{"id":"https://openalex.org/W1985641367","doi":"https://doi.org/10.1002/mrm.1305","title":"A pharmacokinetic model for quantitative evaluation of spinal cord injury with dynamic contrast\u2010enhanced magnetic resonance imaging","display_name":"A pharmacokinetic model for quantitative evaluation of spinal cord injury with dynamic contrast\u2010enhanced magnetic resonance imaging","publication_year":2001,"publication_date":"2001-11-15","ids":{"openalex":"https://openalex.org/W1985641367","doi":"https://doi.org/10.1002/mrm.1305","mag":"1985641367","pmid":"https://pubmed.ncbi.nlm.nih.gov/11746575"},"language":"en","primary_location":{"id":"doi:10.1002/mrm.1305","doi":"https://doi.org/10.1002/mrm.1305","is_oa":false,"landing_page_url":"https://doi.org/10.1002/mrm.1305","pdf_url":null,"source":{"id":"https://openalex.org/S111160002","display_name":"Magnetic Resonance in Medicine","issn_l":"0740-3194","issn":["0740-3194","1522-2594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-2","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Magnetic Resonance in Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042036265","display_name":"Mehmet Bilgen","orcid":"https://orcid.org/0000-0001-5671-2021","observed_orcids":["https://orcid.org/0000-0001-5671-2021"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Mehmet Bilgen","raw_affiliation_strings":["Department of Radiology, University of Texas at Houston Medical School, Houston, Texas 77030, USA. Mehmet.Bilgen@uth.tmc.edu","Department of Radiology, University of Texas at Houston Medical School, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, University of Texas at Houston Medical School, Houston, Texas 77030, USA. Mehmet.Bilgen@uth.tmc.edu","institution_ids":[]},{"raw_affiliation_string":"Department of Radiology, University of Texas at Houston Medical School, Houston, Texas","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040227234","display_name":"Ponnada A. Narayana","orcid":"https://orcid.org/0000-0002-5703-4346","observed_orcids":["https://orcid.org/0000-0002-5703-4346"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ponnada A. Narayana","raw_affiliation_strings":["Department of Radiology, University of Texas at Houston Medical School, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, University of Texas at Houston Medical School, Houston, Texas","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5042036265"],"corresponding_institution_ids":[],"apc_list":{"value":3680,"currency":"USD","value_usd":3680},"apc_paid":null,"fwci":1.7617,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.83000062,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"46","issue":"6","first_page":"1099","last_page":"1106"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.7089999914169312,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.7089999914169312,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.2451000064611435,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.007600000128149986,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spinal-cord-injury","display_name":"spinal cord injury","score":0.9950000047683716},{"id":"https://openalex.org/keywords/pharmacokinetic-modeling","display_name":"pharmacokinetic modeling","score":0.8889999985694885},{"id":"https://openalex.org/keywords/gd-dtpa","display_name":"Gd-DTPA","score":0.9210000038146973},{"id":"https://openalex.org/keywords/dynamic-contrast-enhanced-mri","display_name":"dynamic contrast-enhanced MRI","score":0.9470000267028809},{"id":"https://openalex.org/keywords/blood-spinal-cord-barrier","display_name":"blood-spinal cord barrier","score":0.9520000219345093},{"id":"https://openalex.org/keywords/cerebrospinal-fluid","display_name":"cerebrospinal fluid","score":0.7609999775886536},{"id":"https://openalex.org/keywords/therapeutic-plasma-exchange","display_name":"plasma exchange","score":0.3449999988079071},{"id":"https://openalex.org/keywords/contrast-agent-distribution","display_name":"contrast agent distribution","score":0.7409999966621399},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.6859999895095825}],"concepts":[{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.822719156742096},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.7715654373168945},{"id":"https://openalex.org/C2778334475","wikidata":"https://www.wikidata.org/wiki/Q1415275","display_name":"Spinal cord injury","level":3,"score":0.7585897445678711},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6204715967178345},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5848270058631897},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5628690719604492},{"id":"https://openalex.org/C2779632786","wikidata":"https://www.wikidata.org/wiki/Q920297","display_name":"Cord","level":2,"score":0.5076488256454468},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.46696048974990845},{"id":"https://openalex.org/C41727105","wikidata":"https://www.wikidata.org/wiki/Q17009718","display_name":"Dynamic contrast-enhanced MRI","level":3,"score":0.45769625902175903},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3191978633403778},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.19808915257453918},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.1366640329360962},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.0991833508014679},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013119","descriptor_name":"Spinal Cord Injuries","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D013119","descriptor_name":"Spinal Cord Injuries","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019786","descriptor_name":"Gadolinium DTPA","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/mrm.1305","doi":"https://doi.org/10.1002/mrm.1305","is_oa":false,"landing_page_url":"https://doi.org/10.1002/mrm.1305","pdf_url":null,"source":{"id":"https://openalex.org/S111160002","display_name":"Magnetic Resonance in Medicine","issn_l":"0740-3194","issn":["0740-3194","1522-2594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-2","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Magnetic Resonance in Medicine","raw_type":"journal-article"},{"id":"pmid:11746575","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11746575","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Magnetic resonance in medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1893497283","display_name":"Magnetic Resonance of Spinal Cord Injury","funder_award_id":"R01NS030821","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G253086373","display_name":null,"funder_award_id":"NS30821","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1972817664","https://openalex.org/W1985585695","https://openalex.org/W1987857379","https://openalex.org/W1988642487","https://openalex.org/W2039604691","https://openalex.org/W2042098439","https://openalex.org/W2072626310","https://openalex.org/W2090437724","https://openalex.org/W2092653795","https://openalex.org/W2132072927","https://openalex.org/W2149452746","https://openalex.org/W2149875392"],"related_works":["https://openalex.org/W1998943475","https://openalex.org/W1519600216","https://openalex.org/W2039604691","https://openalex.org/W2159640450","https://openalex.org/W1986248470","https://openalex.org/W2683285261","https://openalex.org/W2323715492","https://openalex.org/W1985209673","https://openalex.org/W7214211663","https://openalex.org/W7096703011"],"abstract_inverted_index":{"A":[0],"multicompartment":[1],"pharmacokinetic":[2],"model":[3,57],"was":[4,27,53],"proposed":[5],"to":[6,55,58,110],"quantitatively":[7],"describe":[8],"the":[9,12,42,56,112,115,123,129,135],"distribution":[10],"of":[11,25,45,70,72,81,99,114,125,131,137],"contrast":[13],"agent":[14],"gadopentetate-dimeglumine":[15],"(Gd)":[16],"in":[17,29,33,41,74,88,101,120],"an":[18],"experimental":[19],"spinal":[20],"cord":[21,76,93,117],"injury":[22,138],"(SCI).":[23],"Concentration":[24],"Gd":[26,73,82,100],"measured":[28],"different":[30,63],"compartments":[31],"with":[32,139],"vivo":[34],"dynamic":[35],"contrast-enhanced":[36],"magnetic":[37],"resonance":[38],"imaging":[39],"(DCE-MRI)":[40],"acute":[43],"phase":[44],"injury.":[46],"The":[47,65],"concentration":[48],"data":[49],"for":[50],"each":[51],"rat":[52],"fitted":[54],"estimate":[59],"transfer":[60],"rates":[61],"between":[62,83],"compartments.":[64],"results":[66],"indicate:":[67],"1)":[68],"lack":[69],"uptake":[71,98],"normal":[75,90],"tissue,":[77],"2)":[78],"rapid":[79],"exchange":[80],"plasma":[84],"and":[85,91,95,133],"cerebrospinal":[86],"fluid":[87],"both":[89],"injured":[92,102,126],"tissues,":[94],"3)":[96],"slower":[97],"cord.":[103],"With":[104],"this":[105],"approach,":[106],"it":[107],"is":[108],"possible":[109],"quantify":[111],"integrity":[113],"blood-spinal":[116],"barrier":[118],"(BSCB)":[119],"vivo,":[121],"evaluate":[122],"pathobiology":[124],"cord,":[127],"assess":[128],"efficacy":[130],"interventions,":[132],"monitor":[134],"progression":[136],"postinjury":[140],"time.":[141]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}