{"id":"https://openalex.org/W1985469910","doi":"https://doi.org/10.4161/cc.9.7.11255","title":"p53 inactivation by MDM2 and MDMX negative feedback loops in testicular germ cell tumors","display_name":"p53 inactivation by MDM2 and MDMX negative feedback loops in testicular germ cell tumors","publication_year":2010,"publication_date":"2010-04-01","ids":{"openalex":"https://openalex.org/W1985469910","doi":"https://doi.org/10.4161/cc.9.7.11255","mag":"1985469910","pmid":"https://pubmed.ncbi.nlm.nih.gov/20372076","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3008305"},"language":"en","primary_location":{"id":"doi:10.4161/cc.9.7.11255","doi":"https://doi.org/10.4161/cc.9.7.11255","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cc.9.7.11255","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.9.7.11255?needAccess=true&role=button","source":{"id":"https://openalex.org/S86011449","display_name":"Cell Cycle","issn_l":"1538-4101","issn":["1538-4101","1551-4005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Cycle","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.9.7.11255?needAccess=true&role=button","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Baozong Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Baozong Li","raw_affiliation_strings":["Molecular Oncology Department, Moffitt Cancer Center, Tampa, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Oncology Department, Moffitt Cancer Center, Tampa, FL, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101699735","display_name":"Qian Cheng","orcid":"https://orcid.org/0000-0002-3674-1025","observed_orcids":["https://orcid.org/0000-0002-3674-1025"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qian Cheng","raw_affiliation_strings":["Molecular Oncology Department; Moffitt Cancer Center; Tampa, FL USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Oncology Department; Moffitt Cancer Center; Tampa, FL USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100330778","display_name":"Zhenyu Li","orcid":"https://orcid.org/0000-0003-1495-4588","observed_orcids":["https://orcid.org/0000-0003-1495-4588"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhenyu Li","raw_affiliation_strings":["Molecular Oncology Department; Moffitt Cancer Center; Tampa, FL USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Oncology Department; Moffitt Cancer Center; Tampa, FL USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101498583","display_name":"Jiandong Chen","orcid":"https://orcid.org/0000-0001-6178-8370","observed_orcids":["https://orcid.org/0000-0001-6178-8370","https://orcid.org/0000-0002-2644-3315"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jiandong Chen","raw_affiliation_strings":["Molecular Oncology Department; Moffitt Cancer Center; Tampa, FL USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Oncology Department; Moffitt Cancer Center; Tampa, FL USA","institution_ids":["https://openalex.org/I3019308854"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5101498583"],"corresponding_institution_ids":["https://openalex.org/I3019308854"],"apc_list":null,"apc_paid":null,"fwci":4.8954,"has_fulltext":true,"cited_by_count":64,"citation_normalized_percentile":{"value":0.95995183,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"9","issue":"7","first_page":"1411","last_page":"1420"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/testicular-germ-cell-tumors","display_name":"testicular germ cell tumors","score":0.9150000214576721},{"id":"https://openalex.org/keywords/p53-inactivation","display_name":"p53 inactivation","score":0.996999979019165},{"id":"https://openalex.org/keywords/mdm2","display_name":"MDM2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mdmx","display_name":"MDMX","score":1.0},{"id":"https://openalex.org/keywords/negative-feedback-loop","display_name":"negative feedback loop","score":0.6759999990463257},{"id":"https://openalex.org/keywords/nutlin","display_name":"nutlin","score":0.9309999942779541},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8460000157356262},{"id":"https://openalex.org/keywords/p53-activation","display_name":"p53 activation","score":0.5950000286102295}],"concepts":[{"id":"https://openalex.org/C2777221213","wikidata":"https://www.wikidata.org/wiki/Q10322346","display_name":"MDMX","level":4,"score":0.9880358576774597},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7717991471290588},{"id":"https://openalex.org/C2776192174","wikidata":"https://www.wikidata.org/wiki/Q18028978","display_name":"Mdm2","level":3,"score":0.7352679371833801},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6645615696907043},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.48112693428993225},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4556482434272766},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.45207855105400085},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.44959747791290283},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.4214574098587036},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3486250042915344},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.25283002853393555},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23703241348266602},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22692346572875977}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009373","descriptor_name":"Neoplasms, Germ Cell and Embryonal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013736","descriptor_name":"Testicular Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013736","descriptor_name":"Testicular Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047369","descriptor_name":"Chromatin Immunoprecipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051736","descriptor_name":"Proto-Oncogene Proteins c-mdm2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.4161/cc.9.7.11255","doi":"https://doi.org/10.4161/cc.9.7.11255","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cc.9.7.11255","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.9.7.11255?needAccess=true&role=button","source":{"id":"https://openalex.org/S86011449","display_name":"Cell Cycle","issn_l":"1538-4101","issn":["1538-4101","1551-4005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Cycle","raw_type":"journal-article"},{"id":"pmid:20372076","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20372076","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell cycle (Georgetown, Tex.)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3008305","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3008305","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cell Cycle","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.4161/cc.9.7.11255","doi":"https://doi.org/10.4161/cc.9.7.11255","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cc.9.7.11255","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.9.7.11255?needAccess=true&role=button","source":{"id":"https://openalex.org/S86011449","display_name":"Cell Cycle","issn_l":"1538-4101","issn":["1538-4101","1551-4005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Cycle","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G283277140","display_name":"Function and regulation of MDMX","funder_award_id":"R01CA109636","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3039817217","display_name":null,"funder_award_id":"CA 109636","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G339021324","display_name":null,"funder_award_id":"CA 118210","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G371726913","display_name":"Targeting Signal Transduction Pathways for Cancer Drug Discovery","funder_award_id":"P01CA118210","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1985469910.pdf","grobid_xml":"https://content.openalex.org/works/W1985469910.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1557569438","https://openalex.org/W1592021885","https://openalex.org/W1598779357","https://openalex.org/W1630176173","https://openalex.org/W1964959920","https://openalex.org/W1971215274","https://openalex.org/W1980494246","https://openalex.org/W1980568546","https://openalex.org/W1989168159","https://openalex.org/W1992360356","https://openalex.org/W1993263392","https://openalex.org/W1995444137","https://openalex.org/W2003899599","https://openalex.org/W2007658328","https://openalex.org/W2015519364","https://openalex.org/W2021789591","https://openalex.org/W2022431825","https://openalex.org/W2025476423","https://openalex.org/W2040827479","https://openalex.org/W2049133549","https://openalex.org/W2049160829","https://openalex.org/W2052516738","https://openalex.org/W2068196972","https://openalex.org/W2074523375","https://openalex.org/W2076940668","https://openalex.org/W2089934507","https://openalex.org/W2091151265","https://openalex.org/W2097933346","https://openalex.org/W2100589388","https://openalex.org/W2103069797","https://openalex.org/W2106718280","https://openalex.org/W2115810762","https://openalex.org/W2117736191","https://openalex.org/W2119118751","https://openalex.org/W2119121049","https://openalex.org/W2128306207","https://openalex.org/W2130191240","https://openalex.org/W2136422121","https://openalex.org/W2145940470","https://openalex.org/W2153410136","https://openalex.org/W2156521746","https://openalex.org/W2161298480","https://openalex.org/W2164115530","https://openalex.org/W2171407623","https://openalex.org/W2313957270","https://openalex.org/W2320028767"],"related_works":["https://openalex.org/W1460703119","https://openalex.org/W2021789591","https://openalex.org/W2065230050","https://openalex.org/W2011654547","https://openalex.org/W2049160829","https://openalex.org/W2161298480","https://openalex.org/W3023524515","https://openalex.org/W2007183717","https://openalex.org/W3083129273","https://openalex.org/W2103069797"],"abstract_inverted_index":{"Testicular":[0],"germ":[1,36],"cell":[2,134],"tumors":[3],"(TGCT)":[4],"are":[5,144,157],"unique":[6,158],"in":[7,19,35,67,96,102,110,132,152,159],"their":[8],"excellent":[9],"response":[10,164],"to":[11,29,73,83,165,187],"DNA-damaging":[12,188],"chemotherapy.":[13],"Mutation":[14],"of":[15,43,49,57,78,130,150,169,184],"p53":[16,27,50,66,90,131,151,170],"is":[17,71,108],"rare":[18],"both":[20],"untreated":[21],"and":[22,70,99,142,174],"relapsed":[23],"TGCTs,":[24],"suggesting":[25,120],"that":[26,55,89,114,121,140],"fails":[28],"respond":[30],"effectively":[31],"against":[32],"malignant":[33],"transformation":[34],"cells.":[37,104],"Previous":[38],"studies":[39],"implicated":[40],"the":[41,61,147,182],"presence":[42],"a":[44,93,116,126,133,161,178],"poorly":[45],"defined":[46],"TGCT-specific":[47],"mechanism":[48],"inactivation.":[51],"Here":[52],"we":[53,87],"show":[54],"disruption":[56],"p53-MDM2":[58],"binding":[59],"using":[60],"MDM2-specific":[62],"inhibitor":[63],"Nutlin":[64,82],"activates":[65],"TGCT":[68,103,155],"cells":[69,156],"sufficient":[72],"induce":[74],"strong":[75,162],"apoptosis.":[76],"Knockdown":[77],"MDMX":[79,97,111,122,143,175],"cooperates":[80],"with":[81],"activate":[84],"p53.":[85,166],"Surprisingly,":[86],"found":[88],"activation":[91,168],"induced":[92],"two-fold":[94],"increase":[95],"mRNA":[98],"protein":[100],"expression":[101],"A":[105],"p53-responsive":[106],"promoter":[107],"identified":[109],"intron":[112],"1":[113],"contains":[115],"functional":[117,148],"p53-binding":[118],"site,":[119],"also":[123],"functions":[124],"as":[125],"negative":[127],"feedback":[128],"regulator":[129],"line-dependent":[135],"fashion.":[136],"These":[137],"findings":[138],"suggest":[139],"MDM2":[141,173],"responsible":[145],"for":[146,181],"inactivation":[149],"TGCT.":[153],"Furthermore,":[154],"having":[160],"apoptosis":[163],"Direct":[167],"by":[171],"targeting":[172],"may":[176],"provide":[177],"backup":[179],"approach":[180],"treatment":[183],"TGCTs":[185],"resistant":[186],"drugs.":[189]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":9}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}