{"id":"https://openalex.org/W1985956754","doi":"https://doi.org/10.1016/0006-2944(73)90025-2","title":"Factors influencing the in vitro production of a myocardial depressant factor","display_name":"Factors influencing the in vitro production of a myocardial depressant factor","publication_year":1973,"publication_date":"1973-10-01","ids":{"openalex":"https://openalex.org/W1985956754","doi":"https://doi.org/10.1016/0006-2944(73)90025-2","mag":"1985956754","pmid":"https://pubmed.ncbi.nlm.nih.gov/4753205"},"language":"en","primary_location":{"id":"doi:10.1016/0006-2944(73)90025-2","doi":"https://doi.org/10.1016/0006-2944(73)90025-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0006-2944(73)90025-2","pdf_url":null,"source":{"id":"https://openalex.org/S110816294","display_name":"Biochemical Medicine","issn_l":"0006-2944","issn":["0006-2944","1557-7996"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319955","host_organization_name":"Academic Press","host_organization_lineage":["https://openalex.org/P4310319955","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Academic Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001259180","display_name":"YAIR LITVIN","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]},{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["IL","US"],"is_corresponding":false,"raw_author_name":"Yair Litvin","raw_affiliation_strings":["Department of Biochemistry, The Hebrew University-Hadassah Medical School, Ierusalem, Israel","Department of Physiology, University of Virginia School of medicine, Charlottesville, Virginia 22901 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, The Hebrew University-Hadassah Medical School, Ierusalem, Israel","institution_ids":["https://openalex.org/I197251160"]},{"raw_affiliation_string":"Department of Physiology, University of Virginia School of medicine, Charlottesville, Virginia 22901 USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053579648","display_name":"Joel N. Leffler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]},{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["IL","US"],"is_corresponding":false,"raw_author_name":"Joel N. Leffler","raw_affiliation_strings":["Department of Biochemistry, The Hebrew University-Hadassah Medical School, Ierusalem, Israel","Department of Physiology, University of Virginia School of medicine, Charlottesville, Virginia 22901 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, The Hebrew University-Hadassah Medical School, Ierusalem, Israel","institution_ids":["https://openalex.org/I197251160"]},{"raw_affiliation_string":"Department of Physiology, University of Virginia School of medicine, Charlottesville, Virginia 22901 USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068725737","display_name":"Yechezkel Barenholz","orcid":"https://orcid.org/0000-0003-4429-9609","observed_orcids":["https://orcid.org/0000-0003-4429-9609"]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]},{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["IL","US"],"is_corresponding":false,"raw_author_name":"Yechezkel Barenholz","raw_affiliation_strings":["Department of Biochemistry, The Hebrew University-Hadassah Medical School, Ierusalem, Israel","Department of Physiology, University of Virginia School of medicine, Charlottesville, Virginia 22901 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, The Hebrew University-Hadassah Medical School, Ierusalem, Israel","institution_ids":["https://openalex.org/I197251160"]},{"raw_affiliation_string":"Department of Physiology, University of Virginia School of medicine, Charlottesville, Virginia 22901 USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110287816","display_name":"Allan M. Lefer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]},{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["IL","US"],"is_corresponding":false,"raw_author_name":"Allan M. Lefer","raw_affiliation_strings":["Department of Biochemistry, The Hebrew University-Hadassah Medical School, Ierusalem, Israel","Department of Physiology, University of Virginia School of medicine, Charlottesville, Virginia 22901 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, The Hebrew University-Hadassah Medical School, Ierusalem, Israel","institution_ids":["https://openalex.org/I197251160"]},{"raw_affiliation_string":"Department of Physiology, University of Virginia School of medicine, Charlottesville, Virginia 22901 USA","institution_ids":["https://openalex.org/I51556381"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.7791,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.935593,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"8","issue":"2","first_page":"199","last_page":"212"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.5565999746322632,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.5565999746322632,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.046799998730421066,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.024399999529123306,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myocardial-depressant-factor","display_name":"myocardial depressant factor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/subcellular-fractions","display_name":"subcellular fractions","score":0.847000002861023},{"id":"https://openalex.org/keywords/lysosomes","display_name":"lysosomes","score":0.7620000243186951},{"id":"https://openalex.org/keywords/zymogen-granules","display_name":"zymogen granules","score":0.9990000128746033},{"id":"https://openalex.org/keywords/protease","display_name":"proteolytic enzymes","score":0.6499999761581421},{"id":"https://openalex.org/keywords/trypsin-inhibition","display_name":"trypsin inhibition","score":0.8360000252723694},{"id":"https://openalex.org/keywords/sulfhydryl-groups","display_name":"sulfhydryl groups","score":0.8920000195503235},{"id":"https://openalex.org/keywords/optimal-ph","display_name":"pH optimum","score":0.4399999976158142},{"id":"https://openalex.org/keywords/incubation-time","display_name":"incubation time","score":0.8870000243186951},{"id":"https://openalex.org/keywords/myocardial-depression","display_name":"myocardial depression","score":0.35499998927116394}],"concepts":[{"id":"https://openalex.org/C2777025580","wikidata":"https://www.wikidata.org/wiki/Q1976211","display_name":"Depressant","level":2,"score":0.807680606842041},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5777782797813416},{"id":"https://openalex.org/C2778348673","wikidata":"https://www.wikidata.org/wiki/Q739302","display_name":"Production (economics)","level":2,"score":0.4677078127861023},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3360709846019745},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.26600468158721924},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19785326719284058},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.07120159268379211},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0617063045501709},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000681","descriptor_name":"Amylases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000693","descriptor_name":"Anaerobiosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000889","descriptor_name":"Anti-Arrhythmia Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002403","descriptor_name":"Cathepsins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002415","descriptor_name":"Cats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002458","descriptor_name":"Cell Fractionation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002729","descriptor_name":"Chloromercuribenzoates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002854","descriptor_name":"Chromatography, Paper","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003594","descriptor_name":"Cytoplasmic Granules","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008247","descriptor_name":"Lysosomes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009994","descriptor_name":"Osmolar Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013347","descriptor_name":"Subcellular Fractions","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013347","descriptor_name":"Subcellular Fractions","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D013385","descriptor_name":"Succinate Dehydrogenase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014357","descriptor_name":"Trypsin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0006-2944(73)90025-2","doi":"https://doi.org/10.1016/0006-2944(73)90025-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0006-2944(73)90025-2","pdf_url":null,"source":{"id":"https://openalex.org/S110816294","display_name":"Biochemical Medicine","issn_l":"0006-2944","issn":["0006-2944","1557-7996"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319955","host_organization_name":"Academic Press","host_organization_lineage":["https://openalex.org/P4310319955","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Academic Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Medicine","raw_type":"journal-article"},{"id":"pmid:4753205","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4753205","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W337228439","https://openalex.org/W1205458192","https://openalex.org/W1485338271","https://openalex.org/W1775749144","https://openalex.org/W1967467383","https://openalex.org/W2001470146","https://openalex.org/W2016470626","https://openalex.org/W2054184685","https://openalex.org/W2115388044","https://openalex.org/W2128047532","https://openalex.org/W2143669668","https://openalex.org/W2172091239","https://openalex.org/W2282054059","https://openalex.org/W2399392129","https://openalex.org/W2407689402","https://openalex.org/W2409111583","https://openalex.org/W2410907125","https://openalex.org/W2411446877","https://openalex.org/W2415251542","https://openalex.org/W2417786789"],"related_works":["https://openalex.org/W2416633298","https://openalex.org/W2410907125","https://openalex.org/W1420803274","https://openalex.org/W2410529704","https://openalex.org/W2083854210","https://openalex.org/W2160759960","https://openalex.org/W2023508205","https://openalex.org/W2061508460","https://openalex.org/W2041757175","https://openalex.org/W2093410285"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}