{"id":"https://openalex.org/W1985338706","doi":"https://doi.org/10.1186/1471-2334-10-86","title":"Changes of tau profiles in brains of the hamsters infected with scrapie strains 263 K or 139 A possibly associated with the alteration of phosphate kinases","display_name":"Changes of tau profiles in brains of the hamsters infected with scrapie strains 263 K or 139 A possibly associated with the alteration of phosphate kinases","publication_year":2010,"publication_date":"2010-04-01","ids":{"openalex":"https://openalex.org/W1985338706","doi":"https://doi.org/10.1186/1471-2334-10-86","mag":"1985338706","pmid":"https://pubmed.ncbi.nlm.nih.gov/20356412","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2868850"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2334-10-86","doi":"https://doi.org/10.1186/1471-2334-10-86","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2334-10-86","pdf_url":"https://bmcinfectdis.biomedcentral.com/counter/pdf/10.1186/1471-2334-10-86","source":{"id":"https://openalex.org/S171015910","display_name":"BMC Infectious Diseases","issn_l":"1471-2334","issn":["1471-2334"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcinfectdis.biomedcentral.com/counter/pdf/10.1186/1471-2334-10-86","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100783081","display_name":"Guirong Wang","orcid":"https://orcid.org/0000-0002-3794-0106","observed_orcids":["https://orcid.org/0000-0002-3794-0106"]},"institutions":[{"id":"https://openalex.org/I184490438","display_name":"Chinese Center For Disease Control and Prevention","ror":"https://ror.org/04wktzw65","country_code":"CN","type":"government","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4210140986","display_name":"National Institute for Viral Disease Control and Prevention","ror":"https://ror.org/04b1sh213","country_code":"CN","type":"government","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210140986","https://openalex.org/I4210151987"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Gui-Rong Wang","raw_affiliation_strings":["State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Ying-Xin Rd 100, Beijing 100052, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Ying-Xin Rd 100, Beijing 100052, PR China","institution_ids":["https://openalex.org/I184490438","https://openalex.org/I4210140986"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113749417","display_name":"Song Shi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184490438","display_name":"Chinese Center For Disease Control and Prevention","ror":"https://ror.org/04wktzw65","country_code":"CN","type":"government","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4210140986","display_name":"National Institute for Viral Disease Control and Prevention","ror":"https://ror.org/04b1sh213","country_code":"CN","type":"government","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210140986","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4391768093","display_name":"State Key Laboratory of Infectious Disease Prevention and Control","ror":"https://ror.org/04bhsv505","country_code":"CN","type":"facility","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210151987","https://openalex.org/I4391768093"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Song Shi","raw_affiliation_strings":["State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Ying-Xin Rd 100, Beijing, 100052, PR, China","State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and prevention, Chinese Center for Disease Control and Prevention, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Ying-Xin Rd 100, Beijing, 100052, PR, China","institution_ids":["https://openalex.org/I184490438","https://openalex.org/I4210140986"]},{"raw_affiliation_string":"State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and prevention, Chinese Center for Disease Control and Prevention, Beijing, China","institution_ids":["https://openalex.org/I184490438","https://openalex.org/I4210140986","https://openalex.org/I4391768093"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100741095","display_name":"Chen Gao","orcid":"https://orcid.org/0000-0001-7883-3270","observed_orcids":["https://orcid.org/0000-0001-7883-3270","https://orcid.org/0000-0001-8236-9028"]},"institutions":[{"id":"https://openalex.org/I184490438","display_name":"Chinese Center For Disease Control and Prevention","ror":"https://ror.org/04wktzw65","country_code":"CN","type":"government","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4210140986","display_name":"National Institute for Viral Disease Control and Prevention","ror":"https://ror.org/04b1sh213","country_code":"CN","type":"government","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210140986","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4391768093","display_name":"State Key Laboratory of Infectious Disease Prevention and Control","ror":"https://ror.org/04bhsv505","country_code":"CN","type":"facility","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210151987","https://openalex.org/I4391768093"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chen Gao","raw_affiliation_strings":["State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Ying-Xin Rd 100, Beijing, 100052, PR, China","State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and prevention, Chinese Center for Disease Control and Prevention, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Ying-Xin Rd 100, Beijing, 100052, PR, China","institution_ids":["https://openalex.org/I184490438","https://openalex.org/I4210140986"]},{"raw_affiliation_string":"State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and prevention, Chinese Center for Disease Control and Prevention, Beijing, China","institution_ids":["https://openalex.org/I184490438","https://openalex.org/I4210140986","https://openalex.org/I4391768093"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038685629","display_name":"Baoyun Zhang","orcid":"https://orcid.org/0000-0002-8177-2752","observed_orcids":["https://orcid.org/0000-0002-8177-2752"]},"institutions":[{"id":"https://openalex.org/I184490438","display_name":"Chinese Center For Disease Control and Prevention","ror":"https://ror.org/04wktzw65","country_code":"CN","type":"government","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4210140986","display_name":"National Institute for Viral Disease Control and Prevention","ror":"https://ror.org/04b1sh213","country_code":"CN","type":"government","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210140986","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4391768093","display_name":"State Key Laboratory of Infectious Disease Prevention and Control","ror":"https://ror.org/04bhsv505","country_code":"CN","type":"facility","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210151987","https://openalex.org/I4391768093"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bao-Yun Zhang","raw_affiliation_strings":["State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Ying-Xin Rd 100, Beijing, 100052, PR, China","State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and prevention, Chinese Center for Disease Control and Prevention, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Ying-Xin Rd 100, Beijing, 100052, PR, China","institution_ids":["https://openalex.org/I184490438","https://openalex.org/I4210140986"]},{"raw_affiliation_string":"State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and prevention, Chinese Center for Disease Control and Prevention, Beijing, China","institution_ids":["https://openalex.org/I184490438","https://openalex.org/I4210140986","https://openalex.org/I4391768093"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101747128","display_name":"Chan Tian","orcid":"https://orcid.org/0000-0002-0488-9025","observed_orcids":["https://orcid.org/0000-0002-0488-9025"]},"institutions":[{"id":"https://openalex.org/I184490438","display_name":"Chinese Center For Disease Control and Prevention","ror":"https://ror.org/04wktzw65","country_code":"CN","type":"government","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4210140986","display_name":"National Institute for Viral Disease Control and Prevention","ror":"https://ror.org/04b1sh213","country_code":"CN","type":"government","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210140986","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4391768093","display_name":"State Key Laboratory of Infectious Disease Prevention and Control","ror":"https://ror.org/04bhsv505","country_code":"CN","type":"facility","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210151987","https://openalex.org/I4391768093"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chan Tian","raw_affiliation_strings":["State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Ying-Xin Rd 100, Beijing, 100052, PR, China","State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and prevention, Chinese Center for Disease Control and Prevention, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Ying-Xin Rd 100, Beijing, 100052, PR, China","institution_ids":["https://openalex.org/I184490438","https://openalex.org/I4210140986"]},{"raw_affiliation_string":"State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and prevention, Chinese Center for Disease Control and Prevention, Beijing, China","institution_ids":["https://openalex.org/I184490438","https://openalex.org/I4210140986","https://openalex.org/I4391768093"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043388396","display_name":"Chenfang Dong","orcid":"https://orcid.org/0000-0003-2964-5876","observed_orcids":["https://orcid.org/0000-0003-2964-5876"]},"institutions":[{"id":"https://openalex.org/I184490438","display_name":"Chinese Center For Disease Control and Prevention","ror":"https://ror.org/04wktzw65","country_code":"CN","type":"government","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4210140986","display_name":"National Institute for Viral Disease Control and Prevention","ror":"https://ror.org/04b1sh213","country_code":"CN","type":"government","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210140986","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4391768093","display_name":"State Key Laboratory of Infectious Disease Prevention and Control","ror":"https://ror.org/04bhsv505","country_code":"CN","type":"facility","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210151987","https://openalex.org/I4391768093"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chen-Fang Dong","raw_affiliation_strings":["State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Ying-Xin Rd 100, Beijing, 100052, PR, China","State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and prevention, Chinese Center for Disease Control and Prevention, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Ying-Xin Rd 100, Beijing, 100052, PR, China","institution_ids":["https://openalex.org/I184490438","https://openalex.org/I4210140986"]},{"raw_affiliation_string":"State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and prevention, Chinese Center for Disease Control and Prevention, Beijing, China","institution_ids":["https://openalex.org/I184490438","https://openalex.org/I4210140986","https://openalex.org/I4391768093"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102209095","display_name":"Ruimin Zhou","orcid":"https://orcid.org/0000-0002-5165-6419","observed_orcids":["https://orcid.org/0000-0002-5165-6419"]},"institutions":[{"id":"https://openalex.org/I184490438","display_name":"Chinese Center For Disease Control and Prevention","ror":"https://ror.org/04wktzw65","country_code":"CN","type":"government","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4210140986","display_name":"National Institute for Viral Disease Control and Prevention","ror":"https://ror.org/04b1sh213","country_code":"CN","type":"government","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210140986","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4391768093","display_name":"State Key Laboratory of Infectious Disease Prevention and Control","ror":"https://ror.org/04bhsv505","country_code":"CN","type":"facility","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210151987","https://openalex.org/I4391768093"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rui-Min Zhou","raw_affiliation_strings":["State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Ying-Xin Rd 100, Beijing, 100052, PR, China","State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and prevention, Chinese Center for Disease Control and Prevention, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Ying-Xin Rd 100, Beijing, 100052, PR, China","institution_ids":["https://openalex.org/I184490438","https://openalex.org/I4210140986"]},{"raw_affiliation_string":"State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and prevention, Chinese Center for Disease Control and Prevention, Beijing, China","institution_ids":["https://openalex.org/I184490438","https://openalex.org/I4210140986","https://openalex.org/I4391768093"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100418679","display_name":"Xiaoli Li","orcid":"https://orcid.org/0000-0001-8106-2358","observed_orcids":["https://orcid.org/0000-0001-8106-2358"]},"institutions":[{"id":"https://openalex.org/I184490438","display_name":"Chinese Center For Disease Control and Prevention","ror":"https://ror.org/04wktzw65","country_code":"CN","type":"government","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4210140986","display_name":"National Institute for Viral Disease Control and Prevention","ror":"https://ror.org/04b1sh213","country_code":"CN","type":"government","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210140986","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4391768093","display_name":"State Key Laboratory of Infectious Disease Prevention and Control","ror":"https://ror.org/04bhsv505","country_code":"CN","type":"facility","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210151987","https://openalex.org/I4391768093"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao-Li Li","raw_affiliation_strings":["State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Ying-Xin Rd 100, Beijing, 100052, PR, China","State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and prevention, Chinese Center for Disease Control and Prevention, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Ying-Xin Rd 100, Beijing, 100052, PR, China","institution_ids":["https://openalex.org/I184490438","https://openalex.org/I4210140986"]},{"raw_affiliation_string":"State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and prevention, Chinese Center for Disease Control and Prevention, Beijing, China","institution_ids":["https://openalex.org/I184490438","https://openalex.org/I4210140986","https://openalex.org/I4391768093"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116773556","display_name":"Cao Chen","orcid":"https://orcid.org/0000-0002-2183-9855","observed_orcids":["https://orcid.org/0000-0002-2183-9855"]},"institutions":[{"id":"https://openalex.org/I184490438","display_name":"Chinese Center For Disease Control and Prevention","ror":"https://ror.org/04wktzw65","country_code":"CN","type":"government","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4210140986","display_name":"National Institute for Viral Disease Control and Prevention","ror":"https://ror.org/04b1sh213","country_code":"CN","type":"government","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210140986","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4391768093","display_name":"State Key Laboratory of Infectious Disease Prevention and Control","ror":"https://ror.org/04bhsv505","country_code":"CN","type":"facility","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210151987","https://openalex.org/I4391768093"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cao Chen","raw_affiliation_strings":["State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Ying-Xin Rd 100, Beijing, 100052, PR, China","State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and prevention, Chinese Center for Disease Control and Prevention, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Ying-Xin Rd 100, Beijing, 100052, PR, China","institution_ids":["https://openalex.org/I184490438","https://openalex.org/I4210140986"]},{"raw_affiliation_string":"State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and prevention, Chinese Center for Disease Control and Prevention, Beijing, China","institution_ids":["https://openalex.org/I184490438","https://openalex.org/I4210140986","https://openalex.org/I4391768093"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062678607","display_name":"Jun Han","orcid":"https://orcid.org/0000-0002-0803-4403","observed_orcids":["https://orcid.org/0000-0002-0803-4403"]},"institutions":[{"id":"https://openalex.org/I184490438","display_name":"Chinese Center For Disease Control and Prevention","ror":"https://ror.org/04wktzw65","country_code":"CN","type":"government","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4210140986","display_name":"National Institute for Viral Disease Control and Prevention","ror":"https://ror.org/04b1sh213","country_code":"CN","type":"government","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210140986","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4391768093","display_name":"State Key Laboratory of Infectious Disease Prevention and Control","ror":"https://ror.org/04bhsv505","country_code":"CN","type":"facility","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210151987","https://openalex.org/I4391768093"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Han","raw_affiliation_strings":["State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Ying-Xin Rd 100, Beijing, 100052, PR, China","State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and prevention, Chinese Center for Disease Control and Prevention, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Ying-Xin Rd 100, Beijing, 100052, PR, China","institution_ids":["https://openalex.org/I184490438","https://openalex.org/I4210140986"]},{"raw_affiliation_string":"State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and prevention, Chinese Center for Disease Control and Prevention, Beijing, China","institution_ids":["https://openalex.org/I184490438","https://openalex.org/I4210140986","https://openalex.org/I4391768093"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084498273","display_name":"Xiao\u2010Ping Dong","orcid":"https://orcid.org/0000-0002-1566-8447","observed_orcids":["https://orcid.org/0000-0002-1566-8447"]},"institutions":[{"id":"https://openalex.org/I184490438","display_name":"Chinese Center For Disease Control and Prevention","ror":"https://ror.org/04wktzw65","country_code":"CN","type":"government","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4210140986","display_name":"National Institute for Viral Disease Control and Prevention","ror":"https://ror.org/04b1sh213","country_code":"CN","type":"government","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210140986","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4391768093","display_name":"State Key Laboratory of Infectious Disease Prevention and Control","ror":"https://ror.org/04bhsv505","country_code":"CN","type":"facility","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210151987","https://openalex.org/I4391768093"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiao-Ping Dong","raw_affiliation_strings":["State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Ying-Xin Rd 100, Beijing, 100052, PR, China","State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and prevention, Chinese Center for Disease Control and Prevention, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Ying-Xin Rd 100, Beijing, 100052, PR, China","institution_ids":["https://openalex.org/I184490438","https://openalex.org/I4210140986"]},{"raw_affiliation_string":"State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and prevention, Chinese Center for Disease Control and Prevention, Beijing, China","institution_ids":["https://openalex.org/I184490438","https://openalex.org/I4210140986","https://openalex.org/I4391768093"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5084498273"],"corresponding_institution_ids":["https://openalex.org/I184490438","https://openalex.org/I4210140986","https://openalex.org/I4391768093"],"apc_list":{"value":3090,"currency":"USD","value_usd":3090},"apc_paid":{"value":3090,"currency":"USD","value_usd":3090},"fwci":1.1681,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.74624477,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"10","issue":"1","first_page":"86","last_page":"86"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tau-protein","display_name":"tau protein","score":0.7919999957084656},{"id":"https://openalex.org/keywords/phosphorylated-tau","display_name":"phosphorylated tau","score":0.9769999980926514},{"id":"https://openalex.org/keywords/scrapie","display_name":"scrapie","score":0.9610000252723694},{"id":"https://openalex.org/keywords/prion-disease","display_name":"prion disease","score":0.984000027179718},{"id":"https://openalex.org/keywords/gsk-3beta","display_name":"GSK3\u03b2","score":0.8220000267028809},{"id":"https://openalex.org/keywords/cdk5","display_name":"cyclin-dependent kinase 5","score":1.0},{"id":"https://openalex.org/keywords/tau-isoforms","display_name":"tau isoforms","score":0.8190000057220459},{"id":"https://openalex.org/keywords/tau-phosphorylation-sites","display_name":"tau phosphorylation sites","score":0.6629999876022339},{"id":"https://openalex.org/keywords/hamster-model","display_name":"hamster model","score":0.5559999942779541},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"pathogenesis","score":0.7049999833106995}],"concepts":[{"id":"https://openalex.org/C2776735649","wikidata":"https://www.wikidata.org/wiki/Q170102","display_name":"Scrapie","level":4,"score":0.8165695667266846},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5683472752571106},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.535259485244751},{"id":"https://openalex.org/C2777739294","wikidata":"https://www.wikidata.org/wiki/Q2397106","display_name":"Tauopathy","level":4,"score":0.5318897366523743},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4916282296180725},{"id":"https://openalex.org/C121738310","wikidata":"https://www.wikidata.org/wiki/Q18248262","display_name":"Cyclin-dependent kinase 5","level":5,"score":0.4812193214893341},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.47037380933761597},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4507741928100586},{"id":"https://openalex.org/C2778670691","wikidata":"https://www.wikidata.org/wiki/Q419507","display_name":"Tau protein","level":4,"score":0.42611566185951233},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.41564521193504333},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3794383704662323},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.2657935619354248},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.24904540181159973},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2462989091873169},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.228289395570755},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21418920159339905},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.20750689506530762},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19807404279708862},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.16663303971290588},{"id":"https://openalex.org/C3019804061","wikidata":"https://www.wikidata.org/wiki/Q14881255","display_name":"Prion protein","level":3,"score":0.1594359576702118},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.09135740995407104},{"id":"https://openalex.org/C90934575","wikidata":"https://www.wikidata.org/wiki/Q6593810","display_name":"Mitogen-activated protein kinase kinase","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000071679","descriptor_name":"Glycogen Synthase Kinase 3 beta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008647","descriptor_name":"Mesocricetus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010710","descriptor_name":"Phosphates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012608","descriptor_name":"Scrapie","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D038362","descriptor_name":"Glycogen Synthase Kinase 3","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D051360","descriptor_name":"Cyclin-Dependent Kinase 5","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1471-2334-10-86","doi":"https://doi.org/10.1186/1471-2334-10-86","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2334-10-86","pdf_url":"https://bmcinfectdis.biomedcentral.com/counter/pdf/10.1186/1471-2334-10-86","source":{"id":"https://openalex.org/S171015910","display_name":"BMC Infectious Diseases","issn_l":"1471-2334","issn":["1471-2334"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Infectious Diseases","raw_type":"journal-article"},{"id":"pmid:20356412","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20356412","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC infectious diseases","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2868850","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2868850/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Infect Dis","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:a14fd5f6ec55415eab3dc74ff5eb5dca","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a14fd5f6ec55415eab3dc74ff5eb5dca","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Infectious Diseases, Vol 10, Iss 1, p 86 (2010)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1471-2334-10-86","doi":"https://doi.org/10.1186/1471-2334-10-86","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2334-10-86","pdf_url":"https://bmcinfectdis.biomedcentral.com/counter/pdf/10.1186/1471-2334-10-86","source":{"id":"https://openalex.org/S171015910","display_name":"BMC Infectious Diseases","issn_l":"1471-2334","issn":["1471-2334"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Infectious Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1284388049","display_name":null,"funder_award_id":"2007CB310505","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"}],"funders":[{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1985338706.pdf","grobid_xml":"https://content.openalex.org/works/W1985338706.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W73029393","https://openalex.org/W1484367531","https://openalex.org/W1508890381","https://openalex.org/W1568595238","https://openalex.org/W1600934558","https://openalex.org/W1970992656","https://openalex.org/W1972240229","https://openalex.org/W1990861420","https://openalex.org/W1992491411","https://openalex.org/W1998276610","https://openalex.org/W1999511871","https://openalex.org/W2003824628","https://openalex.org/W2012862669","https://openalex.org/W2032009532","https://openalex.org/W2037877748","https://openalex.org/W2045690571","https://openalex.org/W2048787560","https://openalex.org/W2050562362","https://openalex.org/W2064167828","https://openalex.org/W2079783134","https://openalex.org/W2080119753","https://openalex.org/W2082088443","https://openalex.org/W2087329033","https://openalex.org/W2107958146","https://openalex.org/W2111055501","https://openalex.org/W2122115272","https://openalex.org/W2159377066","https://openalex.org/W2163981524","https://openalex.org/W2166463382","https://openalex.org/W2169200799","https://openalex.org/W2324660492","https://openalex.org/W2378589597"],"related_works":["https://openalex.org/W7097455144","https://openalex.org/W2193963360","https://openalex.org/W2037877748","https://openalex.org/W3141037108","https://openalex.org/W2370657440","https://openalex.org/W55431967","https://openalex.org/W1982778308","https://openalex.org/W2097309348","https://openalex.org/W2134996189","https://openalex.org/W2390354772"],"abstract_inverted_index":{"BACKGROUND:":[0],"Phospho-tau":[1],"deposition":[2],"has":[3],"been":[4],"described":[5],"in":[6,47,64,92,144,195,223],"a":[7],"rare":[8],"genetic":[9],"human":[10,23],"prion":[11,239],"disease,":[12],"Gerstmann-Str\u00e4ussler-Scheinker":[13],"syndrome,":[14],"but":[15,108,137],"is":[16],"not":[17],"common":[18],"neuropathological":[19],"picture":[20],"for":[21],"other":[22],"and":[24,38,45,56,62,79,85,90,103,112,141,171,190,212,215,226],"animal":[25],"transmissible":[26],"spongiform":[27],"encephalopathies":[28],"(TSEs).":[29],"This":[30],"study":[31],"investigated":[32],"the":[33,65,83,93,116,145,166,201,228,236],"possible":[34],"changes":[35,167,182],"of":[36,54,68,88,100,120,125,147,151,168,183,185,200,203,207,231,238],"tau":[37,40,55,102,127,169],"phosphorylated":[39],"(p-tau,":[41,58],"at":[42,59,105,110,115,187],"Ser396,":[43,60,188],"Ser404,":[44,61,211],"Ser202/Thr205)":[46,63],"scrapie":[48,121],"experimental":[49],"animals.":[50,149],"METHODS:":[51],"The":[52,98],"profiles":[53,170,184],"p-tau":[57,104,109,186,209],"brain":[66,152],"tissues":[67],"agents":[69],"263K-":[70],"or":[71,220],"139A-infected":[72],"hamsters":[73],"were":[74,95,129,174,217],"evaluated":[75],"by":[76],"Western":[77],"blots":[78],"real-time":[80],"PCR.":[81],"Meanwhile,":[82],"transcriptional":[84,140],"expressive":[86,142],"levels":[87,124,143],"GSK3beta":[89,139,214],"CDK5":[91,216],"brains":[94,146],"tested.":[96],"RESULTS:":[97],"contents":[99],"total":[101],"Ser202/Thr205":[106,191],"increased,":[107],"Ser396":[111],"Ser404":[113,189],"decreased":[114],"terminal":[117],"stages,":[118],"regardless":[119],"strains.":[122],"Transcriptional":[123],"two":[126],"isoforms":[128],"also":[130],"increased.":[131],"Additionally,":[132],"it":[133],"showed":[134],"higher":[135],"CDK5,":[136],"lower":[138],"scrapie-infected":[148],"Analysis":[150],"samples":[153],"collected":[154],"from":[155],"different":[156],"times":[157],"after":[158],"inoculated":[159],"with":[160,235],"agent":[161],"263":[162],"K":[163],"revealed":[164],"that":[165,181],"phosphate":[172,204],"kinases":[173],"time-relative":[175],"events.":[176],"CONCLUSION:":[177],"These":[178],"data":[179],"suggest":[180],"are":[192],"illness-correlative":[193],"phenomena":[194],"TSEs,":[196],"which":[197],"may":[198],"arise":[199],"alteration":[202],"kinases.":[205],"Alteration":[206],"tau,":[208],"(Ser396,":[210],"Ser202/Thr205),":[213],"either":[218],"intermediate":[219],"consequent":[221],"events":[222],"TSE":[224],"pathogenesis":[225,237],"proposed":[227],"potential":[229],"linkage":[230],"these":[232],"bioactive":[233],"proteins":[234],"diseases.":[240]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
