{"id":"https://openalex.org/W1985777107","doi":"https://doi.org/10.1161/01.atv.18.3.473","title":"LDL Induces Transcription Factor Activator Protein-1 in Human Endothelial Cells","display_name":"LDL Induces Transcription Factor Activator Protein-1 in Human Endothelial Cells","publication_year":1998,"publication_date":"1998-03-01","ids":{"openalex":"https://openalex.org/W1985777107","doi":"https://doi.org/10.1161/01.atv.18.3.473","mag":"1985777107","pmid":"https://pubmed.ncbi.nlm.nih.gov/9514417"},"language":"en","primary_location":{"id":"doi:10.1161/01.atv.18.3.473","doi":"https://doi.org/10.1161/01.atv.18.3.473","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.atv.18.3.473","pdf_url":null,"source":{"id":"https://openalex.org/S3485792","display_name":"Arteriosclerosis Thrombosis and Vascular Biology","issn_l":"1079-5642","issn":["1079-5642","1524-4636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis, Thrombosis, and Vascular Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062607187","display_name":"Yi Zhu","orcid":"https://orcid.org/0000-0001-7725-9166","observed_orcids":["https://orcid.org/0000-0001-7725-9166"]},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]},{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yi Zhu","raw_affiliation_strings":["From the Division of Biomedical Sciences, University of California, Riverside (Y.Z., H.L.L., O.F., L.V., N.W.M., D.S.S., M.B.S.), and the Department of Pathology, New York Medical College, Valhalla, NY (J.H-C.L.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Biomedical Sciences, University of California, Riverside (Y.Z., H.L.L., O.F., L.V., N.W.M., D.S.S., M.B.S.), and the Department of Pathology, New York Medical College, Valhalla, NY (J.H-C.L.)","institution_ids":["https://openalex.org/I103635307","https://openalex.org/I181190671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111452099","display_name":"Jane H.-C. Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]},{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jane H.-C. Lin","raw_affiliation_strings":["From the Division of Biomedical Sciences, University of California, Riverside (Y.Z., H.L.L., O.F., L.V., N.W.M., D.S.S., M.B.S.), and the Department of Pathology, New York Medical College, Valhalla, NY (J.H-C.L.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Biomedical Sciences, University of California, Riverside (Y.Z., H.L.L., O.F., L.V., N.W.M., D.S.S., M.B.S.), and the Department of Pathology, New York Medical College, Valhalla, NY (J.H-C.L.)","institution_ids":["https://openalex.org/I103635307","https://openalex.org/I181190671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033486796","display_name":"Hailing Liao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]},{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hai-Ling Liao","raw_affiliation_strings":["From the Division of Biomedical Sciences, University of California, Riverside (Y.Z., H.L.L., O.F., L.V., N.W.M., D.S.S., M.B.S.), and the Department of Pathology, New York Medical College, Valhalla, NY (J.H-C.L.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Biomedical Sciences, University of California, Riverside (Y.Z., H.L.L., O.F., L.V., N.W.M., D.S.S., M.B.S.), and the Department of Pathology, New York Medical College, Valhalla, NY (J.H-C.L.)","institution_ids":["https://openalex.org/I103635307","https://openalex.org/I181190671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022927202","display_name":"Otto Friedli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]},{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Otto Friedli","raw_affiliation_strings":["From the Division of Biomedical Sciences, University of California, Riverside (Y.Z., H.L.L., O.F., L.V., N.W.M., D.S.S., M.B.S.), and the Department of Pathology, New York Medical College, Valhalla, NY (J.H-C.L.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Biomedical Sciences, University of California, Riverside (Y.Z., H.L.L., O.F., L.V., N.W.M., D.S.S., M.B.S.), and the Department of Pathology, New York Medical College, Valhalla, NY (J.H-C.L.)","institution_ids":["https://openalex.org/I103635307","https://openalex.org/I181190671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084153205","display_name":"Lynne K. Verna","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]},{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lynne Verna","raw_affiliation_strings":["From the Division of Biomedical Sciences, University of California, Riverside (Y.Z., H.L.L., O.F., L.V., N.W.M., D.S.S., M.B.S.), and the Department of Pathology, New York Medical College, Valhalla, NY (J.H-C.L.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Biomedical Sciences, University of California, Riverside (Y.Z., H.L.L., O.F., L.V., N.W.M., D.S.S., M.B.S.), and the Department of Pathology, New York Medical College, Valhalla, NY (J.H-C.L.)","institution_ids":["https://openalex.org/I103635307","https://openalex.org/I181190671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062430828","display_name":"Norman W. Marten","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]},{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Norman W. Marten","raw_affiliation_strings":["From the Division of Biomedical Sciences, University of California, Riverside (Y.Z., H.L.L., O.F., L.V., N.W.M., D.S.S., M.B.S.), and the Department of Pathology, New York Medical College, Valhalla, NY (J.H-C.L.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Biomedical Sciences, University of California, Riverside (Y.Z., H.L.L., O.F., L.V., N.W.M., D.S.S., M.B.S.), and the Department of Pathology, New York Medical College, Valhalla, NY (J.H-C.L.)","institution_ids":["https://openalex.org/I103635307","https://openalex.org/I181190671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109572296","display_name":"Daniel S. Straus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]},{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel S. Straus","raw_affiliation_strings":["From the Division of Biomedical Sciences, University of California, Riverside (Y.Z., H.L.L., O.F., L.V., N.W.M., D.S.S., M.B.S.), and the Department of Pathology, New York Medical College, Valhalla, NY (J.H-C.L.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Biomedical Sciences, University of California, Riverside (Y.Z., H.L.L., O.F., L.V., N.W.M., D.S.S., M.B.S.), and the Department of Pathology, New York Medical College, Valhalla, NY (J.H-C.L.)","institution_ids":["https://openalex.org/I103635307","https://openalex.org/I181190671"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111617991","display_name":"Michael B. Stemerman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]},{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael B. Stemerman","raw_affiliation_strings":["From the Division of Biomedical Sciences, University of California, Riverside (Y.Z., H.L.L., O.F., L.V., N.W.M., D.S.S., M.B.S.), and the Department of Pathology, New York Medical College, Valhalla, NY (J.H-C.L.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Biomedical Sciences, University of California, Riverside (Y.Z., H.L.L., O.F., L.V., N.W.M., D.S.S., M.B.S.), and the Department of Pathology, New York Medical College, Valhalla, NY (J.H-C.L.)","institution_ids":["https://openalex.org/I103635307","https://openalex.org/I181190671"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.7029,"has_fulltext":false,"cited_by_count":79,"citation_normalized_percentile":{"value":0.90837913,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"18","issue":"3","first_page":"473","last_page":"480"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.5259000062942505,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.5259000062942505,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.32249999046325684,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.07500000298023224,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/low-density-lipoprotein","display_name":"low-density lipoprotein","score":0.9950000047683716},{"id":"https://openalex.org/keywords/activator-protein-1","display_name":"activator protein-1","score":0.9589999914169312},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.7789999842643738},{"id":"https://openalex.org/keywords/c-jun","display_name":"c-Jun","score":0.9269999861717224},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.8830000162124634},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.6669999957084656},{"id":"https://openalex.org/keywords/protein-kinase-signaling","display_name":"protein kinase signaling","score":0.7770000100135803},{"id":"https://openalex.org/keywords/calphostin-c","display_name":"calphostin C","score":0.8980000019073486},{"id":"https://openalex.org/keywords/h89","display_name":"H89","score":0.8389999866485596},{"id":"https://openalex.org/keywords/genistein","display_name":"genistein","score":0.9580000042915344},{"id":"https://openalex.org/keywords/lavendustin-a","display_name":"lavendustin A","score":0.9919999837875366},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.5550000071525574},{"id":"https://openalex.org/keywords/endothelial-activation","display_name":"endothelial activation","score":0.47699999809265137}],"concepts":[{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.6141018271446228},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5530843138694763},{"id":"https://openalex.org/C2780245509","wikidata":"https://www.wikidata.org/wiki/Q5023913","display_name":"Calphostin C","level":4,"score":0.5434056520462036},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.5246981382369995},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5110024213790894},{"id":"https://openalex.org/C2777411675","wikidata":"https://www.wikidata.org/wiki/Q1232438","display_name":"Umbilical vein","level":3,"score":0.5017292499542236},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4928421974182129},{"id":"https://openalex.org/C2780730277","wikidata":"https://www.wikidata.org/wiki/Q24744759","display_name":"Chloramphenicol acetyltransferase","level":5,"score":0.45554226636886597},{"id":"https://openalex.org/C2780043322","wikidata":"https://www.wikidata.org/wiki/Q2705359","display_name":"Phorbol","level":4,"score":0.44129300117492676},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4331291913986206},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38128820061683655},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.28226691484451294},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2318154275417328},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20687854290008545},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.19605016708374023},{"id":"https://openalex.org/C161733203","wikidata":"https://www.wikidata.org/wiki/Q911828","display_name":"Reporter gene","level":4,"score":0.17539525032043457},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09329980611801147},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008077","descriptor_name":"Lipoproteins, LDL","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016755","descriptor_name":"Proto-Oncogene Proteins c-jun","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016755","descriptor_name":"Proto-Oncogene Proteins c-jun","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016760","descriptor_name":"Proto-Oncogene Proteins c-fos","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018808","descriptor_name":"Transcription Factor AP-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019556","descriptor_name":"COS Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1161/01.atv.18.3.473","doi":"https://doi.org/10.1161/01.atv.18.3.473","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.atv.18.3.473","pdf_url":null,"source":{"id":"https://openalex.org/S3485792","display_name":"Arteriosclerosis Thrombosis and Vascular Biology","issn_l":"1079-5642","issn":["1079-5642","1524-4636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis, Thrombosis, and Vascular Biology","raw_type":"journal-article"},{"id":"pmid:9514417","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9514417","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis, thrombosis, and vascular biology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.524.586","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.524.586","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://atvb.ahajournals.org/content/18/3/473.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2168106930","display_name":"ENDOTHELIUM AND VASCULAR FUNCTION","funder_award_id":"P01HL043023","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G535278955","display_name":null,"funder_award_id":"HL 43023","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W142178342","https://openalex.org/W159221804","https://openalex.org/W658098316","https://openalex.org/W1413090982","https://openalex.org/W1537855747","https://openalex.org/W1577403013","https://openalex.org/W1584944565","https://openalex.org/W1692197226","https://openalex.org/W1931341062","https://openalex.org/W1966714249","https://openalex.org/W1968590447","https://openalex.org/W1969785844","https://openalex.org/W1970161435","https://openalex.org/W1977013336","https://openalex.org/W1984903682","https://openalex.org/W1987453246","https://openalex.org/W2000693909","https://openalex.org/W2014431638","https://openalex.org/W2017487826","https://openalex.org/W2024976039","https://openalex.org/W2025480704","https://openalex.org/W2026951979","https://openalex.org/W2030570585","https://openalex.org/W2031805948","https://openalex.org/W2042479492","https://openalex.org/W2046953527","https://openalex.org/W2065257477","https://openalex.org/W2074011532","https://openalex.org/W2078789063","https://openalex.org/W2080486016","https://openalex.org/W2084870400","https://openalex.org/W2093458878","https://openalex.org/W2094872845","https://openalex.org/W2113387942","https://openalex.org/W2114253742","https://openalex.org/W2137570167","https://openalex.org/W2139319526","https://openalex.org/W2156255102","https://openalex.org/W2160678120","https://openalex.org/W2208809877","https://openalex.org/W2410507304","https://openalex.org/W2949031428","https://openalex.org/W4239624232","https://openalex.org/W4242624199"],"related_works":["https://openalex.org/W2006385789","https://openalex.org/W2106600469","https://openalex.org/W7100607202","https://openalex.org/W2019396493","https://openalex.org/W2043461339","https://openalex.org/W2084870400","https://openalex.org/W2000048889","https://openalex.org/W2165674845","https://openalex.org/W2035457973","https://openalex.org/W1756690247"],"abstract_inverted_index":{"Low":[0],"density":[1],"lipoprotein":[2],"(LDL)":[3],"has":[4],"been":[5],"shown":[6,131],"to":[7,22,75,119,160,171,178,238],"perturb":[8],"endothelial":[9,72,220,243],"cells,":[10],"with":[11,45,104],"manifestations":[12],"ranging":[13],"from":[14,223],"alterations":[15],"in":[16,57,68,100],"free":[17],"radicals":[18],"and":[19,26,82,112,137,150,169,203,209,231,251,254,265],"arachidonate":[20],"metabolism":[21],"stress":[23],"fiber":[24],"formation":[25],"monocyte":[27],"recruitment.":[28],"Some":[29],"of":[30],"these":[31],"changes":[32],"are":[33,84,144],"regulated":[34],"by":[35,86,132,146,187],"LDL":[36,217,236,256],"at":[37,154,166],"the":[38,105,113,193,198,204,247],"transcriptional":[39],"level.":[40],"Using":[41],"mobility":[42],"shift":[43],"assays":[44],"consensus":[46],"sequences":[47],"for":[48,173],"various":[49],"transcription":[50,248],"factors,":[51],"we":[52],"have":[53],"detected":[54],"an":[55,219],"increase":[56,124,165],"activator":[58],"protein":[59,163,189],"1":[60],"(AP-1),":[61],"but":[62,127],"not":[63,128,252],"nuclear":[64],"factor-kappaB":[65],"(NF-kappaB),":[66],"binding":[67,123,184],"human":[69,240],"umbilical":[70,241],"vein":[71,242],"cells":[73,244],"exposed":[74],"LDL.":[76,87,120,161,179],"Following":[77],"transfection,":[78],"AP-1-driven":[79],"chloramphenicol":[80,96],"acetyltransferase":[81],"AP-1-driven-luciferase":[83],"upregulated":[85],"In":[88],"contrast,":[89],"there":[90],"is":[91,185,218],"no":[92],"effect":[93],"on":[94],"NF-kappaB-driven":[95],"acetyltransferase.":[97],"AP-1":[98,122,183,250,258],"increases":[99,257],"a":[101],"biphasic":[102],"fashion,":[103],"first":[106],"peak":[107],"occurring":[108],"6":[109],"hours":[110,116,148,157,168,175],"after":[111,117,149,158,176],"second":[114],"48":[115],"exposure":[118,159,177],"This":[121,212],"involves":[125],"c-Jun,":[126],"c-Fos,":[129],"as":[130,228],"gel":[133],"supershift,":[134],"Northern":[135],"hybridization,":[136],"Western":[138],"blotting":[139],"analyses.":[140],"c-Jun":[141,162,266],"mRNA":[142],"levels":[143,164],"elevated":[145],"9":[147],"remain":[151],"so":[152],"until":[153],"least":[155],"24":[156,174],"12":[167],"continue":[170],"rise":[172],"Moreover,":[180],"this":[181],"LDL-increased":[182],"suppressed":[186],"several":[188],"kinase":[190,263],"(PK)":[191],"inhibitors:":[192],"PKC":[194],"inhibitor":[195,201],"calphostin":[196],"C,":[197],"cAMP-dependent":[199],"PK":[200,206],"H89,":[202],"tyrosine":[205],"inhibitors":[207],"genistein":[208],"lavendustin":[210],"A.":[211],"study":[213],"demonstrates":[214],"that":[215],"(1)":[216],"agonist":[221],"distinct":[222],"other":[224],"cell":[225],"stimulators,":[226],"such":[227],"cytokines,":[229],"endotoxin,":[230],"phorbol":[232],"12-myristate":[233],"13-acetate,":[234],"because":[235],"appears":[237],"activate":[239],"predominantly":[245],"through":[246],"factor":[249],"NF-kappaB;":[253],"(2)":[255],"via":[259],"mechanisms":[260],"involving":[261],"multiple":[262],"activities":[264],"transcription.":[267]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
