{"id":"https://openalex.org/W1985693198","doi":"https://doi.org/10.1126/science.1163267","title":"Cardiogenesis and the Complex Biology of Regenerative Cardiovascular Medicine","display_name":"Cardiogenesis and the Complex Biology of Regenerative Cardiovascular Medicine","publication_year":2008,"publication_date":"2008-12-04","ids":{"openalex":"https://openalex.org/W1985693198","doi":"https://doi.org/10.1126/science.1163267","mag":"1985693198","pmid":"https://pubmed.ncbi.nlm.nih.gov/19056974"},"language":"en","primary_location":{"id":"doi:10.1126/science.1163267","doi":"https://doi.org/10.1126/science.1163267","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.1163267","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107559060","display_name":"Kenneth R. Chien","orcid":"https://orcid.org/0000-0002-2759-8378","observed_orcids":["https://orcid.org/0000-0002-2759-8378"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210157861","display_name":"Harvard Stem Cell Institute","ror":"https://ror.org/04kj1hn59","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kenneth R. Chien","raw_affiliation_strings":["Department of Stem Cell and Regenerative Biology, Harvard University and the Harvard Stem Cell Institute, Cambridge, MA 02138, USA","Disease Biophysics Group, School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA","MGH Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stem Cell and Regenerative Biology, Harvard University and the Harvard Stem Cell Institute, Cambridge, MA 02138, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]},{"raw_affiliation_string":"Disease Biophysics Group, School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"MGH Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088957999","display_name":"Ibrahim John Domian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210157861","display_name":"Harvard Stem Cell Institute","ror":"https://ror.org/04kj1hn59","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ibrahim J. Domian","raw_affiliation_strings":["Department of Stem Cell and Regenerative Biology, Harvard University and the Harvard Stem Cell Institute, Cambridge, MA 02138, USA","Disease Biophysics Group, School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA","MGH Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stem Cell and Regenerative Biology, Harvard University and the Harvard Stem Cell Institute, Cambridge, MA 02138, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]},{"raw_affiliation_string":"Disease Biophysics Group, School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"MGH Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028204678","display_name":"Kevin Kit Parker","orcid":"https://orcid.org/0000-0002-5968-7535","observed_orcids":["https://orcid.org/0000-0002-5968-7535"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210157861","display_name":"Harvard Stem Cell Institute","ror":"https://ror.org/04kj1hn59","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin Kit Parker","raw_affiliation_strings":["Department of Stem Cell and Regenerative Biology, Harvard University and the Harvard Stem Cell Institute, Cambridge, MA 02138, USA","Disease Biophysics Group, School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA","MGH Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stem Cell and Regenerative Biology, Harvard University and the Harvard Stem Cell Institute, Cambridge, MA 02138, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]},{"raw_affiliation_string":"Disease Biophysics Group, School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"MGH Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA","institution_ids":["https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5107559060"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210157861"],"apc_list":null,"apc_paid":null,"fwci":2.2253,"has_fulltext":false,"cited_by_count":246,"citation_normalized_percentile":{"value":0.90327056,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":100},"biblio":{"volume":"322","issue":"5907","first_page":"1494","last_page":"1497"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heart-development","display_name":"heart development","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cardiac-progenitor-cells","display_name":"cardiac progenitor cells","score":0.9810000061988831},{"id":"https://openalex.org/keywords/multipotent-progenitors","display_name":"multipotent progenitors","score":0.6869999766349792},{"id":"https://openalex.org/keywords/coronary-vasculature","display_name":"coronary vasculature","score":0.8830000162124634},{"id":"https://openalex.org/keywords/non-cell-autonomous-signaling","display_name":"non-cell-autonomous signaling","score":0.8169999718666077},{"id":"https://openalex.org/keywords/cardiac-tissue-engineering","display_name":"cardiac tissue engineering","score":0.5839999914169312},{"id":"https://openalex.org/keywords/patient-specific-cell-models","display_name":"patient-specific cell models","score":0.6700000166893005}],"concepts":[{"id":"https://openalex.org/C10854531","wikidata":"https://www.wikidata.org/wiki/Q1061415","display_name":"Regenerative medicine","level":3,"score":0.7960008382797241},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.7235422730445862},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5670115351676941},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5230454206466675},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.49987292289733887},{"id":"https://openalex.org/C2991719091","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell biology","level":5,"score":0.4839763641357422},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4806424677371979},{"id":"https://openalex.org/C183074962","wikidata":"https://www.wikidata.org/wiki/Q213713","display_name":"Developmental biology","level":2,"score":0.44557100534439087},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.41775619983673096},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.4170586168766022},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39012205600738525},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3110429346561432},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12403488159179688},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.0},{"id":"https://openalex.org/C2994278967","wikidata":"https://www.wikidata.org/wiki/Q7314318","display_name":"Reproductive technology","level":4,"score":0.0},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003331","descriptor_name":"Coronary Vessels","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D003331","descriptor_name":"Coronary Vessels","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D003331","descriptor_name":"Coronary Vessels","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D006329","descriptor_name":"Heart Conduction System","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D006329","descriptor_name":"Heart Conduction System","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006329","descriptor_name":"Heart Conduction System","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D012038","descriptor_name":"Regeneration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023822","descriptor_name":"Tissue Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024510","descriptor_name":"Muscle Development","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D038081","descriptor_name":"Organogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D039902","descriptor_name":"Multipotent Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D039902","descriptor_name":"Multipotent Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1126/science.1163267","doi":"https://doi.org/10.1126/science.1163267","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.1163267","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:19056974","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19056974","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.46810001134872437,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1564253077","https://openalex.org/W1631250427","https://openalex.org/W1966563415","https://openalex.org/W1976736471","https://openalex.org/W1979091272","https://openalex.org/W1988451304","https://openalex.org/W1994465080","https://openalex.org/W1997362403","https://openalex.org/W2002732720","https://openalex.org/W2009501454","https://openalex.org/W2010417854","https://openalex.org/W2021346518","https://openalex.org/W2041668737","https://openalex.org/W2048989520","https://openalex.org/W2050175631","https://openalex.org/W2050561917","https://openalex.org/W2051341102","https://openalex.org/W2058704011","https://openalex.org/W2064019624","https://openalex.org/W2065171831","https://openalex.org/W2068380542","https://openalex.org/W2072162746","https://openalex.org/W2073420780","https://openalex.org/W2074431288","https://openalex.org/W2075401648","https://openalex.org/W2076837609","https://openalex.org/W2080539468","https://openalex.org/W2080714387","https://openalex.org/W2084109090","https://openalex.org/W2088513836","https://openalex.org/W2090041902","https://openalex.org/W2096151652","https://openalex.org/W2096999174","https://openalex.org/W2098590189","https://openalex.org/W2101228997","https://openalex.org/W2104206289","https://openalex.org/W2111486034","https://openalex.org/W2115833670","https://openalex.org/W2122059700","https://openalex.org/W2123163588","https://openalex.org/W2126271215","https://openalex.org/W2134343411","https://openalex.org/W2146511487","https://openalex.org/W2151908137","https://openalex.org/W2154246827","https://openalex.org/W2167460546","https://openalex.org/W2167595513"],"related_works":["https://openalex.org/W2105988341","https://openalex.org/W2809451650","https://openalex.org/W2050561917","https://openalex.org/W7095174799","https://openalex.org/W2128995496","https://openalex.org/W1973807810","https://openalex.org/W2995193872","https://openalex.org/W1986674426","https://openalex.org/W3022860928","https://openalex.org/W2059209782"],"abstract_inverted_index":{"The":[0],"heart":[1,33,90],"is":[2,45],"a":[3,9,46,64],"complex":[4],"organ":[5],"system":[6],"composed":[7],"of":[8,13,28,58,66,106,110],"highly":[10],"diverse":[11],"set":[12],"muscle":[14,34],"and":[15,26,38,41,84,113],"nonmuscle":[16],"cells.":[17,72],"Understanding":[18],"the":[19,23,32,36,42,55,88,104,116],"pathways":[20],"that":[21],"drive":[22],"formation,":[24],"migration,":[25],"assembly":[27],"these":[29],"cells":[30],"into":[31,87],"tissue,":[35],"pacemaker":[37],"conduction":[39],"system,":[40],"coronary":[43],"vasculature":[44],"central":[47],"problem":[48],"in":[49,59,121],"developmental":[50],"biology.":[51],"Efforts":[52],"to":[53,77,81],"unravel":[54],"biological":[56],"complexity":[57],"vivo":[60],"cardiogenesis":[61],"have":[62],"identified":[63],"family":[65],"closely":[67],"related":[68],"multipotent":[69],"cardiac":[70,97],"progenitor":[71,98],"These":[73],"progenitors":[74],"must":[75],"respond":[76],"non-cell-autonomous":[78],"signaling":[79],"cues":[80],"expand,":[82],"differentiate,":[83],"ultimately":[85],"integrate":[86],"three-dimensional":[89],"structures.":[91],"Coupling":[92],"tissue-engineering":[93],"technologies":[94],"with":[95],"patient-specific":[96],"biology":[99],"holds":[100],"great":[101],"promise":[102],"for":[103,118],"development":[105],"human":[107,111],"cell":[108],"models":[109],"disease":[112],"may":[114],"lay":[115],"foundation":[117],"novel":[119],"approaches":[120],"regenerative":[122],"cardiovascular":[123],"medicine.":[124]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":16},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":27},{"year":2012,"cited_by_count":31}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}