{"id":"https://openalex.org/W198545757","doi":null,"title":"Effect of methanol extract of Bombax malabaricum leaves on nitric oxide production during inflammation.","display_name":"Effect of methanol extract of Bombax malabaricum leaves on nitric oxide production during inflammation.","publication_year":2013,"publication_date":"2013-03-01","ids":{"openalex":"https://openalex.org/W198545757","mag":"198545757","pmid":"https://pubmed.ncbi.nlm.nih.gov/23614281"},"language":"en","primary_location":{"id":"pmid:23614281","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23614281","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta poloniae pharmaceutica","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083554208","display_name":"Emdad Hossain","orcid":"https://orcid.org/0000-0001-9110-6449","observed_orcids":["https://orcid.org/0000-0001-9110-6449"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emdad Hossain","raw_affiliation_strings":["Pharmacy College, Azamgarh 276128, Uttar Pradesh, India. hossainemdad@yahoo.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacy College, Azamgarh 276128, Uttar Pradesh, India. hossainemdad@yahoo.com","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102974650","display_name":"Debjani Sarkar","orcid":"https://orcid.org/0000-0002-9648-1624","observed_orcids":["https://orcid.org/0000-0002-9648-1624"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Debjani Sarkar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034613514","display_name":"Mitali Chatterjee","orcid":"https://orcid.org/0000-0001-5116-7298","observed_orcids":["https://orcid.org/0000-0001-5116-7298"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mitali Chatterjee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061405457","display_name":"Saikat Chakraborty","orcid":"https://orcid.org/0000-0003-1183-2294","observed_orcids":["https://orcid.org/0000-0003-1183-2294"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Saikat Chakraborty","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039097008","display_name":"Subhash Chandra Mandal","orcid":"https://orcid.org/0000-0002-9079-489X","observed_orcids":["https://orcid.org/0000-0002-9079-489X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Subhash C Mandal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5103393986","display_name":"Jayanta Kumar Gupta","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jayanta K Gupta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5999,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.83060797,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"70","issue":"2","first_page":"255","last_page":"60"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.9589999914169312,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.9589999914169312,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12298","display_name":"Phytochemicals and Medicinal Plants","score":0.019700000062584877,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.010099999606609344,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bombax-malabaricum","display_name":"Bombax malabaricum","score":0.9990000128746033},{"id":"https://openalex.org/keywords/methanolic-leaf-extract","display_name":"methanolic leaf extract","score":0.9200000166893005},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.9980000257492065},{"id":"https://openalex.org/keywords/nitric-oxide-production","display_name":"nitric oxide production","score":0.9539999961853027},{"id":"https://openalex.org/keywords/carrageenan-induced-paw-edema","display_name":"carrageenan-induced paw edema","score":0.9789999723434448},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9049999713897705},{"id":"https://openalex.org/keywords/peritoneal-macrophages","display_name":"peritoneal macrophages","score":0.9860000014305115},{"id":"https://openalex.org/keywords/traditional-medicine","display_name":"traditional medicine","score":0.6499999761581421},{"id":"https://openalex.org/keywords/medicinal-plants","display_name":"medicinal plants","score":0.4009999930858612},{"id":"https://openalex.org/keywords/toxicity","display_name":"toxicity","score":0.3400000035762787}],"concepts":[{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.8421182632446289},{"id":"https://openalex.org/C2781227287","wikidata":"https://www.wikidata.org/wiki/Q421991","display_name":"Carrageenan","level":2,"score":0.7250069975852966},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6257237792015076},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.6201973557472229},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.5609867572784424},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.49331775307655334},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.4152093529701233},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41143599152565},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3091428577899933},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1530856490135193},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12449681758880615}],"mesh":[{"descriptor_ui":"D000432","descriptor_name":"Methanol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D002351","descriptor_name":"Carrageenan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D007928","descriptor_name":"Lethal Dose 50","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D010946","descriptor_name":"Plants, Medicinal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012997","descriptor_name":"Solvents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017737","descriptor_name":"Macrophages, Peritoneal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017737","descriptor_name":"Macrophages, Peritoneal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018515","descriptor_name":"Plant Leaves","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020128","descriptor_name":"Inhibitory Concentration 50","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035163","descriptor_name":"Bombax","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:23614281","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23614281","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta poloniae pharmaceutica","raw_type":"Journal Article"},{"id":"mag:198545757","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23614281","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W1771441866"],"related_works":["https://openalex.org/W2791599025","https://openalex.org/W1965607068","https://openalex.org/W2051685540","https://openalex.org/W4214503349","https://openalex.org/W2058062509","https://openalex.org/W898599524","https://openalex.org/W833431860","https://openalex.org/W2102250518","https://openalex.org/W2020618515","https://openalex.org/W1547158781"],"abstract_inverted_index":{"In":[0,135],"different":[1],"parts":[2],"of":[3,24,41,46,54,62,75,92,105,180],"India,":[4],"Bombax":[5,47],"malabaricum":[6,48],"DC.":[7],"(Family:":[8],"Bombacaceae),":[9],"a":[10,59,103,166],"lofty":[11],"deciduous":[12],"tree":[13],"with":[14],"large":[15],"leaves,":[16],"is":[17],"traditionally":[18],"used":[19],"in":[20,58,81,163,165],"inflammation.":[21,64],"The":[22,51],"aim":[23],"the":[25,38,139],"present":[26],"study":[27],"was":[28,56,85,95,99,143,150],"to":[29,35,87,102,153],"confirm":[30],"its":[31,89],"antiinflammatory":[32,175],"activity":[33,53],"and":[34,110,116,148],"search":[36],"for":[37,43,108,141],"possible":[39,90],"mechanism":[40,91],"action":[42],"methanol":[44],"extract":[45],"leaves":[49],"(MEBM).":[50],"anti-inflammatory":[52],"MEBM":[55,76,98,113,142,156,173],"evaluated":[57],"carrageenan-induced":[60,121],"model":[61],"acute":[63],"As":[65],"inflammation":[66],"usually":[67],"involves":[68],"increased":[69],"nitric":[70],"oxide":[71],"(NO)":[72],"production,":[73],"effect":[74],"on":[77],"lipopolysaccharide-induced":[78,160],"NO":[79,161,181],"production":[80,162],"mouse":[82],"peritoneal":[83,137],"macrophages":[84,164],"studied":[86],"evaluate":[88],"action.":[93],"It":[94],"found":[96],"that":[97],"non-toxic":[100,151],"up":[101,152],"dose":[104],"2":[106],"g/kg":[107],"mice":[109,136],"rats,":[111],"orally.":[112],"(100,":[114],"200,":[115],"400":[117],"mg/kg)":[118],"significantly":[119],"reduced":[120,159],"rat":[122],"paw":[123],"edema":[124],"(p":[125,169],"<":[126,129,132,170],"0.05,":[127],"p":[128,131],"0.01,":[130],"0.001,":[133],"respectively).":[134],"macrophages,":[138],"IC50":[140],"258.33":[144],"+/-":[145],"6.96":[146],"microg/mL":[147],"it":[149],"125":[154],"microg/mL.":[155],"(0-100":[157],"microg/mL)":[158],"dose-dependent":[167],"fashion":[168],"0.001).":[171],"Hence,":[172],"possesses":[174],"activity,":[176],"mediated":[177],"through":[178],"inhibition":[179],"production.":[182]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}