{"id":"https://openalex.org/W1985367412","doi":"https://doi.org/10.5966/sctm.2013-0079","title":"Human Bone Marrow-Derived Mesenchymal Stem Cells Display Enhanced Clonogenicity but Impaired Differentiation With Hypoxic Preconditioning","display_name":"Human Bone Marrow-Derived Mesenchymal Stem Cells Display Enhanced Clonogenicity but Impaired Differentiation With Hypoxic Preconditioning","publication_year":2014,"publication_date":"2014-01-16","ids":{"openalex":"https://openalex.org/W1985367412","doi":"https://doi.org/10.5966/sctm.2013-0079","mag":"1985367412","pmid":"https://pubmed.ncbi.nlm.nih.gov/24436440","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3925051"},"language":"en","primary_location":{"id":"doi:10.5966/sctm.2013-0079","doi":"https://doi.org/10.5966/sctm.2013-0079","is_oa":true,"landing_page_url":"https://doi.org/10.5966/sctm.2013-0079","pdf_url":"https://academic.oup.com/stcltm/article-pdf/3/2/241/41886730/stcltm_3_2_241.pdf","source":{"id":"https://openalex.org/S2494728167","display_name":"Stem Cells Translational Medicine","issn_l":"2157-6564","issn":["2157-6564","2157-6580"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cells Translational Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/stcltm/article-pdf/3/2/241/41886730/stcltm_3_2_241.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047105111","display_name":"Lisa B. Boyette","orcid":"https://orcid.org/0009-0005-3724-4943","observed_orcids":["https://orcid.org/0009-0005-3724-4943"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210087962","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210087962"]},{"id":"https://openalex.org/I4210155891","display_name":"McGowan Institute for Regenerative Medicine","ror":"https://ror.org/04js6xx21","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210098814","https://openalex.org/I4210134769","https://openalex.org/I4210155891"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lisa B. Boyette","raw_affiliation_strings":["Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA;","Center for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA","McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA;","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210087962"]},{"raw_affiliation_string":"Center for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210155891"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008820703","display_name":"Olivia A. Creasey","orcid":"https://orcid.org/0000-0002-9225-6278","observed_orcids":["https://orcid.org/0000-0002-9225-6278"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olivia A. Creasey","raw_affiliation_strings":["Center for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA","Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083062140","display_name":"Lynda J. Guzik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210155891","display_name":"McGowan Institute for Regenerative Medicine","ror":"https://ror.org/04js6xx21","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210098814","https://openalex.org/I4210134769","https://openalex.org/I4210155891"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lynda Guzik","raw_affiliation_strings":["McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210155891"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034973849","display_name":"Thomas P. Lozito","orcid":"https://orcid.org/0000-0002-6855-3571","observed_orcids":["https://orcid.org/0000-0002-6855-3571"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210087962","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210087962"]},{"id":"https://openalex.org/I4210155891","display_name":"McGowan Institute for Regenerative Medicine","ror":"https://ror.org/04js6xx21","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210098814","https://openalex.org/I4210134769","https://openalex.org/I4210155891"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Lozito","raw_affiliation_strings":["Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA;","Center for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA","McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA;","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210087962"]},{"raw_affiliation_string":"Center for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210155891"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057499766","display_name":"Rocky S. Tuan","orcid":"https://orcid.org/0000-0001-6067-6705","observed_orcids":["https://orcid.org/0000-0001-6067-6705"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210087962","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210087962"]},{"id":"https://openalex.org/I4210155891","display_name":"McGowan Institute for Regenerative Medicine","ror":"https://ror.org/04js6xx21","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210098814","https://openalex.org/I4210134769","https://openalex.org/I4210155891"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rocky S. Tuan","raw_affiliation_strings":["Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA;","Center for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA","Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA","McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA;","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210087962"]},{"raw_affiliation_string":"Center for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210155891"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5057499766"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I170201317","https://openalex.org/I4210087962","https://openalex.org/I4210155891"],"apc_list":{"value":2963,"currency":"USD","value_usd":2963},"apc_paid":{"value":2963,"currency":"USD","value_usd":2963},"fwci":4.8185,"has_fulltext":true,"cited_by_count":128,"citation_normalized_percentile":{"value":0.96339058,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"3","issue":"2","first_page":"241","last_page":"254"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9660000205039978},{"id":"https://openalex.org/keywords/bone-marrow-derived-stem-cells","display_name":"bone marrow-derived stem cells","score":0.8109999895095825},{"id":"https://openalex.org/keywords/hypoxic-preconditioning","display_name":"hypoxic preconditioning","score":0.949999988079071},{"id":"https://openalex.org/keywords/clonogenicity","display_name":"clonogenicity","score":0.9399999976158142},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.8529999852180481},{"id":"https://openalex.org/keywords/adipogenic-differentiation","display_name":"adipogenesis","score":0.9629999995231628},{"id":"https://openalex.org/keywords/chondrogenesis","display_name":"chondrogenesis","score":0.984000027179718},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.8980000019073486},{"id":"https://openalex.org/keywords/alkaline-phosphatase","display_name":"alkaline phosphatase","score":0.8709999918937683},{"id":"https://openalex.org/keywords/extracellular-matrix-turnover","display_name":"extracellular matrix turnover","score":0.7480000257492065},{"id":"https://openalex.org/keywords/stem-cell-expansion","display_name":"stem cell expansion","score":0.6660000085830688},{"id":"https://openalex.org/keywords/regenerative-medicine","display_name":"regenerative medicine","score":0.5709999799728394}],"concepts":[{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.8149116039276123},{"id":"https://openalex.org/C35496256","wikidata":"https://www.wikidata.org/wiki/Q5104524","display_name":"Chondrogenesis","level":3,"score":0.7038323879241943},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.6385405659675598},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6314613819122314},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5887145400047302},{"id":"https://openalex.org/C117262875","wikidata":"https://www.wikidata.org/wiki/Q5135057","display_name":"Clonogenic assay","level":3,"score":0.5441639423370361},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.5085722208023071},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.5078051686286926},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.48553797602653503},{"id":"https://openalex.org/C10854531","wikidata":"https://www.wikidata.org/wiki/Q1061415","display_name":"Regenerative medicine","level":3,"score":0.44893157482147217},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4366384744644165},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4338568449020386},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.417402982711792},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38376399874687195},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.18981221318244934},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09371474385261536},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002999","descriptor_name":"Clone Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010011","descriptor_name":"Osteocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016130","descriptor_name":"Immunophenotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017667","descriptor_name":"Adipocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D019194","descriptor_name":"Ischemic Preconditioning","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D020782","descriptor_name":"Matrix Metalloproteinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.5966/sctm.2013-0079","doi":"https://doi.org/10.5966/sctm.2013-0079","is_oa":true,"landing_page_url":"https://doi.org/10.5966/sctm.2013-0079","pdf_url":"https://academic.oup.com/stcltm/article-pdf/3/2/241/41886730/stcltm_3_2_241.pdf","source":{"id":"https://openalex.org/S2494728167","display_name":"Stem Cells Translational Medicine","issn_l":"2157-6564","issn":["2157-6564","2157-6580"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cells Translational Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3925051","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3925051","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cells Transl Med","raw_type":"Text"},{"id":"pmid:24436440","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24436440","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem cells translational medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.5966/sctm.2013-0079","doi":"https://doi.org/10.5966/sctm.2013-0079","is_oa":true,"landing_page_url":"https://doi.org/10.5966/sctm.2013-0079","pdf_url":"https://academic.oup.com/stcltm/article-pdf/3/2/241/41886730/stcltm_3_2_241.pdf","source":{"id":"https://openalex.org/S2494728167","display_name":"Stem Cells Translational Medicine","issn_l":"2157-6564","issn":["2157-6564","2157-6580"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cells Translational Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3251813504","display_name":null,"funder_award_id":"SAP 4100050913","funder_id":"https://openalex.org/F4320308109","funder_display_name":"Pennsylvania Department of Health"},{"id":"https://openalex.org/G8727566785","display_name":"Cell and Molecular Biology of Skeletal Development","funder_award_id":"Z01AR041131","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G9000904045","display_name":"Interdisciplinary Training in Transplantation Biology","funder_award_id":"T32AI074490","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320308109","display_name":"Pennsylvania Department of Health","ror":"https://ror.org/00ra1fg11"},{"id":"https://openalex.org/F4320310094","display_name":"University of Washington","ror":"https://ror.org/00cvxb145"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1985367412.pdf","grobid_xml":"https://content.openalex.org/works/W1985367412.grobid-xml"},"referenced_works_count":95,"referenced_works":["https://openalex.org/W1490068297","https://openalex.org/W1502442150","https://openalex.org/W1908612395","https://openalex.org/W1965766281","https://openalex.org/W1967474304","https://openalex.org/W1968084778","https://openalex.org/W1968659815","https://openalex.org/W1969108266","https://openalex.org/W1975055320","https://openalex.org/W1976906682","https://openalex.org/W1977783605","https://openalex.org/W1983324713","https://openalex.org/W1984553504","https://openalex.org/W1988714320","https://openalex.org/W1991162692","https://openalex.org/W1993925802","https://openalex.org/W1993938912","https://openalex.org/W1993943657","https://openalex.org/W1999070656","https://openalex.org/W2002267044","https://openalex.org/W2002751444","https://openalex.org/W2003105246","https://openalex.org/W2004152316","https://openalex.org/W2005484085","https://openalex.org/W2007383919","https://openalex.org/W2008556682","https://openalex.org/W2008630032","https://openalex.org/W2010444241","https://openalex.org/W2012309077","https://openalex.org/W2013189110","https://openalex.org/W2016699099","https://openalex.org/W2016878020","https://openalex.org/W2020358784","https://openalex.org/W2022495001","https://openalex.org/W2022731821","https://openalex.org/W2023060332","https://openalex.org/W2025991178","https://openalex.org/W2033440116","https://openalex.org/W2038043656","https://openalex.org/W2038547468","https://openalex.org/W2038996811","https://openalex.org/W2039661491","https://openalex.org/W2041552691","https://openalex.org/W2041570796","https://openalex.org/W2044322920","https://openalex.org/W2048539785","https://openalex.org/W2050903881","https://openalex.org/W2057597564","https://openalex.org/W2060604173","https://openalex.org/W2065854391","https://openalex.org/W2074121232","https://openalex.org/W2076254268","https://openalex.org/W2078677737","https://openalex.org/W2079242126","https://openalex.org/W2080517328","https://openalex.org/W2083838222","https://openalex.org/W2087527471","https://openalex.org/W2090685680","https://openalex.org/W2093584750","https://openalex.org/W2094260447","https://openalex.org/W2100223622","https://openalex.org/W2101361529","https://openalex.org/W2101962153","https://openalex.org/W2106204137","https://openalex.org/W2107284150","https://openalex.org/W2108358002","https://openalex.org/W2114432926","https://openalex.org/W2117904914","https://openalex.org/W2118939519","https://openalex.org/W2131624895","https://openalex.org/W2135306934","https://openalex.org/W2136325125","https://openalex.org/W2138007542","https://openalex.org/W2142613844","https://openalex.org/W2143451025","https://openalex.org/W2145489725","https://openalex.org/W2147673404","https://openalex.org/W2149265913","https://openalex.org/W2149788186","https://openalex.org/W2150244958","https://openalex.org/W2152471534","https://openalex.org/W2153042507","https://openalex.org/W2154823420","https://openalex.org/W2155243243","https://openalex.org/W2157209689","https://openalex.org/W2158562859","https://openalex.org/W2158739674","https://openalex.org/W2163243408","https://openalex.org/W2165472748","https://openalex.org/W2168224231","https://openalex.org/W2169842119","https://openalex.org/W2171833305","https://openalex.org/W2177706557","https://openalex.org/W2405694227","https://openalex.org/W4296119110"],"related_works":["https://openalex.org/W4240134793","https://openalex.org/W3202764751","https://openalex.org/W2089530989","https://openalex.org/W2010296156","https://openalex.org/W2066954473","https://openalex.org/W6885099880","https://openalex.org/W3151874336","https://openalex.org/W7029022798","https://openalex.org/W1739175806","https://openalex.org/W2970411693"],"abstract_inverted_index":{"Stem":[0],"cells":[1,5,26],"are":[2,28],"promising":[3],"candidate":[4],"for":[6,211],"regenerative":[7,212],"applications":[8],"because":[9],"they":[10],"possess":[11],"high":[12],"proliferative":[13,36],"capacity":[14],"and":[15,37,56,96,139,233,235],"the":[16,48,104,203],"potential":[17,72,205],"to":[18,60,87,112,151,184,189,216,224],"differentiate":[19],"into":[20],"other":[21],"cell":[22,107],"types.":[23],"Mesenchymal":[24],"stem":[25],"(MSCs)":[27],"easily":[29],"sourced":[30],"but":[31],"do":[32],"not":[33,102],"retain":[34],"their":[35,209],"multilineage":[38],"differentiative":[39],"capabilities":[40],"after":[41],"prolonged":[42],"ex":[43],"vivo":[44],"propagation.":[45],"We":[46,80],"investigated":[47],"use":[49],"of":[50,73,106,110,206,230,240],"hypoxia":[51,111,152,172,217],"as":[52],"a":[53,191,227,237],"preconditioning":[54,163,182],"agent":[55],"in":[57,65,116,127,130,137,156,167,226],"differentiating":[58],"cultures":[59,114,159,168],"enhance":[61],"MSC":[62],"function.":[63],"Culture":[64],"5%":[66],"ambient":[67],"O(2)":[68],"consistently":[69],"enhanced":[70,83,117,178],"clonogenic":[71,193],"primary":[74],"MSCs":[75,128],"from":[76],"all":[77],"donors":[78],"tested.":[79],"determined":[81],"that":[82,199],"clonogenicity":[84],"was":[85,124,143,147,160],"attributable":[86],"increased":[88,90,97],"proliferation,":[89],"vascular":[91],"endothelial":[92],"growth":[93],"factor":[94],"secretion,":[95],"matrix":[98],"turnover.":[99],"Hypoxia":[100],"did":[101],"impact":[103],"incidence":[105],"death.":[108],"Application":[109],"osteogenic":[113],"resulted":[115],"total":[118],"mineral":[119],"deposition,":[120],"although":[121],"this":[122],"effect":[123],"detected":[125],"only":[126],"preconditioned":[129],"normoxic":[131],"conditions.":[132],"Osteogenesis-associated":[133],"genes":[134],"were":[135],"upregulated":[136],"hypoxia,":[138],"alkaline":[140],"phosphatase":[141],"activity":[142],"enhanced.":[144],"Adipogenic":[145],"differentiation":[146,204,219],"inhibited":[148,161],"by":[149,162],"exposure":[150],"during":[153,174,218],"differentiation.":[154],"Chondrogenesis":[155],"three-dimensional":[157],"pellet":[158,176],"with":[164],"hypoxia.":[165],"However,":[166],"expanded":[169],"under":[170],"normoxia,":[171],"applied":[173],"subsequent":[175],"culture":[177],"chondrogenesis.":[179],"Whereas":[180],"hypoxic":[181],"appears":[183,223],"be":[185],"an":[186],"excellent":[187],"way":[188],"expand":[190],"highly":[192],"progenitor":[194],"pool,":[195],"our":[196],"findings":[197],"suggest":[198],"it":[200],"may":[201],"blunt":[202],"MSCs,":[207],"compromising":[208],"utility":[210],"tissue":[213],"engineering.":[214],"Exposure":[215],"(post-normoxic":[220],"expansion),":[221],"however,":[222],"result":[225],"greater":[228],"quantity":[229,239],"functional":[231],"osteoblasts":[232],"chondrocytes":[234],"ultimately":[236],"larger":[238],"high-quality":[241],"differentiated":[242],"tissue.":[243]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":18},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
