{"id":"https://openalex.org/W1985385254","doi":"https://doi.org/10.1002/1097-0142(19951001)76:7<1197::aid-cncr2820760715>3.0.co;2-0","title":"Continued local recurrence of carcinoma 15\u201325 years after a diagnosis of low grade ductal carcinoma in situ of the breast treated only by biopsy","display_name":"Continued local recurrence of carcinoma 15\u201325 years after a diagnosis of low grade ductal carcinoma in situ of the breast treated only by biopsy","publication_year":1995,"publication_date":"1995-10-01","ids":{"openalex":"https://openalex.org/W1985385254","doi":"https://doi.org/10.1002/1097-0142(19951001)76:7<1197::aid-cncr2820760715>3.0.co;2-0","mag":"1985385254","pmid":"https://pubmed.ncbi.nlm.nih.gov/8630897"},"language":"en","primary_location":{"id":"doi:10.1002/1097-0142(19951001)76:7<1197::aid-cncr2820760715>3.0.co;2-0","doi":"https://doi.org/10.1002/1097-0142(19951001)76:7<1197::aid-cncr2820760715>3.0.co;2-0","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1097-0142(19951001)76:7<1197::aid-cncr2820760715>3.0.co;2-0","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%2819951001%2976%3A7%3C1197%3A%3AAID-CNCR2820760715%3E3.0.CO%3B2-0","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%2819951001%2976%3A7%3C1197%3A%3AAID-CNCR2820760715%3E3.0.CO%3B2-0","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107857731","display_name":"David L. Page","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David L. Page","raw_affiliation_strings":["Vanderbilt University School of Medicine, Department of Pathology, Nashville, Tennessee, USA","Department of Preventive Medicine, Nashville, Tennessee","Vanderbilt University School of Medicine, Department of Pathology, Nashville, Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt University School of Medicine, Department of Pathology, Nashville, Tennessee, USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Department of Preventive Medicine, Nashville, Tennessee","institution_ids":[]},{"raw_affiliation_string":"Vanderbilt University School of Medicine, Department of Pathology, Nashville, Tennessee","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074107549","display_name":"William D. Dupont","orcid":"https://orcid.org/0000-0002-8166-599X","observed_orcids":["https://orcid.org/0000-0002-8166-599X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William D. Dupont","raw_affiliation_strings":["Department of Preventive Medicine, Nashville, Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine, Nashville, Tennessee","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078666945","display_name":"Lowell W. Rogers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801202167","display_name":"MemorialCare Long Beach Medical Center","ror":"https://ror.org/021kgjd57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801202167","https://openalex.org/I4210125374"]},{"id":"https://openalex.org/I4210111322","display_name":"Long Beach Medical Center","ror":"https://ror.org/02rt3gt49","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210111322","https://openalex.org/I4210125374"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lowell W. Rogers","raw_affiliation_strings":["Long Beach Memorial Medical Center Department of Pathology, Long Beach, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Long Beach Memorial Medical Center Department of Pathology, Long Beach, California","institution_ids":["https://openalex.org/I2801202167","https://openalex.org/I4210111322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024030506","display_name":"Roy A. Jensen","orcid":"https://orcid.org/0000-0003-4430-2281","observed_orcids":["https://orcid.org/0000-0003-4430-2281"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roy A. Jensen","raw_affiliation_strings":["Vanderbilt University School of Medicine, Department of Pathology, Nashville, Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt University School of Medicine, Department of Pathology, Nashville, Tennessee","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053477855","display_name":"Peggy A. Schuyler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peggy A. Schuyler","raw_affiliation_strings":["Department of Preventive Medicine, Nashville, Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine, Nashville, Tennessee","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5107857731"],"corresponding_institution_ids":["https://openalex.org/I200719446"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":11.962,"has_fulltext":true,"cited_by_count":428,"citation_normalized_percentile":{"value":0.98861514,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":100},"biblio":{"volume":"76","issue":"7","first_page":"1197","last_page":"1200"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.9071999788284302,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.9071999788284302,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.0908999964594841,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12103","display_name":"Cancer Risks and Factors","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ductal-carcinoma-in-situ","display_name":"ductal carcinoma in situ","score":0.9909999966621399},{"id":"https://openalex.org/keywords/local-recurrence","display_name":"local recurrence","score":0.7070000171661377},{"id":"https://openalex.org/keywords/invasive-breast-cancer","display_name":"invasive breast cancer","score":0.8360000252723694},{"id":"https://openalex.org/keywords/natural-history-disease","display_name":"natural history (disease)","score":0.6700000166893005},{"id":"https://openalex.org/keywords/long-term-follow-up","display_name":"long-term follow-up","score":0.8389999866485596},{"id":"https://openalex.org/keywords/breast-cancer-prognosis","display_name":"breast cancer prognosis","score":0.4819999933242798},{"id":"https://openalex.org/keywords/histological-patterns","display_name":"histological patterns","score":0.3319999873638153}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8639110326766968},{"id":"https://openalex.org/C2780862961","wikidata":"https://www.wikidata.org/wiki/Q5311598","display_name":"Ductal carcinoma","level":4,"score":0.824433445930481},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.7164106369018555},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.5299404859542847},{"id":"https://openalex.org/C163276114","wikidata":"https://www.wikidata.org/wiki/Q484591","display_name":"Natural history","level":2,"score":0.48953112959861755},{"id":"https://openalex.org/C2780045663","wikidata":"https://www.wikidata.org/wiki/Q1146379","display_name":"Comedo","level":5,"score":0.4817078709602356},{"id":"https://openalex.org/C2777661416","wikidata":"https://www.wikidata.org/wiki/Q1035645","display_name":"Carcinoma in situ","level":3,"score":0.4773010015487671},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4540444612503052},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.4382239878177643},{"id":"https://openalex.org/C2778001805","wikidata":"https://www.wikidata.org/wiki/Q189961","display_name":"Mammary gland","level":4,"score":0.42623552680015564},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.37511366605758667},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34980884194374084},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3288644552230835},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.32081300020217896},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001940","descriptor_name":"Breast","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D002278","descriptor_name":"Carcinoma in Situ","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002278","descriptor_name":"Carcinoma in Situ","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018270","descriptor_name":"Carcinoma, Ductal, Breast","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D018270","descriptor_name":"Carcinoma, Ductal, Breast","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/1097-0142(19951001)76:7<1197::aid-cncr2820760715>3.0.co;2-0","doi":"https://doi.org/10.1002/1097-0142(19951001)76:7<1197::aid-cncr2820760715>3.0.co;2-0","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1097-0142(19951001)76:7<1197::aid-cncr2820760715>3.0.co;2-0","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%2819951001%2976%3A7%3C1197%3A%3AAID-CNCR2820760715%3E3.0.CO%3B2-0","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},{"id":"pmid:8630897","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8630897","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/1097-0142(19951001)76:7<1197::aid-cncr2820760715>3.0.co;2-0","doi":"https://doi.org/10.1002/1097-0142(19951001)76:7<1197::aid-cncr2820760715>3.0.co;2-0","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1097-0142(19951001)76:7<1197::aid-cncr2820760715>3.0.co;2-0","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%2819951001%2976%3A7%3C1197%3A%3AAID-CNCR2820760715%3E3.0.CO%3B2-0","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1208637583","display_name":null,"funder_award_id":"N01-CB-74098","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1428797104","display_name":"Epidemiology of Molecular Risk Factors for Breast Cancer","funder_award_id":"R01CA050468","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1985385254.pdf","grobid_xml":"https://content.openalex.org/works/W1985385254.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W18608689","https://openalex.org/W168637747","https://openalex.org/W189760652","https://openalex.org/W1978196129","https://openalex.org/W1988664748","https://openalex.org/W1989575995","https://openalex.org/W2008452993","https://openalex.org/W2036547499","https://openalex.org/W2044809539","https://openalex.org/W2053355503","https://openalex.org/W2070400746","https://openalex.org/W2071762482","https://openalex.org/W2076337068","https://openalex.org/W2091670521","https://openalex.org/W2093786201","https://openalex.org/W2097761061","https://openalex.org/W2114698200","https://openalex.org/W2312759957","https://openalex.org/W2328561181","https://openalex.org/W2794027193","https://openalex.org/W2796700885","https://openalex.org/W6768621889"],"related_works":["https://openalex.org/W1996212672","https://openalex.org/W2039821491","https://openalex.org/W2091670521","https://openalex.org/W2024489351","https://openalex.org/W83698396","https://openalex.org/W2791389619","https://openalex.org/W4393075788","https://openalex.org/W4206538374","https://openalex.org/W2091476544","https://openalex.org/W2002117944"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,95,196],"stratification":[2],"of":[3,9,37,40,53,57,60,90,98,100,114,139,192,199,228,241,247],"ductal":[4,66],"carcinoma":[5,102,161,212],"in":[6,68,77,129,146,150,158,218,224],"situ":[7,69],"(DCIS)":[8],"the":[10,35,115,126,147,151,215,238],"human":[11],"breast":[12],"into":[13],"prognostically":[14],"relevant":[15],"categories":[16],"by":[17,73,251],"size":[18],"and":[19,165],"histologic":[20],"pattern":[21],"is":[22,50,110,123,234],"a":[23,54,58,225],"current":[24],"concern.":[25],"Few":[26],"studies":[27],"have":[28,44,82,144],"been":[29,84],"able":[30],"to":[31,125],"follow":[32],"women":[33,62,81,105,157,229],"after":[34,135,168,184],"identification":[36],"any":[38,245],"type":[39,246],"DCIS":[41,178,202,220,243,248],"when":[42],"they":[43],"had":[45,174,189],"biopsy":[46,74],"only.":[47],"METHODS:":[48],"This":[49,122,233],"an":[51,88,175],"extension":[52],"follow-up":[55],"study":[56],"group":[59],"28":[61],"with":[63,210],"small,":[64,200],"noncomedo":[65,177,201],"carcinomas":[67,143],"that":[70,113,132,179],"were":[71,155],"excised":[72],"only,":[75],"published":[76],"1982.":[78],"All":[79,141],"these":[80,104],"now":[83],"successfully":[85],"followed":[86],"for":[87,103],"average":[89],"almost":[91,107],"30":[92,108,166],"years.":[93],"RESULTS:":[94],"overall":[96],"risk":[97,131],"development":[99],"invasive":[101,142,160,193,211],"over":[106,205],"years":[109,138,167,183],"nine":[111],"times":[112],"general":[116],"population":[117],"(95%":[118],"confidence":[119],"interval,":[120],"4.7-17).":[121],"similar":[124],"11-fold":[127],"elevation":[128],"relative":[130],"was":[133,180,221],"determined":[134],"about":[136],"15":[137],"follow-up.":[140],"developed":[145,162],"same":[148,152,216],"area":[149],"breast.":[153],"There":[154],"two":[156],"whom":[159],"between":[163,231],"20":[164],"initial":[169,186],"biopsy.":[170],"One":[171],"other":[172],"woman":[173],"extensive":[176],"identified":[181],"25":[182],"her":[185],"biopsy,":[187],"but":[188],"no":[190],"evidence":[191],"disease.":[194],"CONCLUSIONS:":[195],"natural":[197,239],"history":[198,240],"can":[203],"last":[204],"at":[206,214],"least":[207],"2":[208],"decades,":[209],"developing":[213],"site":[217],"which":[219],"previously":[222],"discovered":[223],"significant":[226],"percentage":[227],"(broadly,":[230],"25%-50%).":[232],"quite":[235],"different":[236],"from":[237],"comedo":[242],"or":[244],"treated":[249],"purposefully":[250],"surgery":[252],"alone.":[253]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":20},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":16},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":17},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}