{"id":"https://openalex.org/W1985349820","doi":"https://doi.org/10.1016/s1074-7613(00)80177-6","title":"The Relationship of MHC-Peptide Binding and T Cell Activation Probed Using Chemically Defined MHC Class II Oligomers","display_name":"The Relationship of MHC-Peptide Binding and T Cell Activation Probed Using Chemically Defined MHC Class II Oligomers","publication_year":2000,"publication_date":"2000-03-01","ids":{"openalex":"https://openalex.org/W1985349820","doi":"https://doi.org/10.1016/s1074-7613(00)80177-6","mag":"1985349820","pmid":"https://pubmed.ncbi.nlm.nih.gov/10755611"},"language":"en","primary_location":{"id":"doi:10.1016/s1074-7613(00)80177-6","doi":"https://doi.org/10.1016/s1074-7613(00)80177-6","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1074-7613(00)80177-6","pdf_url":"http://www.cell.com/article/S1074761300801776/pdf","source":{"id":"https://openalex.org/S199671312","display_name":"Immunity","issn_l":"1074-7613","issn":["1074-7613","1097-4180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunity","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1985349820"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.cell.com/article/S1074761300801776/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058204963","display_name":"Jennifer R. Cochran","orcid":"https://orcid.org/0000-0002-6532-9873","observed_orcids":["https://orcid.org/0000-0002-6532-9873"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer R Cochran","raw_affiliation_strings":["Department of Chemistry, Massachusetts Institute of Technology, Cambridge 02139, USA","Department of Chemistry, Massachusetts Institute of Technology, Cambridge,. Massachusetts 02139 (USA)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Massachusetts Institute of Technology, Cambridge 02139, USA","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Department of Chemistry, Massachusetts Institute of Technology, Cambridge,. Massachusetts 02139 (USA)","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079084524","display_name":"Thomas O. Cameron","orcid":"https://orcid.org/0000-0002-4787-1968","observed_orcids":["https://orcid.org/0000-0002-4787-1968"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas O Cameron","raw_affiliation_strings":["Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054495834","display_name":"Lawrence J. Stern","orcid":"https://orcid.org/0000-0001-9870-8557","observed_orcids":["https://orcid.org/0000-0001-9870-8557"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lawrence J Stern","raw_affiliation_strings":["Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA","institution_ids":["https://openalex.org/I63966007"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5054495834"],"corresponding_institution_ids":["https://openalex.org/I63966007"],"apc_list":{"value":10400,"currency":"USD","value_usd":10400},"apc_paid":null,"fwci":8.0295,"has_fulltext":false,"cited_by_count":256,"citation_normalized_percentile":{"value":0.98316109,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"12","issue":"3","first_page":"241","last_page":"250"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9345999956130981,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9345999956130981,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.02850000001490116,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.018300000578165054,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/peptide-mhc-binding","display_name":"peptide-MHC binding","score":0.8840000033378601},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hla-dr1","display_name":"HLA-DR1","score":0.9020000100135803},{"id":"https://openalex.org/keywords/t-cell-receptor-cross-linking","display_name":"T cell receptor cross-linking","score":0.8690000176429749},{"id":"https://openalex.org/keywords/cd69","display_name":"CD69","score":0.7990000247955322},{"id":"https://openalex.org/keywords/cd25","display_name":"CD25","score":0.9919999837875366}],"concepts":[{"id":"https://openalex.org/C139770010","wikidata":"https://www.wikidata.org/wiki/Q1339807","display_name":"Internalization","level":3,"score":0.6569010019302368},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.5946804285049438},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.5910841822624207},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5868856906890869},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5758270025253296},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.572849690914154},{"id":"https://openalex.org/C170627219","wikidata":"https://www.wikidata.org/wiki/Q13218497","display_name":"MHC class I","level":4,"score":0.5335213541984558},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5119908452033997},{"id":"https://openalex.org/C197695756","wikidata":"https://www.wikidata.org/wiki/Q1750372","display_name":"MHC restriction","level":5,"score":0.46896612644195557},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.44941601157188416},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.32355165481567383},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2657819986343384},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.22687748074531555},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.16290372610092163},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.12377271056175232}],"mesh":[{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015375","descriptor_name":"Receptors, Interleukin-2","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015798","descriptor_name":"HLA-DR1 Antigen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015798","descriptor_name":"HLA-DR1 Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015798","descriptor_name":"HLA-DR1 Antigen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017252","descriptor_name":"CD3 Complex","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/s1074-7613(00)80177-6","doi":"https://doi.org/10.1016/s1074-7613(00)80177-6","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1074-7613(00)80177-6","pdf_url":"http://www.cell.com/article/S1074761300801776/pdf","source":{"id":"https://openalex.org/S199671312","display_name":"Immunity","issn_l":"1074-7613","issn":["1074-7613","1097-4180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunity","raw_type":"journal-article"},{"id":"pmid:10755611","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10755611","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunity","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.522.9401","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.522.9401","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://web.mit.edu/stern/www/publications/JRC_Imm_00.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1016/s1074-7613(00)80177-6","doi":"https://doi.org/10.1016/s1074-7613(00)80177-6","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1074-7613(00)80177-6","pdf_url":"http://www.cell.com/article/S1074761300801776/pdf","source":{"id":"https://openalex.org/S199671312","display_name":"Immunity","issn_l":"1074-7613","issn":["1074-7613","1097-4180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunity","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1844325027","display_name":"BAA APPLICATION OF HLA DATA TO DEVELOP &IMPROVE VACCINE","funder_award_id":"n01ai095361-000","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2857659594","display_name":"Interdepartmental Biotechnology Training Program","funder_award_id":"T32GM008334","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G925432463","display_name":null,"funder_award_id":"N01-AI-95361","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1985349820.pdf"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W1490909000","https://openalex.org/W1500469499","https://openalex.org/W1500563338","https://openalex.org/W1506804771","https://openalex.org/W1562441478","https://openalex.org/W1567730870","https://openalex.org/W1622169185","https://openalex.org/W1935791842","https://openalex.org/W1967234833","https://openalex.org/W1969213218","https://openalex.org/W1983558530","https://openalex.org/W1988530230","https://openalex.org/W1998048927","https://openalex.org/W1998386780","https://openalex.org/W1998415250","https://openalex.org/W2007324489","https://openalex.org/W2009335336","https://openalex.org/W2012694659","https://openalex.org/W2014154395","https://openalex.org/W2014478749","https://openalex.org/W2017428346","https://openalex.org/W2019047500","https://openalex.org/W2021922884","https://openalex.org/W2022435663","https://openalex.org/W2022520390","https://openalex.org/W2025783409","https://openalex.org/W2029089280","https://openalex.org/W2042582068","https://openalex.org/W2045747915","https://openalex.org/W2060165194","https://openalex.org/W2063711348","https://openalex.org/W2067069532","https://openalex.org/W2070530924","https://openalex.org/W2072122733","https://openalex.org/W2074173506","https://openalex.org/W2074222872","https://openalex.org/W2077864494","https://openalex.org/W2080956086","https://openalex.org/W2081282655","https://openalex.org/W2084795557","https://openalex.org/W2087526889","https://openalex.org/W2092970886","https://openalex.org/W2094278677","https://openalex.org/W2095520403","https://openalex.org/W2096234619","https://openalex.org/W2115037258","https://openalex.org/W2116364705","https://openalex.org/W2119135162","https://openalex.org/W2124116262","https://openalex.org/W2139823369","https://openalex.org/W2144711633","https://openalex.org/W2147445230","https://openalex.org/W2149764521","https://openalex.org/W2157417177","https://openalex.org/W2159168765","https://openalex.org/W2159756478","https://openalex.org/W2169609116","https://openalex.org/W2170548924","https://openalex.org/W2171483790","https://openalex.org/W2172383460","https://openalex.org/W2172523660","https://openalex.org/W4229698381"],"related_works":["https://openalex.org/W2015127448","https://openalex.org/W2159756478","https://openalex.org/W2058260900","https://openalex.org/W2081929153","https://openalex.org/W2044463780","https://openalex.org/W1666169447","https://openalex.org/W2043837690","https://openalex.org/W2092970886","https://openalex.org/W1522213141"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":7},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}
