{"id":"https://openalex.org/W1985779313","doi":"https://doi.org/10.1016/s0898-6568(01)00219-4","title":"Role of the amino-terminal domains of MEKKs in the activation of NF\u03baB and MAPK pathways and in the regulation of cell proliferation and apoptosis","display_name":"Role of the amino-terminal domains of MEKKs in the activation of NF\u03baB and MAPK pathways and in the regulation of cell proliferation and apoptosis","publication_year":2002,"publication_date":"2002-02-01","ids":{"openalex":"https://openalex.org/W1985779313","doi":"https://doi.org/10.1016/s0898-6568(01)00219-4","mag":"1985779313","pmid":"https://pubmed.ncbi.nlm.nih.gov/11781136"},"language":"en","primary_location":{"id":"doi:10.1016/s0898-6568(01)00219-4","doi":"https://doi.org/10.1016/s0898-6568(01)00219-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0898-6568(01)00219-4","pdf_url":null,"source":{"id":"https://openalex.org/S113768434","display_name":"Cellular Signalling","issn_l":"0898-6568","issn":["0898-6568","1873-3913"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular Signalling","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057783680","display_name":"Christelle Bonvin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Christelle Bonvin","raw_affiliation_strings":["Institute of Cellular Biology and Morphology, Lausanne University, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cellular Biology and Morphology, Lausanne University, Lausanne, Switzerland","institution_ids":["https://openalex.org/I97565354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030973918","display_name":"Audrey Guillon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Audrey Guillon","raw_affiliation_strings":["Institute of Cellular Biology and Morphology, Lausanne University, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cellular Biology and Morphology, Lausanne University, Lausanne, Switzerland","institution_ids":["https://openalex.org/I97565354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006646521","display_name":"Miguel Xavier Van Bemmelen","orcid":"https://orcid.org/0000-0003-2762-6153","observed_orcids":["https://orcid.org/0000-0003-2762-6153"]},"institutions":[{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Miguel X van Bemmelen","raw_affiliation_strings":["Institute of Cellular Biology and Morphology, Lausanne University, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cellular Biology and Morphology, Lausanne University, Lausanne, Switzerland","institution_ids":["https://openalex.org/I97565354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066856648","display_name":"P\u00e4r Gerwins","orcid":"https://orcid.org/0000-0003-3374-3372","observed_orcids":["https://orcid.org/0000-0003-3374-3372"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"P\u00e4r Gerwins","raw_affiliation_strings":["Department of Genetics and Pathology, The Rudbeck Laboratory, Uppsala University-Sweden of Medical and Physiological Chemistry, Uppsala University, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics and Pathology, The Rudbeck Laboratory, Uppsala University-Sweden of Medical and Physiological Chemistry, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047612906","display_name":"Gary L. Johnson","orcid":"https://orcid.org/0000-0003-2867-0551","observed_orcids":["https://orcid.org/0000-0003-2867-0551"]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary L Johnson","raw_affiliation_strings":["Department of Pharmacology, University of Colorado Medical School, Denver, CO 80262, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Colorado Medical School, Denver, CO 80262, USA","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078049464","display_name":"Christian Widmann","orcid":"https://orcid.org/0000-0002-6881-0363","observed_orcids":["https://orcid.org/0000-0002-6881-0363"]},"institutions":[{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]},{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Christian Widmann","raw_affiliation_strings":["Botnar Unit, Department of Internal Medicine, University Hospital, Lausanne, Switzerland","Institute of Cellular Biology and Morphology, Lausanne University, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Botnar Unit, Department of Internal Medicine, University Hospital, Lausanne, Switzerland","institution_ids":["https://openalex.org/I2802229882"]},{"raw_affiliation_string":"Institute of Cellular Biology and Morphology, Lausanne University, Lausanne, Switzerland","institution_ids":["https://openalex.org/I97565354"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5078049464"],"corresponding_institution_ids":["https://openalex.org/I2802229882","https://openalex.org/I97565354"],"apc_list":{"value":3550,"currency":"USD","value_usd":3550},"apc_paid":null,"fwci":2.6393,"has_fulltext":false,"cited_by_count":63,"citation_normalized_percentile":{"value":0.90323839,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"14","issue":"2","first_page":"123","last_page":"131"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.7148000001907349,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.7148000001907349,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.2093999981880188,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.061000000685453415,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/map3k","display_name":"MAP3K","score":0.8059999942779541},{"id":"https://openalex.org/keywords/n-terminal-domain","display_name":"N-terminal domain","score":0.9139999747276306},{"id":"https://openalex.org/keywords/mapk-erk-kinase","display_name":"MAPK/ERK kinase","score":0.6940000057220459},{"id":"https://openalex.org/keywords/nf-kappab-activation","display_name":"NF-\u03baB activation","score":0.734000027179718},{"id":"https://openalex.org/keywords/mapk-erk-pathway","display_name":"MAPK/ERK pathway","score":0.9160000085830688},{"id":"https://openalex.org/keywords/jnk-mapk-pathway","display_name":"JNK MAPK pathway","score":0.9409999847412109},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7929999828338623},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/protein-kinase-domain","display_name":"kinase domain","score":0.6769999861717224},{"id":"https://openalex.org/keywords/signaling-specificity","display_name":"signaling specificity","score":0.5879999995231628}],"concepts":[{"id":"https://openalex.org/C137361374","wikidata":"https://www.wikidata.org/wiki/Q6714442","display_name":"MAP kinase kinase kinase","level":4,"score":0.7979064583778381},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7178992033004761},{"id":"https://openalex.org/C124160383","wikidata":"https://www.wikidata.org/wiki/Q14914383","display_name":"ASK1","level":5,"score":0.6885616779327393},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.6789261698722839},{"id":"https://openalex.org/C90934575","wikidata":"https://www.wikidata.org/wiki/Q6593810","display_name":"Mitogen-activated protein kinase kinase","level":4,"score":0.6385139226913452},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.6256927251815796},{"id":"https://openalex.org/C159479382","wikidata":"https://www.wikidata.org/wiki/Q18030801","display_name":"MAP2K7","level":5,"score":0.6218242049217224},{"id":"https://openalex.org/C99405784","wikidata":"https://www.wikidata.org/wiki/Q410434","display_name":"c-Raf","level":5,"score":0.5981627702713013},{"id":"https://openalex.org/C59143045","wikidata":"https://www.wikidata.org/wiki/Q15314942","display_name":"Cyclin-dependent kinase 9","level":5,"score":0.5448349714279175},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.49685099720954895},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.45070382952690125},{"id":"https://openalex.org/C132149769","wikidata":"https://www.wikidata.org/wiki/Q899651","display_name":"Mitogen-activated protein kinase","level":3,"score":0.4449474811553955},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4276399314403534},{"id":"https://openalex.org/C82495950","wikidata":"https://www.wikidata.org/wiki/Q14911732","display_name":"Cyclin-dependent kinase 2","level":4,"score":0.41456228494644165},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37587404251098633}],"mesh":[{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017384","descriptor_name":"Sequence Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020930","descriptor_name":"MAP Kinase Kinase Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020930","descriptor_name":"MAP Kinase Kinase Kinases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020930","descriptor_name":"MAP Kinase Kinase Kinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D048031","descriptor_name":"JNK Mitogen-Activated Protein Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048728","descriptor_name":"MAP Kinase Kinase Kinase 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D048730","descriptor_name":"MAP Kinase Kinase Kinase 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048748","descriptor_name":"MAP Kinase Kinase Kinase 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048768","descriptor_name":"MAP Kinase Kinase Kinase 4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/s0898-6568(01)00219-4","doi":"https://doi.org/10.1016/s0898-6568(01)00219-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0898-6568(01)00219-4","pdf_url":null,"source":{"id":"https://openalex.org/S113768434","display_name":"Cellular Signalling","issn_l":"0898-6568","issn":["0898-6568","1873-3913"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular Signalling","raw_type":"journal-article"},{"id":"pmid:11781136","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11781136","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular signalling","raw_type":"Comparative Study"},{"id":"pmh:oai:iris.unil.ch:iris/190900","doi":null,"is_oa":false,"landing_page_url":"https://iris.unil.ch/handle/iris/190900","pdf_url":null,"source":{"id":"https://openalex.org/S7407055444","display_name":"IRIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:serval.unil.ch:BIB_99E542E16596","doi":null,"is_oa":false,"landing_page_url":"https://serval.unil.ch/notice/serval:BIB_99E542E16596","pdf_url":null,"source":{"id":"https://openalex.org/S4306401797","display_name":"SERVAL (Universit\u00e9 de Lausanne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210093590","host_organization_name":"Swiss School of Archaeology in Greece","host_organization_lineage":["https://openalex.org/I4210093590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cellular Signalling, vol. 14, no. 2, pp. 123-31","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"},{"id":"https://openalex.org/F4320326958","display_name":"Fondation Botnar","ror":"https://ror.org/033ztm745"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1547637047","https://openalex.org/W1899552864","https://openalex.org/W1963136808","https://openalex.org/W1964681642","https://openalex.org/W1974907467","https://openalex.org/W1975646272","https://openalex.org/W1976271632","https://openalex.org/W1976385326","https://openalex.org/W1978701756","https://openalex.org/W1979097982","https://openalex.org/W1980823210","https://openalex.org/W1995035611","https://openalex.org/W1999325844","https://openalex.org/W2007939817","https://openalex.org/W2013044374","https://openalex.org/W2024940343","https://openalex.org/W2035301267","https://openalex.org/W2035743526","https://openalex.org/W2061497413","https://openalex.org/W2062412222","https://openalex.org/W2063501226","https://openalex.org/W2076485183","https://openalex.org/W2077880395","https://openalex.org/W2085871516","https://openalex.org/W2089465684","https://openalex.org/W2098719212","https://openalex.org/W2104324075","https://openalex.org/W2107720674","https://openalex.org/W2111252945","https://openalex.org/W2125331084","https://openalex.org/W2157720667"],"related_works":["https://openalex.org/W2013044374","https://openalex.org/W2039842428","https://openalex.org/W1995035611","https://openalex.org/W7097927482","https://openalex.org/W2063501226","https://openalex.org/W2080411043","https://openalex.org/W2063189553","https://openalex.org/W2155034082","https://openalex.org/W2062412222","https://openalex.org/W31124784"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}