{"id":"https://openalex.org/W1985677371","doi":"https://doi.org/10.1097/icl.0000000000000001","title":"Topical Tacrolimus 0.03% as Sole Therapy in Vernal Keratoconjunctivitis: A Randomized Double-Masked Study","display_name":"Topical Tacrolimus 0.03% as Sole Therapy in Vernal Keratoconjunctivitis: A Randomized Double-Masked Study","publication_year":2014,"publication_date":"2014-01-14","ids":{"openalex":"https://openalex.org/W1985677371","doi":"https://doi.org/10.1097/icl.0000000000000001","mag":"1985677371","pmid":"https://pubmed.ncbi.nlm.nih.gov/24418865"},"language":"en","primary_location":{"id":"doi:10.1097/icl.0000000000000001","doi":"https://doi.org/10.1097/icl.0000000000000001","is_oa":false,"landing_page_url":"https://doi.org/10.1097/icl.0000000000000001","pdf_url":null,"source":{"id":"https://openalex.org/S204027754","display_name":"Eye & Contact Lens Science & Clinical Practice","issn_l":"0733-8902","issn":["0733-8902","1542-2321","1542-233X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eye & Contact Lens: Science & Clinical Practice","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032631312","display_name":"Guilherme Gubert Muller","orcid":"https://orcid.org/0000-0002-9269-6628","observed_orcids":["https://orcid.org/0000-0002-9269-6628"]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Guilherme Gubert M\u00fcller","raw_affiliation_strings":["Department of Ophthalmology and Otolaryngology, School of Medical Sciences, State University of, Campinas, Campinas, S\u00e3o Paulo, Brazil","e-mail: [email\u00a0protected]","reprint requests to Guilherme Gubert M\u00fcller, M.D., Av. Desembargador Hugo Simas, 333, Curitiba, Paran\u00e1, CEP 82520-250, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology and Otolaryngology, School of Medical Sciences, State University of, Campinas, Campinas, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I181391015"]},{"raw_affiliation_string":"e-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"reprint requests to Guilherme Gubert M\u00fcller, M.D., Av. Desembargador Hugo Simas, 333, Curitiba, Paran\u00e1, CEP 82520-250, Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109260793","display_name":"Newton Kara Jos\u00e9","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Newton Kara Jos\u00e9","raw_affiliation_strings":["Department of Ophthalmology and Otolaryngology, School of Medical Sciences, State University of, Campinas, Campinas, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology and Otolaryngology, School of Medical Sciences, State University of, Campinas, Campinas, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I181391015"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071740575","display_name":"Rosane Silvestre de Castro","orcid":"https://orcid.org/0000-0002-1040-2391","observed_orcids":["https://orcid.org/0000-0002-1040-2391"]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Rosane Silvestre de Castro","raw_affiliation_strings":["Department of Ophthalmology and Otolaryngology, School of Medical Sciences, State University of, Campinas, Campinas, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology and Otolaryngology, School of Medical Sciences, State University of, Campinas, Campinas, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I181391015"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5032631312"],"corresponding_institution_ids":["https://openalex.org/I181391015"],"apc_list":null,"apc_paid":null,"fwci":1.9814,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.8368702,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"40","issue":"2","first_page":"79","last_page":"83"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11826","display_name":"Ocular Infections and Treatments","score":0.007699999958276749,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vernal-keratoconjunctivitis","display_name":"vernal keratoconjunctivitis","score":0.9520000219345093},{"id":"https://openalex.org/keywords/tacrolimus","display_name":"tacrolimus","score":0.9890000224113464},{"id":"https://openalex.org/keywords/olopatadine","display_name":"olopatadine","score":0.9869999885559082},{"id":"https://openalex.org/keywords/topical-immunosuppressive-therapy","display_name":"topical immunosuppressive therapy","score":0.8429999947547913},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.5960000157356262},{"id":"https://openalex.org/keywords/mtor-inhibitors","display_name":"mTOR inhibitors","score":0.5189999938011169},{"id":"https://openalex.org/keywords/ocular-allergy","display_name":"ocular allergy","score":0.5910000205039978},{"id":"https://openalex.org/keywords/treatment-efficacy","display_name":"treatment efficacy","score":0.5590000152587891}],"concepts":[{"id":"https://openalex.org/C2909675724","wikidata":"https://www.wikidata.org/wiki/Q411648","display_name":"Tacrolimus","level":3,"score":0.9131734371185303},{"id":"https://openalex.org/C2776469317","wikidata":"https://www.wikidata.org/wiki/Q3686833","display_name":"Vernal keratoconjunctivitis","level":2,"score":0.9017961621284485},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8387144804000854},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6157525777816772},{"id":"https://openalex.org/C3018023364","wikidata":"https://www.wikidata.org/wiki/Q425265","display_name":"Significant difference","level":2,"score":0.6073912382125854},{"id":"https://openalex.org/C2992053201","wikidata":"https://www.wikidata.org/wiki/Q2585693","display_name":"Clinical efficacy","level":2,"score":0.5214023590087891},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4676140546798706},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.46271511912345886},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.41012006998062134},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35175761580467224},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.08046415448188782},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.05266931653022766},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000287","descriptor_name":"Administration, Topical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003233","descriptor_name":"Conjunctivitis, Allergic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016559","descriptor_name":"Tacrolimus","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/icl.0000000000000001","doi":"https://doi.org/10.1097/icl.0000000000000001","is_oa":false,"landing_page_url":"https://doi.org/10.1097/icl.0000000000000001","pdf_url":null,"source":{"id":"https://openalex.org/S204027754","display_name":"Eye & Contact Lens Science & Clinical Practice","issn_l":"0733-8902","issn":["0733-8902","1542-2321","1542-233X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eye & Contact Lens: Science & Clinical Practice","raw_type":"journal-article"},{"id":"pmid:24418865","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24418865","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eye & contact lens","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W51107003","https://openalex.org/W1963995676","https://openalex.org/W1972369437","https://openalex.org/W1972757334","https://openalex.org/W1985107831","https://openalex.org/W1986422858","https://openalex.org/W1986818203","https://openalex.org/W1993536841","https://openalex.org/W1996042193","https://openalex.org/W2005807456","https://openalex.org/W2021037177","https://openalex.org/W2024630743","https://openalex.org/W2025573123","https://openalex.org/W2030790270","https://openalex.org/W2037958386","https://openalex.org/W2038075308","https://openalex.org/W2040470344","https://openalex.org/W2051839108","https://openalex.org/W2053234631","https://openalex.org/W2059676586","https://openalex.org/W2062427538","https://openalex.org/W2068065489","https://openalex.org/W2068147134","https://openalex.org/W2069093365","https://openalex.org/W2074984233","https://openalex.org/W2078813277","https://openalex.org/W2084455686","https://openalex.org/W2094920684","https://openalex.org/W2100460094","https://openalex.org/W2109109964","https://openalex.org/W2109871913","https://openalex.org/W2111546909","https://openalex.org/W2117037286","https://openalex.org/W2141376912","https://openalex.org/W2782175582","https://openalex.org/W4238751177","https://openalex.org/W6602033168"],"related_works":["https://openalex.org/W3135834896","https://openalex.org/W4297007058","https://openalex.org/W3158912421","https://openalex.org/W4387515092","https://openalex.org/W4378470592","https://openalex.org/W2910810308","https://openalex.org/W2793158685","https://openalex.org/W4390288970","https://openalex.org/W4224228770","https://openalex.org/W4393209887"],"abstract_inverted_index":{"OBJECTIVE:":[0],"This":[1],"study":[2],"sought":[3],"to":[4,75,219,232],"evaluate":[5],"the":[6,9,16,24,55,78,85,88,91,107,110,114,126,135,142,147,164,167,174,190,193,197,201,211,221],"efficacy":[7,79],"of":[8,12,19,26,80,93,102,121,200,208,214],"isolated":[10,206],"use":[11,18,207,213],"tacrolimus":[13,20,46,59,209,215],"compared":[14,124],"with":[15,34,44,49,57,62,150,179,227],"combined":[17,48,61,212],"and":[21,54,69,77,95,109,123,171,196,210,216],"olopatadine":[22,51,217],"for":[23,131,159],"treatment":[25,81,94,122],"severe":[27,35],"vernal":[28],"keratoconjunctivitis":[29],"(VKC).":[30],"METHODS:":[31],"Twenty-one":[32],"patients":[33],"VKC":[36],"were":[37,71,116],"randomized":[38],"into":[39],"two":[40],"groups:":[41],"one":[42],"treated":[43],"0.03%":[45,58],"ointment":[47,60],"1%":[50],"ophthalmic":[52],"solution":[53],"other":[56],"placebo":[63],"eye":[64],"drops.":[65],"The":[66,99,129,157,205],"clinical":[67,100,160,198],"signs":[68,161],"symptoms":[70,132],"graded":[72],"from":[73],"0":[74],"3,":[76],"was":[82,185],"determined":[83],"by":[84,106,113],"difference":[86,153,188],"between":[87,125,134,154,163,189],"score":[89],"at":[90,118],"beginning":[92],"after":[96],"30":[97,120],"days.":[98],"impression":[101,199],"improvement":[103],"as":[104],"perceived":[105],"evaluator":[108,202],"self-assessment":[111,194],"provided":[112],"patient":[115],"scored":[117],"day":[119],"groups.":[127],"RESULTS:":[128],"scores":[130,158],"decreased":[133,162],"assessments":[136,165],"in":[137,141,146,166,173],"both":[138],"groups":[139,155,191],"(-1.7\u00b13.9":[140],"experimental":[143,168],"group;":[144],"-0.6\u00b11.6":[145],"control":[148,175],"group),":[149],"no":[151,180,186],"significant":[152,181,187],"(P=0.205).":[156,183],"group":[169,176],"(-1.1\u00b12.7)":[170],"increased":[172],"(0.3\u00b10.9)":[177],"but":[178],"differences":[182],"There":[184],"regarding":[192],"(P=0.659)":[195],"(P=0.387).":[203],"CONCLUSIONS:":[204],"seems":[218],"have":[220],"same":[222],"efficacy,":[223],"although":[224],"controlled":[225],"studies":[226],"larger":[228],"samples":[229],"are":[230],"required":[231],"confirm":[233],"this":[234],"hypothesis.":[235]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}