{"id":"https://openalex.org/W1985558852","doi":"https://doi.org/10.1016/j.otohns.2004.06.309","title":"Identification of AIM1 as a Hypermethylation\u2010Inactivated Tumor Suppressor Gene in HNSCC","display_name":"Identification of AIM1 as a Hypermethylation\u2010Inactivated Tumor Suppressor Gene in HNSCC","publication_year":2004,"publication_date":"2004-08-01","ids":{"openalex":"https://openalex.org/W1985558852","doi":"https://doi.org/10.1016/j.otohns.2004.06.309","mag":"1985558852"},"language":"en","primary_location":{"id":"doi:10.1016/j.otohns.2004.06.309","doi":"https://doi.org/10.1016/j.otohns.2004.06.309","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.otohns.2004.06.309","pdf_url":null,"source":{"id":"https://openalex.org/S200877091","display_name":"Otolaryngology","issn_l":"0161-6439","issn":["0161-6439","0194-5998","1085-8679","1097-6817"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Otolaryngology\u2013Head and Neck Surgery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081970973","display_name":"Michael M. Kim","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael M Kim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011385272","display_name":"Andr\u00e9 Lopes Carvalho","orcid":"https://orcid.org/0000-0001-7214-6402","observed_orcids":["https://orcid.org/0000-0001-7214-6402"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andre L. Carvalho","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042199157","display_name":"C\u00e1rmen Jer\u00f3nimo","orcid":"https://orcid.org/0000-0003-4186-5345","observed_orcids":["https://orcid.org/0000-0003-4186-5345"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carmen Jeronimo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057879270","display_name":"Rui Henrique","orcid":"https://orcid.org/0000-0003-3171-4666","observed_orcids":["https://orcid.org/0000-0003-3171-4666"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rui Henrique","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033853754","display_name":"Wayne M. Koch","orcid":"https://orcid.org/0000-0002-9499-1516","observed_orcids":["https://orcid.org/0000-0002-9499-1516"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wayne M Koch","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109152183","display_name":"David Sidransky","orcid":"https://orcid.org/0000-0003-4178-2072","observed_orcids":["https://orcid.org/0000-0003-4178-2072"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Sidransky","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5017600358","display_name":"Joseph A. Califano","orcid":"https://orcid.org/0000-0002-4715-6761","observed_orcids":["https://orcid.org/0000-0002-4715-6761"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joseph Califano","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3600,"currency":"USD","value_usd":3600},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.09373613,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"131","issue":"2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9032999873161316,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9032999873161316,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.07850000262260437,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aim1","display_name":"AIM1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.7300000190734863},{"id":"https://openalex.org/keywords/promoter-hypermethylation","display_name":"promoter hypermethylation","score":0.9860000014305115},{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.9419999718666077},{"id":"https://openalex.org/keywords/epigenetic-silencing","display_name":"epigenetic silencing","score":0.8080000281333923},{"id":"https://openalex.org/keywords/hypomethylating-agents","display_name":"hypomethylating agents","score":0.7710000276565552},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.5339999794960022},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.7829999923706055},{"id":"https://openalex.org/keywords/chromosome-6q","display_name":"chromosome 6q","score":0.9819999933242798}],"concepts":[{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6910945773124695},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6741034984588623},{"id":"https://openalex.org/C2776833033","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck squamous-cell carcinoma","level":4,"score":0.6584944725036621},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.6505056619644165},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.6360034346580505},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5871245265007019},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5743873119354248},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.5327166318893433},{"id":"https://openalex.org/C2779277951","wikidata":"https://www.wikidata.org/wiki/Q5255196","display_name":"Demethylating agent","level":5,"score":0.49292922019958496},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.4729941785335541},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4653893709182739},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.37001508474349976},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.30899280309677124},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23594170808792114},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.1930549442768097}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.otohns.2004.06.309","doi":"https://doi.org/10.1016/j.otohns.2004.06.309","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.otohns.2004.06.309","pdf_url":null,"source":{"id":"https://openalex.org/S200877091","display_name":"Otolaryngology","issn_l":"0161-6439","issn":["0161-6439","0194-5998","1085-8679","1097-6817"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Otolaryngology\u2013Head and Neck Surgery","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2064316733","https://openalex.org/W2082385352","https://openalex.org/W2113295178","https://openalex.org/W2064094361","https://openalex.org/W2328054732","https://openalex.org/W2163392272","https://openalex.org/W1980042406","https://openalex.org/W2156776345","https://openalex.org/W2083543694","https://openalex.org/W2032777920"],"abstract_inverted_index":{"Abstract":[0],"Problem:":[3],"Hypermethylation":[4],"of":[5,19,65,69,93,145,221],"tumor":[6,40,190,205],"suppressor":[7,41,191,206],"gene":[8,42,192,207],"(TSG)":[9],"promoter":[10,49,138,176],"regions":[11],"has":[12],"been":[13],"described":[14,134],"for":[15,175,216],"a":[16,31,38,59,127,143,158,188,203,214,231],"limited":[17],"number":[18],"genes":[20,102,178],"in":[21,43,86,117,124,135,140,142,154,162,179,195,208,218,228],"head":[22,163],"and":[23,96,111,164,182],"neck":[24,165],"squamous":[25],"cell":[26,54,183],"carcinoma":[27],"(HNSCC).":[28],"We":[29],"used":[30],"genome-wide":[32],"strategy":[33],"to":[34,62,78,104,113],"identify":[35],"AIM1":[36,122,149,186,217],"as":[37,187],"putative":[39,66,128,189,204],"HNSC":[44],"that":[45],"is":[46],"inactivated":[47],"by":[48,91,109,230],"methylation.":[50],"Methods:":[52],"HNSCC":[53,88,181,196],"lines":[55,184],"were":[56,89,107],"treated":[57],"with":[58],"demethylating":[60],"agent":[61],"disinhibit":[63],"expression":[64,75],"TSGs.":[67],"Identification":[68],"candidates":[70],"was":[71,151],"based":[72],"on":[73,81,130],"significant":[74],"increases":[76],"compared":[77],"untreated":[79],"controls":[80],"cDNA":[82],"microarrays.":[83],"Genes":[84],"downregulated":[85],"primary":[87,118,147,180],"identified":[90,185],"comparison":[92],"normal":[94],"tissue":[95],"tumors":[97],"using":[98],"similar":[99],"arrays.":[100],"Downregulated":[101],"common":[103],"these":[105],"groups":[106],"verified":[108],"RT-PCR":[110],"subjected":[112],"PCR-based":[114],"methylation":[115],"analysis":[116],"tumors.":[119],"Results:":[121],"(absent":[123],"melanoma":[125],"1),":[126],"TSG":[129],"chromosome":[131],"6q":[132],"originally":[133],"melanoma,":[136],"exhibits":[137],"hypermethylation":[139,150],"28%":[141],"study":[144,201],"47":[146],"HNSCC.":[148,209],"only":[152],"8%":[153],"paired":[155],"controls,":[156],"suggesting":[157],"specific":[159],"contributory":[160],"role":[161,215],"cancer":[166,223],"tumorigenesis":[167,220],"(P":[168],"=":[169],"0.011).":[170],"Conclusion:":[172],"Genome-wide":[173],"screening":[174],"hypermethylation-inactivated":[177],"potentially":[193],"important":[194],"development.":[197],"Significance:":[199],"This":[200],"identifies":[202],"Further":[210],"studies":[211],"may":[212],"discover":[213],"the":[219],"many":[222],"types.":[224],"Support:":[226],"Supported":[227],"part":[229],"NIH":[232],"T32.":[233]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-09-21T07:43:02.447757","created_date":"2016-06-24T00:00:00"}