{"id":"https://openalex.org/W1985877668","doi":"https://doi.org/10.1111/j.1399-3062.2012.00757.x","title":"Decreased levels of serum complement C3 and natural killer cells add to the predictive value of total immunoglobulin G for severe infection in heart transplant recipients","display_name":"Decreased levels of serum complement C3 and natural killer cells add to the predictive value of total immunoglobulin G for severe infection in heart transplant recipients","publication_year":2012,"publication_date":"2012-09-26","ids":{"openalex":"https://openalex.org/W1985877668","doi":"https://doi.org/10.1111/j.1399-3062.2012.00757.x","mag":"1985877668","pmid":"https://pubmed.ncbi.nlm.nih.gov/23013361"},"language":"en","primary_location":{"id":"doi:10.1111/j.1399-3062.2012.00757.x","doi":"https://doi.org/10.1111/j.1399-3062.2012.00757.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1399-3062.2012.00757.x","pdf_url":null,"source":{"id":"https://openalex.org/S14534568","display_name":"Transplant Infectious Disease","issn_l":"1398-2273","issn":["1398-2273","1399-3062"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplant Infectious Disease","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045663356","display_name":"Elizabeth Sarmiento","orcid":"https://orcid.org/0000-0001-8435-8912","observed_orcids":["https://orcid.org/0000-0001-8435-8912"]},"institutions":[{"id":"https://openalex.org/I2960094004","display_name":"Hospital General Universitario Gregorio Mara\u00f1\u00f3n","ror":"https://ror.org/0111es613","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2960094004","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"E. Sarmiento","raw_affiliation_strings":["Clinical Immunology Department University Hospital Gregorio Mara\u00f1\u00f3n Madrid Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Immunology Department University Hospital Gregorio Mara\u00f1\u00f3n Madrid Spain","institution_ids":["https://openalex.org/I2960094004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064689083","display_name":"Nadia del Pozo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2960094004","display_name":"Hospital General Universitario Gregorio Mara\u00f1\u00f3n","ror":"https://ror.org/0111es613","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2960094004","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"N. del Pozo","raw_affiliation_strings":["Clinical Immunology Department University Hospital Gregorio Mara\u00f1\u00f3n Madrid Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Immunology Department University Hospital Gregorio Mara\u00f1\u00f3n Madrid Spain","institution_ids":["https://openalex.org/I2960094004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109900856","display_name":"Antonio Gallego","orcid":"https://orcid.org/0000-0001-8515-2801","observed_orcids":["https://orcid.org/0000-0001-8515-2801"]},"institutions":[{"id":"https://openalex.org/I2960094004","display_name":"Hospital General Universitario Gregorio Mara\u00f1\u00f3n","ror":"https://ror.org/0111es613","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2960094004","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"A. Gallego","raw_affiliation_strings":["Clinical Immunology Department University Hospital Gregorio Mara\u00f1\u00f3n Madrid Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Immunology Department University Hospital Gregorio Mara\u00f1\u00f3n Madrid Spain","institution_ids":["https://openalex.org/I2960094004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008821515","display_name":"J. Fern\u00e0ndez-Y\u00e1\u00f1ez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2960094004","display_name":"Hospital General Universitario Gregorio Mara\u00f1\u00f3n","ror":"https://ror.org/0111es613","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2960094004","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"J. Fern\u00e1ndez\u2010Ya\u00f1ez","raw_affiliation_strings":["Cardiology Department University Hospital Gregorio Mara\u00f1\u00f3n Madrid Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Department University Hospital Gregorio Mara\u00f1\u00f3n Madrid Spain","institution_ids":["https://openalex.org/I2960094004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068621337","display_name":"Jes\u00fas Palomo","orcid":"https://orcid.org/0000-0002-1027-449X","observed_orcids":["https://orcid.org/0000-0002-1027-449X"]},"institutions":[{"id":"https://openalex.org/I2960094004","display_name":"Hospital General Universitario Gregorio Mara\u00f1\u00f3n","ror":"https://ror.org/0111es613","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2960094004","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"J. Palomo","raw_affiliation_strings":["Cardiology Department University Hospital Gregorio Mara\u00f1\u00f3n Madrid Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Department University Hospital Gregorio Mara\u00f1\u00f3n Madrid Spain","institution_ids":["https://openalex.org/I2960094004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032510651","display_name":"Adolfo Villa","orcid":"https://orcid.org/0000-0003-4883-4509","observed_orcids":["https://orcid.org/0000-0003-4883-4509"]},"institutions":[{"id":"https://openalex.org/I2960094004","display_name":"Hospital General Universitario Gregorio Mara\u00f1\u00f3n","ror":"https://ror.org/0111es613","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2960094004","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"A. Villa","raw_affiliation_strings":["Cardiology Department University Hospital Gregorio Mara\u00f1\u00f3n Madrid Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Department University Hospital Gregorio Mara\u00f1\u00f3n Madrid Spain","institution_ids":["https://openalex.org/I2960094004"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M. Ruiz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2960094004","display_name":"Hospital General Universitario Gregorio Mara\u00f1\u00f3n","ror":"https://ror.org/0111es613","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2960094004","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"M. Ruiz","raw_affiliation_strings":["Cardiovascular Surgery Department University Hospital Gregorio Mara\u00f1\u00f3n Madrid Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Surgery Department University Hospital Gregorio Mara\u00f1\u00f3n Madrid Spain","institution_ids":["https://openalex.org/I2960094004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071487615","display_name":"Patricia Mu\u00f1\u00f3z","orcid":"https://orcid.org/0000-0001-5706-5583","observed_orcids":["https://orcid.org/0000-0001-5706-5583"]},"institutions":[{"id":"https://openalex.org/I2960094004","display_name":"Hospital General Universitario Gregorio Mara\u00f1\u00f3n","ror":"https://ror.org/0111es613","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2960094004","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"P. Mu\u00f1oz","raw_affiliation_strings":["Microbiology Department University Hospital Gregorio Mara\u00f1\u00f3n Madrid Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology Department University Hospital Gregorio Mara\u00f1\u00f3n Madrid Spain","institution_ids":["https://openalex.org/I2960094004"]}]},{"author_position":"middle","author":{"id":null,"display_name":"C. Rodr\u00edguez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2960094004","display_name":"Hospital General Universitario Gregorio Mara\u00f1\u00f3n","ror":"https://ror.org/0111es613","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2960094004","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"C. Rodr\u00edguez","raw_affiliation_strings":["Biochemistry Department University Hospital Gregorio Mara\u00f1\u00f3n Madrid Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry Department University Hospital Gregorio Mara\u00f1\u00f3n Madrid Spain","institution_ids":["https://openalex.org/I2960094004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111741104","display_name":"J. Rodr\u00edguez-Molina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2960094004","display_name":"Hospital General Universitario Gregorio Mara\u00f1\u00f3n","ror":"https://ror.org/0111es613","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2960094004","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"J. Rodr\u00edguez\u2010Molina","raw_affiliation_strings":["Clinical Immunology Department University Hospital Gregorio Mara\u00f1\u00f3n Madrid Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Immunology Department University Hospital Gregorio Mara\u00f1\u00f3n Madrid Spain","institution_ids":["https://openalex.org/I2960094004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062978051","display_name":"Joaqu\u00edn Navarro","orcid":"https://orcid.org/0000-0002-5428-3566","observed_orcids":["https://orcid.org/0000-0002-5428-3566"]},"institutions":[{"id":"https://openalex.org/I2960094004","display_name":"Hospital General Universitario Gregorio Mara\u00f1\u00f3n","ror":"https://ror.org/0111es613","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2960094004","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"J. Navarro","raw_affiliation_strings":["Clinical Immunology Department University Hospital Gregorio Mara\u00f1\u00f3n Madrid Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Immunology Department University Hospital Gregorio Mara\u00f1\u00f3n Madrid Spain","institution_ids":["https://openalex.org/I2960094004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077483796","display_name":"Katja Kotsch","orcid":"https://orcid.org/0000-0002-3803-0964","observed_orcids":["https://orcid.org/0000-0002-3803-0964"]},"institutions":[{"id":"https://openalex.org/I4210139777","display_name":"Berlin Institute of Health at Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/0493xsw21","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210139777","https://openalex.org/I7877124"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"K. Kotsch","raw_affiliation_strings":["Transplant Immunology Group Immunology Institute Universit\u00e4tsmedizin Charit\u00e9 Berlin Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transplant Immunology Group Immunology Institute Universit\u00e4tsmedizin Charit\u00e9 Berlin Germany","institution_ids":["https://openalex.org/I4210139777","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035391740","display_name":"Eduardo Fern\u00e1ndez\u2010Cruz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2960094004","display_name":"Hospital General Universitario Gregorio Mara\u00f1\u00f3n","ror":"https://ror.org/0111es613","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2960094004","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"E. Fernandez\u2010Cruz","raw_affiliation_strings":["Clinical Immunology Department University Hospital Gregorio Mara\u00f1\u00f3n Madrid Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Immunology Department University Hospital Gregorio Mara\u00f1\u00f3n Madrid Spain","institution_ids":["https://openalex.org/I2960094004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001632831","display_name":"Javier Carbone","orcid":"https://orcid.org/0000-0003-2056-0534","observed_orcids":["https://orcid.org/0000-0003-2056-0534"]},"institutions":[{"id":"https://openalex.org/I2960094004","display_name":"Hospital General Universitario Gregorio Mara\u00f1\u00f3n","ror":"https://ror.org/0111es613","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2960094004","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"J. Carbone","raw_affiliation_strings":["Clinical Immunology Department University Hospital Gregorio Mara\u00f1\u00f3n Madrid Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Immunology Department University Hospital Gregorio Mara\u00f1\u00f3n Madrid Spain","institution_ids":["https://openalex.org/I2960094004"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5001632831"],"corresponding_institution_ids":["https://openalex.org/I2960094004"],"apc_list":{"value":3920,"currency":"USD","value_usd":3920},"apc_paid":null,"fwci":2.0013,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.8509382,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"14","issue":"5","first_page":"526","last_page":"539"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heart-transplantation","display_name":"heart transplantation","score":0.8450000286102295},{"id":"https://openalex.org/keywords/post-transplant-infection","display_name":"post-transplant infection","score":0.906000018119812},{"id":"https://openalex.org/keywords/serum-complement-c3","display_name":"serum complement C3","score":0.8149999976158142},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.9399999976158142},{"id":"https://openalex.org/keywords/igg","display_name":"IgG","score":0.7269999980926514},{"id":"https://openalex.org/keywords/igg2","display_name":"IgG2","score":0.7699999809265137},{"id":"https://openalex.org/keywords/iga","display_name":"IgA","score":0.8659999966621399},{"id":"https://openalex.org/keywords/humoral-immunity","display_name":"humoral immunity","score":0.8019999861717224},{"id":"https://openalex.org/keywords/cell-mediated-immunity","display_name":"cell-mediated immunity","score":0.9890000224113464},{"id":"https://openalex.org/keywords/immune-monitoring","display_name":"immune monitoring","score":0.7049999833106995},{"id":"https://openalex.org/keywords/infection-risk-prediction","display_name":"infection risk prediction","score":0.6470000147819519}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8249950408935547},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6259385943412781},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.6227418780326843},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.600853681564331},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5750341415405273},{"id":"https://openalex.org/C2778849806","wikidata":"https://www.wikidata.org/wiki/Q643396","display_name":"Heart transplantation","level":3,"score":0.5543562173843384},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5014688968658447},{"id":"https://openalex.org/C2780898057","wikidata":"https://www.wikidata.org/wiki/Q79448","display_name":"Immunoglobulin G","level":3,"score":0.4564942419528961},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44894999265670776},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.32530301809310913},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.22975316643714905}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003176","descriptor_name":"Complement C3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D007239","descriptor_name":"Infections","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D007239","descriptor_name":"Infections","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D007239","descriptor_name":"Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007239","descriptor_name":"Infections","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015166","descriptor_name":"Monitoring, Immunologic","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D016027","descriptor_name":"Heart Transplantation","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1399-3062.2012.00757.x","doi":"https://doi.org/10.1111/j.1399-3062.2012.00757.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1399-3062.2012.00757.x","pdf_url":null,"source":{"id":"https://openalex.org/S14534568","display_name":"Transplant Infectious Disease","issn_l":"1398-2273","issn":["1398-2273","1399-3062"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplant Infectious Disease","raw_type":"journal-article"},{"id":"pmid:23013361","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23013361","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplant infectious disease : an official journal of the Transplantation Society","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1539748875","https://openalex.org/W1972836054","https://openalex.org/W1981552711","https://openalex.org/W1990836070","https://openalex.org/W2036711529","https://openalex.org/W2039688361","https://openalex.org/W2045745418","https://openalex.org/W2057823764","https://openalex.org/W2058338960","https://openalex.org/W2061460224","https://openalex.org/W2073060575","https://openalex.org/W2073572679","https://openalex.org/W2081009135","https://openalex.org/W2092265056","https://openalex.org/W2108308567","https://openalex.org/W2121636564","https://openalex.org/W2123727561","https://openalex.org/W2141975506","https://openalex.org/W2142594309","https://openalex.org/W2148979825","https://openalex.org/W2150687681","https://openalex.org/W2521725279","https://openalex.org/W4250483374"],"related_works":["https://openalex.org/W2079672406","https://openalex.org/W1981552711","https://openalex.org/W4255073447","https://openalex.org/W2036711529","https://openalex.org/W1964296760","https://openalex.org/W2944797254","https://openalex.org/W3004549424","https://openalex.org/W1514917162","https://openalex.org/W1582717102","https://openalex.org/W2987730830"],"abstract_inverted_index":{"BACKGROUND:":[0],"Infection":[1],"remains":[2],"a":[3,55],"source":[4],"of":[5,32,45,65,89,212],"mortality":[6],"in":[7,199,214],"heart":[8,52,215],"recipients.":[9,217],"We":[10,26,48],"previously":[11],"reported":[12],"that":[13,164,188],"post-transplant":[14],"immunoglobulin":[15],"G":[16],"(IgG)":[17],"quantification":[18],"can":[19],"help":[20],"identify":[21,209],"the":[22,87,93,210],"risk":[23,44,88,211],"for":[24,181],"infection.":[25,46,67],"assessed":[27],"whether":[28],"other":[29],"standardized":[30],"parameters":[31],"humoral":[33],"and":[34,92,147,172,195],"cellular":[35],"immunity":[36],"could":[37],"prove":[38],"useful":[39,205],"when":[40,206],"identifying":[41],"patients":[42,59],"at":[43,61],"METHODS:":[47],"prospectively":[49],"studied":[50],"133":[51],"recipients":[53],"over":[54],"12-month":[56],"period.":[57],"Forty-eight":[58],"had":[60],"least":[62],"one":[63],"episode":[64],"severe":[66],"An":[68],"event":[69],"was":[70],"defined":[71],"as":[72],"an":[73,84],"infection":[74,91,213],"requiring":[75],"intravenous":[76],"antimicrobial":[77],"therapy.":[78],"RESULTS:":[79],"Cox":[80,159],"regression":[81,160],"analysis":[82,162],"revealed":[83,163],"association":[85],"between":[86],"developing":[90],"following:":[94],"lower":[95,109,120,128,136,148,165],"IgG2":[96,170],"subclass":[97],"levels":[98,111],"(day":[99,112,124,132,143,151],"7:":[100,113,125,144,152],"relative":[101],"hazard":[102],"[RH]":[103],"1.71;":[104],"day":[105,116,155,166],"30:":[106,117,133,156],"RH":[107,114,118,126,134,145,153,157],"1.76),":[108],"IgA":[110],"1.61;":[115],"1.91),":[119],"complement":[121],"C3":[122,168],"values":[123],"1.25),":[127],"CD3":[129],"absolute":[130,137,173],"counts":[131],"1.10),":[135],"natural":[138],"killer":[139],"[NK]":[140],"cell":[141,175,197],"count":[142,176],"1.24),":[146],"IgG":[149,183,202],"concentrations":[150,203],"1.31;":[154],"1.36).":[158],"bivariate":[161],"7":[167],"levels,":[169],"concentration,":[171],"NK":[174,196],"remained":[177],"significant":[178],"after":[179],"adjustment":[180],"total":[182],"levels.":[184],"CONCLUSIONS:":[185],"Data":[186],"suggest":[187],"early":[189],"immune":[190],"monitoring":[191],"including":[192],"C3,":[193],"IgG2,":[194],"testing":[198],"addition":[200],"to":[201,208],"is":[204],"attempting":[207],"transplant":[216]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}