{"id":"https://openalex.org/W1985469977","doi":"https://doi.org/10.1074/jbc.m608966200","title":"Novel Mechanism of Activation of NADPH Oxidase 5","display_name":"Novel Mechanism of Activation of NADPH Oxidase 5","publication_year":2006,"publication_date":"2006-12-12","ids":{"openalex":"https://openalex.org/W1985469977","doi":"https://doi.org/10.1074/jbc.m608966200","mag":"1985469977","pmid":"https://pubmed.ncbi.nlm.nih.gov/17164239"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m608966200","doi":"https://doi.org/10.1074/jbc.m608966200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m608966200","pdf_url":"http://www.jbc.org/article/S002192582052259X/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S002192582052259X/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037857241","display_name":"Davin Jagnandan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Davin Jagnandan","raw_affiliation_strings":["Department of Pharmacology and the Vascular Biology Center, Medical College of Georgia, Augusta, Georgia 30912-2500, USA","Department of Pharmacology and the Vascular Biology Center, Medical College of Georgia, Augusta, Georgia 30912-2500"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and the Vascular Biology Center, Medical College of Georgia, Augusta, Georgia 30912-2500, USA","institution_ids":["https://openalex.org/I25041050"]},{"raw_affiliation_string":"Department of Pharmacology and the Vascular Biology Center, Medical College of Georgia, Augusta, Georgia 30912-2500","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064322508","display_name":"Jarrod E. Church","orcid":"https://orcid.org/0000-0001-8266-4043","observed_orcids":["https://orcid.org/0000-0001-8266-4043"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jarrod E. Church","raw_affiliation_strings":["Department of Pharmacology and the Vascular Biology Center, Medical College of Georgia, Augusta, Georgia 30912-2500"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and the Vascular Biology Center, Medical College of Georgia, Augusta, Georgia 30912-2500","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035762419","display_name":"Botond B\u00e1nfi","orcid":"https://orcid.org/0000-0001-9273-1318","observed_orcids":["https://orcid.org/0000-0001-9273-1318"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Botond Banfi","raw_affiliation_strings":["Department of Anatomy, University of Iowa College of Medicine, Coralville, Iowa 52241"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, University of Iowa College of Medicine, Coralville, Iowa 52241","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067430639","display_name":"Dennis J. Stuehr","orcid":"https://orcid.org/0000-0002-0960-6848","observed_orcids":["https://orcid.org/0000-0002-0960-6848"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dennis J. Stuehr","raw_affiliation_strings":["Department of Immunology and Pathobiology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Pathobiology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111460113","display_name":"Mario B. Marrero","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mario B. Marrero","raw_affiliation_strings":["Department of Pharmacology and the Vascular Biology Center, Medical College of Georgia, Augusta, Georgia 30912-2500"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and the Vascular Biology Center, Medical College of Georgia, Augusta, Georgia 30912-2500","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075774578","display_name":"David J. Fulton","orcid":"https://orcid.org/0000-0002-1528-1517","observed_orcids":["https://orcid.org/0000-0002-1528-1517"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David J.R. Fulton","raw_affiliation_strings":["Department of Pharmacology and the Vascular Biology Center, Medical College of Georgia, Augusta, Georgia 30912-2500"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and the Vascular Biology Center, Medical College of Georgia, Augusta, Georgia 30912-2500","institution_ids":["https://openalex.org/I25041050"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5075774578"],"corresponding_institution_ids":["https://openalex.org/I25041050"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":5.2896,"has_fulltext":true,"cited_by_count":208,"citation_normalized_percentile":{"value":0.96958563,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"282","issue":"9","first_page":"6494","last_page":"6507"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.6230000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.6230000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.10750000178813934,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.08980000019073486,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nox5","display_name":"NADPH oxidase 5","score":0.9580000042915344},{"id":"https://openalex.org/keywords/enzyme-activation","display_name":"enzyme activation","score":0.8090000152587891},{"id":"https://openalex.org/keywords/intracellular-calcium","display_name":"intracellular calcium","score":0.703000009059906},{"id":"https://openalex.org/keywords/phorbol-myristate-acetate","display_name":"phorbol myristate acetate","score":0.9409999847412109},{"id":"https://openalex.org/keywords/protein-phosphorylation","display_name":"protein phosphorylation","score":0.8560000061988831},{"id":"https://openalex.org/keywords/calcium-sensitivity","display_name":"calcium sensitivity","score":0.859000027179718},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9480000138282776},{"id":"https://openalex.org/keywords/ionomycin","display_name":"ionomycin","score":0.7429999709129333},{"id":"https://openalex.org/keywords/gain-of-function-mutants","display_name":"gain-of-function mutants","score":0.8169999718666077}],"concepts":[{"id":"https://openalex.org/C2776989580","wikidata":"https://www.wikidata.org/wiki/Q421320","display_name":"Ionomycin","level":3,"score":0.9657742977142334},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.6219791173934937},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5771141648292542},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5443060994148254},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5299331545829773},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.5237308144569397},{"id":"https://openalex.org/C181080969","wikidata":"https://www.wikidata.org/wiki/Q60097","display_name":"Calcium in biology","level":3,"score":0.5199128985404968},{"id":"https://openalex.org/C2780043322","wikidata":"https://www.wikidata.org/wiki/Q2705359","display_name":"Phorbol","level":4,"score":0.5115748047828674},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.510382354259491},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4844229519367218},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4684968590736389},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.41607725620269775},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2913721799850464},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000074664","descriptor_name":"NADPH Oxidase 5","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D002522","descriptor_name":"Chlorocebus aethiops","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013755","descriptor_name":"Tetradecanoylphorbol Acetate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019255","descriptor_name":"NADPH Oxidases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019255","descriptor_name":"NADPH Oxidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019556","descriptor_name":"COS Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m608966200","doi":"https://doi.org/10.1074/jbc.m608966200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m608966200","pdf_url":"http://www.jbc.org/article/S002192582052259X/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:17164239","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17164239","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m608966200","doi":"https://doi.org/10.1074/jbc.m608966200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m608966200","pdf_url":"http://www.jbc.org/article/S002192582052259X/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3118291912","display_name":"Regulation of eNOS by Subcellular Targeting","funder_award_id":"R01HL074279","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5302271393","display_name":null,"funder_award_id":"HL-74279","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1985469977.pdf","grobid_xml":"https://content.openalex.org/works/W1985469977.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W1678800844","https://openalex.org/W1995247596","https://openalex.org/W1999880393","https://openalex.org/W2003241255","https://openalex.org/W2008149338","https://openalex.org/W2018207304","https://openalex.org/W2020319663","https://openalex.org/W2057397798","https://openalex.org/W2060785208","https://openalex.org/W2064358616","https://openalex.org/W2073241455","https://openalex.org/W2073801857","https://openalex.org/W2079228647","https://openalex.org/W2098316218","https://openalex.org/W2101692904","https://openalex.org/W2102619095","https://openalex.org/W2105940831","https://openalex.org/W2107913200","https://openalex.org/W2116706953","https://openalex.org/W2141616450","https://openalex.org/W2153291568","https://openalex.org/W2166468339","https://openalex.org/W4242182607"],"related_works":["https://openalex.org/W2132021477","https://openalex.org/W1550647421","https://openalex.org/W2158757718","https://openalex.org/W3002842993","https://openalex.org/W2093669649","https://openalex.org/W7100097891","https://openalex.org/W2088653554","https://openalex.org/W2023064969","https://openalex.org/W2105940831","https://openalex.org/W2989875435"],"abstract_inverted_index":{"In":[0,64,216],"contrast":[1],"to":[2,84,106,117,126,170,185,244],"other":[3],"Nox":[4],"isoforms,":[5],"the":[6,13,23,33,44,65,75,103,111,146,157,204,213,218],"activity":[7,76,112,129,197],"of":[8,15,25,35,46,61,77,80,113,120,124,149,160,167,181,191,201,212,220,231,248],"Nox5":[9,36,48,83,114,128,150,161,206,221],"does":[10],"not":[11,57],"require":[12],"presence":[14],"accessory":[16],"proteins":[17],"and":[18,42,93,135,164,176,183,234],"is":[19,39],"entirely":[20],"dependent":[21],"on":[22,140,162],"elevation":[24],"intracellular":[26,62,232],"calcium.":[27,63],"Previous":[28],"studies":[29],"have":[30,69],"shown":[31],"that":[32,55,194],"EC(50)":[34],"for":[37,239],"calcium":[38,133,147,177,233],"relatively":[40],"high":[41],"raises":[43],"question":[45],"whether":[47],"can":[49],"be":[50],"sufficiently":[51],"activated":[52],"in":[53,90,96,115,151,209,242],"cells":[54,81],"do":[56],"experience":[58],"extreme":[59],"elevations":[60],"current":[66],"study,":[67],"we":[68],"identified":[70],"a":[71,91,137,152,189,245],"novel":[72],"mechanism":[73],"governing":[74],"Nox5.":[78],"Exposure":[79],"expressing":[82],"phorbol":[85],"12-myristate":[86],"13-acetate":[87],"(PMA)":[88],"resulted":[89],"slow":[92],"sustained":[94],"increase":[95,127],"ROS,":[97],"which":[98],"was":[99,130,136,207],"markedly":[100],"different":[101],"from":[102],"rapid":[104],"response":[105,116,243],"ionomycin.":[107,121,202],"PMA":[108,125,144,155],"greatly":[109],"potentiated":[110],"low":[118,199],"concentrations":[119,200],"The":[122],"ability":[123],"abolished":[131,172],"by":[132],"chelation":[134],"direct":[138],"effect":[139],"enzyme":[141,226,240],"activity,":[142],"since":[143],"increased":[145,196],"sensitivity":[148],"cell-free":[153],"assay.":[154],"stimulated":[156],"time-dependent":[158],"phosphorylation":[159,175,219],"Thr(494)":[163,182],"Ser(498).":[165],"Mutation":[166],"these":[168],"residues":[169,224],"alanine":[171],"both":[173],"PMA-dependent":[174],"sensitization.":[178],"Conversely,":[179],"mutation":[180],"Ser(498)":[184],"glutamic":[186],"acid":[187],"produced":[188],"gain":[190],"function":[192],"mutant":[193],"had":[195],"at":[198,222,228],"Within":[203],"cell,":[205],"detected":[208],"detergent-resistant":[210],"microdomains":[211],"endoplasmic":[214],"reticulum.":[215],"summary,":[217],"key":[223],"facilitates":[225],"activation":[227,241],"lower":[229],"levels":[230],"may":[235],"provide":[236],"an":[237],"avenue":[238],"greater":[246],"variety":[247],"extracellular":[249],"stimuli.":[250]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":20}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}