{"id":"https://openalex.org/W1985690775","doi":"https://doi.org/10.1126/science.472716","title":"Lithium Transport Across Red Cell Membrane: A Cell Membrane Abnormality in Manic-Depressive Illness","display_name":"Lithium Transport Across Red Cell Membrane: A Cell Membrane Abnormality in Manic-Depressive Illness","publication_year":1979,"publication_date":"1979-08-31","ids":{"openalex":"https://openalex.org/W1985690775","doi":"https://doi.org/10.1126/science.472716","mag":"1985690775","pmid":"https://pubmed.ncbi.nlm.nih.gov/472716"},"language":"en","primary_location":{"id":"doi:10.1126/science.472716","doi":"https://doi.org/10.1126/science.472716","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.472716","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073246469","display_name":"Elizabeth Dorus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth Dorus","raw_affiliation_strings":["Department of Psychiatry, University of Chicago, Chicago, Illinois 60637"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Chicago, Chicago, Illinois 60637","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101832917","display_name":"Ghanshyam N. Pandey","orcid":"https://orcid.org/0000-0001-9253-4939","observed_orcids":["https://orcid.org/0000-0001-9253-4939","https://orcid.org/0000-0002-0329-8303"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ghanshyam N. Pandey","raw_affiliation_strings":["Department of Research, Illinois State Psychiatric Institute, Chicago 60612"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Research, Illinois State Psychiatric Institute, Chicago 60612","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034062371","display_name":"Rita A. Shaughnessy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rita Shaughnessy","raw_affiliation_strings":["Department of Research, Illinois State Psychiatric Institute, Chicago 60612"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Research, Illinois State Psychiatric Institute, Chicago 60612","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111666865","display_name":"Mois\u00e9s Gaviria","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Moises Gaviria","raw_affiliation_strings":["Department of Psychiatry, University of Illinois School of Medicine, Chicago 60612"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Illinois School of Medicine, Chicago 60612","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001225430","display_name":"EDUARDO R. VAL","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eduardo Val","raw_affiliation_strings":["Department of Psychiatry, University of Illinois School of Medicine, Chicago 60612"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Illinois School of Medicine, Chicago 60612","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023590222","display_name":"Stephen E. Ericksen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen Ericksen","raw_affiliation_strings":["Department of Psychiatry, University of California, Davis, Sacramento 95817"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of California, Davis, Sacramento 95817","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052344963","display_name":"John M. Davis","orcid":"https://orcid.org/0000-0003-3963-1654","observed_orcids":["https://orcid.org/0000-0003-3963-1654"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John M. Davis","raw_affiliation_strings":["Department of Research, Illinois State Psychiatric Institute, Chicago 60612"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Research, Illinois State Psychiatric Institute, Chicago 60612","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.6632,"has_fulltext":false,"cited_by_count":60,"citation_normalized_percentile":{"value":0.95770677,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"205","issue":"4409","first_page":"932","last_page":"934"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lithium-transport","display_name":"lithium transport","score":0.9679999947547913},{"id":"https://openalex.org/keywords/erythrocyte-membrane","display_name":"erythrocyte membrane","score":0.824999988079071},{"id":"https://openalex.org/keywords/bipolar-disorder","display_name":"bipolar disorder","score":0.9660000205039978},{"id":"https://openalex.org/keywords/mood-disorders","display_name":"mood disorders","score":0.8450000286102295},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.550000011920929},{"id":"https://openalex.org/keywords/plasma-lithium","display_name":"plasma lithium","score":0.5299999713897705},{"id":"https://openalex.org/keywords/family-history-medicine","display_name":"family history (medicine)","score":0.3659999966621399},{"id":"https://openalex.org/keywords/membrane-abnormalities","display_name":"membrane abnormalities","score":0.5619999766349792}],"concepts":[{"id":"https://openalex.org/C2778541603","wikidata":"https://www.wikidata.org/wiki/Q152763","display_name":"Lithium (medication)","level":2,"score":0.8306468725204468},{"id":"https://openalex.org/C50965678","wikidata":"https://www.wikidata.org/wiki/Q2724302","display_name":"Abnormality","level":2,"score":0.7613292336463928},{"id":"https://openalex.org/C137627325","wikidata":"https://www.wikidata.org/wiki/Q156318","display_name":"Etiology","level":2,"score":0.5206465125083923},{"id":"https://openalex.org/C2910604615","wikidata":"https://www.wikidata.org/wiki/Q131755","display_name":"Bipolar illness","level":5,"score":0.5008499622344971},{"id":"https://openalex.org/C2776174506","wikidata":"https://www.wikidata.org/wiki/Q131755","display_name":"Bipolar disorder","level":3,"score":0.4335528314113617},{"id":"https://openalex.org/C2777208419","wikidata":"https://www.wikidata.org/wiki/Q4347672","display_name":"Red Cell","level":2,"score":0.433121919631958},{"id":"https://openalex.org/C2778106830","wikidata":"https://www.wikidata.org/wiki/Q29548","display_name":"Cell membrane","level":3,"score":0.42973199486732483},{"id":"https://openalex.org/C2781179581","wikidata":"https://www.wikidata.org/wiki/Q2857712","display_name":"Family history","level":2,"score":0.4121393859386444},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40937507152557373},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3892204761505127},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.3797251582145691},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.35788196325302124},{"id":"https://openalex.org/C2776809841","wikidata":"https://www.wikidata.org/wiki/Q185935","display_name":"Mania","level":4,"score":0.34803271293640137},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2627670168876648},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17925366759300232}],"mesh":[{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002414","descriptor_name":"Cations, Monovalent","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004910","descriptor_name":"Erythrocyte Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008094","descriptor_name":"Lithium","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D010375","descriptor_name":"Pedigree","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1126/science.472716","doi":"https://doi.org/10.1126/science.472716","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.472716","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:472716","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/472716","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1483439847","https://openalex.org/W1592918949","https://openalex.org/W1977092156","https://openalex.org/W1980785605","https://openalex.org/W1987447059","https://openalex.org/W1999170902","https://openalex.org/W2010629411","https://openalex.org/W2018083617","https://openalex.org/W2049165791","https://openalex.org/W2054599067","https://openalex.org/W2071407276","https://openalex.org/W2092109943","https://openalex.org/W2096595229","https://openalex.org/W2100266937","https://openalex.org/W2115087819","https://openalex.org/W2115587955","https://openalex.org/W2118410347","https://openalex.org/W2150287316","https://openalex.org/W2170839252","https://openalex.org/W2401274105","https://openalex.org/W2414901615","https://openalex.org/W2419496880","https://openalex.org/W2422626775","https://openalex.org/W2798510847","https://openalex.org/W3163606667"],"related_works":["https://openalex.org/W2414901615","https://openalex.org/W6989874401","https://openalex.org/W1970368134","https://openalex.org/W2407418471","https://openalex.org/W2078385956","https://openalex.org/W86611299","https://openalex.org/W2075301565","https://openalex.org/W2407266898","https://openalex.org/W2406095011","https://openalex.org/W2041026189"],"abstract_inverted_index":{"In":[0],"the":[1,41,45,53],"families":[2],"of":[3,10,18,55,58],"manic-depressive":[4],"patients,":[5],"relatives":[6,29],"with":[7,30],"a":[8,14,50],"history":[9],"affective":[11,59],"disorders":[12],"had":[13],"significantly":[15],"higher":[16],"ratio":[17],"mean":[19],"red":[20],"cell":[21],"lithium":[22,25,46],"to":[23],"plasma":[24],"in":[26,38,52],"vitro":[27],"than":[28],"no":[31],"such":[32],"history.":[33],"A":[34],"genetically":[35],"controlled":[36],"abnormality":[37],"lithium-sodium":[39],"transport,":[40],"mechanism":[42],"that":[43],"determines":[44],"ratio,":[47],"may":[48],"play":[49],"role":[51],"etiology":[54],"some":[56],"forms":[57],"disorders.":[60]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
