{"id":"https://openalex.org/W1985463875","doi":"https://doi.org/10.1002/1097-0142(1971)28:4<907::aid-cncr2820280414>3.0.co;2-9","title":"5-fluorouracil given once weekly: Comparison of intravenous and oral administration","display_name":"5-fluorouracil given once weekly: Comparison of intravenous and oral administration","publication_year":1971,"publication_date":"1971-01-01","ids":{"openalex":"https://openalex.org/W1985463875","doi":"https://doi.org/10.1002/1097-0142(1971)28:4<907::aid-cncr2820280414>3.0.co;2-9","mag":"1985463875","pmid":"https://pubmed.ncbi.nlm.nih.gov/5111743"},"language":"en","primary_location":{"id":"doi:10.1002/1097-0142(1971)28:4<907::aid-cncr2820280414>3.0.co;2-9","doi":"https://doi.org/10.1002/1097-0142(1971)28:4<907::aid-cncr2820280414>3.0.co;2-9","is_oa":false,"landing_page_url":"https://doi.org/10.1002/1097-0142(1971)28:4<907::aid-cncr2820280414>3.0.co;2-9","pdf_url":null,"source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109105626","display_name":"Joseph R. Bateman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joseph R. Bateman","raw_affiliation_strings":["Associate Professor of Medicine, University of Southern California School of Medicine, Los Angeles, Calif"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Associate Professor of Medicine, University of Southern California School of Medicine, Los Angeles, Calif","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110091451","display_name":"Reginald P. Pugh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Reginald P. Pugh","raw_affiliation_strings":["Chief of Internal Medicine, Ellis Fischel State Cancer Hospital, Columbia, Mo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chief of Internal Medicine, Ellis Fischel State Cancer Hospital, Columbia, Mo","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056189243","display_name":"Frank R. Cassidy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Frank R. Cassidy","raw_affiliation_strings":["Department of Internal Medicine, Southern California Permanente Medical Group, Los Angeles, Calif"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Southern California Permanente Medical Group, Los Angeles, Calif","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069599747","display_name":"G. June Marshall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. June Marshall","raw_affiliation_strings":["Associate Professor of Medicine and Anatomy, University of Southern California School of Medicine, Los Angeles, Calif"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Associate Professor of Medicine and Anatomy, University of Southern California School of Medicine, Los Angeles, Calif","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110189404","display_name":"Lowell E. Irwin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lowell E. Irwin","raw_affiliation_strings":["Assistant Professor of Medicine, University of Southern California School of Medicine, Los Angeles, Calif"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assistant Professor of Medicine, University of Southern California School of Medicine, Los Angeles, Calif","institution_ids":["https://openalex.org/I1174212"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5109105626"],"corresponding_institution_ids":["https://openalex.org/I1174212"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":6.0296,"has_fulltext":false,"cited_by_count":91,"citation_normalized_percentile":{"value":0.9588272,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"28","issue":"4","first_page":"907","last_page":"913"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":1.0},{"id":"https://openalex.org/keywords/once-weekly-dosing","display_name":"weekly dosing","score":0.7229999899864197},{"id":"https://openalex.org/keywords/intravenous-administration","display_name":"intravenous administration","score":0.9380000233650208},{"id":"https://openalex.org/keywords/oral-administration","display_name":"oral administration","score":0.9990000128746033},{"id":"https://openalex.org/keywords/gastrointestinal-toxicity","display_name":"gastrointestinal toxicity","score":0.5709999799728394},{"id":"https://openalex.org/keywords/hematological-toxicity","display_name":"hematologic toxicity","score":0.9990000128746033},{"id":"https://openalex.org/keywords/response-rate","display_name":"response rate","score":0.550000011920929},{"id":"https://openalex.org/keywords/duration-of-response","display_name":"duration of response","score":0.8130000233650208},{"id":"https://openalex.org/keywords/cumulative-dose","display_name":"cumulative dose","score":0.5260000228881836}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9323564767837524},{"id":"https://openalex.org/C2780456651","wikidata":"https://www.wikidata.org/wiki/Q238512","display_name":"Fluorouracil","level":3,"score":0.8106001615524292},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.6797928214073181},{"id":"https://openalex.org/C2777785397","wikidata":"https://www.wikidata.org/wiki/Q492194","display_name":"Group B","level":2,"score":0.6612906455993652},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.6161083579063416},{"id":"https://openalex.org/C147583825","wikidata":"https://www.wikidata.org/wiki/Q620876","display_name":"Body weight","level":2,"score":0.5399087071418762},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5017778873443604},{"id":"https://openalex.org/C2780678043","wikidata":"https://www.wikidata.org/wiki/Q743241","display_name":"Group A","level":2,"score":0.4821440875530243},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4513801336288452},{"id":"https://openalex.org/C151032500","wikidata":"https://www.wikidata.org/wiki/Q5194182","display_name":"Cumulative dose","level":2,"score":0.4306353032588959},{"id":"https://openalex.org/C3019096185","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Complete response","level":3,"score":0.4295230805873871},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.4235790967941284},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.36303913593292236},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.34644392132759094},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.32112187147140503}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001660","descriptor_name":"Biliary Tract Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D005770","descriptor_name":"Gastrointestinal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007275","descriptor_name":"Injections, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D012075","descriptor_name":"Remission, Spontaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/1097-0142(1971)28:4<907::aid-cncr2820280414>3.0.co;2-9","doi":"https://doi.org/10.1002/1097-0142(1971)28:4<907::aid-cncr2820280414>3.0.co;2-9","is_oa":false,"landing_page_url":"https://doi.org/10.1002/1097-0142(1971)28:4<907::aid-cncr2820280414>3.0.co;2-9","pdf_url":null,"source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},{"id":"pmid:5111743","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/5111743","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W1896066594","https://openalex.org/W1985026088","https://openalex.org/W2004322406","https://openalex.org/W2037201734","https://openalex.org/W2079355389","https://openalex.org/W2091184636","https://openalex.org/W2341994882","https://openalex.org/W2438325455"],"related_works":["https://openalex.org/W2030175426","https://openalex.org/W2091184636","https://openalex.org/W2055346610","https://openalex.org/W1988899682","https://openalex.org/W1522712696","https://openalex.org/W2040758479","https://openalex.org/W2055983050","https://openalex.org/W2404330316","https://openalex.org/W1993801226","https://openalex.org/W1989566891"],"abstract_inverted_index":{"One":[0],"hundred":[1],"seven":[2],"patients":[3],"with":[4],"disseminated":[5],"adenocarcinoma":[6],"were":[7,64,71],"randomized":[8],"to":[9,61],"receive":[10],"5-Fluorouracil":[11],"(5-FU)":[12],"by":[13,20],"vein,":[14],"Group":[15,22,45,51,85,95],"A":[16,46,96],"(52":[17],"patients),":[18],"or":[19],"mouth,":[21],"B":[23,52,86],"(55":[24],"patients).":[25],"Dosage":[26],"for":[27,44,50],"both":[28,67],"groups":[29],"was":[30,42,81,91],"15":[31],"mg/kg":[32],"body":[33],"weight":[34],"given":[35],"once":[36],"weekly.":[37],"Clinically":[38],"useful":[39],"response":[40,56,63],"rate":[41],"21%":[43],"(IV)":[47],"and":[48,57,88],"40%":[49],"(oral).":[53],"Duration":[54],"of":[55],"mean":[58],"cumulative":[59],"dose":[60],"beginning":[62],"comparable":[65],"in":[66,73,75,84,94],"groups.":[68,78],"Slight":[69],"differences":[70],"observed":[72],"toxicities":[74],"the":[76],"2":[77],"G.I.":[79],"toxicity":[80,90],"more":[82,92],"frequent":[83],"(oral)":[87],"hematologic":[89],"common":[93],"(IV).":[97]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
