{"id":"https://openalex.org/W1985651318","doi":"https://doi.org/10.3171/2009.9.jns09844","title":"Delayed administration of erythropoietin reducing hippocampal cell loss, enhancing angiogenesis and neurogenesis, and improving functional outcome following traumatic brain injury in rats: comparison of treatment with single and triple dose","display_name":"Delayed administration of erythropoietin reducing hippocampal cell loss, enhancing angiogenesis and neurogenesis, and improving functional outcome following traumatic brain injury in rats: comparison of treatment with single and triple dose","publication_year":2009,"publication_date":"2009-10-09","ids":{"openalex":"https://openalex.org/W1985651318","doi":"https://doi.org/10.3171/2009.9.jns09844","mag":"1985651318","pmid":"https://pubmed.ncbi.nlm.nih.gov/19817538","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2898921"},"language":"en","primary_location":{"id":"doi:10.3171/2009.9.jns09844","doi":"https://doi.org/10.3171/2009.9.jns09844","is_oa":false,"landing_page_url":"https://doi.org/10.3171/2009.9.jns09844","pdf_url":null,"source":{"id":"https://openalex.org/S1995308","display_name":"Journal of neurosurgery","issn_l":"0022-3085","issn":["0022-3085","1933-0693"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316861","host_organization_name":"American Association of Neurological Surgeons","host_organization_lineage":["https://openalex.org/P4310316861"],"host_organization_lineage_names":["American Association of Neurological Surgeons"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurosurgery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2898921","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101737223","display_name":"Ye Xiong","orcid":"https://orcid.org/0000-0001-9770-6031","observed_orcids":["https://orcid.org/0000-0001-9770-6031"]},"institutions":[{"id":"https://openalex.org/I154057602","display_name":"Henry Ford Health","ror":"https://ror.org/02kwnkm68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I154057602"]},{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ye Xiong","raw_affiliation_strings":["Departments of Neurosurgery and","Department of Neurosurgery, Henry Ford Health System, Detroit, Michigan 48202, USA. nsxye@neuro.hfh.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurosurgery and","institution_ids":[]},{"raw_affiliation_string":"Department of Neurosurgery, Henry Ford Health System, Detroit, Michigan 48202, USA. nsxye@neuro.hfh.edu","institution_ids":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102972682","display_name":"Asim Mahmood","orcid":"https://orcid.org/0009-0008-3559-962X","observed_orcids":["https://orcid.org/0009-0008-3559-962X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Asim Mahmood","raw_affiliation_strings":["Departments of Neurosurgery and","1Departments of Neurosurgery and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurosurgery and","institution_ids":[]},{"raw_affiliation_string":"1Departments of Neurosurgery and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085097885","display_name":"Yuling Meng","orcid":"https://orcid.org/0000-0001-6778-3773","observed_orcids":["https://orcid.org/0000-0001-6778-3773"]},"institutions":[{"id":"https://openalex.org/I154057602","display_name":"Henry Ford Health","ror":"https://ror.org/02kwnkm68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I154057602"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuling Meng","raw_affiliation_strings":["Departments of Neurosurgery and","Henry Ford Health System"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurosurgery and","institution_ids":[]},{"raw_affiliation_string":"Henry Ford Health System","institution_ids":["https://openalex.org/I154057602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102762729","display_name":"Yanlu Zhang","orcid":"https://orcid.org/0000-0002-6538-3052","observed_orcids":["https://orcid.org/0000-0002-6538-3052"]},"institutions":[{"id":"https://openalex.org/I154057602","display_name":"Henry Ford Health","ror":"https://ror.org/02kwnkm68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I154057602"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yanlu Zhang","raw_affiliation_strings":["Departments of Neurosurgery and","Henry Ford Health System"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurosurgery and","institution_ids":[]},{"raw_affiliation_string":"Henry Ford Health System","institution_ids":["https://openalex.org/I154057602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041553960","display_name":"Changsheng Qu","orcid":"https://orcid.org/0009-0007-8684-0818","observed_orcids":["https://orcid.org/0009-0007-8684-0818"]},"institutions":[{"id":"https://openalex.org/I154057602","display_name":"Henry Ford Health","ror":"https://ror.org/02kwnkm68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I154057602"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Changsheng Qu","raw_affiliation_strings":["Departments of Neurosurgery and","Henry Ford Health System"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurosurgery and","institution_ids":[]},{"raw_affiliation_string":"Henry Ford Health System","institution_ids":["https://openalex.org/I154057602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087782377","display_name":"Timothy J. Schallert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy Schallert","raw_affiliation_strings":["Department of Psychology and Institute for Neuroscience, University of Texas at Austin, Texas","4Department of Psychology and Institute for Neuroscience, University of Texas at Austin, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology and Institute for Neuroscience, University of Texas at Austin, Texas","institution_ids":["https://openalex.org/I86519309"]},{"raw_affiliation_string":"4Department of Psychology and Institute for Neuroscience, University of Texas at Austin, Texas","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005508444","display_name":"Michael Chopp","orcid":"https://orcid.org/0000-0002-1948-4493","observed_orcids":["https://orcid.org/0000-0002-1948-4493"]},"institutions":[{"id":"https://openalex.org/I154057602","display_name":"Henry Ford Health","ror":"https://ror.org/02kwnkm68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I154057602"]},{"id":"https://openalex.org/I177721651","display_name":"Oakland University","ror":"https://ror.org/01ythxj32","country_code":"US","type":"education","lineage":["https://openalex.org/I177721651"]},{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Chopp","raw_affiliation_strings":["Department of Physics, Oakland University, Rochester, Michigan; and","Neurology, Henry Ford Health System, Detroit;","2Neurology, Henry Ford Health System, Detroit;","3Department of Physics, Oakland University, Rochester, Michigan; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics, Oakland University, Rochester, Michigan; and","institution_ids":["https://openalex.org/I177721651"]},{"raw_affiliation_string":"Neurology, Henry Ford Health System, Detroit;","institution_ids":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]},{"raw_affiliation_string":"2Neurology, Henry Ford Health System, Detroit;","institution_ids":["https://openalex.org/I154057602"]},{"raw_affiliation_string":"3Department of Physics, Oakland University, Rochester, Michigan; and","institution_ids":["https://openalex.org/I177721651"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5101737223"],"corresponding_institution_ids":["https://openalex.org/I154057602","https://openalex.org/I2803043754"],"apc_list":null,"apc_paid":null,"fwci":5.5302,"has_fulltext":false,"cited_by_count":110,"citation_normalized_percentile":{"value":0.95626669,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"113","issue":"3","first_page":"598","last_page":"608"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11534","display_name":"Erythropoietin and Anemia Treatment","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10416","display_name":"Traumatic Brain Injury Research","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/erythropoietin","display_name":"erythropoietin","score":0.9829999804496765},{"id":"https://openalex.org/keywords/traumatic-brain-injury","display_name":"traumatic brain injury","score":0.9639999866485596},{"id":"https://openalex.org/keywords/treatment-delay","display_name":"treatment delay","score":0.7860000133514404},{"id":"https://openalex.org/keywords/hippocampal-neuronal-loss","display_name":"hippocampal neuronal loss","score":0.859000027179718},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.9399999976158142},{"id":"https://openalex.org/keywords/neurogenesis","display_name":"neurogenesis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/functional-recovery","display_name":"functional recovery","score":0.6930000185966492},{"id":"https://openalex.org/keywords/dose-comparison","display_name":"dose comparison","score":0.675000011920929},{"id":"https://openalex.org/keywords/controlled-cortical-impact","display_name":"controlled cortical impact","score":0.8980000019073486},{"id":"https://openalex.org/keywords/neurological-severity-score","display_name":"neurological severity score","score":0.753000020980835},{"id":"https://openalex.org/keywords/morris-water-maze","display_name":"Morris water maze","score":0.6050000190734863},{"id":"https://openalex.org/keywords/long-term-functional-outcome","display_name":"long-term functional outcome","score":0.5019999742507935}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9011081457138062},{"id":"https://openalex.org/C2778534260","wikidata":"https://www.wikidata.org/wiki/Q218706","display_name":"Erythropoietin","level":2,"score":0.8445309996604919},{"id":"https://openalex.org/C2781017439","wikidata":"https://www.wikidata.org/wiki/Q1995526","display_name":"Traumatic brain injury","level":2,"score":0.7690895795822144},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.5716419219970703},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.5055291652679443},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.5040818452835083},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4918830394744873},{"id":"https://openalex.org/C4746552","wikidata":"https://www.wikidata.org/wiki/Q1456827","display_name":"Neurogenesis","level":2,"score":0.478400319814682},{"id":"https://openalex.org/C44752575","wikidata":"https://www.wikidata.org/wiki/Q1417562","display_name":"Morris water navigation task","level":3,"score":0.475420743227005},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33244311809539795},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.11880287528038025},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.07560953497886658},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004921","descriptor_name":"Erythropoietin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D004921","descriptor_name":"Erythropoietin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010296","descriptor_name":"Parietal Lobe","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D010296","descriptor_name":"Parietal Lobe","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010296","descriptor_name":"Parietal Lobe","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D018919","descriptor_name":"Neovascularization, Physiologic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020127","descriptor_name":"Recovery of Function","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055495","descriptor_name":"Neurogenesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3171/2009.9.jns09844","doi":"https://doi.org/10.3171/2009.9.jns09844","is_oa":false,"landing_page_url":"https://doi.org/10.3171/2009.9.jns09844","pdf_url":null,"source":{"id":"https://openalex.org/S1995308","display_name":"Journal of neurosurgery","issn_l":"0022-3085","issn":["0022-3085","1933-0693"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316861","host_organization_name":"American Association of Neurological Surgeons","host_organization_lineage":["https://openalex.org/P4310316861"],"host_organization_lineage_names":["American Association of Neurological Surgeons"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurosurgery","raw_type":"journal-article"},{"id":"pmid:19817538","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19817538","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurosurgery","raw_type":"Comparative Study"},{"id":"pmh:oai:europepmc.org:2169431","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2898921","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2898921","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2898921","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Neurosurg","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2169431","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2898921","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.7599999904632568,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1077317123","display_name":"Treatment of 'Traumatic Brain Injury with Erythropoietin","funder_award_id":"R01NS062002","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G7887966810","display_name":"Treatment of Neural Injury with MSCs","funder_award_id":"P01NS042345","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W51916832","https://openalex.org/W1498420568","https://openalex.org/W1576809620","https://openalex.org/W1951772246","https://openalex.org/W1968424090","https://openalex.org/W1969951251","https://openalex.org/W1974387239","https://openalex.org/W1974662613","https://openalex.org/W1977152335","https://openalex.org/W1978726693","https://openalex.org/W1981117745","https://openalex.org/W1981688184","https://openalex.org/W1983089266","https://openalex.org/W1988086690","https://openalex.org/W1989229171","https://openalex.org/W2001068966","https://openalex.org/W2001082025","https://openalex.org/W2017169966","https://openalex.org/W2017559797","https://openalex.org/W2021442315","https://openalex.org/W2021547970","https://openalex.org/W2026112841","https://openalex.org/W2029758417","https://openalex.org/W2031057488","https://openalex.org/W2032114206","https://openalex.org/W2034679108","https://openalex.org/W2034987918","https://openalex.org/W2038979543","https://openalex.org/W2045550957","https://openalex.org/W2045663952","https://openalex.org/W2048608744","https://openalex.org/W2067629356","https://openalex.org/W2067739198","https://openalex.org/W2071969118","https://openalex.org/W2078880359","https://openalex.org/W2081869387","https://openalex.org/W2089153438","https://openalex.org/W2093447454","https://openalex.org/W2105711200","https://openalex.org/W2110727611","https://openalex.org/W2121567769","https://openalex.org/W2122041373","https://openalex.org/W2125619731","https://openalex.org/W2142463112","https://openalex.org/W2143058635","https://openalex.org/W2167315608","https://openalex.org/W2169473035","https://openalex.org/W6643999789","https://openalex.org/W6662761510"],"related_works":["https://openalex.org/W1544239819","https://openalex.org/W2087385724","https://openalex.org/W2098887145","https://openalex.org/W2115900673","https://openalex.org/W1498420568","https://openalex.org/W1981688184","https://openalex.org/W2301044584","https://openalex.org/W2789391164","https://openalex.org/W2558668987","https://openalex.org/W20324343"],"abstract_inverted_index":{"OBJECT:":[0],"This":[1],"efficacy":[2],"study":[3],"was":[4,66,82,102],"designed":[5],"to":[6],"investigate":[7],"traumatic":[8],"brain":[9,64,124],"injury":[10,65,122],"(TBI)":[11],"in":[12,20,138,154,198,215],"rats":[13,34,199],"treated":[14],"with":[15,25,132,177,225],"delayed":[16,186,206],"erythropoietin":[17],"(EPO)":[18],"administered":[19,83],"a":[21,26,105,218],"single":[22,219],"dose":[23,220],"compared":[24,176,224],"triple":[27,203],"dose.":[28],"METHODS:":[29],"Young":[30],"adult":[31],"male":[32],"Wistar":[33],"were":[35,117,126],"randomly":[36],"divided":[37],"into":[38],"the":[39,73,133,140,155,178],"following":[40],"groups:":[41],"1)":[42],"sham":[43],"group":[44,49,54,60,168],"(6":[45,50,55],"animals);":[46,51,56],"2)":[47],"TBI/saline":[48],"3)":[52],"TBI/EPOx1":[53],"and":[57,95,111,123,142,152,158,160,173,194,212],"4)":[58],"TBI/EPOx3":[59],"(7":[61],"animals).":[62],"Traumatic":[63],"induced":[67],"by":[68],"controlled":[69],"cortical":[70],"impact":[71],"over":[72],"left":[74],"parietal":[75],"cortex.":[76],"Erythropoietin":[77],"(5000":[78],"U/kg)":[79],"or":[80,90],"saline":[81,134,226],"intraperitoneally":[84],"on":[85,91],"Day":[86],"1":[87],"(EPOx1":[88],"group)":[89,98],"Days":[92],"1,":[93],"2,":[94],"3":[96],"(EPOx3":[97],"postinjury.":[99],"Neurological":[100],"function":[101],"assessed":[103],"using":[104],"modified":[106],"neurological":[107,163],"severity":[108],"score,":[109],"foot-fault,":[110],"Morris":[112],"water":[113],"maze":[114],"tests.":[115],"Animals":[116],"killed":[118],"35":[119],"days":[120],"after":[121,200],"sections":[125],"stained":[127],"for":[128],"immunohistochemistry.":[129],"RESULTS:":[130],"Compared":[131],"treatment,":[135],"EPO":[136,190,207],"treatment":[137,208],"both":[139],"EPOx1":[141,179],"EPOx3":[143,167],"groups":[144],"significantly":[145,161,170,191],"reduced":[146],"hippocampal":[147],"cell":[148],"loss,":[149],"enhanced":[150],"angiogenesis":[151],"neurogenesis":[153],"injured":[156],"cortex":[157],"hippocampus,":[159],"improved":[162,171,192],"functional":[164,172,196,213],"outcome.":[165],"The":[166,202],"exhibited":[169],"histological":[174,193,211],"outcomes":[175,197,214],"group.":[180],"CONCLUSIONS:":[181],"These":[182],"data":[183],"demonstrate":[184],"that":[185],"posttraumatic":[187],"administration":[188],"of":[189,205],"long-term":[195],"TBI.":[201],"doses":[204],"produced":[209],"better":[210],"rats,":[216],"although":[217],"provided":[221],"substantial":[222],"benefits":[223],"treatment.":[227]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":15},{"year":2012,"cited_by_count":14}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}