{"id":"https://openalex.org/W1985543437","doi":"https://doi.org/10.1371/journal.pone.0010846","title":"A Chemical Genetic Screen for Modulators of Asymmetrical 2,2\u2032-Dimeric Naphthoquinones Cytotoxicity in Yeast","display_name":"A Chemical Genetic Screen for Modulators of Asymmetrical 2,2\u2032-Dimeric Naphthoquinones Cytotoxicity in Yeast","publication_year":2010,"publication_date":"2010-05-26","ids":{"openalex":"https://openalex.org/W1985543437","doi":"https://doi.org/10.1371/journal.pone.0010846","mag":"1985543437","pmid":"https://pubmed.ncbi.nlm.nih.gov/20520766","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2877097"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0010846","doi":"https://doi.org/10.1371/journal.pone.0010846","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0010846","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0010846&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0010846&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018403340","display_name":"Ashkan Emadi","orcid":"https://orcid.org/0000-0003-3769-3210","observed_orcids":["https://orcid.org/0000-0003-3769-3210"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashkan Emadi","raw_affiliation_strings":["Department of Internal Medicine and Oncology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA","Department of Internal Medicine and Oncology, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine and Oncology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Department of Internal Medicine and Oncology, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039646183","display_name":"Ashley Evan Ross","orcid":"https://orcid.org/0000-0001-7044-9688","observed_orcids":["https://orcid.org/0000-0001-7044-9688"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashley E. Ross","raw_affiliation_strings":["Department of Urology, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050466594","display_name":"Kathleen M. Cowan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathleen M. Cowan","raw_affiliation_strings":["Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090151782","display_name":"Yolanda M. Fortenberry","orcid":"https://orcid.org/0000-0002-3646-0602","observed_orcids":["https://orcid.org/0000-0002-3646-0602"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yolanda M. Fortenberry","raw_affiliation_strings":["Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006926447","display_name":"Milena Vuica\u2010Ross","orcid":"https://orcid.org/0000-0001-5308-8550","observed_orcids":["https://orcid.org/0000-0001-5308-8550"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Milena Vuica-Ross","raw_affiliation_strings":["Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5006926447"],"corresponding_institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":1.2755,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.83765859,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"5","issue":"5","first_page":"e10846","last_page":"e10846"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytotoxicity-mechanism","display_name":"cytotoxicity mechanism","score":0.7910000085830688},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.7620000243186951},{"id":"https://openalex.org/keywords/cellular-respiration","display_name":"cellular respiration","score":0.9120000004768372},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.843999981880188},{"id":"https://openalex.org/keywords/mitochondrial-membrane-potential","display_name":"mitochondrial membrane potential","score":0.9769999980926514},{"id":"https://openalex.org/keywords/nad-p-h-dehydrogenase","display_name":"NAD(P)H dehydrogenase","score":0.921999990940094},{"id":"https://openalex.org/keywords/nde1","display_name":"NDE1","score":0.9810000061988831},{"id":"https://openalex.org/keywords/drug-sensitivity-and-resistance","display_name":"drug sensitivity and resistance","score":0.7089999914169312},{"id":"https://openalex.org/keywords/hiv-integrase-inhibitors","display_name":"HIV integrase inhibitors","score":0.8550000190734863},{"id":"https://openalex.org/keywords/acute-lymphoblastic-leukemia","display_name":"acute lymphoblastic leukemia","score":0.7509999871253967},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.8450000286102295}],"concepts":[{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.7665367126464844},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.6744063496589661},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5860426425933838},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.42416226863861084},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.32980644702911377},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.321765661239624},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2787761390209198},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.10715913772583008}],"mesh":[{"descriptor_ui":"D000332","descriptor_name":"Aerobiosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005285","descriptor_name":"Fermentation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005820","descriptor_name":"Genetic Testing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007536","descriptor_name":"Isomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009285","descriptor_name":"Naphthoquinones","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D009285","descriptor_name":"Naphthoquinones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016681","descriptor_name":"Genome, Fungal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050296","descriptor_name":"Microbial Viability","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D053078","descriptor_name":"Membrane Potential, Mitochondrial","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pone.0010846","doi":"https://doi.org/10.1371/journal.pone.0010846","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0010846","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0010846&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1921625","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2877097","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2877097","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2877097","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:20520766","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20520766","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.354.8314","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.354.8314","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/6a/bd/PLoS_One_2010_May_26_5(5)_e10846.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:92df8c9750da40568c1c3adb597c9d8c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/92df8c9750da40568c1c3adb597c9d8c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 5, Iss 5, p e10846 (2010)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/143310","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/A_Chemical_Genetic_Screen_for_Modulators_of_Asymmetrical_2_2_Dimeric_Naphthoquinones_Cytotoxicity_in_Yeast/143310","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0010846","doi":"https://doi.org/10.1371/journal.pone.0010846","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0010846","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0010846&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310145","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1985543437.pdf","grobid_xml":"https://content.openalex.org/works/W1985543437.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W992145940","https://openalex.org/W1492029572","https://openalex.org/W1581031482","https://openalex.org/W1591489535","https://openalex.org/W1613809967","https://openalex.org/W1887517876","https://openalex.org/W1968426696","https://openalex.org/W1973612987","https://openalex.org/W1979328799","https://openalex.org/W1986961470","https://openalex.org/W1990283519","https://openalex.org/W1990340142","https://openalex.org/W1994084197","https://openalex.org/W1999368137","https://openalex.org/W2019065245","https://openalex.org/W2020042020","https://openalex.org/W2028427446","https://openalex.org/W2029019958","https://openalex.org/W2037393746","https://openalex.org/W2038426380","https://openalex.org/W2044313365","https://openalex.org/W2049516586","https://openalex.org/W2061298521","https://openalex.org/W2065666684","https://openalex.org/W2070920469","https://openalex.org/W2074927626","https://openalex.org/W2082442667","https://openalex.org/W2087469797","https://openalex.org/W2103017472","https://openalex.org/W2106747102","https://openalex.org/W2110041043","https://openalex.org/W2112252275","https://openalex.org/W2123819911","https://openalex.org/W2130338082","https://openalex.org/W2133148204","https://openalex.org/W2139837746","https://openalex.org/W2142437744","https://openalex.org/W2166574880","https://openalex.org/W2166792274","https://openalex.org/W2429336089","https://openalex.org/W2951027085","https://openalex.org/W2951070010"],"related_works":["https://openalex.org/W7100765219","https://openalex.org/W2560260772","https://openalex.org/W2322023670","https://openalex.org/W2806346753","https://openalex.org/W4405220387","https://openalex.org/W2555325296","https://openalex.org/W64588914","https://openalex.org/W4392199875","https://openalex.org/W2951403672","https://openalex.org/W2909813931"],"abstract_inverted_index":{"BACKGROUND:":[0],"Dimeric":[1],"naphthoquinones":[2],"(BiQ)":[3],"were":[4,102,154],"originally":[5],"synthesized":[6],"as":[7,29,133,219],"a":[8,54,59,108,150],"new":[9],"class":[10],"of":[11,35,48,50,73,78,88,107,149,176,204,226,237],"HIV":[12],"integrase":[13],"inhibitors":[14],"but":[15],"have":[16],"shown":[17,164],"integrase-independent":[18],"cytotoxicity":[19,37,247],"in":[20,58,70,93,146,185,230,269],"acute":[21],"lymphoblastic":[22],"leukemia":[23],"cell":[24],"lines":[25],"suggesting":[26],"their":[27,119],"use":[28],"potential":[30,170],"anti-neoplastic":[31],"agents.":[32],"The":[33],"mechanism":[34,268],"this":[36,227,267],"is":[38,248],"unknown.":[39],"In":[40,244],"order":[41],"to":[42,83,114,137,140,157,165,173,193,209,221,241,255,265],"gain":[43],"insight":[44],"into":[45],"the":[46,71,94,147,167,174,202,213],"mode":[47],"action":[49,211],"binaphthoquinones":[51],"we":[52],"performed":[53,103],"systematic":[55],"high-throughput":[56],"screen":[57],"yeast":[60,81,89,110,124,144,240],"isogenic":[61],"deletion":[62,111],"mutant":[63,112,188],"array":[64],"for":[65,207],"enhanced":[66],"or":[67],"suppressed":[68],"growth":[69,90],"presence":[72,203],"binaphthoquinones.":[74],"METHODOLOGY/PRINCIPAL":[75],"FINDINGS:":[76],"Exposure":[77],"wild":[79,142,194,238],"type":[80,143,195,239],"strains":[82,189],"various":[84],"BiQs":[85,115,162],"demonstrated":[86],"inhibition":[87],"with":[91,125,161],"IC(50)s":[92],"microM":[95],"range.":[96],"Drug":[97],"sensitivity":[98,136,236],"and":[99,130,159,171,196,224,234,258],"resistance":[100,208],"screens":[101,122],"by":[104,201],"exposing":[105],"arrays":[106],"haploid":[109],"library":[113],"at":[116],"concentrations":[117],"near":[118],"IC(50).":[120],"Sensitivity":[121],"identified":[123,212],"deletions":[126],"affecting":[127],"mitochondrial":[128,168,214],"function":[129],"cellular":[131],"respiration":[132],"having":[134],"increased":[135,191,231,235],"BiQs.":[138],"Corresponding":[139],"this,":[141],"grown":[145],"absence":[148],"fermentable":[151],"carbon":[152],"source":[153],"particularly":[155],"sensitive":[156,187],"BiQs,":[158],"treatment":[160],"was":[163,190],"disrupt":[166],"membrane":[169],"lead":[172],"generation":[175],"reactive":[177],"oxygen":[178],"species":[179],"(ROS).":[180],"Furthermore,":[181],"baseline":[182],"ROS":[183,232,256],"production":[184,233,257],"BiQ":[186,210,222],"compared":[192],"could":[197],"be":[198],"further":[199],"augmented":[200],"BiQ.":[205,242],"Screens":[206],"external":[215],"NAD(P)H":[216],"dehydrogenase,":[217],"NDE1,":[218],"critical":[220],"toxicity":[223],"over-expression":[225],"gene":[228],"resulted":[229],"CONCLUSIONS/SIGNIFICANCE:":[243],"yeast,":[245],"binaphthoquinone":[246],"likely":[249],"mediated":[250],"through":[251],"NAD(P)H:quonine":[252],"oxidoreductases":[253],"leading":[254],"dysfunctional":[259],"mitochondria.":[260],"Further":[261],"studies":[262],"are":[263],"required":[264],"validate":[266],"mammalian":[270],"cells.":[271]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
