{"id":"https://openalex.org/W1985481419","doi":"https://doi.org/10.1111/j.1432-1033.1994.tb19947.x","title":"Cloning and expression of cDNA of human \u03944\u20103\u2010oxosteroid 5\u03b2\u2010reductase and substrate specificity of the expressed enzyme","display_name":"Cloning and expression of cDNA of human \u03944\u20103\u2010oxosteroid 5\u03b2\u2010reductase and substrate specificity of the expressed enzyme","publication_year":1994,"publication_date":"1994-01-01","ids":{"openalex":"https://openalex.org/W1985481419","doi":"https://doi.org/10.1111/j.1432-1033.1994.tb19947.x","mag":"1985481419","pmid":"https://pubmed.ncbi.nlm.nih.gov/7508385"},"language":"en","primary_location":{"id":"doi:10.1111/j.1432-1033.1994.tb19947.x","doi":"https://doi.org/10.1111/j.1432-1033.1994.tb19947.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1432-1033.1994.tb19947.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1432-1033.1994.tb19947.x","source":{"id":"https://openalex.org/S4210214924","display_name":"European Journal of Biochemistry","issn_l":"0014-2956","issn":["0014-2956","0945-5795","1432-1033"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1432-1033.1994.tb19947.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022577091","display_name":"K H Kondo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Kazu\u2010Hiro KONDO","raw_affiliation_strings":["Department of Clinical Chemistry, Karolinska Institute at Huddinge University Hospital, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry, Karolinska Institute at Huddinge University Hospital, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Masa\u2010Hiro KAI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masa\u2010Hiro KAI","raw_affiliation_strings":["Department of Surgery I, Miyazaki Medical College, Miyazaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery I, Miyazaki Medical College, Miyazaki, Japan","institution_ids":["https://openalex.org/I118574687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037353257","display_name":"Yoshiko Setoguchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshiko SETOGUCHI","raw_affiliation_strings":["Department of Surgery I, Miyazaki Medical College, Miyazaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery I, Miyazaki Medical College, Miyazaki, Japan","institution_ids":["https://openalex.org/I118574687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040863697","display_name":"G\u00f6sta Eggertsen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"G\u00f6sta EGGERTSEN","raw_affiliation_strings":["Department of Clinical Chemistry, Karolinska Institute at Huddinge University Hospital, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry, Karolinska Institute at Huddinge University Hospital, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051120406","display_name":"Peter Sj\u00f6blom","orcid":"https://orcid.org/0000-0001-6164-4908","observed_orcids":["https://orcid.org/0000-0001-6164-4908"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Peter SJ\u00d6BLOM","raw_affiliation_strings":["Department of Clinical Chemistry, Karolinska Institute at Huddinge University Hospital, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry, Karolinska Institute at Huddinge University Hospital, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015110810","display_name":"Toshiaki Setoguchi","orcid":"https://orcid.org/0000-0001-7278-3487","observed_orcids":["https://orcid.org/0000-0001-7278-3487"]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiaki SETOGUCHI","raw_affiliation_strings":["Department of Surgery I, Miyazaki Medical College, Miyazaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery I, Miyazaki Medical College, Miyazaki, Japan","institution_ids":["https://openalex.org/I118574687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102089861","display_name":"Kyuichiro Okuda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Kyu\u2010Ichiro OKUDA","raw_affiliation_strings":["Department of Clinical Chemistry, Karolinska Institute at Huddinge University Hospital, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry, Karolinska Institute at Huddinge University Hospital, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108028161","display_name":"Ingemar Bj\u00f6rkhem","orcid":"https://orcid.org/0000-0002-0575-9425","observed_orcids":["https://orcid.org/0000-0002-0575-9425"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Ingemar BJ\u00d6RKHEM","raw_affiliation_strings":["Department of Clinical Chemistry, Karolinska Institute at Huddinge University Hospital, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry, Karolinska Institute at Huddinge University Hospital, Sweden","institution_ids":["https://openalex.org/I28166907"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5022577091"],"corresponding_institution_ids":["https://openalex.org/I28166907"],"apc_list":null,"apc_paid":null,"fwci":3.5627,"has_fulltext":true,"cited_by_count":138,"citation_normalized_percentile":{"value":0.93184968,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"219","issue":"1-2","first_page":"357","last_page":"363"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13736","display_name":"Steroid Chemistry and Biochemistry","score":0.9067000150680542,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13736","display_name":"Steroid Chemistry and Biochemistry","score":0.9067000150680542,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.03849999979138374,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12533","display_name":"Aldose Reductase and Taurine","score":0.029400000348687172,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-cdna-cloning","display_name":"human cDNA cloning","score":0.7289999723434448},{"id":"https://openalex.org/keywords/substrate-specificity","display_name":"substrate specificity","score":0.6919999718666077},{"id":"https://openalex.org/keywords/bile-acid-intermediates","display_name":"bile acid intermediates","score":0.8429999947547913},{"id":"https://openalex.org/keywords/3alpha-hydroxysteroid-dehydrogenase","display_name":"3\u03b1-hydroxysteroid dehydrogenase","score":0.8769999742507935},{"id":"https://openalex.org/keywords/aldose-reductase","display_name":"aldose reductase","score":0.7889999747276306},{"id":"https://openalex.org/keywords/liver-mrna","display_name":"liver mRNA","score":0.48500001430511475},{"id":"https://openalex.org/keywords/recombinant-enzyme-production","display_name":"recombinant enzyme expression","score":0.722000002861023},{"id":"https://openalex.org/keywords/cortisol-reduction","display_name":"cortisol reduction","score":0.453000009059906},{"id":"https://openalex.org/keywords/testosterone-suppression","display_name":"testosterone suppression","score":0.8149999976158142}],"concepts":[{"id":"https://openalex.org/C187882448","wikidata":"https://www.wikidata.org/wiki/Q283478","display_name":"Complementary DNA","level":3,"score":0.723939061164856},{"id":"https://openalex.org/C134651460","wikidata":"https://www.wikidata.org/wiki/Q3100717","display_name":"Reductase","level":3,"score":0.62413090467453},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5286757349967957},{"id":"https://openalex.org/C189482833","wikidata":"https://www.wikidata.org/wiki/Q869146","display_name":"cDNA library","level":4,"score":0.5247012376785278},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.49787044525146484},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.46869397163391113},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.45393264293670654},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44734877347946167},{"id":"https://openalex.org/C2779268744","wikidata":"https://www.wikidata.org/wiki/Q407479","display_name":"Oxidoreductase","level":3,"score":0.4420090913772583},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.4286675453186035},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35093453526496887},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13348159193992615}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010088","descriptor_name":"Oxidoreductases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D010088","descriptor_name":"Oxidoreductases","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D010088","descriptor_name":"Oxidoreductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015151","descriptor_name":"Immunoblotting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015183","descriptor_name":"Restriction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1432-1033.1994.tb19947.x","doi":"https://doi.org/10.1111/j.1432-1033.1994.tb19947.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1432-1033.1994.tb19947.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1432-1033.1994.tb19947.x","source":{"id":"https://openalex.org/S4210214924","display_name":"European Journal of Biochemistry","issn_l":"0014-2956","issn":["0014-2956","0945-5795","1432-1033"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Biochemistry","raw_type":"journal-article"},{"id":"pmid:7508385","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7508385","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of biochemistry","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1111/j.1432-1033.1994.tb19947.x","doi":"https://doi.org/10.1111/j.1432-1033.1994.tb19947.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1432-1033.1994.tb19947.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1432-1033.1994.tb19947.x","source":{"id":"https://openalex.org/S4210214924","display_name":"European Journal of Biochemistry","issn_l":"0014-2956","issn":["0014-2956","0945-5795","1432-1033"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Biochemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4043000042438507}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1985481419.pdf","grobid_xml":"https://content.openalex.org/works/W1985481419.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W52875024","https://openalex.org/W1444335506","https://openalex.org/W1479947558","https://openalex.org/W1496024315","https://openalex.org/W1501373755","https://openalex.org/W1520561085","https://openalex.org/W1543974626","https://openalex.org/W1557438712","https://openalex.org/W1557519226","https://openalex.org/W1576975040","https://openalex.org/W1582722192","https://openalex.org/W1596291903","https://openalex.org/W1604507293","https://openalex.org/W1696248281","https://openalex.org/W1775749144","https://openalex.org/W2014669590","https://openalex.org/W2025701628","https://openalex.org/W2026621866","https://openalex.org/W2032462421","https://openalex.org/W2039804294","https://openalex.org/W2051897188","https://openalex.org/W2053916731","https://openalex.org/W2074122548","https://openalex.org/W2075023867","https://openalex.org/W2080532845","https://openalex.org/W2083418969","https://openalex.org/W2100837269","https://openalex.org/W2101108802","https://openalex.org/W2126719129","https://openalex.org/W2129059830","https://openalex.org/W2134812217","https://openalex.org/W2138270253","https://openalex.org/W2168526937","https://openalex.org/W2314225431","https://openalex.org/W2993773260"],"related_works":["https://openalex.org/W2293318399","https://openalex.org/W2993773260","https://openalex.org/W2070885472","https://openalex.org/W2026621866","https://openalex.org/W1987983918","https://openalex.org/W1520561085","https://openalex.org/W2016309630","https://openalex.org/W2022065845","https://openalex.org/W2113680750","https://openalex.org/W1999062035"],"abstract_inverted_index":{"The":[0,103,229],"enzyme":[1,121,176,196,235,247],"delta":[2,14,21,34,43,94,110,150,222,226],"4-3-oxosteroid":[3,44,95,111,151],"5":[4,45,96,112,152,202],"beta-reductase":[5,46,97,113,153],"(3-oxo-5":[6],"beta-steroid:":[7],"NADP+":[8,13],"oxidoreductase":[9],"and":[10,29,127,136,189,211,245],"4,5":[11],"beta-dihydrocortisone:":[12],"4-oxidoreductase)":[15],"catalyzes":[16],"the":[17,20,33,38,92,108,119,145,164,171,182,194,233,242,246],"reduction":[18],"of":[19,25,87,107,147,155,163,173,232,241,260],"4":[22],"double":[23],"bond":[24],"bile":[26,183,254],"acid":[27,105,184,255],"intermediates":[28,185],"steroid":[30,261],"hormones":[31],"carrying":[32],"4-3-one":[35],"structure":[36],"in":[37,159,170],"A/B":[39],"cis":[40],"configuration.":[41],"Human":[42],"cDNA":[47,53,165],"was":[48,65,219],"isolated":[49],"from":[50],"a":[51,59,68,88,148,178,198],"liver":[52],"library":[54],"by":[55],"cross":[56],"hybridization":[57],"with":[58,131,177],"previously":[60],"cloned":[61],"rat":[62,120,132,243],"cDNA,":[63],"which":[64],"used":[66],"as":[67],"probe":[69],"[Onishi,":[70],"Y.":[71],"Noshiro,":[72],"M.,":[73],"Shimosato,":[74],"T.":[75],"&":[76],"Okuda,":[77],"K.-I.":[78],"(1991)":[79],"FEBS":[80],"Lett.":[81],"283,":[82],"215-218].":[83],"DNA":[84],"sequence":[85,106],"analysis":[86,143],"hybridization-positive":[89],"clone":[90],"predicted":[91],"human":[93,109,137,160,234],"to":[98,118,249],"contain":[99],"326":[100],"amino":[101,104],"acids.":[102],"had":[114],"79%":[115],"overall":[116,129],"identity":[117,130],"sequence.":[122],"It":[123],"also":[124],"showed":[125,197],"54%":[126],"50%":[128],"3":[133],"alpha-hydroxysteroid":[134],"dehydrogenase":[135],"aldose":[138],"reductase,":[139],"respectively.":[140],"RNA":[141],"blotting":[142],"demonstrated":[144],"existence":[146],"single":[149],"mRNA":[154],"approximately":[156],"2.7":[157],"kb":[158],"liver.":[161],"Transfection":[162],"into":[166],"COS":[167],"cells":[168],"resulted":[169],"expression":[172],"an":[174],"active":[175],"high":[179],"activity":[180,204,218],"toward":[181,205,221],"7":[186,190],"alpha,12":[187],"alpha-dihydroxy-4-cholesten-3-one":[188],"alpha-hydroxy-4-cholesten-3-one.":[191],"In":[192],"addition,":[193],"expressed":[195],"small":[199],"but":[200],"significant":[201],"beta-reduction":[203],"11":[206],"beta,17":[207],"alpha,21-trihydroxy-delta":[208],"4-pregnene-3,20-dione":[209,223],"(cortisol)":[210],"17":[212],"beta-hydroxy-delta":[213],"4-androsten-3-one":[214],"(testosterone)":[215],"whereas":[216],"no":[217],"observed":[220],"(progesterone)":[224],"or":[225],"4-androstene-3-17-dione":[227],"(androstenedione).":[228],"substrate":[230],"specificity":[231],"is":[236],"considerably":[237],"narrower":[238],"than":[239,257],"that":[240],"enzyme,":[244],"seems":[248],"be":[250],"more":[251],"important":[252],"for":[253,258],"biosynthesis":[256],"metabolism":[259],"hormones.":[262]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
