{"id":"https://openalex.org/W1985367386","doi":"https://doi.org/10.1002/cm.20189","title":"Accelerated mortality from hydrocephalus and pneumonia in mice with a combined deficiency of SPAG6 and SPAG16L reveals a functional interrelationship between the two central apparatus proteins","display_name":"Accelerated mortality from hydrocephalus and pneumonia in mice with a combined deficiency of SPAG6 and SPAG16L reveals a functional interrelationship between the two central apparatus proteins","publication_year":2007,"publication_date":"2007-02-23","ids":{"openalex":"https://openalex.org/W1985367386","doi":"https://doi.org/10.1002/cm.20189","mag":"1985367386","pmid":"https://pubmed.ncbi.nlm.nih.gov/17323374"},"language":"en","primary_location":{"id":"doi:10.1002/cm.20189","doi":"https://doi.org/10.1002/cm.20189","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cm.20189","pdf_url":null,"source":{"id":"https://openalex.org/S67371178","display_name":"Cell Motility and the Cytoskeleton","issn_l":"0886-1544","issn":["0886-1544","1097-0169"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Motility","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101458521","display_name":"Zhibing Zhang","orcid":"https://orcid.org/0000-0002-7873-7921","observed_orcids":["https://orcid.org/0000-0002-7873-7921"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Zhibing Zhang","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Virginia Commonwealth University, Richmond, Virginia 23298, USA. zzhang4@vcu.edu","Department of Obstetrics and Gynecology, Virginia Commonwealth University, Richmond, Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Virginia Commonwealth University, Richmond, Virginia 23298, USA. zzhang4@vcu.edu","institution_ids":["https://openalex.org/I184840846"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Virginia Commonwealth University, Richmond, Virginia","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111902340","display_name":"Waixing Tang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Waixing Tang","raw_affiliation_strings":["Department of Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069305433","display_name":"Rong Zhou","orcid":"https://orcid.org/0000-0003-4018-381X","observed_orcids":["https://orcid.org/0000-0003-4018-381X"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rong Zhou","raw_affiliation_strings":["Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112273624","display_name":"Xue\u2010Ning Shen","orcid":"https://orcid.org/0009-0001-2658-3799","observed_orcids":["https://orcid.org/0009-0001-2658-3799"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xuening Shen","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Virginia Commonwealth University, Richmond, Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Virginia Commonwealth University, Richmond, Virginia","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109011247","display_name":"Zhangyong Wei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhangyong Wei","raw_affiliation_strings":["Department of Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011271764","display_name":"Aatish M. Patel","orcid":"https://orcid.org/0000-0002-2503-2602","observed_orcids":["https://orcid.org/0000-0002-2503-2602"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aatish M. Patel","raw_affiliation_strings":["Department of Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110439979","display_name":"John Theodore Povlishock","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John T. Povlishock","raw_affiliation_strings":["Department of Anatomy and Neurobiology, Virginia Commonwealth University, Richmond, Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Neurobiology, Virginia Commonwealth University, Richmond, Virginia","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051555445","display_name":"Jean Bennett","orcid":"https://orcid.org/0000-0003-3378-8263","observed_orcids":["https://orcid.org/0000-0003-3378-8263"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jean Bennett","raw_affiliation_strings":["Department of Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090491933","display_name":"Jerome F. Strauss","orcid":"https://orcid.org/0000-0001-6199-0480","observed_orcids":["https://orcid.org/0000-0001-6199-0480"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jerome F. Strauss","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Virginia Commonwealth University, Richmond, Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Virginia Commonwealth University, Richmond, Virginia","institution_ids":["https://openalex.org/I184840846"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5101458521"],"corresponding_institution_ids":["https://openalex.org/I184840846"],"apc_list":null,"apc_paid":null,"fwci":1.8355,"has_fulltext":false,"cited_by_count":56,"citation_normalized_percentile":{"value":0.85413225,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"64","issue":"5","first_page":"360","last_page":"376"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.7778000235557556,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.7778000235557556,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.2167000025510788,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11406","display_name":"Cerebrospinal fluid and hydrocephalus","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spag6","display_name":"SPAG6","score":1.0},{"id":"https://openalex.org/keywords/axoneme","display_name":"axoneme","score":0.8880000114440918},{"id":"https://openalex.org/keywords/primary-ciliary-dyskinesia","display_name":"primary ciliary dyskinesia","score":0.9269999861717224},{"id":"https://openalex.org/keywords/hydrocephalus","display_name":"hydrocephalus","score":0.8650000095367432},{"id":"https://openalex.org/keywords/pneumonia","display_name":"pneumonia","score":0.9789999723434448},{"id":"https://openalex.org/keywords/cilia","display_name":"cilia","score":0.5},{"id":"https://openalex.org/keywords/ciliary-motility","display_name":"ciliary motility","score":0.5329999923706055},{"id":"https://openalex.org/keywords/male-fertility","display_name":"male fertility","score":0.5860000252723694},{"id":"https://openalex.org/keywords/growth-retardation","display_name":"growth retardation","score":0.7279999852180481},{"id":"https://openalex.org/keywords/atelectasis","display_name":"atelectasis","score":0.6669999957084656}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8679872155189514},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.6443942785263062},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5849605798721313},{"id":"https://openalex.org/C2778206077","wikidata":"https://www.wikidata.org/wiki/Q1690779","display_name":"Primary ciliary dyskinesia","level":4,"score":0.5438876152038574},{"id":"https://openalex.org/C100094513","wikidata":"https://www.wikidata.org/wiki/Q180436","display_name":"Cilium","level":2,"score":0.5397786498069763},{"id":"https://openalex.org/C58207958","wikidata":"https://www.wikidata.org/wiki/Q33596","display_name":"Motility","level":2,"score":0.4840368628501892},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4699065089225769},{"id":"https://openalex.org/C24870808","wikidata":"https://www.wikidata.org/wiki/Q792605","display_name":"Axoneme","level":4,"score":0.4643917679786682},{"id":"https://openalex.org/C2910722709","wikidata":"https://www.wikidata.org/wiki/Q180436","display_name":"Motile cilium","level":3,"score":0.427731454372406},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3996070921421051},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33070123195648193},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.32186099886894226},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.26429587602615356},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2608961760997772},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18352872133255005},{"id":"https://openalex.org/C2779379686","wikidata":"https://www.wikidata.org/wiki/Q32778","display_name":"Bronchiectasis","level":3,"score":0.16321682929992676},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C115811362","wikidata":"https://www.wikidata.org/wiki/Q189998","display_name":"Flagellum","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D002923","descriptor_name":"Cilia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002923","descriptor_name":"Cilia","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D006579","descriptor_name":"Heterozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006849","descriptor_name":"Hydrocephalus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006849","descriptor_name":"Hydrocephalus","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008817","descriptor_name":"Mice, Mutant Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008868","descriptor_name":"Microtubule Proteins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D008868","descriptor_name":"Microtubule Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008868","descriptor_name":"Microtubule Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008869","descriptor_name":"Microtubule-Associated Proteins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D008869","descriptor_name":"Microtubule-Associated Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008869","descriptor_name":"Microtubule-Associated Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011014","descriptor_name":"Pneumonia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011014","descriptor_name":"Pneumonia","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D011859","descriptor_name":"Radiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/cm.20189","doi":"https://doi.org/10.1002/cm.20189","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cm.20189","pdf_url":null,"source":{"id":"https://openalex.org/S67371178","display_name":"Cell Motility and the Cytoskeleton","issn_l":"0886-1544","issn":["0886-1544","1097-0169"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Motility","raw_type":"journal-article"},{"id":"pmid:17323374","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17323374","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell motility and the cytoskeleton","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3957042963","display_name":null,"funder_award_id":"HS06724","funder_id":"https://openalex.org/F4320332177","funder_display_name":"Agency for Healthcare Research and Quality"},{"id":"https://openalex.org/G5513291093","display_name":"Molecular Basis of Mammalian Sperm Motility","funder_award_id":"R01HD037416","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G9000878197","display_name":"University of Pennsylvania Diabetes Research Center","funder_award_id":"P30DK019525","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320309370","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10"},{"id":"https://openalex.org/F4320332177","display_name":"Agency for Healthcare Research and Quality","ror":"https://ror.org/03jmfdf59"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":70,"referenced_works":["https://openalex.org/W1606774023","https://openalex.org/W1964295450","https://openalex.org/W1967087018","https://openalex.org/W1970264904","https://openalex.org/W1970759489","https://openalex.org/W1979485887","https://openalex.org/W1983538981","https://openalex.org/W1985157254","https://openalex.org/W1996743997","https://openalex.org/W1997079461","https://openalex.org/W2001536138","https://openalex.org/W2004491021","https://openalex.org/W2005787819","https://openalex.org/W2006776573","https://openalex.org/W2009045981","https://openalex.org/W2011697505","https://openalex.org/W2017629456","https://openalex.org/W2018474276","https://openalex.org/W2022192316","https://openalex.org/W2023078775","https://openalex.org/W2025206687","https://openalex.org/W2028932782","https://openalex.org/W2033925514","https://openalex.org/W2038297891","https://openalex.org/W2039944559","https://openalex.org/W2041341923","https://openalex.org/W2046093970","https://openalex.org/W2049335442","https://openalex.org/W2049876198","https://openalex.org/W2054380610","https://openalex.org/W2057427700","https://openalex.org/W2060648871","https://openalex.org/W2077760143","https://openalex.org/W2079891083","https://openalex.org/W2079919032","https://openalex.org/W2083278935","https://openalex.org/W2083413944","https://openalex.org/W2083904901","https://openalex.org/W2089665250","https://openalex.org/W2092699601","https://openalex.org/W2093363858","https://openalex.org/W2093543973","https://openalex.org/W2104520647","https://openalex.org/W2107887733","https://openalex.org/W2112331825","https://openalex.org/W2115687133","https://openalex.org/W2115950347","https://openalex.org/W2120077307","https://openalex.org/W2120455375","https://openalex.org/W2121166094","https://openalex.org/W2124589223","https://openalex.org/W2126695143","https://openalex.org/W2127352376","https://openalex.org/W2131959123","https://openalex.org/W2136639827","https://openalex.org/W2139417948","https://openalex.org/W2147372549","https://openalex.org/W2147579338","https://openalex.org/W2152188117","https://openalex.org/W2153120377","https://openalex.org/W2155652989","https://openalex.org/W2156149443","https://openalex.org/W2163976949","https://openalex.org/W2187554833","https://openalex.org/W2404688518","https://openalex.org/W2411389029","https://openalex.org/W2411486834","https://openalex.org/W2599128200","https://openalex.org/W4244866895","https://openalex.org/W6610883157"],"related_works":["https://openalex.org/W2053424546","https://openalex.org/W2152188117","https://openalex.org/W4365483587","https://openalex.org/W3044019720","https://openalex.org/W2046027843","https://openalex.org/W2120077307","https://openalex.org/W2025846113","https://openalex.org/W4205414284","https://openalex.org/W2937423491","https://openalex.org/W3084025438"],"abstract_inverted_index":{"SPAG6":[0,75,158,176],"and":[1,18,36,68,76,85,103,109,145,159,177,191],"SPAG16L":[2,77,160,178],"are":[3,13,24],"proteins":[4,23],"localized":[5],"to":[6,71,166],"the":[7,40,97,120,143,148,184,189],"\"9+2\"":[8],"axoneme":[9],"central":[10],"apparatus.":[11],"Both":[12],"essential":[14],"for":[15,74,117],"sperm":[16],"motility":[17],"male":[19],"fertility.":[20],"These":[21],"two":[22,47],"also":[25,173],"expressed":[26],"in":[27,91,114,119,130,141,182,188],"other":[28,124],"tissues":[29],"containing":[30],"ciliated":[31],"cells,":[32],"such":[33],"as":[34],"brain":[35,144,190],"lung.":[37,192],"To":[38],"study":[39,167],"effects":[41],"of":[42,45,65,139,147,156,186],"combined":[43,157],"deficiency":[44,161],"these":[46],"proteins,":[48],"a":[49,61,163],"double":[50,57,80,98,131,149],"mutant":[51,58,81,93,99,132,150],"mouse":[52],"model":[53,155],"was":[54,87,128],"created.":[55],"The":[56,79,137,171],"mice":[59,72,82,100,115,133,151],"displayed":[60],"more":[62],"profound":[63],"phenotype":[64],"growth":[66],"retardation":[67],"hydrocephalus":[69],"compared":[70],"nullizygous":[73,116],"alone.":[78],"died":[83],"younger,":[84],"mortality":[86],"significantly":[88],"higher":[89],"than":[90],"single":[92],"mice.":[94],"In":[95],"addition,":[96],"demonstrated":[101],"pneumonia":[102],"its":[104],"complications,":[105],"including":[106,134],"hemorrhage,":[107],"edema,":[108],"atelectasis,":[110],"phenotypes":[111],"not":[112],"observed":[113],"mutations":[118],"individual":[121],"genes.":[122],"No":[123],"cilia-related":[125],"phenotypic":[126],"change":[127],"detected":[129],"lateralization":[135],"defects.":[136],"ultrastructure":[138],"cilia":[140,187],"both":[142],"lung":[146],"appeared":[152],"normal.":[153],"This":[154],"provides":[162],"new":[164],"platform":[165],"primary":[168],"ciliary":[169],"dyskinesia.":[170],"findings":[172],"demonstrate":[174],"that":[175],"have":[179],"related":[180],"roles":[181],"controlling":[183],"function":[185]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
