{"id":"https://openalex.org/W1985687905","doi":"https://doi.org/10.1073/pnas.73.6.1921","title":"Affinity label for beta-adrenergic receptor in turkey erythrocytes.","display_name":"Affinity label for beta-adrenergic receptor in turkey erythrocytes.","publication_year":1976,"publication_date":"1976-06-01","ids":{"openalex":"https://openalex.org/W1985687905","doi":"https://doi.org/10.1073/pnas.73.6.1921","mag":"1985687905","pmid":"https://pubmed.ncbi.nlm.nih.gov/180528","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/430419"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.73.6.1921","doi":"https://doi.org/10.1073/pnas.73.6.1921","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.73.6.1921","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC430419","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052588819","display_name":"Daphn\u00e9 Atlas","orcid":"https://orcid.org/0000-0002-5160-722X","observed_orcids":["https://orcid.org/0000-0002-5160-722X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Atlas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089990723","display_name":"Michael L. Steer","orcid":"https://orcid.org/0000-0002-5365-8215","observed_orcids":["https://orcid.org/0000-0002-5365-8215"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M L Steer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5086404962","display_name":"Alexander Levitzki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Levitzki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.9814,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.84922051,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"73","issue":"6","first_page":"1921","last_page":"1925"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-adrenergic-receptors","display_name":"beta-adrenergic receptors","score":0.9959999918937683},{"id":"https://openalex.org/keywords/affinity-labeling","display_name":"affinity labeling","score":0.7929999828338623},{"id":"https://openalex.org/keywords/turkey-erythrocytes","display_name":"turkey erythrocytes","score":0.8960000276565552},{"id":"https://openalex.org/keywords/adenylyl-cyclase-inhibition","display_name":"adenylate cyclase inhibition","score":0.843999981880188},{"id":"https://openalex.org/keywords/receptor-inactivation","display_name":"receptor inactivation","score":0.4440000057220459}],"concepts":[{"id":"https://openalex.org/C2778151854","wikidata":"https://www.wikidata.org/wiki/Q423364","display_name":"Propranolol","level":2,"score":0.7752454280853271},{"id":"https://openalex.org/C180526460","wikidata":"https://www.wikidata.org/wiki/Q356240","display_name":"Adenylate kinase","level":3,"score":0.7107239961624146},{"id":"https://openalex.org/C2780069284","wikidata":"https://www.wikidata.org/wiki/Q5198121","display_name":"Cyclase","level":3,"score":0.6580495834350586},{"id":"https://openalex.org/C2780679169","wikidata":"https://www.wikidata.org/wiki/Q4688981","display_name":"Affinity label","level":3,"score":0.6182289123535156},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6037814617156982},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5248998403549194},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.5248263478279114},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5044642686843872},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.4979255199432373},{"id":"https://openalex.org/C40465926","wikidata":"https://www.wikidata.org/wiki/Q410568","display_name":"Adrenergic receptor","level":3,"score":0.49534597992897034},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.47150176763534546},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.46016713976860046},{"id":"https://openalex.org/C2775859304","wikidata":"https://www.wikidata.org/wiki/Q132621","display_name":"Epinephrine","level":2,"score":0.4583825469017029},{"id":"https://openalex.org/C2776043855","wikidata":"https://www.wikidata.org/wiki/Q55506489","display_name":"Pyrophosphate","level":3,"score":0.4415885806083679},{"id":"https://openalex.org/C180577832","wikidata":"https://www.wikidata.org/wiki/Q127920","display_name":"Covalent bond","level":2,"score":0.4251958727836609},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.215552419424057},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.21537715196609497},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000067956","descriptor_name":"Adenylyl Cyclase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D000345","descriptor_name":"Affinity Labels","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000345","descriptor_name":"Affinity Labels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004837","descriptor_name":"Epinephrine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011433","descriptor_name":"Propranolol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011941","descriptor_name":"Receptors, Adrenergic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014422","descriptor_name":"Turkeys","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.73.6.1921","doi":"https://doi.org/10.1073/pnas.73.6.1921","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.73.6.1921","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:65473","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC430419","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:430419","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/430419","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:180528","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/180528","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:65473","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC430419","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1577436652","https://openalex.org/W1775749144","https://openalex.org/W1907944131","https://openalex.org/W1971836830","https://openalex.org/W1982637660","https://openalex.org/W1996466550","https://openalex.org/W1998121507","https://openalex.org/W2004376903","https://openalex.org/W2004760419","https://openalex.org/W2036199911","https://openalex.org/W2047168686","https://openalex.org/W2068015386","https://openalex.org/W2088037679","https://openalex.org/W2168123443","https://openalex.org/W2169503005","https://openalex.org/W2397231873","https://openalex.org/W4323966432"],"related_works":["https://openalex.org/W1982637660","https://openalex.org/W2085225358","https://openalex.org/W2030310020","https://openalex.org/W1968298237","https://openalex.org/W1798979870","https://openalex.org/W1972805550","https://openalex.org/W2007341906","https://openalex.org/W1480412527","https://openalex.org/W2412876221","https://openalex.org/W7047725047"],"abstract_inverted_index":{"The":[0,15,43,94],"compound":[1,16],"N-[2-hydroxy-3-(1-naphthoxy)-propyl]-N'-bromoacetylethylenediamine":[2],"(NHNP-NBE)":[3],"was":[4],"found":[5],"to":[6],"label":[7,45,80],"covalently":[8],"the":[9,29,37,41,49,78],"beta-adrenergic":[10],"receptor":[11],"in":[12,28,36,81,88],"turkey":[13,31,83],"erythrocytes.":[14],"inhibits":[17],"irreversibly":[18],"1-epinephrine-dependent":[19],"adenylate":[20],"cyclase":[21],"activity":[22],"[ATP":[23],"pyrophosphate-lyase":[24],"(cyclizing),":[25],"EC":[26],"4.6.1.1]":[27],"whole":[30,82],"erythrocyte":[32,38],"as":[33,35,85,87],"well":[34,86],"membranes":[39,89],"possessing":[40],"beta-receptor.":[42],"affinity":[44,79],"blocks,":[46],"also":[47],"irreversibly,":[48],"specific":[50],"[3H]":[51],"propranolol":[52,74],"binding,":[53,63],"whereas":[54],"other":[55],"bromoacetyl":[56],"compounds":[57],"tested":[58],"have":[59],"no":[60],"effect":[61],"on":[62],"even":[64],"at":[65],"high":[66],"concentrations,":[67],"which":[68],"cause":[69],"enzyme":[70],"inactivation.":[71],"1-Epinephrine":[72],"and":[73],"offer":[75],"protection":[76],"against":[77],"erythrocytes":[84],"prepared":[90],"from":[91],"these":[92],"cells.":[93],"potential":[95],"usefulness":[96],"of":[97],"an":[98],"irreversible":[99],"beta-antagonist":[100],"is":[101],"discussed.":[102]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
