{"id":"https://openalex.org/W1985694376","doi":"https://doi.org/10.1016/0014-5793(80)81223-3","title":"WHHL\u2010Rabbit: a low density lipoprotein receptor\u2010deficient animal model for familial hypercholesterolemia","display_name":"WHHL\u2010Rabbit: a low density lipoprotein receptor\u2010deficient animal model for familial hypercholesterolemia","publication_year":1980,"publication_date":"1980-08-25","ids":{"openalex":"https://openalex.org/W1985694376","doi":"https://doi.org/10.1016/0014-5793(80)81223-3","mag":"1985694376","pmid":"https://pubmed.ncbi.nlm.nih.gov/7409195"},"language":"en","primary_location":{"id":"doi:10.1016/0014-5793(80)81223-3","doi":"https://doi.org/10.1016/0014-5793(80)81223-3","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0014-5793(80)81223-3","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/0014-5793%2880%2981223-3","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/0014-5793%2880%2981223-3","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112323991","display_name":"Kazuhiko Tanzawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104626","display_name":"Daiichi-Sankyo (Japan)","ror":"https://ror.org/027y26122","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210104626"]},{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuhiko Tanzawa","raw_affiliation_strings":["Experimental Animal Laboratory, School of Medicine, University of Kobe, Kusunoki-cho, Ikuta-ku, Kobe 650, Japan","Fermentation Research Laboratories, Sankyo Co., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Animal Laboratory, School of Medicine, University of Kobe, Kusunoki-cho, Ikuta-ku, Kobe 650, Japan","institution_ids":["https://openalex.org/I65837984"]},{"raw_affiliation_string":"Fermentation Research Laboratories, Sankyo Co., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140 Japan","institution_ids":["https://openalex.org/I4210104626"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yoko Shimada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104626","display_name":"Daiichi-Sankyo (Japan)","ror":"https://ror.org/027y26122","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210104626"]},{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoko Shimada","raw_affiliation_strings":["Experimental Animal Laboratory, School of Medicine, University of Kobe, Kusunoki-cho, Ikuta-ku, Kobe 650, Japan","Fermentation Research Laboratories, Sankyo Co., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Animal Laboratory, School of Medicine, University of Kobe, Kusunoki-cho, Ikuta-ku, Kobe 650, Japan","institution_ids":["https://openalex.org/I65837984"]},{"raw_affiliation_string":"Fermentation Research Laboratories, Sankyo Co., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140 Japan","institution_ids":["https://openalex.org/I4210104626"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Masao Kuroda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104626","display_name":"Daiichi-Sankyo (Japan)","ror":"https://ror.org/027y26122","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210104626"]},{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masao Kuroda","raw_affiliation_strings":["Experimental Animal Laboratory, School of Medicine, University of Kobe, Kusunoki-cho, Ikuta-ku, Kobe 650, Japan","Fermentation Research Laboratories, Sankyo Co., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Animal Laboratory, School of Medicine, University of Kobe, Kusunoki-cho, Ikuta-ku, Kobe 650, Japan","institution_ids":["https://openalex.org/I65837984"]},{"raw_affiliation_string":"Fermentation Research Laboratories, Sankyo Co., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140 Japan","institution_ids":["https://openalex.org/I4210104626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111519067","display_name":"Yoshio Tsujita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104626","display_name":"Daiichi-Sankyo (Japan)","ror":"https://ror.org/027y26122","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210104626"]},{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshio Tsujita","raw_affiliation_strings":["Experimental Animal Laboratory, School of Medicine, University of Kobe, Kusunoki-cho, Ikuta-ku, Kobe 650, Japan","Fermentation Research Laboratories, Sankyo Co., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Animal Laboratory, School of Medicine, University of Kobe, Kusunoki-cho, Ikuta-ku, Kobe 650, Japan","institution_ids":["https://openalex.org/I65837984"]},{"raw_affiliation_string":"Fermentation Research Laboratories, Sankyo Co., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140 Japan","institution_ids":["https://openalex.org/I4210104626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108250272","display_name":"MAMORU ARAI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104626","display_name":"Daiichi-Sankyo (Japan)","ror":"https://ror.org/027y26122","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210104626"]},{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mamoru Arai","raw_affiliation_strings":["Experimental Animal Laboratory, School of Medicine, University of Kobe, Kusunoki-cho, Ikuta-ku, Kobe 650, Japan","Fermentation Research Laboratories, Sankyo Co., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Animal Laboratory, School of Medicine, University of Kobe, Kusunoki-cho, Ikuta-ku, Kobe 650, Japan","institution_ids":["https://openalex.org/I65837984"]},{"raw_affiliation_string":"Fermentation Research Laboratories, Sankyo Co., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140 Japan","institution_ids":["https://openalex.org/I4210104626"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014227548","display_name":"H Watanabe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104626","display_name":"Daiichi-Sankyo (Japan)","ror":"https://ror.org/027y26122","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210104626"]},{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hoshio Watanabe","raw_affiliation_strings":["Experimental Animal Laboratory, School of Medicine, University of Kobe, Kusunoki-cho, Ikuta-ku, Kobe 650, Japan","Fermentation Research Laboratories, Sankyo Co., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Animal Laboratory, School of Medicine, University of Kobe, Kusunoki-cho, Ikuta-ku, Kobe 650, Japan","institution_ids":["https://openalex.org/I65837984"]},{"raw_affiliation_string":"Fermentation Research Laboratories, Sankyo Co., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140 Japan","institution_ids":["https://openalex.org/I4210104626"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3980,"currency":"USD","value_usd":3980},"apc_paid":null,"fwci":5.245,"has_fulltext":true,"cited_by_count":194,"citation_normalized_percentile":{"value":0.96826439,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"118","issue":"1","first_page":"81","last_page":"84"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.5479000210762024,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.5479000210762024,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.44040000438690186,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/whhl-rabbits","display_name":"WHHL rabbits","score":0.8069999814033508},{"id":"https://openalex.org/keywords/ldl-receptor","display_name":"LDL receptor","score":0.8970000147819519},{"id":"https://openalex.org/keywords/familial-hypercholesterolemia","display_name":"familial hypercholesterolemia","score":0.9959999918937683},{"id":"https://openalex.org/keywords/animal-models","display_name":"animal models","score":0.9210000038146973},{"id":"https://openalex.org/keywords/hypercholesterolemia","display_name":"hypercholesterolemia","score":0.7630000114440918},{"id":"https://openalex.org/keywords/lipoprotein-metabolism","display_name":"lipoprotein metabolism","score":0.6510000228881836}],"concepts":[{"id":"https://openalex.org/C2778117688","wikidata":"https://www.wikidata.org/wiki/Q264024","display_name":"Animal model","level":2,"score":0.5470247864723206},{"id":"https://openalex.org/C2779120738","wikidata":"https://www.wikidata.org/wiki/Q2711291","display_name":"Familial hypercholesterolemia","level":3,"score":0.47729671001434326},{"id":"https://openalex.org/C3020000481","wikidata":"https://www.wikidata.org/wiki/Q38344","display_name":"Experimental animal","level":2,"score":0.44706398248672485},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4015406668186188},{"id":"https://openalex.org/C161191863","wikidata":"https://www.wikidata.org/wiki/Q199655","display_name":"Library science","level":1,"score":0.39519959688186646},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20811322331428528},{"id":"https://openalex.org/C42972112","wikidata":"https://www.wikidata.org/wiki/Q170201","display_name":"Veterinary medicine","level":1,"score":0.20416921377182007},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.07007846236228943},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006903","descriptor_name":"Hydroxymethylglutaryl CoA Reductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006938","descriptor_name":"Hyperlipoproteinemia Type II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008077","descriptor_name":"Lipoproteins, LDL","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011955","descriptor_name":"Receptors, Drug","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0014-5793(80)81223-3","doi":"https://doi.org/10.1016/0014-5793(80)81223-3","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0014-5793(80)81223-3","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/0014-5793%2880%2981223-3","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},{"id":"pmid:7409195","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7409195","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS letters","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/0014-5793(80)81223-3","doi":"https://doi.org/10.1016/0014-5793(80)81223-3","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0014-5793(80)81223-3","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/0014-5793%2880%2981223-3","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1985694376.pdf","grobid_xml":"https://content.openalex.org/works/W1985694376.grobid-xml"},"referenced_works_count":14,"referenced_works":["https://openalex.org/W8124201","https://openalex.org/W1952062893","https://openalex.org/W1972677139","https://openalex.org/W1981704568","https://openalex.org/W2032731208","https://openalex.org/W2049023634","https://openalex.org/W2061584802","https://openalex.org/W2076907924","https://openalex.org/W2084779432","https://openalex.org/W2085649019","https://openalex.org/W2135503869","https://openalex.org/W2156799866","https://openalex.org/W2414857663","https://openalex.org/W3145894777"],"related_works":["https://openalex.org/W151077279","https://openalex.org/W2412691080","https://openalex.org/W2004854768","https://openalex.org/W2323726105","https://openalex.org/W2085648828","https://openalex.org/W2325626026","https://openalex.org/W2313187379","https://openalex.org/W1975648628","https://openalex.org/W2606189281","https://openalex.org/W3149064297"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}