{"id":"https://openalex.org/W1985872973","doi":"https://doi.org/10.1097/ppo.0000000000000077","title":"The Use of Proton Therapy in the Treatment of Head and Neck Cancers","display_name":"The Use of Proton Therapy in the Treatment of Head and Neck Cancers","publication_year":2014,"publication_date":"2014-11-01","ids":{"openalex":"https://openalex.org/W1985872973","doi":"https://doi.org/10.1097/ppo.0000000000000077","mag":"1985872973","pmid":"https://pubmed.ncbi.nlm.nih.gov/25415689"},"language":"en","primary_location":{"id":"doi:10.1097/ppo.0000000000000077","doi":"https://doi.org/10.1097/ppo.0000000000000077","is_oa":false,"landing_page_url":"https://doi.org/10.1097/ppo.0000000000000077","pdf_url":null,"source":{"id":"https://openalex.org/S4210176243","display_name":"The Cancer Journal","issn_l":"1528-9117","issn":["1528-9117","1540-336X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Cancer Journal","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108358603","display_name":"Peter H. Ahn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter H. Ahn","raw_affiliation_strings":["From the Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA","the Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"the Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009745981","display_name":"John Nicholas Lukens","orcid":"https://orcid.org/0000-0001-7104-413X","observed_orcids":["https://orcid.org/0000-0001-7104-413X"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Nicholas Lukens","raw_affiliation_strings":["the Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016001698","display_name":"Boon-Keng Kevin Teo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Boon-Keng Kevin Teo","raw_affiliation_strings":["the Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110443964","display_name":"Maura L. Kirk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maura Kirk","raw_affiliation_strings":["the Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064825362","display_name":"Alexander Lin","orcid":"https://orcid.org/0000-0003-1254-8324","observed_orcids":["https://orcid.org/0000-0003-1254-8324"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander Lin","raw_affiliation_strings":["the Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":null,"apc_paid":null,"fwci":0.4561,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.37998327,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"20","issue":"6","first_page":"421","last_page":"426"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/proton-therapy","display_name":"proton therapy","score":1.0},{"id":"https://openalex.org/keywords/head-and-neck-cancer","display_name":"head and neck cancer","score":1.0},{"id":"https://openalex.org/keywords/intensity-modulated-proton-therapy","display_name":"intensity-modulated proton therapy","score":0.875},{"id":"https://openalex.org/keywords/pencil-beam-scanning","display_name":"pencil beam scanning","score":0.9340000152587891},{"id":"https://openalex.org/keywords/radiation-toxicity","display_name":"radiation toxicity","score":0.6769999861717224},{"id":"https://openalex.org/keywords/normal-tissue-sparing","display_name":"normal tissue sparing","score":0.9179999828338623},{"id":"https://openalex.org/keywords/adaptive-radiotherapy","display_name":"adaptive radiotherapy","score":0.7409999966621399},{"id":"https://openalex.org/keywords/quality-assurance","display_name":"quality assurance","score":0.7059999704360962},{"id":"https://openalex.org/keywords/disease-control","display_name":"disease control","score":0.4959999918937683},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.9929999709129333}],"concepts":[{"id":"https://openalex.org/C2779244869","wikidata":"https://www.wikidata.org/wiki/Q507667","display_name":"Proton therapy","level":3,"score":0.8627225160598755},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.7878935933113098},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.7734392285346985},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7595763206481934},{"id":"https://openalex.org/C2775881188","wikidata":"https://www.wikidata.org/wiki/Q7162317","display_name":"Pencil-beam scanning","level":4,"score":0.6528857350349426},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.5256891250610352},{"id":"https://openalex.org/C3018411727","wikidata":"https://www.wikidata.org/wiki/Q3867488","display_name":"Head and neck","level":2,"score":0.47462689876556396},{"id":"https://openalex.org/C201645570","wikidata":"https://www.wikidata.org/wiki/Q830637","display_name":"Radiation treatment planning","level":3,"score":0.4250427782535553},{"id":"https://openalex.org/C2778418280","wikidata":"https://www.wikidata.org/wiki/Q38276304","display_name":"Particle therapy","level":3,"score":0.41153115034103394},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.4006451666355133},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.3316107988357544},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.19701015949249268}],"mesh":[{"descriptor_ui":"D002813","descriptor_name":"Chondrosarcoma","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D002817","descriptor_name":"Chordoma","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009959","descriptor_name":"Oropharyngeal Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D010255","descriptor_name":"Paranasal Sinus Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D011829","descriptor_name":"Radiation Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011880","descriptor_name":"Radiotherapy Planning, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018714","descriptor_name":"Radiotherapy, Adjuvant","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019292","descriptor_name":"Skull Base Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D030361","descriptor_name":"Papillomavirus Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D056888","descriptor_name":"Patient Positioning","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D061766","descriptor_name":"Proton Therapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D061766","descriptor_name":"Proton Therapy","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":true},{"descriptor_ui":"D061766","descriptor_name":"Proton Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/ppo.0000000000000077","doi":"https://doi.org/10.1097/ppo.0000000000000077","is_oa":false,"landing_page_url":"https://doi.org/10.1097/ppo.0000000000000077","pdf_url":null,"source":{"id":"https://openalex.org/S4210176243","display_name":"The Cancer Journal","issn_l":"1528-9117","issn":["1528-9117","1540-336X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Cancer Journal","raw_type":"journal-article"},{"id":"pmid:25415689","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25415689","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer journal (Sudbury, Mass.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9790999889373779,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W1649893202","https://openalex.org/W1968218090","https://openalex.org/W1973808938","https://openalex.org/W1976594584","https://openalex.org/W1979169907","https://openalex.org/W1981576515","https://openalex.org/W1983869432","https://openalex.org/W1984541015","https://openalex.org/W1986493711","https://openalex.org/W1988936862","https://openalex.org/W1994572649","https://openalex.org/W2015091362","https://openalex.org/W2018844481","https://openalex.org/W2024409025","https://openalex.org/W2025555885","https://openalex.org/W2029537185","https://openalex.org/W2029728138","https://openalex.org/W2029753133","https://openalex.org/W2032968239","https://openalex.org/W2050196300","https://openalex.org/W2052020668","https://openalex.org/W2060017885","https://openalex.org/W2064712772","https://openalex.org/W2066616656","https://openalex.org/W2070982653","https://openalex.org/W2072818743","https://openalex.org/W2075121774","https://openalex.org/W2075173808","https://openalex.org/W2092201288","https://openalex.org/W2096267659","https://openalex.org/W2100961085","https://openalex.org/W2110664940","https://openalex.org/W2110876229","https://openalex.org/W2112155597","https://openalex.org/W2112915889","https://openalex.org/W2113092282","https://openalex.org/W2116867754","https://openalex.org/W2119302956","https://openalex.org/W2120068217","https://openalex.org/W2122097462","https://openalex.org/W2122237708","https://openalex.org/W2124891284","https://openalex.org/W2125401374","https://openalex.org/W2125919881","https://openalex.org/W2127494183","https://openalex.org/W2129121210","https://openalex.org/W2137898685","https://openalex.org/W2141313402","https://openalex.org/W2142222095","https://openalex.org/W2144586199","https://openalex.org/W2144674549","https://openalex.org/W2145078756","https://openalex.org/W2151404455","https://openalex.org/W2154592481","https://openalex.org/W2164874555","https://openalex.org/W2562414697"],"related_works":["https://openalex.org/W4249467111","https://openalex.org/W4403101904","https://openalex.org/W2608005949","https://openalex.org/W2122097462","https://openalex.org/W3170412332","https://openalex.org/W2044130197","https://openalex.org/W3041312056","https://openalex.org/W2750320583","https://openalex.org/W4200036212","https://openalex.org/W4239260373"],"abstract_inverted_index":{"External":[0],"beam":[1,34,108],"radiation":[2,35,55,89,157],"therapy":[3,36,140],"is":[4],"a":[5,65,160],"commonly":[6],"utilized":[7],"treatment":[8,70],"modality":[9],"in":[10,39,68,126],"the":[11,19,30,69,78,95,133],"management":[12],"of":[13,22,32,61,71,83,98,115,138,171],"head":[14,73,142],"and":[15,28,42,74,118,136,143,169],"neck":[16,75,144],"cancer.":[17],"Given":[18],"close":[20],"proximity":[21],"disease":[23,130,167],"to":[24,80,121,124,129,151],"critical":[25],"normal":[26,84],"tissues":[27,85],"structures,":[29],"delivery":[31],"external":[33],"can":[37],"result":[38],"severe":[40],"acute":[41],"late":[43],"toxicities,":[44],"even":[45],"when":[46],"delivered":[47],"with":[48,77,159],"advanced":[49,72,99],"photon-based":[50],"techniques,":[51],"such":[52,101,154,164],"as":[53,102,110,112,155,165],"intensity-modulated":[54,103,156],"therapy.":[56],"The":[57],"unique":[58],"physical":[59],"characteristics":[60],"protons":[62],"make":[63],"it":[64],"promising":[66],"option":[67],"cancer,":[76],"potential":[79],"improve":[81],"sparing":[82],"and/or":[86],"safely":[87],"escalate":[88],"doses.":[90],"Clinical":[91],"implementation":[92,137],"will":[93,146],"require":[94,147],"continued":[96],"development":[97],"techniques":[100,120,153],"proton":[104,139],"therapy,":[105,158],"using":[106],"pencil":[107],"scanning,":[109],"well":[111],"rigorous":[113],"methods":[114],"quality":[116,170],"assurance":[117],"adaptive":[119],"accurately":[122],"adjust":[123],"changes":[125],"anatomy":[127],"due":[128],"response.":[131],"Ultimately,":[132],"widespread":[134],"adaptation":[135],"for":[141],"cancer":[145],"direct,":[148],"prospective":[149],"comparisons":[150],"standard":[152],"focus":[161],"on":[162],"measures":[163],"toxicity,":[166],"control,":[168],"life.":[172]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
