{"id":"https://openalex.org/W1985697512","doi":"https://doi.org/10.1097/00000542-199309000-00009","title":"Clonidine Comparably Decreases the Thermoregulatory Thresholds for Vasoconstriction and Shivering in Humans","display_name":"Clonidine Comparably Decreases the Thermoregulatory Thresholds for Vasoconstriction and Shivering in Humans","publication_year":1993,"publication_date":"1993-09-01","ids":{"openalex":"https://openalex.org/W1985697512","doi":"https://doi.org/10.1097/00000542-199309000-00009","mag":"1985697512","pmid":"https://pubmed.ncbi.nlm.nih.gov/8363071"},"language":"en","primary_location":{"id":"doi:10.1097/00000542-199309000-00009","doi":"https://doi.org/10.1097/00000542-199309000-00009","is_oa":true,"landing_page_url":"https://doi.org/10.1097/00000542-199309000-00009","pdf_url":"https://pubs.asahq.org/anesthesiology/article-pdf/79/3/470/603430/0000542-199309000-00009.pdf","source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://pubs.asahq.org/anesthesiology/article-pdf/79/3/470/603430/0000542-199309000-00009.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073587016","display_name":"Laurent Delaunay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019246885","display_name":"Centre Hospitalier Universitaire Henri-Mondor","ror":"https://ror.org/04m61mj84","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019246885"]},{"id":"https://openalex.org/I4210130325","display_name":"H\u00f4pitaux Universitaires Henri-Mondor","ror":"https://ror.org/033yb0967","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210130325"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Laurent Delaunay","raw_affiliation_strings":["Associate Professor of Anesthesia, D\u00e9partement d'Anesth\u00e9sie R\u00e9animation, H\u00f4pital Henri Mondor"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Associate Professor of Anesthesia, D\u00e9partement d'Anesth\u00e9sie R\u00e9animation, H\u00f4pital Henri Mondor","institution_ids":["https://openalex.org/I3019246885","https://openalex.org/I4210130325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065601279","display_name":"Francis J. Bonnet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019246885","display_name":"Centre Hospitalier Universitaire Henri-Mondor","ror":"https://ror.org/04m61mj84","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019246885"]},{"id":"https://openalex.org/I4210130325","display_name":"H\u00f4pitaux Universitaires Henri-Mondor","ror":"https://ror.org/033yb0967","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210130325"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Francis Bonnet","raw_affiliation_strings":["Professor of Anesthesia, D\u00e9partement d'Anesth\u00e9sie R\u00e9animation, H\u00f4pital Henri Mondor"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Professor of Anesthesia, D\u00e9partement d'Anesth\u00e9sie R\u00e9animation, H\u00f4pital Henri Mondor","institution_ids":["https://openalex.org/I3019246885","https://openalex.org/I4210130325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029260939","display_name":"Ngai Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019246885","display_name":"Centre Hospitalier Universitaire Henri-Mondor","ror":"https://ror.org/04m61mj84","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019246885"]},{"id":"https://openalex.org/I4210130325","display_name":"H\u00f4pitaux Universitaires Henri-Mondor","ror":"https://ror.org/033yb0967","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210130325"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Ngai Liu","raw_affiliation_strings":["Associate Professor of Anesthesia, D\u00e9partement d'Anesth\u00e9sie R\u00e9animation, H\u00f4pital Henri Mondor"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Associate Professor of Anesthesia, D\u00e9partement d'Anesth\u00e9sie R\u00e9animation, H\u00f4pital Henri Mondor","institution_ids":["https://openalex.org/I3019246885","https://openalex.org/I4210130325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068627424","display_name":"Laurent Beydon","orcid":"https://orcid.org/0000-0001-6060-1623","observed_orcids":["https://orcid.org/0000-0001-6060-1623"]},"institutions":[{"id":"https://openalex.org/I3019246885","display_name":"Centre Hospitalier Universitaire Henri-Mondor","ror":"https://ror.org/04m61mj84","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019246885"]},{"id":"https://openalex.org/I4210130325","display_name":"H\u00f4pitaux Universitaires Henri-Mondor","ror":"https://ror.org/033yb0967","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210130325"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Laurent Beydon","raw_affiliation_strings":["Associate Professor of Anesthesia, D\u00e9partement d'Anesth\u00e9sie R\u00e9animation, H\u00f4pital Henri Mondor"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Associate Professor of Anesthesia, D\u00e9partement d'Anesth\u00e9sie R\u00e9animation, H\u00f4pital Henri Mondor","institution_ids":["https://openalex.org/I3019246885","https://openalex.org/I4210130325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111756410","display_name":"Patrick Catoire","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019246885","display_name":"Centre Hospitalier Universitaire Henri-Mondor","ror":"https://ror.org/04m61mj84","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019246885"]},{"id":"https://openalex.org/I4210130325","display_name":"H\u00f4pitaux Universitaires Henri-Mondor","ror":"https://ror.org/033yb0967","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210130325"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Patrick Catoire","raw_affiliation_strings":["Associate Professor of Anesthesia, D\u00e9partement d'Anesth\u00e9sie R\u00e9animation, H\u00f4pital Henri Mondor"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Associate Professor of Anesthesia, D\u00e9partement d'Anesth\u00e9sie R\u00e9animation, H\u00f4pital Henri Mondor","institution_ids":["https://openalex.org/I3019246885","https://openalex.org/I4210130325"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042996287","display_name":"Daniel I. Sessler","orcid":"https://orcid.org/0000-0001-9932-3077","observed_orcids":["https://orcid.org/0000-0001-9932-3077"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel\u00a0I. Sessler","raw_affiliation_strings":["Associate Professor of Anesthesia, Department of Anesthesia, University of California, San Francisco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Associate Professor of Anesthesia, Department of Anesthesia, University of California, San Francisco","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.5021,"has_fulltext":false,"cited_by_count":153,"citation_normalized_percentile":{"value":0.92127739,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":99},"biblio":{"volume":"79","issue":"3","first_page":"470","last_page":"474"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11861","display_name":"Thermal Regulation in Medicine","score":0.7734000086784363,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11861","display_name":"Thermal Regulation in Medicine","score":0.7734000086784363,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11109","display_name":"Thermoregulation and physiological responses","score":0.21780000627040863,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clonidine","display_name":"clonidine","score":1.0},{"id":"https://openalex.org/keywords/thermoregulation","display_name":"thermoregulation","score":0.9390000104904175},{"id":"https://openalex.org/keywords/shivering","display_name":"shivering","score":0.7549999952316284},{"id":"https://openalex.org/keywords/vasoconstriction","display_name":"vasoconstriction","score":0.9509999752044678},{"id":"https://openalex.org/keywords/cold-exposure","display_name":"cold exposure","score":0.5960000157356262},{"id":"https://openalex.org/keywords/postoperative-shivering","display_name":"postoperative shivering","score":0.796999990940094},{"id":"https://openalex.org/keywords/skin-temperature-gradient","display_name":"skin temperature gradient","score":0.6029999852180481},{"id":"https://openalex.org/keywords/oxygen-consumption","display_name":"oxygen consumption","score":0.7440000176429749}],"concepts":[{"id":"https://openalex.org/C2781258859","wikidata":"https://www.wikidata.org/wiki/Q1060890","display_name":"Shivering","level":2,"score":0.9582982659339905},{"id":"https://openalex.org/C2778399450","wikidata":"https://www.wikidata.org/wiki/Q412221","display_name":"Clonidine","level":2,"score":0.8761995434761047},{"id":"https://openalex.org/C2779961880","wikidata":"https://www.wikidata.org/wiki/Q1067506","display_name":"Vasoconstriction","level":2,"score":0.8133989572525024},{"id":"https://openalex.org/C100564792","wikidata":"https://www.wikidata.org/wiki/Q190259","display_name":"Thermoregulation","level":2,"score":0.7711095809936523},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7501847743988037},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.7499754428863525},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1910439431667328}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001833","descriptor_name":"Body Temperature Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001833","descriptor_name":"Body Temperature Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003000","descriptor_name":"Clonidine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012768","descriptor_name":"Shivering","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012768","descriptor_name":"Shivering","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014661","descriptor_name":"Vasoconstriction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014661","descriptor_name":"Vasoconstriction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00000542-199309000-00009","doi":"https://doi.org/10.1097/00000542-199309000-00009","is_oa":true,"landing_page_url":"https://doi.org/10.1097/00000542-199309000-00009","pdf_url":"https://pubs.asahq.org/anesthesiology/article-pdf/79/3/470/603430/0000542-199309000-00009.pdf","source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},{"id":"pmid:8363071","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8363071","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"Clinical Trial"}],"best_oa_location":{"id":"doi:10.1097/00000542-199309000-00009","doi":"https://doi.org/10.1097/00000542-199309000-00009","is_oa":true,"landing_page_url":"https://doi.org/10.1097/00000542-199309000-00009","pdf_url":"https://pubs.asahq.org/anesthesiology/article-pdf/79/3/470/603430/0000542-199309000-00009.pdf","source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G8837788875","display_name":"PERIANETHETIC TREMOR AND THERMOREGULATION","funder_award_id":"R29GM039723","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1985697512.pdf","grobid_xml":"https://content.openalex.org/works/W1985697512.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W431385366","https://openalex.org/W2025203122","https://openalex.org/W2141362232","https://openalex.org/W2194239393","https://openalex.org/W2039979982","https://openalex.org/W2030400586","https://openalex.org/W1864032968","https://openalex.org/W2129518263","https://openalex.org/W2417729757","https://openalex.org/W2010447217"],"abstract_inverted_index":{"BACKGROUND:":[0],"Clonidine":[1,13],"stops":[2],"postoperative":[3],"shivering,":[4],"but":[5],"its":[6],"underlying":[7],"mechanism":[8],"of":[9,18,143,176],"action":[10],"is":[11],"unknown.":[12],"may":[14],"impair":[15],"central":[16,44,140],"control":[17],"thermoregulation":[19],"or":[20,180],"act":[21],"on":[22],"peripheral":[23],"receptors.":[24],"Accordingly,":[25],"the":[26,29,35,53,120,123,186],"authors":[27],"tested":[28],"hypothesis":[30],"that":[31],"clonidine":[32,179,193],"reduces":[33],"both":[34],"vasoconstriction":[36,56,111],"and":[37,112,136,167,197],"shivering":[38,88,115,187],"thresholds,":[39],"a":[40,83,93,131,181],"pattern":[41],"consistent":[42],"with":[43,82],"thermoregulatory":[45,125],"impairment.":[46],"METHODS:":[47],"Seven":[48],"healthy":[49],"volunteers":[50],"participated":[51],"in":[52],"study.":[54],"Thermoregulatory":[55],"was":[57,80,89,153,194],"evaluated":[58,91,154],"using":[59,92],"forearm":[60],"minus":[61],"fingertip,":[62],"skin-temperature":[63],"gradients;":[64],"values":[65],"exceeding":[66],"4":[67,148],"degrees":[68,149],"C":[69],"were":[70,116,128,165],"considered":[71,117],"to":[72,101,118,170,201],"be":[73,119],"significant":[74,110],"vasoconstriction.":[75],"Systemic":[76],"oxygen":[77],"consumption":[78],"(VO2)":[79],"measured":[81],"canopy":[84],"system.":[85],"In":[86],"addition,":[87],"qualitatively":[90],"simple":[94],"scale,":[95],"graduated":[96],"from":[97],"0":[98],"(no":[99],"shivering)":[100],"2":[102],"(intense":[103],"shivering).":[104],"The":[105],"tympanic":[106],"membrane":[107],"temperatures":[108],"triggering":[109],"grade":[113],"1":[114],"thresholds":[121],"for":[122],"two":[124,156],"responses.":[126],"Measurements":[127],"performed":[129],"after":[130],"10-min":[132],"steady":[133],"state":[134],"period":[135],"during":[137],"cooling":[138],"by":[139,159],"venous":[141],"infusion":[142],"Ringer's":[144],"lactate":[145],"solution":[146],"at":[147,155,160],"C.":[150],"Each":[151],"subject":[152],"sessions,":[157],"separated":[158],"least":[161],"48":[162],"h.":[163],"They":[164],"randomly":[166],"blindly":[168],"assigned":[169],"received":[171],"either":[172],"an":[173],"intravenous":[174],"bolus":[175],"75":[177,191],"micrograms":[178,192],"placebo":[182],"before":[183],"cooling.":[184],"When":[185],"score":[188],"equaled":[189],"2,":[190],"injected":[195],"intravenously,":[196],"repeated":[198],"if":[199],"necessary,":[200],"completely":[202],"stop":[203],"shivering.":[204]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}