{"id":"https://openalex.org/W1985357192","doi":"https://doi.org/10.1167/iovs.05-0354","title":"Influence of Treatment Parameters on Selectivity of Verteporfin Therapy","display_name":"Influence of Treatment Parameters on Selectivity of Verteporfin Therapy","publication_year":2005,"publication_date":"2005-12-29","ids":{"openalex":"https://openalex.org/W1985357192","doi":"https://doi.org/10.1167/iovs.05-0354","mag":"1985357192","pmid":"https://pubmed.ncbi.nlm.nih.gov/16384987"},"language":"en","primary_location":{"id":"doi:10.1167/iovs.05-0354","doi":"https://doi.org/10.1167/iovs.05-0354","is_oa":false,"landing_page_url":"https://doi.org/10.1167/iovs.05-0354","pdf_url":null,"source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative Opthalmology &amp; Visual Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113827770","display_name":"Stephan Michels","orcid":"https://orcid.org/0000-0002-3146-7805","observed_orcids":["https://orcid.org/0000-0002-3146-7805"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephan Michels","raw_affiliation_strings":["From the University Eye Hospital Vienna, Vienna, Austria; and the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the University Eye Hospital Vienna, Vienna, Austria; and the","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069423022","display_name":"Fabian Hansmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Fabian Hansmann","raw_affiliation_strings":["University Eye Hospital Schleswig-Hostein, Lu\u00a8beck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Eye Hospital Schleswig-Hostein, Lu\u00a8beck, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069133257","display_name":"Wolfgang Geitzenauer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wolfgang Geitzenauer","raw_affiliation_strings":["From the University Eye Hospital Vienna, Vienna, Austria; and the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the University Eye Hospital Vienna, Vienna, Austria; and the","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053563726","display_name":"Ursula Margarethe Schmidt-Erfurth","orcid":"https://orcid.org/0000-0002-7788-7311","observed_orcids":["https://orcid.org/0000-0002-7788-7311"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ursula Schmidt-Erfurth","raw_affiliation_strings":["From the University Eye Hospital Vienna, Vienna, Austria; and the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the University Eye Hospital Vienna, Vienna, Austria; and the","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":null,"fwci":9.1387,"has_fulltext":false,"cited_by_count":104,"citation_normalized_percentile":{"value":0.98313958,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"47","issue":"1","first_page":"371","last_page":"371"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.02810000069439411,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11377","display_name":"Retinal and Macular Surgery","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/verteporfin","display_name":"verteporfin","score":0.9940000176429749},{"id":"https://openalex.org/keywords/photodynamic-therapy","display_name":"photodynamic therapy","score":0.9959999918937683},{"id":"https://openalex.org/keywords/neovascular-age-related-macular-degeneration","display_name":"neovascular age-related macular degeneration","score":0.984000027179718},{"id":"https://openalex.org/keywords/choroidal-neovascularization","display_name":"choroidal neovascularization","score":0.9909999966621399},{"id":"https://openalex.org/keywords/light-fluence","display_name":"light fluence","score":0.875},{"id":"https://openalex.org/keywords/bolus-infusion","display_name":"bolus infusion","score":0.656000018119812},{"id":"https://openalex.org/keywords/choroidal-circulation","display_name":"choroidal blood flow","score":0.9110000133514404}],"concepts":[{"id":"https://openalex.org/C2781148688","wikidata":"https://www.wikidata.org/wiki/Q782318","display_name":"Verteporfin","level":4,"score":0.9873967170715332},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8536075353622437},{"id":"https://openalex.org/C2781359195","wikidata":"https://www.wikidata.org/wiki/Q5105209","display_name":"Choroidal neovascularization","level":3,"score":0.8234860897064209},{"id":"https://openalex.org/C2776403814","wikidata":"https://www.wikidata.org/wiki/Q27429789","display_name":"Macular degeneration","level":2,"score":0.7079044580459595},{"id":"https://openalex.org/C2776694393","wikidata":"https://www.wikidata.org/wiki/Q271762","display_name":"Choroid","level":3,"score":0.6456029415130615},{"id":"https://openalex.org/C2781323092","wikidata":"https://www.wikidata.org/wiki/Q1428072","display_name":"Photodynamic therapy","level":2,"score":0.6418852806091309},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.5962740778923035},{"id":"https://openalex.org/C2780248432","wikidata":"https://www.wikidata.org/wiki/Q1434206","display_name":"Fluorescein angiography","level":3,"score":0.5613524317741394},{"id":"https://openalex.org/C2781065829","wikidata":"https://www.wikidata.org/wiki/Q905662","display_name":"Indocyanine green","level":2,"score":0.5485584735870361},{"id":"https://openalex.org/C2778257484","wikidata":"https://www.wikidata.org/wiki/Q555066","display_name":"Visual acuity","level":2,"score":0.5101735591888428},{"id":"https://openalex.org/C43376680","wikidata":"https://www.wikidata.org/wiki/Q6580786","display_name":"Bolus (digestion)","level":2,"score":0.498410701751709},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.44142821431159973},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4136570990085602},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17647111415863037},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.12355723977088928},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000077362","descriptor_name":"Verteporfin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002199","descriptor_name":"Capillary Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002829","descriptor_name":"Choroid","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D005451","descriptor_name":"Fluorescein Angiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007208","descriptor_name":"Indocyanine Green","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008268","descriptor_name":"Macular Degeneration","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D008268","descriptor_name":"Macular Degeneration","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010778","descriptor_name":"Photochemotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011166","descriptor_name":"Porphyrins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014792","descriptor_name":"Visual Acuity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017319","descriptor_name":"Photosensitizing Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D020256","descriptor_name":"Choroidal Neovascularization","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D020256","descriptor_name":"Choroidal Neovascularization","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D041623","descriptor_name":"Tomography, Optical Coherence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1167/iovs.05-0354","doi":"https://doi.org/10.1167/iovs.05-0354","is_oa":false,"landing_page_url":"https://doi.org/10.1167/iovs.05-0354","pdf_url":null,"source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative Opthalmology &amp; Visual Science","raw_type":"journal-article"},{"id":"pmid:16384987","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16384987","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.6899999976158142,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W3425171","https://openalex.org/W5086926","https://openalex.org/W45954904","https://openalex.org/W1521184302","https://openalex.org/W1588907756","https://openalex.org/W1592045168","https://openalex.org/W1601975653","https://openalex.org/W1802218256","https://openalex.org/W1996870435","https://openalex.org/W2001263805","https://openalex.org/W2004351400","https://openalex.org/W2004681222","https://openalex.org/W2009175584","https://openalex.org/W2030931889","https://openalex.org/W2045317893","https://openalex.org/W2058443344","https://openalex.org/W2058775052","https://openalex.org/W2062594120","https://openalex.org/W2113050427","https://openalex.org/W2133251726","https://openalex.org/W2161235995","https://openalex.org/W2298592572","https://openalex.org/W2403571602","https://openalex.org/W2612675835","https://openalex.org/W3133924569"],"related_works":["https://openalex.org/W4242893149","https://openalex.org/W2365422538","https://openalex.org/W5086926","https://openalex.org/W2371813585","https://openalex.org/W181962414","https://openalex.org/W2343130529","https://openalex.org/W2335564589","https://openalex.org/W2515450372","https://openalex.org/W2152765645","https://openalex.org/W2097800636"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1],"improve":[2],"selectivity":[3,178,196],"of":[4,46,89,121,168,179,185,206],"verteporfin":[5,35,169,209],"therapy":[6],"(PDT)":[7],"in":[8,28,104,114,147,150,161,208,214],"neovascular":[9],"age-related":[10],"macular":[11],"degeneration":[12],"(AMD)":[13],"using":[14],"modified":[15],"treatment":[16,91],"parameters.":[17],"METHODS:":[18],"Nineteen":[19],"consecutive":[20],"patients":[21,106,125],"with":[22,32,43,94,117,127,171,197],"predominantly":[23],"classic":[24],"choroidal":[25],"neovascularization":[26],"(CNV)":[27],"AMD":[29],"were":[30,55,75],"treated":[31,116,126],"6":[33],"mg/m2":[34],"given":[36],"as":[37,138,140,211,213],"bolus":[38],"infusion.":[39],"Patients":[40],"received":[41],"PDT":[42],"a":[44,118,172],"fluence":[45,120],"either":[47],"25":[48,122],"or":[49],"50":[50,128],"J/cm2.":[51,123],"Choroidal":[52,110],"perfusion":[53],"changes":[54],"evaluated":[56],"by":[57,83],"indocyanine":[58],"green":[59],"angiography":[60,85],"(ICGA)":[61],"at":[62,107,134,152],"baseline,":[63],"day":[64,108,153],"1,":[65,67,136],"week":[66,68,135],"4,":[69],"and":[70,79],"month":[71],"3.":[72],"Secondary":[73],"outcomes":[74],"CNV":[76,100,192],"closure":[77,101],"rate":[78],"therapy-induced":[80],"leakage":[81,148],"documented":[82],"fluorescein":[84],"(FA).":[86],"The":[87],"safety":[88],"the":[90,162,186,201],"was":[92,102,112,155],"assessed":[93],"ETDRS":[95],"visual":[96],"acuity.":[97],"RESULTS:":[98],"Complete":[99],"achieved":[103,176],"all":[105],"1.":[109],"hypoperfusion":[111],"minimal":[113],"eyes":[115],"reduced":[119,173],"Most":[124],"J/cm2":[129],"showed":[130],"significant":[131],"choriocapillary":[132],"nonperfusion":[133],"lasting":[137],"long":[139],"3":[141],"months.":[142],"A":[143],"transient":[144],"PDT-induced":[145],"increase":[146],"area":[149],"FA":[151],"1":[154],"found":[156],"to":[157],"be":[158,205],"more":[159],"extensive":[160],"50-J/cm2":[163],"group.":[164],"CONCLUSIONS:":[165],"Bolus":[166],"administration":[167],"combined":[170],"light":[174],"dose":[175],"improved":[177],"photodynamic":[180],"effects,":[181],"avoiding":[182],"collateral":[183],"alteration":[184],"physiologic":[187],"choroid":[188,203],"while":[189],"obtaining":[190],"complete":[191],"closure.":[193],"An":[194],"increased":[195],"decreased":[198],"effect":[199],"on":[200],"surrounding":[202],"should":[204],"advantage":[207],"monotherapy":[210],"well":[212],"combination":[215],"strategies.":[216]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":9}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
