{"id":"https://openalex.org/W1985665159","doi":"https://doi.org/10.1111/j.1468-3083.2009.03216.x","title":"Moderate to severe psoriasis: from topical to biological treatment","display_name":"Moderate to severe psoriasis: from topical to biological treatment","publication_year":2009,"publication_date":"2009-03-11","ids":{"openalex":"https://openalex.org/W1985665159","doi":"https://doi.org/10.1111/j.1468-3083.2009.03216.x","mag":"1985665159","pmid":"https://pubmed.ncbi.nlm.nih.gov/19470061"},"language":"en","primary_location":{"id":"doi:10.1111/j.1468-3083.2009.03216.x","doi":"https://doi.org/10.1111/j.1468-3083.2009.03216.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1468-3083.2009.03216.x","pdf_url":null,"source":{"id":"https://openalex.org/S137740113","display_name":"Journal of the European Academy of Dermatology and Venereology","issn_l":"0926-9959","issn":["0926-9959","1468-3083"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the European Academy of Dermatology and Venereology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031172305","display_name":"I. Gardinal\u2010Galera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I4210138343","display_name":"H\u00f4pital Purpan","ror":"https://ror.org/03vcx3f97","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017","https://openalex.org/I4210138343"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"I Gardinal","raw_affiliation_strings":["Department of Dermatology, Purpan University Hospital and Paul Sabatier University, Toulouse, France. isa.gardinal@club-internet.fr","Department of Dermatology, Purpan University Hospital and Paul Sabatier University, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Purpan University Hospital and Paul Sabatier University, Toulouse, France. isa.gardinal@club-internet.fr","institution_ids":["https://openalex.org/I134560555","https://openalex.org/I4210138343"]},{"raw_affiliation_string":"Department of Dermatology, Purpan University Hospital and Paul Sabatier University, Toulouse, France","institution_ids":["https://openalex.org/I134560555","https://openalex.org/I4210138343"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049812967","display_name":"Alfred Ammoury","orcid":"https://orcid.org/0000-0001-8260-1261","observed_orcids":["https://orcid.org/0000-0001-8260-1261"]},"institutions":[{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I4210138343","display_name":"H\u00f4pital Purpan","ror":"https://ror.org/03vcx3f97","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017","https://openalex.org/I4210138343"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"A Ammoury","raw_affiliation_strings":["The first two authors have equally participated in this manuscript","Department of Dermatology, Purpan University Hospital and Paul Sabatier University, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The first two authors have equally participated in this manuscript","institution_ids":[]},{"raw_affiliation_string":"Department of Dermatology, Purpan University Hospital and Paul Sabatier University, Toulouse, France","institution_ids":["https://openalex.org/I134560555","https://openalex.org/I4210138343"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082011794","display_name":"Carle F. Paul","orcid":"https://orcid.org/0000-0003-0165-5263","observed_orcids":["https://orcid.org/0000-0003-0165-5263"]},"institutions":[{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I4210138343","display_name":"H\u00f4pital Purpan","ror":"https://ror.org/03vcx3f97","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017","https://openalex.org/I4210138343"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C Paul","raw_affiliation_strings":["Department of Dermatology, Purpan University Hospital and Paul Sabatier University, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Purpan University Hospital and Paul Sabatier University, Toulouse, France","institution_ids":["https://openalex.org/I134560555","https://openalex.org/I4210138343"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5031172305"],"corresponding_institution_ids":["https://openalex.org/I134560555","https://openalex.org/I4210138343"],"apc_list":{"value":5450,"currency":"USD","value_usd":5450},"apc_paid":null,"fwci":0.689,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.69215398,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"23","issue":"11","first_page":"1324","last_page":"1326"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11092","display_name":"Spondyloarthritis Studies and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/severe-psoriasis","display_name":"severe psoriasis","score":0.9660000205039978},{"id":"https://openalex.org/keywords/topical-corticosteroids","display_name":"topical corticosteroids","score":0.9660000205039978},{"id":"https://openalex.org/keywords/corticosteroid-side-effects","display_name":"corticosteroid adverse effects","score":0.7789999842643738},{"id":"https://openalex.org/keywords/systemic-treatment","display_name":"systemic therapy","score":0.7710000276565552},{"id":"https://openalex.org/keywords/methotrexate","display_name":"methotrexate","score":0.9490000009536743},{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.9369999766349792},{"id":"https://openalex.org/keywords/phototherapy","display_name":"phototherapy","score":0.9900000095367432},{"id":"https://openalex.org/keywords/biological-therapy","display_name":"biologic therapy","score":0.9290000200271606},{"id":"https://openalex.org/keywords/treatment-timing","display_name":"treatment timing","score":0.6000000238418579},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.8859999775886536}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9411797523498535},{"id":"https://openalex.org/C2780564577","wikidata":"https://www.wikidata.org/wiki/Q179945","display_name":"Psoriasis","level":2,"score":0.9112472534179688},{"id":"https://openalex.org/C185926286","wikidata":"https://www.wikidata.org/wiki/Q1929812","display_name":"Systemic therapy","level":4,"score":0.7346721887588501},{"id":"https://openalex.org/C2781059491","wikidata":"https://www.wikidata.org/wiki/Q422232","display_name":"Methotrexate","level":2,"score":0.6614106893539429},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.6037116646766663},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.5154653191566467},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.37863296270370483},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.26726025342941284},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.24598798155784607},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15211203694343567},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000287","descriptor_name":"Administration, Topical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000305","descriptor_name":"Adrenal Cortex Hormones","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000305","descriptor_name":"Adrenal Cortex Hormones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011565","descriptor_name":"Psoriasis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1468-3083.2009.03216.x","doi":"https://doi.org/10.1111/j.1468-3083.2009.03216.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1468-3083.2009.03216.x","pdf_url":null,"source":{"id":"https://openalex.org/S137740113","display_name":"Journal of the European Academy of Dermatology and Venereology","issn_l":"0926-9959","issn":["0926-9959","1468-3083"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the European Academy of Dermatology and Venereology","raw_type":"journal-article"},{"id":"pmid:19470061","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19470061","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the European Academy of Dermatology and Venereology : JEADV","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1556049736","https://openalex.org/W1980724699","https://openalex.org/W2020776325","https://openalex.org/W2075934703","https://openalex.org/W2080165152","https://openalex.org/W2082707600","https://openalex.org/W2085417241","https://openalex.org/W2086861262","https://openalex.org/W2088314729","https://openalex.org/W2134206785","https://openalex.org/W2149526224","https://openalex.org/W2165992061","https://openalex.org/W2167963388","https://openalex.org/W2171502385","https://openalex.org/W2442686562"],"related_works":["https://openalex.org/W2948804013","https://openalex.org/W3090168531","https://openalex.org/W1842389009","https://openalex.org/W2150869018","https://openalex.org/W4301744395","https://openalex.org/W2122730035","https://openalex.org/W4297577450","https://openalex.org/W2167430586","https://openalex.org/W2005186389","https://openalex.org/W7095539705"],"abstract_inverted_index":{"INTRODUCTION:":[0],"The":[1,18],"simple":[2],"use":[3,162],"of":[4,10,21,49,75,102,136,142,204],"topical":[5,57,137],"corticosteroids":[6,58,138],"in":[7,23],"the":[8,100,123,134,171,190],"treatment":[9,22,86],"severe":[11,50,119],"psoriasis":[12,51,120],"is":[13,26,105,163],"often":[14,164,181],"inefficient":[15],"and":[16,35,63,69,91,104,127],"harmful.":[17],"first":[19],"line":[20],"these":[24,197],"cases":[25,48],"based":[27],"on":[28,99],"systemic":[29,82,148,159,172],"therapies":[30],"such":[31],"as":[32],"methotrexate,":[33],"cyclosporin":[34],"phototherapy.":[36],"Later":[37],"on,":[38],"biological":[39,85],"treatments":[40,179,198],"can":[41],"be":[42],"used.":[43],"OBSERVATIONS:":[44],"We":[45],"present":[46],"three":[47],"that":[52,174],"have":[53,78,118],"been":[54],"treated":[55],"by":[56],"for":[59,122,139],"a":[60,81,84,88,96],"long":[61],"time":[62,143],"with":[64,87,109,158],"large":[65],"doses":[66],"without":[67,150],"success":[68],"many":[70],"side-effects.":[71],"For":[72],"each":[73],"one":[74],"them,":[76],"we":[77],"introduced":[79],"either":[80],"or":[83,114,147],"good":[89],"efficacy":[90],"tolerance.":[92],"DISCUSSION:":[93],"Psoriasis":[94],"has":[95],"strong":[97],"impact":[98],"quality":[101,203],"life":[103],"comparable":[106],"to":[107],"patients":[108,154],"major":[110],"diseases":[111],"like":[112],"cancer":[113],"depression.":[115],"Patients":[116,185],"who":[117],"are":[121,155,168,180,186,193],"most":[124],"part":[125],"disappointed":[126],"dissatisfied":[128],"from":[129,170,189],"their":[130,161],"treatment.":[131],"In":[132],"fact,":[133],"misuse":[135],"prolonged":[140],"periods":[141],"may":[144,175,200],"induce":[145],"local":[146],"side-effects":[149,173],"any":[151],"improvement.":[152],"Although":[153],"more":[156],"pleased":[157,188],"treatments,":[160],"limited":[165],"because":[166],"physicians":[167],"anxious":[169],"occur.":[176],"CONCLUSION:":[177],"Systemic":[178],"used":[182],"too":[183],"late.":[184],"not":[187],"way":[191],"they":[192],"treated.":[194],"Accordingly,":[195],"using":[196],"earlier":[199],"improve":[201],"patients'":[202],"life.":[205]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
