{"id":"https://openalex.org/W1985484598","doi":"https://doi.org/10.1172/jci110470","title":"Contribution of Plasma Protease Inhibitors to the Inactivation of Kallikrein in Plasma","display_name":"Contribution of Plasma Protease Inhibitors to the Inactivation of Kallikrein in Plasma","publication_year":1982,"publication_date":"1982-02-01","ids":{"openalex":"https://openalex.org/W1985484598","doi":"https://doi.org/10.1172/jci110470","mag":"1985484598","pmid":"https://pubmed.ncbi.nlm.nih.gov/6173399","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/370996"},"language":"en","primary_location":{"id":"doi:10.1172/jci110470","doi":"https://doi.org/10.1172/jci110470","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci110470","pdf_url":"http://www.jci.org/articles/view/110470/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/110470/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008948102","display_name":"Marc Schapira","orcid":"https://orcid.org/0000-0003-0384-0075","observed_orcids":["https://orcid.org/0000-0003-0384-0075"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marc Schapira","raw_affiliation_strings":["Thrombosis Research Center , Temple University School of Medicine , Philadelphia , Pennsylvania 19140","Research Center, Temple University School of Medicine, Philadelphia, Pennsylvania 19140"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thrombosis Research Center , Temple University School of Medicine , Philadelphia , Pennsylvania 19140","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Research Center, Temple University School of Medicine, Philadelphia, Pennsylvania 19140","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109438465","display_name":"Cheryl F. Scott","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cheryl F. Scott","raw_affiliation_strings":["Thrombosis Research Center , Temple University School of Medicine , Philadelphia , Pennsylvania 19140","Research Center, Temple University School of Medicine, Philadelphia, Pennsylvania 19140"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thrombosis Research Center , Temple University School of Medicine , Philadelphia , Pennsylvania 19140","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Research Center, Temple University School of Medicine, Philadelphia, Pennsylvania 19140","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5104652394","display_name":"Robert W. Colman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert W. Colman","raw_affiliation_strings":["Thrombosis Research Center , Temple University School of Medicine , Philadelphia , Pennsylvania 19140","Research Center, Temple University School of Medicine, Philadelphia, Pennsylvania 19140"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thrombosis Research Center , Temple University School of Medicine , Philadelphia , Pennsylvania 19140","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Research Center, Temple University School of Medicine, Philadelphia, Pennsylvania 19140","institution_ids":["https://openalex.org/I84392919"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I84392919"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":10.0137,"has_fulltext":true,"cited_by_count":212,"citation_normalized_percentile":{"value":0.98369344,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"69","issue":"2","first_page":"462","last_page":"468"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasma-kallikrein","display_name":"plasma kallikrein","score":0.8859999775886536},{"id":"https://openalex.org/keywords/plasma-protease-inhibitors","display_name":"plasma protease inhibitors","score":0.8830000162124634},{"id":"https://openalex.org/keywords/c1-inhibitor","display_name":"C1 inhibitor","score":0.8679999709129333},{"id":"https://openalex.org/keywords/alpha-2-macroglobulin","display_name":"alpha2-macroglobulin","score":0.9670000076293945},{"id":"https://openalex.org/keywords/antithrombin-iii","display_name":"antithrombin III","score":0.9120000004768372},{"id":"https://openalex.org/keywords/alpha1-proteinase-inhibitor","display_name":"alpha 1-proteinase inhibitor","score":0.9710000157356262}],"concepts":[{"id":"https://openalex.org/C52853521","wikidata":"https://www.wikidata.org/wiki/Q423285","display_name":"Kallikrein","level":3,"score":0.9320069551467896},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7604138851165771},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.6105520725250244},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.530849814414978},{"id":"https://openalex.org/C2781054842","wikidata":"https://www.wikidata.org/wiki/Q6725283","display_name":"Macroglobulin","level":2,"score":0.48727214336395264},{"id":"https://openalex.org/C148898269","wikidata":"https://www.wikidata.org/wiki/Q1108792","display_name":"Kinetics","level":2,"score":0.4461984634399414},{"id":"https://openalex.org/C3020134792","wikidata":"https://www.wikidata.org/wiki/Q79749","display_name":"Human plasma","level":2,"score":0.42995893955230713},{"id":"https://openalex.org/C2781143361","wikidata":"https://www.wikidata.org/wiki/Q55761529","display_name":"Protease inhibitor (pharmacology)","level":5,"score":0.4182671010494232},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.369562566280365},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.25285598635673523},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1104283332824707},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.05723574757575989},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000511","descriptor_name":"alpha-Macroglobulins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D000511","descriptor_name":"alpha-Macroglobulins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000799","descriptor_name":"Angioedema","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D000799","descriptor_name":"Angioedema","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002850","descriptor_name":"Chromatography, Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003174","descriptor_name":"Complement C1 Inactivator Proteins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D003174","descriptor_name":"Complement C1 Inactivator Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007610","descriptor_name":"Kallikreins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008744","descriptor_name":"Methylamines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011480","descriptor_name":"Protease Inhibitors","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011480","descriptor_name":"Protease Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1172/jci110470","doi":"https://doi.org/10.1172/jci110470","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci110470","pdf_url":"http://www.jci.org/articles/view/110470/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:370996","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/370996","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:6173399","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6173399","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unil.ch:iris/137259","doi":null,"is_oa":false,"landing_page_url":"https://iris.unil.ch/handle/iris/137259","pdf_url":null,"source":{"id":"https://openalex.org/S7407055444","display_name":"IRIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:serval.unil.ch:BIB_6AF7F5F3DA1D","doi":null,"is_oa":false,"landing_page_url":"https://serval.unil.ch/notice/serval:BIB_6AF7F5F3DA1D","pdf_url":null,"source":{"id":"https://openalex.org/S4306401797","display_name":"SERVAL (Universit\u00e9 de Lausanne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210093590","host_organization_name":"Swiss School of Archaeology in Greece","host_organization_lineage":["https://openalex.org/I4210093590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Clinical Investigation, vol. 69, no. 2, pp. 462-8","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1172/jci110470","doi":"https://doi.org/10.1172/jci110470","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci110470","pdf_url":"http://www.jci.org/articles/view/110470/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320312387","display_name":"Temple University","ror":"https://ror.org/00kx1jb78"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1985484598.pdf","grobid_xml":"https://content.openalex.org/works/W1985484598.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W258376682","https://openalex.org/W1497280552","https://openalex.org/W1552888107","https://openalex.org/W1565096783","https://openalex.org/W1606378510","https://openalex.org/W1625660792","https://openalex.org/W1788802884","https://openalex.org/W1964747434","https://openalex.org/W1969537125","https://openalex.org/W1990986783","https://openalex.org/W2002983094","https://openalex.org/W2003880335","https://openalex.org/W2005380345","https://openalex.org/W2012663405","https://openalex.org/W2027400712","https://openalex.org/W2034405640","https://openalex.org/W2064958205","https://openalex.org/W2065141688","https://openalex.org/W2065466229","https://openalex.org/W2066823977","https://openalex.org/W2068224839","https://openalex.org/W2077906735","https://openalex.org/W2089682872","https://openalex.org/W2092331199","https://openalex.org/W2102613564","https://openalex.org/W2280143171","https://openalex.org/W2321234878","https://openalex.org/W2405234435","https://openalex.org/W2416161514","https://openalex.org/W2420269280","https://openalex.org/W2946354155"],"related_works":["https://openalex.org/W2014720148","https://openalex.org/W2883987660","https://openalex.org/W2012663405","https://openalex.org/W2409799785","https://openalex.org/W2884876711","https://openalex.org/W167647799","https://openalex.org/W2946734412","https://openalex.org/W2034405640","https://openalex.org/W2417481151","https://openalex.org/W1868691364"],"abstract_inverted_index":{"Although":[0],"Cl-inhibitor":[1],"(Cl-INH)":[2],"and":[3,83,99,149,234,286],"alpha(2)-macroglobulin":[4],"(alpha(2)M)":[5],"have":[6],"been":[7],"reported":[8],"as":[9,38,40],"the":[10,30,56,63,106,116,129,132,150,163,175,204,215,266,275,289,309,316,325],"major":[11,107,327],"inhibitors":[12,108,119,292],"of":[13,32,50,55,67,109,131,165,174,203,214,243,268,277,293,311,318],"plasma":[14,42,71,87,123,147,222,229,297],"kallikrein":[15,34,68,110,294,319],"in":[16,35,41,45,69,86,90,111,121,221,224,231,262,265,295,304,308],"normal":[17,36,70,112,122,171,296],"plasma,":[18,37,172,201],"there":[19],"is":[20],"little":[21],"quantitative":[22],"support":[23],"for":[24,126,162],"this":[25],"conclusion.":[26],"Thus,":[27],"we":[28],"studied":[29],"inactivation":[31,64,130,169,198,227,317],"purified":[33,305],"well":[39],"congenitally":[43],"deficient":[44,88,223,230],"Cl-INH,":[46,91,187],"or":[47,93,271,314],"artificially":[48],"depleted":[49],"alpha(2)M":[51,100,287],"by":[52,145,155,170,199,228],"chemical":[53],"modification":[54],"inhibitor":[57],"with":[58,186,195,209,219],"methylamine.":[59],"Under":[60],"pseudo-first-order":[61],"conditions,":[62],"rate":[65,76],"constant":[66,77],"was":[72,78,142,207,217,237,259],"0.60":[73],"min(-1).":[74],"This":[75,246],"reduced":[79],"to":[80,104,128,180,239],"0.35,":[81],"0.30,":[82],"0.06":[84],"min(-1),":[85],"respectively":[89],"alpha(2)M,":[92,235,272,315],"both":[94,232],"inhibitors.":[95],"Thus":[96],"Cl-INH":[97,220,233,270,285,313],"(42%)":[98],"(50%)":[101],"were":[102,153,178],"found":[103,179,238],"be":[105],"plasma.":[113],"Moreover":[114],"all":[115],"other":[117,326],"protease":[118],"present":[120],"contributed":[124],"only":[125,290],"8%":[127],"enzyme.":[133],"To":[134],"confirm":[135],"these":[136],"kinetic":[137],"results,":[138],"(125)I-kallikrein":[139,206,236],"(M(r)":[140,184,193],"85,000)":[141],"completely":[143],"inactivated":[144],"various":[146],"samples,":[148],"resulting":[151],"mixtures":[152],"analyzed":[154],"gel":[156],"filtration":[157],"on":[158,302,324],"Sepharose":[159],"6B":[160],"CL":[161],"appearance":[164],"(125)I-kallikrein-inhibitor":[166],"complexes.":[167],"After":[168,197,226],"52%":[173],"active":[176,205],"enzyme":[177],"form":[181,240],"a":[182,191,241],"complex":[183,192,242],"370,000)":[185],"while":[188],"48%":[189],"formed":[190],"850,000)":[194],"alpha(2)M.":[196,210,225],"Cl-INH-deficient":[200],">90%":[202],"associated":[208,218],"A":[211],"similar":[212],"proportion":[213],"label":[216],"M(r)":[244],"185,000.":[245],"latter":[247],"complex,":[248],"which":[249],"may":[250],"involve":[251],"antithrombin":[252],"III,":[253],"alpha(1)-protease":[254],"inhibitor,":[255,258],"and/or":[256],"alpha(1)-plasmin":[257],"not":[260],"detectable":[261],"appreciable":[263],"concentrations":[264],"presence":[267],"either":[269,312],"even":[273],"after":[274],"addition":[276],"heparin":[278],"(2":[279],"U/ml).":[280],"These":[281],"observations":[282],"demonstrate":[283],"that":[284],"are":[288],"significant":[291],"confirming":[298],"previous":[299],"predictions":[300],"based":[301],"experiments":[303],"systems.":[306],"Moreover,":[307],"absence":[310],"becomes":[320],"almost":[321],"entirely":[322],"dependent":[323],"inhibitor.":[328]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}