{"id":"https://openalex.org/W1985841545","doi":"https://doi.org/10.1177/1933719112459244","title":"The Extrapituitary Effects of GnRH Antagonists and Their Potential Clinical Implications: A Narrated Review","display_name":"The Extrapituitary Effects of GnRH Antagonists and Their Potential Clinical Implications: A Narrated Review","publication_year":2012,"publication_date":"2012-09-26","ids":{"openalex":"https://openalex.org/W1985841545","doi":"https://doi.org/10.1177/1933719112459244","mag":"1985841545","pmid":"https://pubmed.ncbi.nlm.nih.gov/23012318"},"language":"en","primary_location":{"id":"doi:10.1177/1933719112459244","doi":"https://doi.org/10.1177/1933719112459244","is_oa":false,"landing_page_url":"https://doi.org/10.1177/1933719112459244","pdf_url":null,"source":{"id":"https://openalex.org/S68157034","display_name":"Reproductive Sciences","issn_l":"1933-7191","issn":["1933-7191","1933-7205"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproductive Sciences","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030128369","display_name":"Orkun Tan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I162577319","display_name":"The University of Texas at Dallas","ror":"https://ror.org/049emcs32","country_code":"US","type":"education","lineage":["https://openalex.org/I162577319"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Orkun Tan","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. orkun.tan@utsouthwestern.edu","University of Texas at Dallas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. orkun.tan@utsouthwestern.edu","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"University of Texas at Dallas","institution_ids":["https://openalex.org/I162577319"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103407886","display_name":"Bruce Richard Carr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruce R. Carr","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd. J6, 75390, Dallas, TX, USA","Obstetrics & Gynecology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd. J6, 75390, Dallas, TX, USA","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Obstetrics & Gynecology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063123607","display_name":"Victor E. Beshay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I162577319","display_name":"The University of Texas at Dallas","ror":"https://ror.org/049emcs32","country_code":"US","type":"education","lineage":["https://openalex.org/I162577319"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victor E. Beshay","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd. J6, 75390, Dallas, TX, USA","University of Texas at Dallas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd. J6, 75390, Dallas, TX, USA","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"University of Texas at Dallas","institution_ids":["https://openalex.org/I162577319"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088036401","display_name":"Orhan B\u00fck\u00fclmez","orcid":"https://orcid.org/0009-0000-4251-7604","observed_orcids":["https://orcid.org/0009-0000-4251-7604"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Orhan Bukulmez","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd. J6, 75390, Dallas, TX, USA","Obstetrics & Gynecology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd. J6, 75390, Dallas, TX, USA","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Obstetrics & Gynecology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5030128369"],"corresponding_institution_ids":["https://openalex.org/I162577319","https://openalex.org/I867280407"],"apc_list":{"value":3090,"currency":"USD","value_usd":3090},"apc_paid":null,"fwci":0.3074,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.2141527,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"20","issue":"1","first_page":"16","last_page":"25"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.9351000189781189,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.9351000189781189,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.03700000047683716,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gnrh-antagonist","display_name":"GnRH antagonist","score":0.984000027179718},{"id":"https://openalex.org/keywords/gnrh-receptor","display_name":"GnRH receptor","score":0.6370000243186951},{"id":"https://openalex.org/keywords/granulosa-cells","display_name":"granulosa cells","score":0.9120000004768372},{"id":"https://openalex.org/keywords/endometrial-receptivity","display_name":"endometrial receptivity","score":0.9980000257492065},{"id":"https://openalex.org/keywords/embryo-implantation","display_name":"embryo implantation","score":0.8999999761581421},{"id":"https://openalex.org/keywords/placental-development","display_name":"placental development","score":0.8640000224113464},{"id":"https://openalex.org/keywords/cytotrophoblast-invasion","display_name":"cytotrophoblast invasion","score":0.8650000095367432},{"id":"https://openalex.org/keywords/congenital-malformations","display_name":"congenital malformations","score":0.9539999961853027},{"id":"https://openalex.org/keywords/cardiac-function","display_name":"cardiac function","score":0.5509999990463257}],"concepts":[{"id":"https://openalex.org/C45167389","wikidata":"https://www.wikidata.org/wiki/Q1114520","display_name":"Placentation","level":5,"score":0.8590283393859863},{"id":"https://openalex.org/C2779742232","wikidata":"https://www.wikidata.org/wiki/Q839508","display_name":"Endometrium","level":2,"score":0.6741219162940979},{"id":"https://openalex.org/C2778324911","wikidata":"https://www.wikidata.org/wiki/Q9631","display_name":"Ovary","level":2,"score":0.6098913550376892},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5863845348358154},{"id":"https://openalex.org/C2778894405","wikidata":"https://www.wikidata.org/wiki/Q318896","display_name":"Gonadotropin-releasing hormone","level":4,"score":0.5817080736160278},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5237793326377869},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5195046663284302},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4698100686073303},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.43898436427116394},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.3748430013656616},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.3166828751564026},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31204336881637573},{"id":"https://openalex.org/C2776953305","wikidata":"https://www.wikidata.org/wiki/Q1212935","display_name":"Placenta","level":4,"score":0.29769980907440186},{"id":"https://openalex.org/C2778575703","wikidata":"https://www.wikidata.org/wiki/Q50265477","display_name":"Luteinizing hormone","level":3,"score":0.22587236762046814},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006727","descriptor_name":"Hormone Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006727","descriptor_name":"Hormone Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010053","descriptor_name":"Ovary","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010053","descriptor_name":"Ovary","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010064","descriptor_name":"Embryo Implantation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010064","descriptor_name":"Embryo Implantation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011966","descriptor_name":"Receptors, LHRH","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D011966","descriptor_name":"Receptors, LHRH","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014565","descriptor_name":"Urogenital Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D014565","descriptor_name":"Urogenital Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018873","descriptor_name":"Pregnancy Rate","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D018931","descriptor_name":"Antineoplastic Agents, Hormonal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018931","descriptor_name":"Antineoplastic Agents, Hormonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1177/1933719112459244","doi":"https://doi.org/10.1177/1933719112459244","is_oa":false,"landing_page_url":"https://doi.org/10.1177/1933719112459244","pdf_url":null,"source":{"id":"https://openalex.org/S68157034","display_name":"Reproductive Sciences","issn_l":"1933-7191","issn":["1933-7191","1933-7205"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproductive Sciences","raw_type":"journal-article"},{"id":"pmid:23012318","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23012318","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproductive sciences (Thousand Oaks, Calif.)","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.915.1357","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.915.1357","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rsx.sagepub.com/content/early/2012/09/24/1933719112459244.full.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.933.2321","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.933.2321","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rsx.sagepub.com/content/20/1/16.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":87,"referenced_works":["https://openalex.org/W110566743","https://openalex.org/W1603023934","https://openalex.org/W1767857570","https://openalex.org/W1918938119","https://openalex.org/W1938451549","https://openalex.org/W1951785345","https://openalex.org/W1963761453","https://openalex.org/W1964428652","https://openalex.org/W1966707514","https://openalex.org/W1970039681","https://openalex.org/W1978193519","https://openalex.org/W1979337429","https://openalex.org/W1983793324","https://openalex.org/W1985679508","https://openalex.org/W1999543114","https://openalex.org/W2002788608","https://openalex.org/W2002986164","https://openalex.org/W2003556265","https://openalex.org/W2008002645","https://openalex.org/W2012600128","https://openalex.org/W2013821069","https://openalex.org/W2016998301","https://openalex.org/W2022448263","https://openalex.org/W2029803518","https://openalex.org/W2034254687","https://openalex.org/W2034901953","https://openalex.org/W2038706902","https://openalex.org/W2043136148","https://openalex.org/W2052768984","https://openalex.org/W2061851280","https://openalex.org/W2064264164","https://openalex.org/W2066715261","https://openalex.org/W2070378389","https://openalex.org/W2071161416","https://openalex.org/W2075308247","https://openalex.org/W2076807678","https://openalex.org/W2077697209","https://openalex.org/W2081663477","https://openalex.org/W2085320423","https://openalex.org/W2089670528","https://openalex.org/W2090707309","https://openalex.org/W2098067089","https://openalex.org/W2100196866","https://openalex.org/W2104696616","https://openalex.org/W2105642338","https://openalex.org/W2109325762","https://openalex.org/W2110434847","https://openalex.org/W2111500256","https://openalex.org/W2114201941","https://openalex.org/W2114773867","https://openalex.org/W2117170250","https://openalex.org/W2117381179","https://openalex.org/W2118330723","https://openalex.org/W2119255622","https://openalex.org/W2122080693","https://openalex.org/W2122507908","https://openalex.org/W2123704253","https://openalex.org/W2124091258","https://openalex.org/W2124636437","https://openalex.org/W2125625600","https://openalex.org/W2127368795","https://openalex.org/W2134568054","https://openalex.org/W2134915338","https://openalex.org/W2136216720","https://openalex.org/W2136488022","https://openalex.org/W2138170248","https://openalex.org/W2140905531","https://openalex.org/W2142423961","https://openalex.org/W2142617733","https://openalex.org/W2143968818","https://openalex.org/W2147620271","https://openalex.org/W2150296078","https://openalex.org/W2153083446","https://openalex.org/W2153283433","https://openalex.org/W2153955918","https://openalex.org/W2154559552","https://openalex.org/W2155269388","https://openalex.org/W2157598013","https://openalex.org/W2158827225","https://openalex.org/W2161828674","https://openalex.org/W2162811754","https://openalex.org/W2165316591","https://openalex.org/W2165510178","https://openalex.org/W2165990809","https://openalex.org/W2166874814","https://openalex.org/W2170380565","https://openalex.org/W2422674100"],"related_works":["https://openalex.org/W7100708049","https://openalex.org/W7097153705","https://openalex.org/W1767857570","https://openalex.org/W2126893308","https://openalex.org/W2333583213","https://openalex.org/W2014713908","https://openalex.org/W2005554596","https://openalex.org/W2027889831","https://openalex.org/W2070378389","https://openalex.org/W2472522404"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}