{"id":"https://openalex.org/W1985334285","doi":"https://doi.org/10.1073/pnas.95.19.11034","title":"Aging, life span, and senescence","display_name":"Aging, life span, and senescence","publication_year":1998,"publication_date":"1998-09-15","ids":{"openalex":"https://openalex.org/W1985334285","doi":"https://doi.org/10.1073/pnas.95.19.11034","mag":"1985334285","pmid":"https://pubmed.ncbi.nlm.nih.gov/9736682","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/33892"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.95.19.11034","doi":"https://doi.org/10.1073/pnas.95.19.11034","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.95.19.11034","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC33892","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5115604308","display_name":"Leonard Guarente","orcid":"https://orcid.org/0000-0003-4064-2510","observed_orcids":["https://orcid.org/0000-0003-4064-2510","https://orcid.org/0000-0003-0690-4089"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leonard Guarente","raw_affiliation_strings":["Department of Biology, Massachusetts Institute of Technology,\r Cambridge, MA 02139; Department of Molecular Biology,\r Massachusetts General Hospital, Boston, MA 02114; and\r Department of Biochemistry, University of Wisconsin, Madison,\r WI 53706"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Massachusetts Institute of Technology,\r Cambridge, MA 02139; Department of Molecular Biology,\r Massachusetts General Hospital, Boston, MA 02114; and\r Department of Biochemistry, University of Wisconsin, Madison,\r WI 53706","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I4210087915","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066998461","display_name":"Gary Ruvkun","orcid":"https://orcid.org/0000-0002-7473-8484","observed_orcids":["https://orcid.org/0000-0002-7473-8484"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary Ruvkun","raw_affiliation_strings":["Department of Biology, Massachusetts Institute of Technology,\r Cambridge, MA 02139; Department of Molecular Biology,\r Massachusetts General Hospital, Boston, MA 02114; and\r Department of Biochemistry, University of Wisconsin, Madison,\r WI 53706"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Massachusetts Institute of Technology,\r Cambridge, MA 02139; Department of Molecular Biology,\r Massachusetts General Hospital, Boston, MA 02114; and\r Department of Biochemistry, University of Wisconsin, Madison,\r WI 53706","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I4210087915","https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063564018","display_name":"Richard M. Amasino","orcid":"https://orcid.org/0000-0003-3068-5402","observed_orcids":["https://orcid.org/0000-0003-3068-5402"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Amasino","raw_affiliation_strings":["Department of Biology, Massachusetts Institute of Technology,\r Cambridge, MA 02139; Department of Molecular Biology,\r Massachusetts General Hospital, Boston, MA 02114; and\r Department of Biochemistry, University of Wisconsin, Madison,\r WI 53706"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Massachusetts Institute of Technology,\r Cambridge, MA 02139; Department of Molecular Biology,\r Massachusetts General Hospital, Boston, MA 02114; and\r Department of Biochemistry, University of Wisconsin, Madison,\r WI 53706","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I4210087915","https://openalex.org/I63966007"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.6146,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.88695652,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"95","issue":"19","first_page":"11034","last_page":"11036"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11265","display_name":"Aging and Gerontology Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/3206","display_name":"Neuropsychology and Physiological Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.9959999918937683},{"id":"https://openalex.org/keywords/lifespan","display_name":"lifespan","score":0.9269999861717224},{"id":"https://openalex.org/keywords/senescence","display_name":"senescence","score":0.8640000224113464},{"id":"https://openalex.org/keywords/biological-aging","display_name":"biological aging","score":0.47600001096725464}],"concepts":[{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.7121680378913879},{"id":"https://openalex.org/C2988516024","wikidata":"https://www.wikidata.org/wiki/Q441195","display_name":"Life span","level":2,"score":0.6987577676773071},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49589118361473083},{"id":"https://openalex.org/C2776759703","wikidata":"https://www.wikidata.org/wiki/Q1066907","display_name":"Longevity","level":2,"score":0.4753517806529999},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.39890187978744507},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23670470714569092},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.23551252484321594},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2107010781764984}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008136","descriptor_name":"Longevity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008136","descriptor_name":"Longevity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008136","descriptor_name":"Longevity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018521","descriptor_name":"Plant Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018521","descriptor_name":"Plant Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018521","descriptor_name":"Plant Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.95.19.11034","doi":"https://doi.org/10.1073/pnas.95.19.11034","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.95.19.11034","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:192240","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC33892","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:33892","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/33892","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:9736682","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9736682","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:192240","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC33892","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.4699999988079071}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1561048091","https://openalex.org/W1631908837","https://openalex.org/W1668817969","https://openalex.org/W1963578989","https://openalex.org/W1965523765","https://openalex.org/W1976300122","https://openalex.org/W1983744282","https://openalex.org/W1994369498","https://openalex.org/W2043409652","https://openalex.org/W2046351190","https://openalex.org/W2046989794","https://openalex.org/W2052722944","https://openalex.org/W2062629127","https://openalex.org/W2064310741","https://openalex.org/W2078030859","https://openalex.org/W2094231976","https://openalex.org/W2107358212","https://openalex.org/W2107638414","https://openalex.org/W2109714973","https://openalex.org/W2111882191","https://openalex.org/W2330148479","https://openalex.org/W4236394930"],"related_works":["https://openalex.org/W2047945565","https://openalex.org/W2074467340","https://openalex.org/W7132141085","https://openalex.org/W2141389019","https://openalex.org/W2114123456","https://openalex.org/W2969850070","https://openalex.org/W2200736706","https://openalex.org/W2039306101","https://openalex.org/W4415027562","https://openalex.org/W1606585408"],"abstract_inverted_index":{"In":[0],"the":[1,9,29,33,37,44,92],"budding":[2],"yeast":[3],"Saccharomyces":[4],"cerevisiae,":[5],"aging":[6],"results":[7],"from":[8,28],"asymmetry":[10],"of":[11,32,36,66,80,86,91],"cell":[12,21,26,39,51,59,67,93,95],"division,":[13],"which":[14],"gives":[15],"rise":[16],"to":[17],"a":[18,23,56,76,89],"large":[19],"mother":[20,58],"and":[22,82,97],"small":[24],"daughter":[25,38],"arising":[27],"bud.":[30],"Much":[31],"macromolecular":[34],"composition":[35,46],"is":[40],"newly":[41],"synthesized,":[42],"whereas":[43],"mother\u2019s":[45],"grows":[47],"older":[48],"with":[49],"each":[50],"division.":[52,68],"By":[53],"microscopic":[54],"analysis,":[55],"single":[57],"may":[60],"be":[61],"followed":[62],"through":[63],"multiple":[64],"rounds":[65],"Thus,":[69],"it":[70],"was":[71],"shown":[72],"that":[73],"mothers":[74],"divide":[75],"relatively":[77],"fixed":[78],"number":[79],"times":[81],"undergo":[83],"morphological":[84],"changes":[85],"aging,":[87],"including":[88],"slowing":[90],"cycle,":[94],"enlargement,":[96],"sterility":[98],"(1).":[99]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}
