{"id":"https://openalex.org/W1985686819","doi":"https://doi.org/10.1185/03007995.2012.743457","title":"Impact of self-treated hypoglycaemia in type 2 diabetes: a multinational survey in patients and physicians","display_name":"Impact of self-treated hypoglycaemia in type 2 diabetes: a multinational survey in patients and physicians","publication_year":2012,"publication_date":"2012-11-14","ids":{"openalex":"https://openalex.org/W1985686819","doi":"https://doi.org/10.1185/03007995.2012.743457","mag":"1985686819","pmid":"https://pubmed.ncbi.nlm.nih.gov/23150950"},"language":"en","primary_location":{"id":"doi:10.1185/03007995.2012.743457","doi":"https://doi.org/10.1185/03007995.2012.743457","is_oa":false,"landing_page_url":"https://doi.org/10.1185/03007995.2012.743457","pdf_url":null,"source":{"id":"https://openalex.org/S206643269","display_name":"Current Medical Research and Opinion","issn_l":"0300-7995","issn":["0300-7995","1473-4877"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Medical Research and Opinion","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046688221","display_name":"Meryl I. Brod","orcid":"https://orcid.org/0000-0002-0663-5838","observed_orcids":["https://orcid.org/0000-0002-0663-5838"]},"institutions":[{"id":"https://openalex.org/I4210113151","display_name":"Brod Group","ror":"https://ror.org/023tdcb12","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210113151"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Meryl Brod","raw_affiliation_strings":["The Brod Group\rMill Valley, CAUSA","The Brod Group, Mill Valley, CA 94941, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Brod Group\rMill Valley, CAUSA","institution_ids":["https://openalex.org/I4210113151"]},{"raw_affiliation_string":"The Brod Group, Mill Valley, CA 94941, USA","institution_ids":["https://openalex.org/I4210113151"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111912516","display_name":"Azhar Rana","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Azhar Rana","raw_affiliation_strings":["Global Medical Affairs Novo Nordisk A/S, SoeborgDenmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Global Medical Affairs Novo Nordisk A/S, SoeborgDenmark","institution_ids":["https://openalex.org/I189090001"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023295361","display_name":"Anthony H Barnett","orcid":"https://orcid.org/0000-0002-6320-4073","observed_orcids":["https://orcid.org/0000-0002-6320-4073"]},"institutions":[{"id":"https://openalex.org/I2799726393","display_name":"Heart of England NHS Foundation Trust","ror":"https://ror.org/041rme308","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1308923049","https://openalex.org/I2799726393"]},{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anthony H. Barnett","raw_affiliation_strings":["University of Birmingham and Diabetes Centre, Heart of England National Health Service Foundation Trust BirminghamUK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Birmingham and Diabetes Centre, Heart of England National Health Service Foundation Trust BirminghamUK","institution_ids":["https://openalex.org/I2799726393","https://openalex.org/I79619799"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5046688221"],"corresponding_institution_ids":["https://openalex.org/I4210113151"],"apc_list":null,"apc_paid":null,"fwci":3.5011,"has_fulltext":false,"cited_by_count":63,"citation_normalized_percentile":{"value":0.92416278,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"28","issue":"12","first_page":"1947","last_page":"1958"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.028999999165534973,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10793","display_name":"Diabetes Management and Education","score":0.006200000178068876,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9760000109672546},{"id":"https://openalex.org/keywords/basal-insulin-analogues","display_name":"basal insulin analogues","score":0.9980000257492065},{"id":"https://openalex.org/keywords/insulin-dose-adjustment","display_name":"insulin dose adjustment","score":0.531000018119812},{"id":"https://openalex.org/keywords/nocturnal-hypoglycemia","display_name":"nocturnal hypoglycemia","score":0.9240000247955322},{"id":"https://openalex.org/keywords/patient-worry","display_name":"patient worry","score":0.5609999895095825},{"id":"https://openalex.org/keywords/health-care-utilization","display_name":"health care utilization","score":0.6690000295639038},{"id":"https://openalex.org/keywords/physician-attitudes","display_name":"physician attitudes","score":0.6110000014305115},{"id":"https://openalex.org/keywords/nph-insulin","display_name":"NPH insulin","score":0.6800000071525574},{"id":"https://openalex.org/keywords/patient-well-being","display_name":"patient well-being","score":0.578000009059906},{"id":"https://openalex.org/keywords/glucose-monitoring","display_name":"glucose monitoring","score":0.4690000116825104},{"id":"https://openalex.org/keywords/patient-physician-communication","display_name":"patient-physician communication","score":0.652999997138977}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9723750352859497},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.6506317853927612},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5831676721572876},{"id":"https://openalex.org/C158016649","wikidata":"https://www.wikidata.org/wiki/Q161726","display_name":"Multinational corporation","level":2,"score":0.4909649193286896},{"id":"https://openalex.org/C2780668416","wikidata":"https://www.wikidata.org/wiki/Q202758","display_name":"Hypoglycemia","level":3,"score":0.4497400224208832},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.44898277521133423},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.393758088350296},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.37161511182785034},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.34004032611846924},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.21694278717041016},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003625","descriptor_name":"Data Collection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007003","descriptor_name":"Hypoglycemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007003","descriptor_name":"Hypoglycemia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D007003","descriptor_name":"Hypoglycemia","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012646","descriptor_name":"Self Administration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048909","descriptor_name":"Diabetes Complications","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D048909","descriptor_name":"Diabetes Complications","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1185/03007995.2012.743457","doi":"https://doi.org/10.1185/03007995.2012.743457","is_oa":false,"landing_page_url":"https://doi.org/10.1185/03007995.2012.743457","pdf_url":null,"source":{"id":"https://openalex.org/S206643269","display_name":"Current Medical Research and Opinion","issn_l":"0300-7995","issn":["0300-7995","1473-4877"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Medical Research and Opinion","raw_type":"journal-article"},{"id":"pmid:23150950","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23150950","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current medical research and opinion","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322436","display_name":"Novo Nordisk","ror":"https://ror.org/0435rc536"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W66041704","https://openalex.org/W181320477","https://openalex.org/W1959317204","https://openalex.org/W1965510020","https://openalex.org/W1995411908","https://openalex.org/W1999804954","https://openalex.org/W2004910803","https://openalex.org/W2006800582","https://openalex.org/W2079889285","https://openalex.org/W2100442612","https://openalex.org/W2105502859","https://openalex.org/W2111876001","https://openalex.org/W2114117378","https://openalex.org/W2117304511","https://openalex.org/W2144002425","https://openalex.org/W2146901298","https://openalex.org/W2148263465","https://openalex.org/W2153476503","https://openalex.org/W2158312041","https://openalex.org/W2159062207","https://openalex.org/W2190748907","https://openalex.org/W4250647894"],"related_works":["https://openalex.org/W2309084344","https://openalex.org/W4237745516","https://openalex.org/W1976061504","https://openalex.org/W2114280478","https://openalex.org/W2103035695","https://openalex.org/W2413611017","https://openalex.org/W1978845787","https://openalex.org/W2110623635","https://openalex.org/W1992753954","https://openalex.org/W2613962821"],"abstract_inverted_index":{"OBJECTIVES:":[0],"The":[1,38,75],"objectives":[2],"were":[3,161,223],"to":[4,31,121,166,253,294,326],"estimate":[5],"the":[6,70,84,103,115,137,174,226,246,314,324,330],"prevalence":[7],"of":[8,42,54,72,78,91,108,139,170,234,248,283,317],"self-treated":[9,81,112,122,171,235,271,290],"hypoglycaemia":[10,82,113,172,250,276,291],"in":[11,69,173,279],"patients":[12,55,93,109,124,203,269,284],"using":[13,285],"basal":[14,63,96,133,151,221],"insulin":[15,97,134,152,217,243,267,286],"analogues;":[16],"identify":[17],"demographic,":[18],"treatment":[19],"related":[20],"and":[21,25,28,44,65,99,190,219,304,307,310,334],"behavioural":[22],"risk":[23,233,247],"factors;":[24],"describe":[26],"patient":[27,302,306],"physician":[29,308],"responses":[30],"these":[32],"events.":[33,237,273],"RESEARCH":[34],"DESIGN":[35],"AND":[36],"METHODS:":[37],"GAPP2":[39],"(Global":[40],"Attitude":[41],"Patients":[43,148],"Physicians":[45],"2)":[46],"study":[47,53],"was":[48,80,292],"an":[49,168,318],"online":[50,319],"multinational":[51],"cross-sectional":[52],"with":[56,62,95,231,297],"type":[57],"2":[58],"diabetes":[59],"currently":[60],"treated":[61,94],"insulin,":[64],"healthcare":[66,145,311],"professionals":[67],"involved":[68],"care":[71],"such":[73,322],"patients.":[74],"primary":[76],"variable":[77],"interest":[79],"within":[83],"last":[85],"30":[86,117],"days.":[87,118],"RESULTS:":[88],"A":[89],"total":[90],"3042":[92],"analogues":[98,244],"1222":[100],"prescribers":[101,239],"completed":[102],"full":[104],"survey.":[105],"Overall,":[106],"36%":[107],"had":[110],"experienced":[111],"during":[114],"previous":[116],"In":[119],"response":[120],"hypoglycaemia,":[123,216],"reported":[125,258],"missing":[126],"(7%),":[127],"reducing":[128,158],"(11%)":[129],"or":[130,143,157],"mistiming":[131,156],"(4%)":[132],"doses,":[135],"increasing":[136],"level":[138],"glucose":[140],"monitoring":[141],"(40%)":[142],"utilising":[144],"resources":[146],"(7%).":[147],"reporting":[149],"irregular":[150],"dosing":[153,222],"by":[154,266],"missing,":[155],"a":[159,264],"dose":[160],"also":[162,257],"significantly":[163,201],"more":[164,202],"likely":[165],"report":[167],"episode":[169],"same":[175],"time":[176],"period:":[177],"41%":[178],"versus":[179,185,192,208],"34%":[180],"(p":[181,187,194],"=":[182],"0.004),":[183],"43%":[184],"33%":[186],"<":[188,195,211],"0.001),":[189],"56%":[191],"32%":[193],"0.001)":[196],"respectively.":[197],"Nocturnal":[198],"events":[199,206],"worried":[200],"than":[204],"diurnal":[205],"(42%":[207],"23%,":[209],"p":[210],"0.001).":[212],"Patient":[213],"worry":[214],"about":[215],"regimen":[218],"reduced":[220],"identified":[224],"as":[225,323],"key":[227],"differentiating":[228],"variables":[229],"associated":[230,296],"increased":[232],"hypoglycaemic":[236,272],"Most":[238],"(76%)":[240],"believed":[241],"that":[242],"minimised":[245],"nocturnal":[249],"when":[251],"compared":[252],"NPH":[254],"insulin;":[255],"46%":[256],"being":[259],"contacted":[260],"at":[261],"least":[262],"once":[263],"month":[265],"analogue":[268,287],"after":[270],"CONCLUSIONS:":[274],"Self-treated":[275],"is":[277],"common":[278],"approximately":[280],"one":[281],"third":[282],"regimens.":[288],"Additionally,":[289],"found":[293],"be":[295,327],"clinically":[298],"significant":[299],"effects":[300],"on":[301],"well-being":[303],"functioning,":[305],"management":[309],"utilisation":[312],"despite":[313],"potential":[315,331],"limitations":[316],"self-complete":[320],"survey":[321],"need":[325],"topic":[328],"focused,":[329],"for":[332],"under-reporting":[333],"social":[335],"bias.":[336]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}