{"id":"https://openalex.org/W1985491070","doi":"https://doi.org/10.1158/1538-7445.am2011-135","title":"Abstract 135: MicroRNA repression of BIRC4/XIAP in lung cancer","display_name":"Abstract 135: MicroRNA repression of BIRC4/XIAP in lung cancer","publication_year":2011,"publication_date":"2011-04-01","ids":{"openalex":"https://openalex.org/W1985491070","doi":"https://doi.org/10.1158/1538-7445.am2011-135","mag":"1985491070"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2011-135","doi":"https://doi.org/10.1158/1538-7445.am2011-135","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2011-135","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081400805","display_name":"Yili Xie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yili Xie","raw_affiliation_strings":["1National Cancer Inst., Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1National Cancer Inst., Bethesda, MD","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032660970","display_name":"Jordi Camps","orcid":"https://orcid.org/0000-0003-2929-4228","observed_orcids":["https://orcid.org/0000-0003-2929-4228","https://orcid.org/0000-0002-7484-6717"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jordi Camps","raw_affiliation_strings":["1National Cancer Inst., Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1National Cancer Inst., Bethesda, MD","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065736142","display_name":"Keytam S. Awad","orcid":"https://orcid.org/0000-0002-0165-6939","observed_orcids":["https://orcid.org/0000-0002-0165-6939"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keytam S. Awad","raw_affiliation_strings":["1National Cancer Inst., Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1National Cancer Inst., Bethesda, MD","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055865720","display_name":"Danny Wangsa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Danny Wangsa","raw_affiliation_strings":["1National Cancer Inst., Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1National Cancer Inst., Bethesda, MD","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052012838","display_name":"Jianhui Yang","orcid":"https://orcid.org/0000-0002-8710-1722","observed_orcids":["https://orcid.org/0000-0002-8710-1722"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianhui Yang","raw_affiliation_strings":["1National Cancer Inst., Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1National Cancer Inst., Bethesda, MD","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054259815","display_name":"Nina Yoo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nina Yoo","raw_affiliation_strings":["1National Cancer Inst., Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1National Cancer Inst., Bethesda, MD","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031392514","display_name":"Thomas Ried","orcid":"https://orcid.org/0000-0002-0767-6009","observed_orcids":["https://orcid.org/0000-0002-0767-6009"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Ried","raw_affiliation_strings":["1National Cancer Inst., Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1National Cancer Inst., Bethesda, MD","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083608970","display_name":"King F. Kwong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"King F. Kwong","raw_affiliation_strings":["1National Cancer Inst., Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1National Cancer Inst., Bethesda, MD","institution_ids":["https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210140884"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"71","issue":"8_Supplement","first_page":"135","last_page":"135"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.656000018119812},{"id":"https://openalex.org/keywords/mir-24","display_name":"miR-24","score":0.9890000224113464},{"id":"https://openalex.org/keywords/xiap","display_name":"XIAP","score":0.9990000128746033},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9750000238418579},{"id":"https://openalex.org/keywords/3-untranslated-region","display_name":"3' untranslated region","score":0.8830000162124634},{"id":"https://openalex.org/keywords/microrna-target-regulation","display_name":"microRNA target regulation","score":0.6330000162124634},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9100000262260437},{"id":"https://openalex.org/keywords/trail-resistance","display_name":"TRAIL resistance","score":0.9580000042915344},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.859000027179718},{"id":"https://openalex.org/keywords/parp-cleavage","display_name":"PARP cleavage","score":0.9100000262260437},{"id":"https://openalex.org/keywords/iap-family-proteins","display_name":"IAP family proteins","score":0.5659999847412109},{"id":"https://openalex.org/keywords/chromosomal-abnormalities","display_name":"chromosomal abnormalities","score":0.5809999704360962},{"id":"https://openalex.org/keywords/a549-cells","display_name":"A549 cells","score":0.7020000219345093},{"id":"https://openalex.org/keywords/gene-silencing","display_name":"gene silencing","score":0.4819999933242798},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.3179999887943268}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.7149025201797485},{"id":"https://openalex.org/C33195913","wikidata":"https://www.wikidata.org/wiki/Q20970121","display_name":"XIAP","level":5,"score":0.6363261938095093},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6167897582054138},{"id":"https://openalex.org/C89604277","wikidata":"https://www.wikidata.org/wiki/Q424345","display_name":"Untranslated region","level":4,"score":0.5930275321006775},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5822398066520691},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.5350151658058167},{"id":"https://openalex.org/C22667442","wikidata":"https://www.wikidata.org/wiki/Q3272830","display_name":"Three prime untranslated region","level":5,"score":0.48077601194381714},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4368259012699127},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4330219328403473},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.40272194147109985},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3206281065940857},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.26890861988067627},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.2210771143436432},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.21794924139976501},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18612629175186157}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2011-135","doi":"https://doi.org/10.1158/1538-7445.am2011-135","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2011-135","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9789000153541565}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6600000262260437}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1992616769","https://openalex.org/W2331558733","https://openalex.org/W2077259663","https://openalex.org/W1527599612","https://openalex.org/W2953061759","https://openalex.org/W2992435032","https://openalex.org/W2811041739","https://openalex.org/W154034622","https://openalex.org/W2781407218","https://openalex.org/W2734674739"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"MicroRNAs":[2],"(miRNAs,":[3],"miR)":[4],"are":[5],"short":[6],"\u223c22":[7],"nucleotide":[8,257],"(nt)":[9],"noncoding":[10],"RNA":[11],"molecules":[12],"capable":[13],"of":[14,32,35,38,102,188,194,235,278,306,316,354,368,382,393,398],"regulating":[15],"gene":[16],"expression":[17,137,234,242,277,332,353],"by":[18,79,140,152,202,275,333],"targeting":[19,335],"mRNA.":[20],"Baculovirus":[21],"IAP":[22],"repeat":[23],"containing":[24,157],"protein-4":[25],"(BIRC4/XIAP)":[26],"is":[27,105,283],"the":[28,33,147,158,189,252,286,293,324,336,351,361,379,394,399],"most":[29],"potent":[30],"member":[31],"Inhibitor":[34],"apoptosis":[36,117,198,208,288],"family":[37],"proteins":[39],"(IAP)":[40],"and":[41,56,92,114,123,131,143,210,216,339],"an":[42],"important":[43],"cellular":[44],"pro-survival":[45],"stimulus.":[46],"BIRC4":[47,93,113,135,148,159,177,241,253,331,337],"mRNA":[48],"contains":[49],"a":[50,81,185],"long":[51],"3\u2019":[52,77,254],"untranslated":[53],"region":[54,296],"(UTR)":[55],"its":[57],"function":[58],"remains":[59],"unclear.":[60],"Previously,":[61],"we":[62],"have":[63],"shown":[64],"that":[65,72,229,249,363],"17":[66],"candidate":[67],"miRNAs":[68],"can":[69,110,272,340],"be":[70,273,367],"identified":[71],"potentially":[73],"interacted":[74],"with":[75,146,302,313,372],"BIRC4's":[76],"UTR":[78,255],"using":[80,153],"computerized":[82],"heuristic":[83],"algorithm.":[84],"An":[85],"inverse":[86],"relationship":[87],"was":[88,138,150,167,200,297],"discovered":[89],"between":[90],"miR-24":[91,109,238,250,260,281,294,317,325,329,355,364],"in":[94,118,128,178,243,292,299,323,356,370,378],"non-small":[95],"cell":[96,197,204,269],"lung":[97,311,383],"cancers":[98],"(NSCLC).":[99],"The":[100,192],"objective":[101],"this":[103],"study":[104],"to":[106,172,180,225,267,344,350],"determine":[107],"whether":[108],"directly":[111,334],"target":[112],"consequently":[115],"regulate":[116],"NSCLC.":[119,357],"Methods:":[120],"miRNA":[121,195],"precursors":[122],"anti-miRNA":[124],"inhibitors":[125],"were":[126,223],"transfected":[127],"NSCLC":[129,244,300,308,342],"cells":[130,171,266,301,312,343],"their":[132,144],"effect":[133],"on":[134,184,196],"protein":[136],"evaluated":[139],"western":[141],"blot":[142,212],"interaction":[145],"3\u2019UTR":[149,160,338],"detected":[151],"luciferase":[154],"reporter":[155],"plasmids":[156],"(wild":[161],"type":[162],"&":[163],"mutant).":[164],"Lentiviral":[165],"p-Receiver-lv19-BIRC4":[166],"transduced":[168],"into":[169],"A549":[170,265],"generate":[173],"stable":[174],"clones":[175],"overexpressing":[176],"order":[179],"examine":[181],"miR-24's":[182],"effects":[183,193],"transcript":[186],"devoid":[187],"native":[190],"3\u2019-UTR.":[191],"signaling":[199],"determined":[201],"MTT":[203],"viability":[205],"assay,":[206],"TdT":[207],"assay":[209,247],"Western":[211],"for":[213,232,402],"caspase-3":[214],"activation":[215],"PARP":[217],"cleavage.":[218],"Cytogenetic":[219],"analyses":[220],"(SKY":[221],"&CGH)":[222],"performed":[224],"detect":[226],"chromosomal":[227],"abnormalities":[228],"may":[230,366],"account":[231],"reduced":[233,352],"miRNA.":[236],"Results:":[237],"transfection":[239],"down-regulates":[240,330],"cells.":[245],"Luciferase":[246],"confirmed":[248],"targets":[251],"at":[256],"positions":[258],"2294-2310.":[259],"also":[261],"sensitizes":[262],"intrinsically":[263],"TRAIL-resistant":[264],"TRAIL-induced":[268,345],"apoptosis,":[270],"which":[271],"reversed":[274],"ectopic":[276],"miR-24-insensitive":[279],"BIRC4.":[280],"sensitized-apoptosis":[282],"modulated":[284],"via":[285],"canonical":[287],"pathway.":[289],"Genomic":[290,347],"deletion":[291,322,348],"coding":[295,326],"found":[298],"corresponding":[303],"low":[304],"levels":[305,315],"miR-24.":[307],"or":[309,374],"normal":[310],"normal/high":[314],"did":[318],"not":[319],"exhibit":[320],"cytogenetic":[321],"region.":[327],"Conclusions:":[328],"sensitize":[341],"apoptosis.":[346],"contributes":[349],"This":[358],"finding":[359],"raises":[360],"possibility":[362],"mimetics":[365],"value":[369],"combination":[371],"TRAIL":[373],"other":[375],"therapeutic":[376],"strategies":[377],"future":[380],"treatment":[381],"cancer.":[384],"Citation":[385],"Format:":[386],"{Authors}.":[387],"{Abstract":[388],"title}":[389],"[abstract].":[390],"In:":[391],"Proceedings":[392],"102nd":[395],"Annual":[396],"Meeting":[397],"American":[400],"Association":[401],"Cancer":[403,413],"Research;":[404],"2011":[405],"Apr":[406],"2-6;":[407],"Orlando,":[408],"FL.":[409],"Philadelphia":[410],"(PA):":[411],"AACR;":[412],"Res":[414],"2011;71(8":[415],"Suppl):Abstract":[416],"nr":[417],"135.":[418],"doi:10.1158/1538-7445.AM2011-135":[419]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}
