{"id":"https://openalex.org/W1985498624","doi":"https://doi.org/10.1158/1940-6207.prev-10-b21","title":"Abstract B21: Relationship of the global metabolome in blood to smoking behavior: A pilot study","display_name":"Abstract B21: Relationship of the global metabolome in blood to smoking behavior: A pilot study","publication_year":2010,"publication_date":"2010-12-01","ids":{"openalex":"https://openalex.org/W1985498624","doi":"https://doi.org/10.1158/1940-6207.prev-10-b21","mag":"1985498624"},"language":"en","primary_location":{"id":"doi:10.1158/1940-6207.prev-10-b21","doi":"https://doi.org/10.1158/1940-6207.prev-10-b21","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1940-6207.prev-10-b21","pdf_url":null,"source":{"id":"https://openalex.org/S68240649","display_name":"Cancer Prevention Research","issn_l":"1940-6207","issn":["1940-6207","1940-6215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Prevention Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040281765","display_name":"Ping-Ching Hsu","orcid":"https://orcid.org/0000-0002-1749-0662","observed_orcids":["https://orcid.org/0000-0002-1749-0662"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ping-Ching Hsu","raw_affiliation_strings":["1Georgetown University, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Georgetown University, Washington, DC","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Bin Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bin Zhou","raw_affiliation_strings":["2Virginia Tech, Arlington, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Virginia Tech, Arlington, VA","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025125310","display_name":"Habtom W. Ressom","orcid":"https://orcid.org/0000-0001-9296-2132","observed_orcids":["https://orcid.org/0000-0001-9296-2132"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Habtom Ressom","raw_affiliation_strings":["3Georgetown University, Falls Church, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Georgetown University, Falls Church, VA","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003800447","display_name":"Amrita K. Cheema","orcid":"https://orcid.org/0000-0003-4877-7583","observed_orcids":["https://orcid.org/0000-0003-4877-7583"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amrita Cheema","raw_affiliation_strings":["3Georgetown University, Falls Church, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Georgetown University, Falls Church, VA","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016346283","display_name":"Kathryn D. Sheikh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathryn Sheikh","raw_affiliation_strings":["3Georgetown University, Falls Church, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Georgetown University, Falls Church, VA","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088899243","display_name":"Wallace B. Pickworth","orcid":"https://orcid.org/0000-0003-3310-2567","observed_orcids":["https://orcid.org/0000-0003-3310-2567"]},"institutions":[{"id":"https://openalex.org/I1325736334","display_name":"Battelle","ror":"https://ror.org/01h5tnr73","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1325736334"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wallace Pickworth","raw_affiliation_strings":["4Battelle Centers for Public Health Research and Evaluation, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Battelle Centers for Public Health Research and Evaluation, Baltimore, MD","institution_ids":["https://openalex.org/I1325736334"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079716545","display_name":"Peter G. Shields","orcid":"https://orcid.org/0000-0002-7404-217X","observed_orcids":["https://orcid.org/0000-0002-7404-217X"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Shields","raw_affiliation_strings":["3Georgetown University, Falls Church, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Georgetown University, Falls Church, VA","institution_ids":["https://openalex.org/I184565670"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"3","issue":"12_Supplement","first_page":"B21","last_page":"B21"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.7300000190734863,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.7300000190734863,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.25220000743865967,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11667","display_name":"Advanced Chemical Sensor Technologies","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasma-metabolome","display_name":"plasma metabolome","score":0.8640000224113464},{"id":"https://openalex.org/keywords/number-of-cigarettes-per-day","display_name":"number of cigarettes per day","score":0.781000018119812},{"id":"https://openalex.org/keywords/cancer-risk-biomarkers","display_name":"cancer risk biomarkers","score":0.7879999876022339},{"id":"https://openalex.org/keywords/heavy-smokers","display_name":"heavy smokers","score":0.4659999907016754},{"id":"https://openalex.org/keywords/light-smokers","display_name":"light smokers","score":0.8220000267028809},{"id":"https://openalex.org/keywords/smoking-topography","display_name":"smoking topography","score":0.5019999742507935},{"id":"https://openalex.org/keywords/nicotine-metabolism","display_name":"nicotine metabolism","score":0.5260000228881836},{"id":"https://openalex.org/keywords/carbon-monoxide","display_name":"carbon monoxide","score":0.7929999828338623},{"id":"https://openalex.org/keywords/bile-acid-synthesis","display_name":"bile acid synthesis","score":0.8669999837875366},{"id":"https://openalex.org/keywords/phospholipid-degradation","display_name":"phospholipid degradation","score":0.8999999761581421},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.7310000061988831},{"id":"https://openalex.org/keywords/cell-death","display_name":"cell death","score":0.5289999842643738},{"id":"https://openalex.org/keywords/smoking-cessation-pharmacotherapy","display_name":"smoking cessation pharmacotherapy","score":0.47200000286102295}],"concepts":[{"id":"https://openalex.org/C135870905","wikidata":"https://www.wikidata.org/wiki/Q903667","display_name":"Metabolome","level":3,"score":0.8662762641906738},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.6815317869186401},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5671981573104858},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.5143729448318481},{"id":"https://openalex.org/C161584116","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate statistics","level":2,"score":0.501082181930542},{"id":"https://openalex.org/C169258074","wikidata":"https://www.wikidata.org/wiki/Q245748","display_name":"Random forest","level":2,"score":0.43592238426208496},{"id":"https://openalex.org/C148483581","wikidata":"https://www.wikidata.org/wiki/Q446488","display_name":"Feature selection","level":2,"score":0.41311341524124146},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29916518926620483},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.26976799964904785},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19423329830169678},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.14779546856880188},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.1366153359413147},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.10831931233406067}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1940-6207.prev-10-b21","doi":"https://doi.org/10.1158/1940-6207.prev-10-b21","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1940-6207.prev-10-b21","pdf_url":null,"source":{"id":"https://openalex.org/S68240649","display_name":"Cancer Prevention Research","issn_l":"1940-6207","issn":["1940-6207","1940-6215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Prevention Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2062322586","https://openalex.org/W2563781570","https://openalex.org/W2473634482","https://openalex.org/W2337353829","https://openalex.org/W2090798613","https://openalex.org/W2333142264","https://openalex.org/W2747926459","https://openalex.org/W4221088176","https://openalex.org/W4400316722","https://openalex.org/W2065127110"],"abstract_inverted_index":{"Abstract":[0],"Introduction:":[1],"Better":[2],"biomarkers":[3,38],"of":[4,59,117,124,133,158,171,178,220,393],"cancer":[5],"risk":[6],"are":[7],"needed":[8],"for":[9,29,93,185,207,227,288,308],"smokers":[10,104,161],"to":[11,44,216,296,358],"enhance":[12],"early":[13],"detection":[14],"and":[15,25,48,68,80,86,105,113,162,167,198,224,246,255,260,269,282,293,301,336,347,350,370,378,381],"support":[16],"the":[17,111,122,131,176,202,218,225,243,250,266,298,302],"FDA":[18],"as":[19,329,372],"it":[20],"considers":[21],"cigarette":[22],"performance":[23,219,226],"standards":[24],"evaluate":[26,366],"health":[27],"claims":[28],"modified":[30],"tobacco":[31],"products.":[32],"This":[33],"study":[34,58,98,112],"will":[35,364],"identify":[36,45],"new":[37],"through":[39,142],"metabolomics,":[40],"a":[41,54,76,375],"powerful":[42],"method":[43],"numerous":[46],"metabolites":[47],"profiles.":[49,181],"Study":[50],"Design:":[51],"We":[52,128,363],"utilized":[53],"previously":[55],"conducted":[56,100],"epidemiology":[57],"well-characterized":[60],"smokers.":[61],"These":[62],"subjects":[63],"completed":[64],"an":[65],"extensive":[66],"interview":[67],"smoked":[69],"two":[70],"cigarettes,":[71],"one":[72],"hour":[73],"apart,":[74],"in":[75,148,242,249,265],"smoking":[77,320,368],"laboratory.":[78],"Blood":[79],"CO":[81,379],"measurements":[82],"were":[83,205,253,263,285,306],"collected":[84],"before":[85],"after":[87,256],"each":[88],"cigarette.":[89],"Plasma":[90],"is":[91,322,385],"available":[92],"metabolomic":[94,156,180],"profiling.":[95],"A":[96],"pilot":[97,150],"was":[99,214,229],"on":[101,140],"5":[102,106,159,163],"light":[103,160],"heavy":[107,164,359],"smokers\u2019":[108,165,388],"plasma":[109,166],"from":[110,201,276],"evaluated":[114,168],"whether":[115,169,367,382],"number":[116,132,170],"cigarettes":[118,134,172],"per":[119,135,173],"day":[120,136,174],"mediates":[121],"influence":[123,139,177],"global":[125,143,155,179,389],"metabolome.":[126,144],"Hypothesis:":[127],"hypothesized":[129],"that":[130,319],"exerts":[137],"their":[138],"phenotype":[141],"Methods:":[145],"Using":[146],"UPLC-TOFMS":[147],"our":[149,238],"study,":[151],"we":[152],"first":[153],"analyzed":[154],"profiles":[157],"mediate":[175],"The":[182,210,339],"data":[183,187],"obtained":[184],"multivariate":[186],"analyses":[188],"using":[189,231,290],"Scripps\u2019":[190],"XCMS.":[191],"t-test,":[192],"SVM":[193,281],"(Support":[194],"Vector":[195],"Machine":[196],"analysis),":[197],"Random":[199,221,283],"Forest":[200,222],"Metaboanalyst":[203],"(www.metaboanalyst)":[204],"used":[206,215,307],"feature":[208,257],"selection.":[209],"OOB":[211],"(out-of-bag)":[212],"error":[213],"measure":[217],"classification":[223],"SVMs":[228],"estimated":[230],"leave-one-out":[232],"cross":[233],"validation":[234],"(LOOCV).":[235],"Results:":[236],"In":[237],"results,":[239],"1199":[240],"peaks":[241,248,262],"positive":[244,267],"mode":[245,252,268],"497":[247],"negative":[251,270],"detected":[254],"selection,":[258],"816":[259],"361":[261],"selected":[264],"mode,":[271],"separately.":[272],"Those":[273],"significant":[274],"features":[275],"all":[277],"three":[278],"methods":[279],"(t-test,":[280],"Forest)":[284],"pooled":[286,303],"together":[287],"identification":[289],"Metlin,":[291],"MMCD":[292],"HMDB":[294],"databases":[295],"obtain":[297],"KEGG":[299,304],"IDs,":[300],"IDs":[305],"Ingenuity":[309],"Pathways":[310,340],"Analysis":[311,341],"(Ingenuity@":[312],"Systems,":[313],"www.ingenuity.com).":[314],"Our":[315],"preliminary":[316],"results":[317],"suggest":[318],"behavior":[321],"associated":[323,386],"with":[324,387],"several":[325,344],"biological":[326],"pathways":[327],"such":[328],"cell":[330],"death,":[331],"gene":[332],"expression,":[333],"cell-cell":[334],"interaction,":[335],"lipid":[337],"metabolism.":[338],"also":[342],"reveals":[343],"liver,":[345],"heart":[346],"renal":[348],"toxicity":[349],"altered":[351],"bile":[352],"acid":[353],"biosynthesis,":[354],"phospholipid":[355],"degradation":[356],"due":[357],"smoking.":[360,394],"Future":[361],"Studies:":[362],"further":[365],"topography":[369],"inhalation,":[371],"measured":[373],"by":[374,391],"nicotine":[376,383],"boost":[377],"boost,":[380],"metabolism":[384],"metabolome":[390],"level":[392],"Citation":[395],"Information:":[396],"Cancer":[397],"Prev":[398],"Res":[399],"2010;3(12":[400],"Suppl):B21.":[401]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}