{"id":"https://openalex.org/W1985346266","doi":"https://doi.org/10.1136/bmj.312.7027.338","title":"Single or multiple daily doses of aminoglycosides: a meta- analysis","display_name":"Single or multiple daily doses of aminoglycosides: a meta- analysis","publication_year":1996,"publication_date":"1996-02-10","ids":{"openalex":"https://openalex.org/W1985346266","doi":"https://doi.org/10.1136/bmj.312.7027.338","mag":"1985346266","pmid":"https://pubmed.ncbi.nlm.nih.gov/8611830","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2350289"},"language":"en","primary_location":{"id":"doi:10.1136/bmj.312.7027.338","doi":"https://doi.org/10.1136/bmj.312.7027.338","is_oa":false,"landing_page_url":"https://doi.org/10.1136/bmj.312.7027.338","pdf_url":null,"source":{"id":"https://openalex.org/S4393911389","display_name":"BMJ","issn_l":"0007-1447","issn":["0007-1447","0267-0623","1468-5833"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["anvur-scientific","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2350289","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110328967","display_name":"Michael J. Barza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Barza","raw_affiliation_strings":["Division of Geographic Medicine and Infectious Diseases, New England Medical Center Hospitals, Tufts University School of Medicine, Boston, MA 02111, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Geographic Medicine and Infectious Diseases, New England Medical Center Hospitals, Tufts University School of Medicine, Boston, MA 02111, USA","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070446713","display_name":"John P. A. Ioannidis","orcid":"https://orcid.org/0000-0003-3118-6859","observed_orcids":["https://orcid.org/0000-0003-3118-6859"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Pa Ioannidis","raw_affiliation_strings":["Division of Geographic Medicine and Infectious Diseases, New England Medical Center Hospitals, Tufts University School of Medicine, Boston, MA 02111, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Geographic Medicine and Infectious Diseases, New England Medical Center Hospitals, Tufts University School of Medicine, Boston, MA 02111, USA","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064892797","display_name":"J.C. Cappelleri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph C Cappelleri","raw_affiliation_strings":["Division of Clinical Care Research, New England Medical Center Hospitals, Tufts University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Care Research, New England Medical Center Hospitals, Tufts University School of Medicine","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I1290900354"]}]},{"author_position":"last","author":{"id":null,"display_name":"Joseph Lau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Lau","raw_affiliation_strings":["Division of Clinical Care Research, New England Medical Center Hospitals, Tufts University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Care Research, New England Medical Center Hospitals, Tufts University School of Medicine","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I1290900354"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.2427,"has_fulltext":false,"cited_by_count":447,"citation_normalized_percentile":{"value":0.98214286,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"312","issue":"7027","first_page":"338","last_page":"344"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10897","display_name":"Antibiotic Use and Resistance","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12172","display_name":"Neutropenia and Cancer Infections","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aminoglycosides","display_name":"aminoglycosides","score":0.996999979019165},{"id":"https://openalex.org/keywords/once-daily-dosing","display_name":"once-daily dosing","score":0.9110000133514404},{"id":"https://openalex.org/keywords/multiple-daily-dosing","display_name":"multiple daily dosing","score":0.7730000019073486},{"id":"https://openalex.org/keywords/dosing-regimen","display_name":"dosing regimen","score":0.7239999771118164},{"id":"https://openalex.org/keywords/nephrotoxicity","display_name":"nephrotoxicity","score":0.953000009059906},{"id":"https://openalex.org/keywords/ototoxicity","display_name":"ototoxicity","score":1.0},{"id":"https://openalex.org/keywords/bacterial-infection","display_name":"bacterial infection","score":0.7730000019073486},{"id":"https://openalex.org/keywords/febrile-neutropenia","display_name":"febrile neutropenia","score":0.8759999871253967},{"id":"https://openalex.org/keywords/pseudomonas","display_name":"Pseudomonas","score":0.7440000176429749},{"id":"https://openalex.org/keywords/antibiotic-efficacy","display_name":"antibiotic efficacy","score":0.5270000100135803},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.7310000061988831},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.7369999885559082}],"concepts":[{"id":"https://openalex.org/C2778534666","wikidata":"https://www.wikidata.org/wiki/Q1351381","display_name":"Ototoxicity","level":4,"score":0.8918285369873047},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8059651255607605},{"id":"https://openalex.org/C126189478","wikidata":"https://www.wikidata.org/wiki/Q1468324","display_name":"Nephrotoxicity","level":3,"score":0.7660826444625854},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.7378813028335571},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.5747043490409851},{"id":"https://openalex.org/C82789193","wikidata":"https://www.wikidata.org/wiki/Q2142611","display_name":"Relative risk","level":3,"score":0.5258979201316833},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.5031253695487976},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.4979381561279297},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4646897315979004},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.38671958446502686},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.21478357911109924},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000617","descriptor_name":"Aminoglycosides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004427","descriptor_name":"Ear Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1136/bmj.312.7027.338","doi":"https://doi.org/10.1136/bmj.312.7027.338","is_oa":false,"landing_page_url":"https://doi.org/10.1136/bmj.312.7027.338","pdf_url":null,"source":{"id":"https://openalex.org/S4393911389","display_name":"BMJ","issn_l":"0007-1447","issn":["0007-1447","0267-0623","1468-5833"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["anvur-scientific","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2350289","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2350289","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2351842","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2351842","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ","raw_type":"Text"},{"id":"pmid:8611830","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8611830","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ (Clinical research ed.)","raw_type":"Journal Article"},{"id":"pmh:oai:open-archive.highwire.org:bmj:312/7027/338","doi":null,"is_oa":false,"landing_page_url":"http://www.bmj.com/cgi/content/short/312/7027/338","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2350289","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2350289","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[{"id":"https://openalex.org/G2544763378","display_name":null,"funder_award_id":"R01-HS07782","funder_id":"https://openalex.org/F4320332177","funder_display_name":"Agency for Healthcare Research and Quality"}],"funders":[{"id":"https://openalex.org/F4320332177","display_name":"Agency for Healthcare Research and Quality","ror":"https://ror.org/03jmfdf59"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W6699019","https://openalex.org/W1558228294","https://openalex.org/W1601146568","https://openalex.org/W1963748741","https://openalex.org/W1968871492","https://openalex.org/W1979588294","https://openalex.org/W1980982717","https://openalex.org/W1988308062","https://openalex.org/W1988444337","https://openalex.org/W1990477615","https://openalex.org/W1991148060","https://openalex.org/W1994959188","https://openalex.org/W1995681210","https://openalex.org/W1998614168","https://openalex.org/W2001156991","https://openalex.org/W2004705457","https://openalex.org/W2005117246","https://openalex.org/W2010427057","https://openalex.org/W2011985830","https://openalex.org/W2024355003","https://openalex.org/W2027304644","https://openalex.org/W2030223911","https://openalex.org/W2035328555","https://openalex.org/W2037017106","https://openalex.org/W2037974456","https://openalex.org/W2040889647","https://openalex.org/W2046313935","https://openalex.org/W2051710516","https://openalex.org/W2058088364","https://openalex.org/W2059275495","https://openalex.org/W2061128792","https://openalex.org/W2063239492","https://openalex.org/W2072806957","https://openalex.org/W2073267185","https://openalex.org/W2083109379","https://openalex.org/W2084896777","https://openalex.org/W2088188414","https://openalex.org/W2089016219","https://openalex.org/W2098646215","https://openalex.org/W2099357454","https://openalex.org/W2110507893","https://openalex.org/W2114422486","https://openalex.org/W2129284415","https://openalex.org/W2131324579","https://openalex.org/W2142368294","https://openalex.org/W2143995372","https://openalex.org/W2154177544","https://openalex.org/W2160535155","https://openalex.org/W2161348008","https://openalex.org/W2161909147","https://openalex.org/W2168259885","https://openalex.org/W2316786951","https://openalex.org/W2332262919","https://openalex.org/W2338790966","https://openalex.org/W2475122591","https://openalex.org/W2725911219","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W1952110683","https://openalex.org/W2737419783","https://openalex.org/W1963965934","https://openalex.org/W2150275908","https://openalex.org/W2070417799","https://openalex.org/W2281695568","https://openalex.org/W2157451665","https://openalex.org/W2394973832","https://openalex.org/W4385514151","https://openalex.org/W2001193207"],"abstract_inverted_index":{"Abstract":[0],"Objective":[1],":":[2,22,50,64,85,95,199],"To":[3],"assess":[4],"relative":[5],"efficacy":[6],"and":[7,41,45,92,162,224,234,266,308,311,341],"toxicity":[8],"of":[9,24,52,88,106,121,130,143,180,203,222,228,245,258,285,315,323,332,338,343,345],"aminoglycosides":[10,70,204,259],"given":[11],"by":[12],"single":[13,255],"daily":[14,19,72,76,80,97,123,139,201,216,238,256,274,297,317,334],"dose":[15,98],"compared":[16],"with":[17,38,46,55,77,159,305,320],"multiple":[18,74,215,273],"doses.":[20],"Design":[21],"Meta-analysis":[23],"21":[25],"randomised":[26,67],"trials":[27,183],"identified":[28],"through":[29],"MEDLARS":[30],"(1966":[31],"to":[32,68,118,151,184,290],"January":[33],"1995).":[34],"Data":[35],"were":[36,66,155,260],"overviewed":[37],"fixed":[39],"effects":[40,43,110,146],"random":[42],"models":[44],"meta-regression":[47],"analysis.":[48],"Subjects":[49],"Total":[51],"3091":[53],"patients":[54,158,206,304],"bacterial":[56],"infection,":[57],"most":[58],"without":[59,207],"pre-existing":[60,208],"renal":[61,209],"disease.":[62],"Interventions":[63],"Patients":[65],"receive":[69],"once":[71,122,237,316,333],"or":[73],"times":[75],"similar":[78],"total":[79],"dose.":[81],"Main":[82],"outcome":[83],"measures":[84],"Clinical":[86],"failure":[87],"treatment,":[89],"nephrotoxicity,":[90,223],"ototoxicity,":[91,286],"mortality.":[93,197],"Results":[94],"Single":[96],"regimen":[99],"produced":[100],"a":[101,134,186,219,292,327],"non-significant":[102],"decrease":[103],"in":[104,133,170,196,205,303,309,326,351],"risk":[105,111,142,147,221,227],"antibiotic":[107,347],"failures":[108],"(random":[109],"ratio":[112,148],"0.83":[113],"(95%":[114],"confidence":[115],"interval":[116],"0.57":[117],"1.21)).":[119],"Benefit":[120],"dosing":[124,175,239,277,298,318],"was":[125,136,166,189,192,294,299],"greater":[126,226],"when":[127],"the":[128,173,178,181,231,242,283,288,312,330],"percentage":[129],"pseudomonas":[131,324],"isolates":[132,325],"trial":[135,328],"larger.":[137],"Once":[138,200,296],"administration":[140,202,340],"reduced":[141,235,336],"nephrotoxicity":[144],"(fixed":[145],"0.74":[149],"(0.54":[150],"1.00)).":[152],"Similar":[153],"trends":[154],"noted":[156],"for":[157,163],"febrile":[160,306],"neutropenia":[161,307],"children.":[164],"There":[165,191],"no":[167,193,225],"significant":[168,194],"difference":[169,188,195,293],"ototoxicity":[171],"between":[172],"two":[174],"regimens,":[176],"but":[177,287],"power":[179,289],"pooled":[182],"detect":[185,291],"meaningful":[187],"low.":[190],"Conclusions":[198],"impairment":[210],"is":[211],"as":[212,214,269,272],"effective":[213,270,302],"dosing,":[217,335],"has":[218],"lower":[220],"ototoxicity.":[229],"Given":[230],"additional":[232],"convenience":[233,331],"cost,":[236],"should":[240,349],"be":[241],"preferred":[243],"mode":[244],"administration.":[246],"Key":[247,249],"messages":[248,250],"This":[251],"meta-analysis":[252],"shows":[253],"that":[254],"doses":[257,275],"about":[261],"25%":[262],"less":[263],"nephrotoxic":[264],"than":[265],"at":[267],"least":[268],"clinically":[271],"The":[276],"schedule":[278],"did":[279],"not":[280],"significantly":[281],"affect":[282],"incidence":[284],"small":[295],"non-significantly":[300],"more":[301],"children,":[310],"apparent":[313],"benefit":[314],"increased":[319],"increasing":[321],"proportion":[322],"Besides":[329],"costs":[337],"drug":[339],"omission":[342],"measurements":[344],"peak":[346],"concentrations":[348],"result":[350],"substantial":[352],"cost":[353],"savings":[354]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":19},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":21},{"year":2013,"cited_by_count":20},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}