{"id":"https://openalex.org/W1985644714","doi":"https://doi.org/10.1073/pnas.0901807106","title":"Quantitative magnetic resonance and optical imaging biomarkers of melanoma metastatic potential","display_name":"Quantitative magnetic resonance and optical imaging biomarkers of melanoma metastatic potential","publication_year":2009,"publication_date":"2009-04-06","ids":{"openalex":"https://openalex.org/W1985644714","doi":"https://doi.org/10.1073/pnas.0901807106","mag":"1985644714","pmid":"https://pubmed.ncbi.nlm.nih.gov/19366661","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2672511"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.0901807106","doi":"https://doi.org/10.1073/pnas.0901807106","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0901807106","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/articles/PMC2672511","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086105299","display_name":"Lin Z. Li","orcid":"https://orcid.org/0000-0001-9447-7982","observed_orcids":["https://orcid.org/0000-0001-9447-7982"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lin Z. Li","raw_affiliation_strings":["Department of Radiology, School of Medicine, University of Pennsylvania, B6 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104;","Department of Radiology, School of Medicine, University of Pennsylvania, B6 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, School of Medicine, University of Pennsylvania, B6 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104;","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Radiology, School of Medicine, University of Pennsylvania, B6 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069305433","display_name":"Rong Zhou","orcid":"https://orcid.org/0000-0003-4018-381X","observed_orcids":["https://orcid.org/0000-0003-4018-381X"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rong Zhou","raw_affiliation_strings":["Department of Radiology, School of Medicine, University of Pennsylvania, B6 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, School of Medicine, University of Pennsylvania, B6 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104;","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050304042","display_name":"He N. Xu","orcid":"https://orcid.org/0000-0001-5127-2629","observed_orcids":["https://orcid.org/0000-0001-5127-2629"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"He N. Xu","raw_affiliation_strings":["Department of Radiology, School of Medicine, University of Pennsylvania, B6 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, School of Medicine, University of Pennsylvania, B6 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104;","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039378863","display_name":"Lily Moon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lily Moon","raw_affiliation_strings":["Johnson Research Foundation, Department of Biochemistry and Molecular Biophysics, School of Medicine, University of Pennsylvania, 250 Anatomy Chemistry Building, Philadelphia, PA 19104;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johnson Research Foundation, Department of Biochemistry and Molecular Biophysics, School of Medicine, University of Pennsylvania, 250 Anatomy Chemistry Building, Philadelphia, PA 19104;","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055933257","display_name":"Tuoxiu Zhong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tuoxiu Zhong","raw_affiliation_strings":["Johnson Research Foundation, Department of Biochemistry and Molecular Biophysics, School of Medicine, University of Pennsylvania, 250 Anatomy Chemistry Building, Philadelphia, PA 19104;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johnson Research Foundation, Department of Biochemistry and Molecular Biophysics, School of Medicine, University of Pennsylvania, 250 Anatomy Chemistry Building, Philadelphia, PA 19104;","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109885734","display_name":"Eun Ju Kim","orcid":"https://orcid.org/0000-0002-7332-8301","observed_orcids":["https://orcid.org/0000-0002-7332-8301","https://orcid.org/0000-0003-2696-170X"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eun Ju Kim","raw_affiliation_strings":["Department of Radiology, School of Medicine, University of Pennsylvania, B6 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, School of Medicine, University of Pennsylvania, B6 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104;","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hui Qiao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hui Qiao","raw_affiliation_strings":["Department of Radiology, School of Medicine, University of Pennsylvania, B6 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, School of Medicine, University of Pennsylvania, B6 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104;","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007238841","display_name":"Ravinder D Reddy","orcid":"https://orcid.org/0000-0003-4580-2392","observed_orcids":["https://orcid.org/0000-0003-4580-2392"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ravinder Reddy","raw_affiliation_strings":["Metabolic Magnetic Resonance Research and Computing Center, B1 Stellar-Chance Laboratories, Department of Radiology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolic Magnetic Resonance Research and Computing Center, B1 Stellar-Chance Laboratories, Department of Radiology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111593529","display_name":"Dennis B. Leeper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]},{"id":"https://openalex.org/I4210106595","display_name":"Sidney Kimmel Cancer Center","ror":"https://ror.org/010h6g454","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210106595"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dennis Leeper","raw_affiliation_strings":["Division of Experimental Radiation Oncology, Department of Radiation Oncology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Experimental Radiation Oncology, Department of Radiation Oncology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107; and","institution_ids":["https://openalex.org/I149251103","https://openalex.org/I4210106595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112728827","display_name":"Britton Chance","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Britton Chance","raw_affiliation_strings":["Johnson Research Foundation, Department of Biochemistry and Molecular Biophysics, School of Medicine, University of Pennsylvania, 250 Anatomy Chemistry Building, Philadelphia, PA 19104;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johnson Research Foundation, Department of Biochemistry and Molecular Biophysics, School of Medicine, University of Pennsylvania, 250 Anatomy Chemistry Building, Philadelphia, PA 19104;","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108442630","display_name":"Jerry D. Glickson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jerry D. Glickson","raw_affiliation_strings":["Department of Radiology, School of Medicine, University of Pennsylvania, B6 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, School of Medicine, University of Pennsylvania, B6 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104;","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5112728827"],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":null,"apc_paid":null,"fwci":7.1749,"has_fulltext":false,"cited_by_count":94,"citation_normalized_percentile":{"value":0.97440695,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"106","issue":"16","first_page":"6608","last_page":"6613"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11885","display_name":"MRI in cancer diagnosis","score":0.7656000256538391,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11885","display_name":"MRI in cancer diagnosis","score":0.7656000256538391,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.094200000166893,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.0494999997317791,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.8980000019073486},{"id":"https://openalex.org/keywords/metastatic-potential","display_name":"metastatic potential","score":0.8930000066757202},{"id":"https://openalex.org/keywords/metastasis-biomarkers","display_name":"metastasis biomarkers","score":0.7680000066757202},{"id":"https://openalex.org/keywords/dynamic-contrast-enhanced-mri","display_name":"dynamic contrast-enhanced MRI","score":0.9399999976158142},{"id":"https://openalex.org/keywords/t1rho-mri","display_name":"T1rho MRI","score":0.8960000276565552},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.6729999780654907},{"id":"https://openalex.org/keywords/melanoma-xenografts","display_name":"melanoma xenografts","score":0.8309999704360962},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.6179999709129333}],"concepts":[{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.8373202085494995},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.599040150642395},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.589255690574646},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5747258067131042},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5589997172355652},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.48793837428092957},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.4726238250732422},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.4681929051876068},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.4118977189064026},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3872186541557312},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3342071771621704},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3152744472026825},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21676722168922424},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1865626573562622},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.15143153071403503},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003952","descriptor_name":"Diagnostic Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.0901807106","doi":"https://doi.org/10.1073/pnas.0901807106","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0901807106","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1849074","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC2672511","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2672511","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2672511","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:19366661","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19366661","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1849074","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC2672511","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3034927146","display_name":"CYTOKERATIN AND VIMENTIN EXPRESSION UNDERLIES METASTASIS","funder_award_id":"R01CA059702","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3073193658","display_name":null,"funder_award_id":"CA 59702","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4993918357","display_name":"Network for Translational Research: Optical Imaging","funder_award_id":"U54CA105008","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5278794819","display_name":"Endothelial Transdifferentiation of Invasive Tumor Cells","funder_award_id":"R37CA059702","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5938853855","display_name":"Modification of hyperthermia response","funder_award_id":"P01CA056690","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6442871445","display_name":"SPORE in Skin Cancer","funder_award_id":"P50CA093372","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6525419565","display_name":"Mechanisms of breast cancer progression","funder_award_id":"U01CA105490","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G712405616","display_name":null,"funder_award_id":"UO1CA105490","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8014464397","display_name":"Imaging Stem Cell Grafted in the Infarcted Myocardium","funder_award_id":"R01HL081185","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8031788421","display_name":null,"funder_award_id":"P01-CA56690-09A2","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8636128097","display_name":"A resource for magnetic resonance and optical imaging","funder_award_id":"P41RR002305","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W42871399","https://openalex.org/W102820553","https://openalex.org/W122518273","https://openalex.org/W1497174676","https://openalex.org/W1795798219","https://openalex.org/W1892152977","https://openalex.org/W1907082099","https://openalex.org/W1951046932","https://openalex.org/W1968354566","https://openalex.org/W1974671305","https://openalex.org/W1976436058","https://openalex.org/W1984780011","https://openalex.org/W1996459206","https://openalex.org/W1997995944","https://openalex.org/W1998739717","https://openalex.org/W2002344878","https://openalex.org/W2002600006","https://openalex.org/W2012276721","https://openalex.org/W2014822355","https://openalex.org/W2018737825","https://openalex.org/W2019295139","https://openalex.org/W2022351846","https://openalex.org/W2026103498","https://openalex.org/W2028756812","https://openalex.org/W2040150238","https://openalex.org/W2042098439","https://openalex.org/W2048408428","https://openalex.org/W2051195459","https://openalex.org/W2056033279","https://openalex.org/W2061537686","https://openalex.org/W2070964604","https://openalex.org/W2075744841","https://openalex.org/W2077846988","https://openalex.org/W2090249671","https://openalex.org/W2094543320","https://openalex.org/W2101275059","https://openalex.org/W2107765422","https://openalex.org/W2111365962","https://openalex.org/W2118604693","https://openalex.org/W2124496728","https://openalex.org/W2131365547","https://openalex.org/W2132618190","https://openalex.org/W2142478546","https://openalex.org/W2171559903","https://openalex.org/W2274355266","https://openalex.org/W3021099835","https://openalex.org/W4242063396"],"related_works":["https://openalex.org/W2274355266","https://openalex.org/W1271417708","https://openalex.org/W4240496128","https://openalex.org/W2119820054","https://openalex.org/W2142213463","https://openalex.org/W2026859468","https://openalex.org/W104146420","https://openalex.org/W2608137169","https://openalex.org/W2596055975","https://openalex.org/W2115059865"],"abstract_inverted_index":{"Noninvasive":[0],"or":[1],"minimally":[2],"invasive":[3,214],"prediction":[4],"of":[5,20,29,102,124,134,168,172,200,216,243],"tumor":[6],"metastatic":[7,30,73,76,127,137,244],"potential":[8,31,215,241],"would":[9],"facilitate":[10],"individualized":[11],"cancer":[12],"management.":[13],"Studies":[14],"were":[15,163],"performed":[16],"on":[17,66],"a":[18,107,232],"panel":[19],"human":[21,77],"melanoma":[22,78,128,138,141,157,219,237],"xenografts":[23,79],"that":[24,113,162,231],"spanned":[25],"the":[26,54,86,99,103,122,125,132,135,198,211,217],"full":[27],"range":[28],"measured":[32,97],"by":[33],"an":[34,41,92],"in":[35,42,80,98,121,131,212],"vivo":[36],"lung":[37],"colony":[38],"assay":[39],"and":[40,61,74,90,174,195,203,226,239],"vitro":[43,213],"membrane":[44],"invasion":[45],"culture":[46],"system.":[47],"Three":[48],"imaging":[49,64],"methods":[50],"potentially":[51],"transferable":[52],"to":[53],"clinic":[55],"[dynamic":[56],"contrast-enhanced":[57],"(DCE)":[58],"MRI,":[59],"T(1(rho))-MRI,":[60],"low-temperature":[62],"fluorescence":[63],"(measurable":[65],"biopsy":[67],"specimens)]":[68],"distinguished":[69],"between":[70,182],"relatively":[71],"less":[72],"more":[75,143],"nude":[81],"mice.":[82],"DCE-MRI,":[83],"analyzed":[84],"with":[85,210],"shutter-speed":[87],"relaxometric":[88],"algorithm":[89],"using":[91],"arterial":[93],"input":[94],"function":[95],"simultaneously":[96],"left":[100],"ventricle":[101],"mouse":[104],"heart,":[105],"yielded":[106],"blood":[108,144,150],"transfer":[109],"rate":[110],"constant,":[111],"K(trans),":[112],"measures":[114],"vascular":[115,145],"perfusion/permeability.":[116],"K(trans)":[117],"was":[118],"significantly":[119,164,181],"higher":[120,165],"core":[123,133],"least":[126],"(A375P)":[129],"than":[130,152,166],"most":[136],"(C8161).":[139],"C8161":[140,169],"had":[142],"structures":[146],"but":[147],"fewer":[148],"functional":[149],"vessels":[151],"A375P":[153,156],"melanoma.":[154,170],"The":[155,186],"exhibited":[158],"mean":[159],"T(1(rho))":[160],"values":[161],"those":[167],"Measurements":[171],"T(1)":[173],"T(2)":[175],"relaxation":[176],"times":[177],"did":[178],"not":[179],"differ":[180],"these":[183],"2":[184],"melanomas.":[185],"mitochondrial":[187],"redox":[188],"ratio,":[189],"Fp/(Fp":[190],"+":[191],"NADH),":[192],"where":[193],"Fp":[194],"NADH":[196],"are":[197],"fluorescences":[199],"oxidized":[201],"flavoproteins":[202],"reduced":[204],"pyridine":[205],"nucleotides,":[206],"respectively,":[207],"varied":[208],"linearly":[209],"5":[218],"cell":[220],"lines":[221],"(A375P,":[222],"A375M,":[223],"A375P10,":[224],"A375P5,":[225],"C8161).":[227],"This":[228],"study":[229],"shows":[230],"harsh":[233],"microenvironment":[234],"may":[235],"promote":[236],"metastasis":[238],"provides":[240],"biomarkers":[242],"potential.":[245]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
