{"id":"https://openalex.org/W1985446291","doi":"https://doi.org/10.1111/j.1471-4159.2005.03599.x","title":"Interleukin\u20101 beta\u2010induced expression of the prostaglandin E2\u2010receptor subtype EP3 in U373 astrocytoma cells depends on protein kinase C and nuclear factor\u2010kappaB","display_name":"Interleukin\u20101 beta\u2010induced expression of the prostaglandin E2\u2010receptor subtype EP3 in U373 astrocytoma cells depends on protein kinase C and nuclear factor\u2010kappaB","publication_year":2006,"publication_date":"2006-01-09","ids":{"openalex":"https://openalex.org/W1985446291","doi":"https://doi.org/10.1111/j.1471-4159.2005.03599.x","mag":"1985446291","pmid":"https://pubmed.ncbi.nlm.nih.gov/16405508"},"language":"en","primary_location":{"id":"doi:10.1111/j.1471-4159.2005.03599.x","doi":"https://doi.org/10.1111/j.1471-4159.2005.03599.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1471-4159.2005.03599.x","pdf_url":null,"source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1985446291"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076511422","display_name":"Anne Waschbisch","orcid":"https://orcid.org/0000-0002-9305-1979","observed_orcids":["https://orcid.org/0000-0002-9305-1979"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anne Waschbisch","raw_affiliation_strings":["Department of Psychiatry, University of Freiburg Medical School, Freiburg, Germany","Anne Waschbisch and Bernd L. Fiebich share first authorship"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Freiburg Medical School, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"]},{"raw_affiliation_string":"Anne Waschbisch and Bernd L. Fiebich share first authorship","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035925368","display_name":"Bernd L. Fiebich","orcid":"https://orcid.org/0000-0002-9261-6771","observed_orcids":["https://orcid.org/0000-0002-9261-6771"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Bernd L. Fiebich","raw_affiliation_strings":["Anne Waschbisch and Bernd L. Fiebich share first authorship","Department of Psychiatry, University of Freiburg Medical School, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anne Waschbisch and Bernd L. Fiebich share first authorship","institution_ids":[]},{"raw_affiliation_string":"Department of Psychiatry, University of Freiburg Medical School, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052138367","display_name":"Ravi Shankar Akundi","orcid":"https://orcid.org/0000-0003-3782-5965","observed_orcids":["https://orcid.org/0000-0003-3782-5965"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ravi Shankar Akundi","raw_affiliation_strings":["Department of Psychiatry, University of Freiburg Medical School, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Freiburg Medical School, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012807189","display_name":"Michael Lienhard Schmitz","orcid":"https://orcid.org/0000-0002-6984-7192","observed_orcids":["https://orcid.org/0000-0002-6984-7192"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"M. Lienhard Schmitz","raw_affiliation_strings":["Department of Biochemistry, University of Bern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027733537","display_name":"Jeroen J.M. Hoozemans","orcid":"https://orcid.org/0000-0002-2888-8967","observed_orcids":["https://orcid.org/0000-0002-2888-8967"]},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]},{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jeroen J. M. Hoozemans","raw_affiliation_strings":["Department of Psychiatry, Institute Neurosciences Vrije Universiteit, VU University Medical Center, Amsterdam, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Institute Neurosciences Vrije Universiteit, VU University Medical Center, Amsterdam, the Netherlands","institution_ids":["https://openalex.org/I865915315","https://openalex.org/I911458345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064044893","display_name":"Eduardo Candelario\u2010Jalil","orcid":"https://orcid.org/0000-0003-3631-1989","observed_orcids":["https://orcid.org/0000-0003-3631-1989"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Eduardo Candelario\u2010Jalil","raw_affiliation_strings":["Department of Psychiatry, University of Freiburg Medical School, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Freiburg Medical School, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063726248","display_name":"Nina Virtainen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nina Virtainen","raw_affiliation_strings":["Cerebricon Ltd, Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cerebricon Ltd, Kuopio, Finland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053882105","display_name":"Robert Veerhuis","orcid":"https://orcid.org/0000-0003-0869-621X","observed_orcids":["https://orcid.org/0000-0003-0869-621X"]},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]},{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Robert Veerhuis","raw_affiliation_strings":["Department of Psychiatry, Institute Neurosciences Vrije Universiteit, VU University Medical Center, Amsterdam, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Institute Neurosciences Vrije Universiteit, VU University Medical Center, Amsterdam, the Netherlands","institution_ids":["https://openalex.org/I865915315","https://openalex.org/I911458345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030406364","display_name":"Helen Christina Slawik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Helen Slawik","raw_affiliation_strings":["Department of Psychiatry, University of Freiburg Medical School, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Freiburg Medical School, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027124641","display_name":"Juha Yrj\u00e4nheikki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Juha Yrj\u00e4nheikki","raw_affiliation_strings":["Cerebricon Ltd, Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cerebricon Ltd, Kuopio, Finland","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108515876","display_name":"Michael H\u00fcll","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael H\u00fcll","raw_affiliation_strings":["Department of Psychiatry, University of Freiburg Medical School, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Freiburg Medical School, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5035925368"],"corresponding_institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"],"apc_list":{"value":5330,"currency":"USD","value_usd":5330},"apc_paid":null,"fwci":2.1172,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.85518868,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"96","issue":"3","first_page":"680","last_page":"693"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.8384000062942505,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.8384000062942505,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.06440000236034393,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.050599999725818634,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9800000190734863},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.925000011920929},{"id":"https://openalex.org/keywords/astrocytoma-cells","display_name":"astrocytoma cells","score":0.8870000243186951},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.9789999723434448},{"id":"https://openalex.org/keywords/nuclear-factor-kappab","display_name":"nuclear factor-kappaB","score":0.9760000109672546},{"id":"https://openalex.org/keywords/receptor-upregulation","display_name":"receptor up-regulation","score":0.7699999809265137},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.8119999766349792},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.6240000128746033},{"id":"https://openalex.org/keywords/cerebral-ischemia","display_name":"cerebral ischemia","score":0.7089999914169312},{"id":"https://openalex.org/keywords/traumatic-brain-injury","display_name":"traumatic brain injury","score":0.9890000224113464},{"id":"https://openalex.org/keywords/hiv-encephalitis","display_name":"HIV encephalitis","score":0.8989999890327454},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9800000190734863},{"id":"https://openalex.org/keywords/prion-disease","display_name":"prion disease","score":0.9959999918937683}],"concepts":[{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6107418537139893},{"id":"https://openalex.org/C178592051","wikidata":"https://www.wikidata.org/wiki/Q28208812","display_name":"Prostaglandin E2 receptor","level":4,"score":0.5615398287773132},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5600980520248413},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4651551842689514},{"id":"https://openalex.org/C2777198256","wikidata":"https://www.wikidata.org/wiki/Q4860325","display_name":"Prostaglandin E","level":2,"score":0.42817968130111694},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4198700189590454},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40283870697021484},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38963907957077026},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3121824264526367},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001254","descriptor_name":"Astrocytoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018078","descriptor_name":"Receptors, Prostaglandin E","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018078","descriptor_name":"Receptors, Prostaglandin E","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058308","descriptor_name":"Receptors, Prostaglandin E, EP3 Subtype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1111/j.1471-4159.2005.03599.x","doi":"https://doi.org/10.1111/j.1471-4159.2005.03599.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1471-4159.2005.03599.x","pdf_url":null,"source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},{"id":"pmid:16405508","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16405508","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurochemistry","raw_type":"Comparative Study"},{"id":"pmh:oai:freidok.uni-freiburg.de:60587","doi":null,"is_oa":false,"landing_page_url":"https://freidok.uni-freiburg.de/data/60587","pdf_url":null,"source":{"id":"https://openalex.org/S4306401057","display_name":"FreiDok plus (Universit\u00e4tsbibliothek Freiburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I161046081","host_organization_name":"University of Freiburg","host_organization_lineage":["https://openalex.org/I161046081"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Neurochemistry. - 96, 3 (2006) , 680-693, ISSN: 0022-3042","raw_type":"article"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire_cris_publications/f4aa8447-a1fc-47c7-a98d-e0bdd2dfcf4e","doi":null,"is_oa":false,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/f4aa8447-a1fc-47c7-a98d-e0bdd2dfcf4e","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Waschbisch, A, Fiebich, B L, Akundi, R S, Schmitz, M L, Hoozemans, J J M, Candelario-Jalil, E, Virtainen, N, Veerhuis, R, Slawik, H, Yrj\u00e4nheikki, J & H\u00fcll, M 2006, 'Interleukin-1 beta-induced expression of the prostaglandin E-receptor subtype EP3 in U373 astrocytoma cells depends on protein kinase C and nuclear factor-kappaB', Journal of neurochemistry, vol. 96, no. 3, pp. 680-93. https://doi.org/10.1111/j.1471-4159.2005.03599.x","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:vumc:oai:pure.atira.dk:publications/aefdfdeb-41ba-4359-a94d-96bbd96ba897","doi":null,"is_oa":false,"landing_page_url":"https://research.vumc.nl/en/publications/aefdfdeb-41ba-4359-a94d-96bbd96ba897","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Neurochemistry, 96(3), 680 - 93. Wiley-Blackwell","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320308269","display_name":"Alexander von Humboldt-Stiftung","ror":"https://ror.org/012kf4317"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":73,"referenced_works":["https://openalex.org/W22231678","https://openalex.org/W1502766931","https://openalex.org/W1505624094","https://openalex.org/W1511649432","https://openalex.org/W1525605527","https://openalex.org/W1641731911","https://openalex.org/W1647648618","https://openalex.org/W1676270203","https://openalex.org/W1755902553","https://openalex.org/W1860299403","https://openalex.org/W1968210939","https://openalex.org/W1969083923","https://openalex.org/W1969435781","https://openalex.org/W1972773032","https://openalex.org/W1975096886","https://openalex.org/W1975995627","https://openalex.org/W1979004076","https://openalex.org/W1986115629","https://openalex.org/W1991403431","https://openalex.org/W1993098410","https://openalex.org/W1996498199","https://openalex.org/W1999422411","https://openalex.org/W2000663601","https://openalex.org/W2002241501","https://openalex.org/W2002506131","https://openalex.org/W2009828027","https://openalex.org/W2011937563","https://openalex.org/W2021862402","https://openalex.org/W2022711144","https://openalex.org/W2022971687","https://openalex.org/W2023353555","https://openalex.org/W2030571587","https://openalex.org/W2041797033","https://openalex.org/W2042865016","https://openalex.org/W2046349571","https://openalex.org/W2047841570","https://openalex.org/W2057919063","https://openalex.org/W2059994807","https://openalex.org/W2061314718","https://openalex.org/W2067150920","https://openalex.org/W2070015689","https://openalex.org/W2071712507","https://openalex.org/W2073917214","https://openalex.org/W2076324223","https://openalex.org/W2081526369","https://openalex.org/W2082437340","https://openalex.org/W2082831925","https://openalex.org/W2092169738","https://openalex.org/W2092527190","https://openalex.org/W2093881154","https://openalex.org/W2095573430","https://openalex.org/W2097298436","https://openalex.org/W2098153006","https://openalex.org/W2100486171","https://openalex.org/W2100837269","https://openalex.org/W2101759139","https://openalex.org/W2114232159","https://openalex.org/W2120688765","https://openalex.org/W2134405522","https://openalex.org/W2134812217","https://openalex.org/W2135339492","https://openalex.org/W2137004069","https://openalex.org/W2138092510","https://openalex.org/W2140131793","https://openalex.org/W2141549406","https://openalex.org/W2146957909","https://openalex.org/W2159940930","https://openalex.org/W2164845121","https://openalex.org/W2170370671","https://openalex.org/W2188779778","https://openalex.org/W2299422902","https://openalex.org/W4232678241","https://openalex.org/W4313347901"],"related_works":["https://openalex.org/W2067905549","https://openalex.org/W7046492231","https://openalex.org/W1511649432","https://openalex.org/W2010146219","https://openalex.org/W1969435781","https://openalex.org/W1993098410","https://openalex.org/W2045605935","https://openalex.org/W2037591650","https://openalex.org/W2015856462","https://openalex.org/W2013892546"],"abstract_inverted_index":{"Both":[0],"interleukin-1beta":[1],"(IL-1beta)":[2],"and":[3,11,70,73,91,125,162,175],"prostaglandins":[4],"(PGs)":[5],"are":[6],"important":[7,158],"mediators":[8],"of":[9,27,42,68,85,98,109,121,151,183,191],"physiological":[10],"pathophysiological":[12],"processes":[13],"in":[14,38,44,51,62,74,89,104,128,139,160,178,194],"the":[15,52,140,195],"brain.":[16,76,196],"PGE2":[17,28,137,192],"exerts":[18],"its":[19],"effects":[20],"by":[21,114,187],"binding":[22],"to":[23,35,149],"four":[24],"different":[25],"types":[26],"receptors":[29],"named":[30],"EP1-EP4.":[31],"EP3":[32,43,59,86,101,131,152],"has":[33,47],"found":[34,81],"be":[36,143],"expressed":[37],"neurons,":[39],"whereas":[40],"expression":[41,61],"glial":[45,94],"cells":[46],"not":[48],"been":[49],"reported":[50],"brain":[53,141,170],"yet.":[54],"Here":[55],"we":[56,80],"describe":[57],"IL-1beta-induced":[58,130],"receptor":[60,87,102],"human":[63,71,90],"astrocytoma":[64],"cells,":[65],"primary":[66,93],"astrocytes":[67],"rat":[69,75,92,105],"origin":[72],"Using":[77],"western":[78],"blot,":[79],"a":[82,180,188],"marked":[83,181],"up-regulation":[84,150,182],"synthesis":[88,103],"cells.":[95],"Intracerebroventricular":[96],"administration":[97],"IL-1beta":[99,146,184],"stimulated":[100],"hippocampus.":[106],"The":[107],"analysis":[108],"involved":[110],"signal":[111],"transduction":[112],"pathways":[113],"pathway-specific":[115],"inhibitors":[116],"revealed":[117],"an":[118,157],"essential":[119],"role":[120,159],"protein":[122],"kinase":[123],"C":[124],"nuclear":[126],"factor-kappaB":[127],"astrocytic":[129],"synthesis.":[132],"Our":[133],"data":[134],"suggest":[135],"that":[136],"signaling":[138],"may":[142],"altered":[144],"after":[145],"release":[147],"due":[148],"receptors.":[153],"This":[154],"might":[155],"play":[156],"acute":[161],"chronic":[163],"conditions":[164],"such":[165],"as":[166],"cerebral":[167],"ischemia,":[168],"traumatic":[169],"injury,":[171],"HIV-encephalitis,":[172],"Alzheimer's":[173],"disease":[174],"prion":[176],"diseases":[177],"which":[179],"is":[185],"followed":[186],"prolonged":[189],"increase":[190],"levels":[193]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}