{"id":"https://openalex.org/W1985335364","doi":"https://doi.org/10.1158/1538-7445.am2012-3057","title":"Abstract 3057: CDK5 modulates the cell cycle, apoptosis and paclitaxel sensitivity in human ovarian cancer cells with wild-type p53 function","display_name":"Abstract 3057: CDK5 modulates the cell cycle, apoptosis and paclitaxel sensitivity in human ovarian cancer cells with wild-type p53 function","publication_year":2012,"publication_date":"2012-04-01","ids":{"openalex":"https://openalex.org/W1985335364","doi":"https://doi.org/10.1158/1538-7445.am2012-3057","mag":"1985335364"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2012-3057","doi":"https://doi.org/10.1158/1538-7445.am2012-3057","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2012-3057","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100452863","display_name":"Shu Zhang","orcid":"https://orcid.org/0000-0002-3442-4309","observed_orcids":["https://orcid.org/0000-0002-3442-4309"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shu Zhang","raw_affiliation_strings":["1The University of Texas M. D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Texas M. D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111381332","display_name":"Weiqun Mao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weiqun Mao","raw_affiliation_strings":["1The University of Texas M. D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Texas M. D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011464110","display_name":"Ahmed A. Ahmed","orcid":"https://orcid.org/0000-0001-6509-2581","observed_orcids":["https://orcid.org/0000-0001-6509-2581"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ahmed A. Ahmed","raw_affiliation_strings":["2University of Oxford, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030511983","display_name":"Zongfang Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131893","display_name":"Second Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/03aq7kf18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131893"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zong-Fang Li","raw_affiliation_strings":["3Second Affiliated Hospital, School of Medicine, Xian Jiaotong University, Xian, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Second Affiliated Hospital, School of Medicine, Xian Jiaotong University, Xian, China","institution_ids":["https://openalex.org/I4210131893","https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077290971","display_name":"Xiao\u2010Feng Le","orcid":"https://orcid.org/0000-0002-2381-5929","observed_orcids":["https://orcid.org/0000-0002-2381-5929"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiao-Feng Le","raw_affiliation_strings":["1The University of Texas M. D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Texas M. D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067595997","display_name":"Robert C. Bast","orcid":"https://orcid.org/0000-0003-4621-8462","observed_orcids":["https://orcid.org/0000-0003-4621-8462"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert C. Bast","raw_affiliation_strings":["1The University of Texas M. D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Texas M. D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"72","issue":"8_Supplement","first_page":"3057","last_page":"3057"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.02449999935925007,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cdk5","display_name":"cyclin-dependent kinase 5","score":0.9539999961853027},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.953000009059906},{"id":"https://openalex.org/keywords/paclitaxel-sensitivity","display_name":"paclitaxel sensitivity","score":0.9919999837875366},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.8140000104904175},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.8840000033378601},{"id":"https://openalex.org/keywords/p27","display_name":"p27","score":1.0},{"id":"https://openalex.org/keywords/g1-cell-cycle-arrest","display_name":"G1 cell cycle arrest","score":0.9879999756813049},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":1.0},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9089999794960022},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.996999979019165},{"id":"https://openalex.org/keywords/p53-transcriptional-activation","display_name":"p53 transcriptional activation","score":0.6259999871253967},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.546999990940094},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.5989999771118164}],"concepts":[{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.824999988079071},{"id":"https://openalex.org/C121738310","wikidata":"https://www.wikidata.org/wiki/Q18248262","display_name":"Cyclin-dependent kinase 5","level":5,"score":0.6524577140808105},{"id":"https://openalex.org/C120504264","wikidata":"https://www.wikidata.org/wiki/Q1147372","display_name":"Cyclin-dependent kinase 1","level":4,"score":0.5204465985298157},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5188983082771301},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5088701248168945},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4543229937553406},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4535461664199829},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4514736533164978},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.42629265785217285},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3976217806339264},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3477957844734192},{"id":"https://openalex.org/C82495950","wikidata":"https://www.wikidata.org/wiki/Q14911732","display_name":"Cyclin-dependent kinase 2","level":4,"score":0.32890528440475464},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.21007660031318665},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08202946186065674}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2012-3057","doi":"https://doi.org/10.1158/1538-7445.am2012-3057","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2012-3057","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W748013821","https://openalex.org/W7100228714","https://openalex.org/W2978212552","https://openalex.org/W2091739733","https://openalex.org/W2082248619","https://openalex.org/W2066327730","https://openalex.org/W2330574480","https://openalex.org/W1558532670","https://openalex.org/W1965259411","https://openalex.org/W2325740123"],"abstract_inverted_index":{"Abstract":[0],"Cyclin-dependent":[1],"kinase":[2,10,57],"5":[3],"(CDK5)":[4],"is":[5,72,275,287],"a":[6,48,56,94,174,238,262,330],"ubiquitously":[7],"expressed":[8],"serine/threonine":[9],"that":[11,58,122,300],"was":[12],"initially":[13],"identified":[14,53],"in":[15,24,42,62,82,98,112,137,242,277,320,345],"bovine":[16],"brain":[17],"extracts":[18],"and":[19,28,117,133,151,168,180,195,222,234,253,261,281,292,312],"plays":[20],"an":[21],"important":[22],"role":[23,95],"normal":[25],"neuron":[26],"development":[27],"neurodegenerative":[29],"diseases.":[30],"This":[31],"molecule":[32],"has":[33],"recently":[34],"been":[35],"shown":[36],"to":[37,73,173,217,223],"possess":[38],"many":[39],"cellular":[40],"functions":[41],"non-neuronal":[43],"tissues":[44],"as":[45,55,225],"well.":[46],"Using":[47],"kinome":[49],"siRNA":[50],"screen,":[51],"we":[52,106],"CDK5":[54,78,97,111,125,154,188,204,209,218,230,239,257,267,278,291,301,314],"modulates":[59],"paclitaxel":[60,80,135,159,293,304,318],"sensitivity":[61,81,136,305],"human":[63,83,92,321],"ovarian":[64,84,142,322,343],"cancer":[65,85,143,323,344],"cells.":[66,86],"The":[67],"aim":[68],"of":[69,96,110,124,164,177,184,193,212,272,284,337,356,361],"this":[70],"report":[71],"identify":[74],"mechanisms":[75],"by":[76,251],"which":[77],"regulates":[79],"Despite":[87],"nucleotide":[88],"sequence":[89],"homology":[90],"with":[91,126,156,289,325],"CDK1,":[93],"regulating":[99,113,307],"the":[100,114,165,309,335,346,357,362],"cell":[101,115,131,144,149,166,170,310],"cycle":[102,116,167,311],"remains":[103],"unclear.":[104],"Here":[105],"demonstrate":[107],"dual":[108],"roles":[109],"apoptosis.":[118,235,269,313],"We":[119],"have":[120],"found":[121,276,288],"knockdown":[123,155,189,258],"multiple":[127],"siRNAs":[128],"markedly":[129,228],"inhibits":[130],"proliferation":[132],"increases":[134],"several":[138],"p53":[139,213,227,327],"wild":[140],"type":[141],"lines":[145],"using":[146],"assays":[147],"for":[148,333,340,365],"viability":[150],"clonogenic":[152],"growth.":[153],"or":[157],"without":[158],"treatment":[160],"induces":[161],"G1":[162,185,206,220,232],"arrest":[163,186,221,233],"apoptotic":[169],"death":[171],"linked":[172],"significant":[175],"induction":[176,192],"p53,":[178],"p21Cip1":[179,194,199,243],"p27Kip1":[181,201],"proteins.":[182],"Induction":[183],"following":[187],"depends":[190,245],"on":[191,246],"p27Kip1,":[196],"since":[197],"silencing":[198,226],"and/or":[200],"dramatically":[202],"reduces":[203],"knockdown-induced":[205,210,219,231,240,268,279],"arrest.":[207],"A":[208],"increase":[211,241],"expression":[214,244,274,286],"contributes":[215],"both":[216,308],"apoptosis,":[224],"diminishes":[229],"As":[236],"expected,":[237],"p53-mediated":[247],"transcriptional":[248],"activation":[249],"demonstrated":[250],"QRT-PCR":[252],"reporter":[254],"luciferase":[255],"assays.":[256],"activates":[259],"caspase-3":[260],"pan-caspase":[263],"inhibitor":[264],"completely":[265],"blocks":[266],"Significant":[270],"Inhibition":[271],"Bcl-2":[273,285],"apoptosis":[280],"additional":[282],"inhibition":[283,315],"combined":[290],"treatment.":[294],"Taken":[295],"together,":[296],"these":[297],"data":[298],"suggest":[299],"can":[302,316],"modulate":[303],"through":[306],"potentiate":[317],"activity":[319],"cells":[324],"wild-type":[326],"function,":[328],"providing":[329],"novel":[331],"approach":[332],"enhancing":[334],"efficacies":[336],"paclitaxel-based":[338],"regimens":[339],"low":[341],"grade":[342],"clinic.":[347],"Citation":[348],"Format:":[349],"{Authors}.":[350],"{Abstract":[351],"title}":[352],"[abstract].":[353],"In:":[354],"Proceedings":[355],"103rd":[358],"Annual":[359],"Meeting":[360],"American":[363],"Association":[364],"Cancer":[366,377],"Research;":[367],"2012":[368],"Mar":[369],"31-Apr":[370],"4;":[371],"Chicago,":[372],"IL.":[373],"Philadelphia":[374],"(PA):":[375],"AACR;":[376],"Res":[378],"2012;72(8":[379],"Suppl):Abstract":[380],"nr":[381],"3057.":[382],"doi:1538-7445.AM2012-3057":[383]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
