title":"Prostate cancer genomics: towards a new understanding","display_name":"Prostate cancer genomics: towards a new understanding","publication_year":2008,"publication_date":"2008-12-23","ids":{"openalex":"https://openalex.org/W1985993090","doi":"https://doi.org/10.1038/nrg2507","mag":"1985993090","pmid":"https://pubmed.ncbi.nlm.nih.gov/19104501","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2721916"},"language":"en","primary_location":{"id":"doi:10.1038/nrg2507","doi":"https://doi.org/10.1038/nrg2507","is_oa":true,"landing_page_url":"https://doi.org/10.1038/nrg2507","pdf_url":"https://www.nature.com/articles/nrg2507.pdf","source":{"id":"https://openalex.org/S8553189","display_name":"Nature Reviews Genetics","issn_l":"1471-0056","issn":["1471-0056","1471-0064"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Genetics","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.nature.com/articles/nrg2507.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035070420","display_name":"John S. Witte","orcid":"https://orcid.org/0000-0003-0146-1434","observed_orcids":["https://orcid.org/0000-0003-0146-1434"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John S. Witte","raw_affiliation_strings":["Department of Epidemiology and Biostatistics, Institute for Human Genetics, University of California, San Francisco, 513 Parnassus Avenue, Room S965, San Francisco, California 94143-0794, USA. jwitte@ucsf.edu","Department of Epidemiology and Biostatistics, Institute for Human Genetics, University of California, San Francisco, 513 Parnassus Avenue, Room S965, San Francisco, California 94143-0794, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Biostatistics, Institute for Human Genetics, University of California, San Francisco, 513 Parnassus Avenue, Room S965, San Francisco, California 94143-0794, USA. jwitte@ucsf.edu","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Epidemiology and Biostatistics, Institute for Human Genetics, University of California, San Francisco, 513 Parnassus Avenue, Room S965, San Francisco, California 94143-0794, USA","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5035070420"],"corresponding_institution_ids":["https://openalex.org/I180670191"],"apc_list":null,"apc_paid":null,"fwci":3.4161,"has_fulltext":true,"cited_by_count":133,"citation_normalized_percentile":{"value":0.95452392,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"10","issue":"2","first_page":"77","last_page":"82"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.014100000262260437,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9649999737739563},{"id":"https://openalex.org/keywords/germline-mutations","display_name":"germline mutations","score":0.9470000267028809},{"id":"https://openalex.org/keywords/somatic-mutations","display_name":"somatic mutations","score":0.984000027179718},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"genome-wide association study","score":0.7269999980926514},{"id":"https://openalex.org/keywords/gene-expression-signatures","display_name":"gene expression signatures","score":0.8529999852180481},{"id":"https://openalex.org/keywords/gene-fusion","display_name":"gene fusion","score":0.9710000157356262},{"id":"https://openalex.org/keywords/prostate-cancer-risk-prediction","display_name":"prostate cancer risk prediction","score":0.7400000095367432},{"id":"https://openalex.org/keywords/disease-aggressiveness","display_name":"disease aggressiveness","score":0.8690000176429749},{"id":"https://openalex.org/keywords/prostate-cancer-treatment","display_name":"prostate cancer treatment","score":0.8100000023841858}],"concepts":[{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.8546296954154968},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.7333037853240967},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6901415586471558},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6712839007377625},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5361435413360596},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.48334357142448425},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.4638286828994751},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.42892026901245117},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.39967963099479675},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3737146854400635},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3506489396095276},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18446600437164307},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1550183892250061}],"mesh":[{"descriptor_ui":"D005820","descriptor_name":"Genetic Testing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1038/nrg2507","doi":"https://doi.org/10.1038/nrg2507","is_oa":true,"landing_page_url":"https://doi.org/10.1038/nrg2507","pdf_url":"https://www.nature.com/articles/nrg2507.pdf","source":{"id":"https://openalex.org/S8553189","display_name":"Nature Reviews Genetics","issn_l":"1471-0056","issn":["1471-0056","1471-0064"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Genetics","raw_type":"journal-article"},{"id":"pmid:19104501","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19104501","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature reviews. Genetics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2721916","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2721916","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Nat Rev Genet","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/nrg2507","doi":"https://doi.org/10.1038/nrg2507","is_oa":true,"landing_page_url":"https://doi.org/10.1038/nrg2507","pdf_url":"https://www.nature.com/articles/nrg2507.pdf","source":{"id":"https://openalex.org/S8553189","display_name":"Nature Reviews Genetics","issn_l":"1471-0056","issn":["1471-0056","1471-0064"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Genetics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3389368987","display_name":"Genetic Epidemiology of Prostate Cancer Risk and Progression","funder_award_id":"R01CA088164","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6191305262","display_name":null,"funder_award_id":"CA 88164","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7996752325","display_name":"Genomewide Association Study of Prostate Cancer","funder_award_id":"U01CA127298","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8850026470","display_name":null,"funder_award_id":"CA127298","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1985993090.pdf","grobid_xml":"https://content.openalex.org/works/W1985993090.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1974326568","https://openalex.org/W1977546001","https://openalex.org/W1987424755","https://openalex.org/W1995404520","https://openalex.org/W2002384741","https://openalex.org/W2004944207","https://openalex.org/W2006423274","https://openalex.org/W2015437876","https://openalex.org/W2015449882","https://openalex.org/W2016371780","https://openalex.org/W2021986944","https://openalex.org/W2030104557","https://openalex.org/W2037030165","https://openalex.org/W2037119446","https://openalex.org/W2040827479","https://openalex.org/W2042103448","https://openalex.org/W2044916117","https://openalex.org/W2047200356","https://openalex.org/W2058849125","https://openalex.org/W2060312754","https://openalex.org/W2065218625","https://openalex.org/W2073184521","https://openalex.org/W2074465378","https://openalex.org/W2074718000","https://openalex.org/W2076758225","https://openalex.org/W2101272978","https://openalex.org/W2105616386","https://openalex.org/W2107561657","https://openalex.org/W2108860692","https://openalex.org/W2110860781","https://openalex.org/W2121158863","https://openalex.org/W2122296279","https://openalex.org/W2126245040","https://openalex.org/W2129251677","https://openalex.org/W2132281105","https://openalex.org/W2138155367","https://openalex.org/W2145657085","https://openalex.org/W2147010946","https://openalex.org/W2147111825","https://openalex.org/W2150554965","https://openalex.org/W2151726393","https://openalex.org/W2154165363","https://openalex.org/W2157043398","https://openalex.org/W2158944729","https://openalex.org/W2164716330","https://openalex.org/W2168272873","https://openalex.org/W2170500510","https://openalex.org/W2170641343","https://openalex.org/W2171682260","https://openalex.org/W4211195653"],"related_works":["https://openalex.org/W4292060891","https://openalex.org/W3130304325","https://openalex.org/W2087345933","https://openalex.org/W2789238142","https://openalex.org/W2009310531","https://openalex.org/W3124590659","https://openalex.org/W1498883658","https://openalex.org/W2399768138","https://openalex.org/W4409734674","https://openalex.org/W7097192695"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":15}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}