{"id":"https://openalex.org/W1985368964","doi":"https://doi.org/10.2174/1389200023337388","title":"The Metabolism and Toxicity of Quinones, Quinonimines, Quinone Methides, and Quinone-Thioethers","display_name":"The Metabolism and Toxicity of Quinones, Quinonimines, Quinone Methides, and Quinone-Thioethers","publication_year":2002,"publication_date":"2002-08-01","ids":{"openalex":"https://openalex.org/W1985368964","doi":"https://doi.org/10.2174/1389200023337388","mag":"1985368964","pmid":"https://pubmed.ncbi.nlm.nih.gov/12093358"},"language":"en","primary_location":{"id":"doi:10.2174/1389200023337388","doi":"https://doi.org/10.2174/1389200023337388","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1389200023337388","pdf_url":null,"source":{"id":"https://openalex.org/S195680726","display_name":"Current Drug Metabolism","issn_l":"1389-2002","issn":["1389-2002","1875-5453"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Drug Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086522629","display_name":"Terrence J. Monks","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Terrence Monks","raw_affiliation_strings":["Center for Molecular and Cellular Toxicology, Division of Pharmacology and Toxicology, College of Pharmacy, University of Texas at Austin, Austin, TX 78712-1074, USA. scouser@mail.utexas.edu","Center for Molecular and Cellular Toxicology, Division of Pharmacology and Toxicology, College of Pharmacy, University of Texas at Austin, Austin, TX 78712-1074, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular and Cellular Toxicology, Division of Pharmacology and Toxicology, College of Pharmacy, University of Texas at Austin, Austin, TX 78712-1074, USA. scouser@mail.utexas.edu","institution_ids":["https://openalex.org/I86519309"]},{"raw_affiliation_string":"Center for Molecular and Cellular Toxicology, Division of Pharmacology and Toxicology, College of Pharmacy, University of Texas at Austin, Austin, TX 78712-1074, USA","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111338529","display_name":"Douglas C. Jones","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas Jones","raw_affiliation_strings":["University of Texas at Austin#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas at Austin#TAB#","institution_ids":["https://openalex.org/I86519309"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I86519309"],"apc_list":null,"apc_paid":null,"fwci":7.2935,"has_fulltext":false,"cited_by_count":334,"citation_normalized_percentile":{"value":0.97606048,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"3","issue":"4","first_page":"425","last_page":"438"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13012","display_name":"Coenzyme Q10 studies and effects","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/quinones","display_name":"quinones","score":0.9990000128746033},{"id":"https://openalex.org/keywords/quinone-metabolism","display_name":"quinone metabolism","score":0.8349999785423279},{"id":"https://openalex.org/keywords/quinone-toxicity","display_name":"quinone toxicity","score":0.9869999885559082},{"id":"https://openalex.org/keywords/quinone-methides","display_name":"quinone methides","score":0.996999979019165},{"id":"https://openalex.org/keywords/polycyclic-aromatic-hydrocarbons","display_name":"polycyclic aromatic hydrocarbons","score":0.9430000185966492},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.75},{"id":"https://openalex.org/keywords/substituent-effects","display_name":"substituent effects","score":0.8930000066757202},{"id":"https://openalex.org/keywords/environmental-contaminants","display_name":"environmental pollutants","score":0.4410000145435333}],"concepts":[{"id":"https://openalex.org/C2780643102","wikidata":"https://www.wikidata.org/wiki/Q412382","display_name":"Quinone","level":2,"score":0.9460434913635254},{"id":"https://openalex.org/C50027330","wikidata":"https://www.wikidata.org/wiki/Q908086","display_name":"Electrophile","level":3,"score":0.6928561329841614},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6783710718154907},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.5474066734313965},{"id":"https://openalex.org/C2778689049","wikidata":"https://www.wikidata.org/wiki/Q898422","display_name":"Substituent","level":2,"score":0.4600375294685364},{"id":"https://openalex.org/C2776910235","wikidata":"https://www.wikidata.org/wiki/Q18574","display_name":"Reactivity (psychology)","level":3,"score":0.45385441184043884},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.42678675055503845},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.31678006052970886},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000478","descriptor_name":"Alkylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007097","descriptor_name":"Imines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007097","descriptor_name":"Imines","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D007097","descriptor_name":"Imines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010636","descriptor_name":"Phenols","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011809","descriptor_name":"Quinones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011809","descriptor_name":"Quinones","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D011809","descriptor_name":"Quinones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013440","descriptor_name":"Sulfides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013440","descriptor_name":"Sulfides","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D013440","descriptor_name":"Sulfides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059808","descriptor_name":"Polyphenols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2174/1389200023337388","doi":"https://doi.org/10.2174/1389200023337388","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1389200023337388","pdf_url":null,"source":{"id":"https://openalex.org/S195680726","display_name":"Current Drug Metabolism","issn_l":"1389-2002","issn":["1389-2002","1875-5453"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Drug Metabolism","raw_type":"journal-article"},{"id":"pmid:12093358","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12093358","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current drug metabolism","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2339575910","https://openalex.org/W2902206547","https://openalex.org/W4213294159","https://openalex.org/W7033462033","https://openalex.org/W2090990681","https://openalex.org/W1558893136","https://openalex.org/W2161262276","https://openalex.org/W2036061844","https://openalex.org/W2024229295","https://openalex.org/W2086317499"],"abstract_inverted_index":{"Quinones":[0,101],"are":[1,44,102],"ubiquitous":[2],"in":[3,15,98,121,142],"nature":[4],"and":[5,18,49,66,79,104,106,144,148,174],"constitute":[6],"an":[7],"important":[8],"class":[9],"of":[10,40,54,70,81,110,146],"naturally":[11],"occurring":[12],"compounds":[13],"found":[14],"plants,":[16],"fungi":[17],"bacteria.":[19],"Human":[20],"exposure":[21,57,63],"to":[22,58,64,113,126,160,172],"quinones":[23,39,88,167],"therefore":[24,137],"occurs":[25],"via":[26,33],"the":[27,38,67,77,107,127,140,162],"diet,":[28],"but":[29],"also":[30,130],"clinically":[31],"or":[32],"airborne":[34],"pollutants.":[35],"For":[36],"example,":[37],"polycyclic":[41],"aromatic":[42],"hydrocarbons":[43],"prevalent":[45],"as":[46],"environmental":[47],"contaminants":[48],"provide":[50],"a":[51,85,176],"major":[52],"source":[53],"current":[55],"human":[56,62],"quinones.":[59],"The":[60],"inevitable":[61],"quinones,":[65,71,147],"inherent":[68],"reactivity":[69,97],"has":[72],"stimulated":[73],"substantial":[74],"research":[75],"on":[76,139],"chemistry":[78],"toxicology":[80],"these":[82,111],"compounds.":[83],"From":[84],"toxicological":[86],"perspective,":[87],"possess":[89],"two":[90],"principal":[91],"chemical":[92,119],"properties":[93,112],"that":[94],"confer":[95],"their":[96],"biological":[99,170],"systems.":[100],"oxidants":[103],"electrophiles,":[105],"relative":[108],"contribution":[109],"quinone":[114,128,132,153],"toxicity":[115],"is":[116],"influenced":[117],"by":[118,165],"structure,":[120],"particular":[122],"substituent":[123],"effects.":[124],"Modification":[125],"nucleus":[129],"influences":[131],"metabolism.":[133],"This":[134],"review":[135],"will":[136,157],"focus":[138],"differences":[141,151],"structure":[143],"metabolism":[145],"how":[149],"such":[150],"influence":[152],"toxicology.":[154],"Specific":[155],"examples":[156],"be":[158],"discussed":[159],"illustrate":[161],"diverse":[163],"manner":[164],"which":[166],"interact":[168],"with":[169],"systems":[171],"initiate":[173],"propagate":[175],"toxic":[177],"response.":[178]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":18},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":18},{"year":2019,"cited_by_count":17},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":26},{"year":2016,"cited_by_count":16},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":20},{"year":2013,"cited_by_count":15},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}