{"id":"https://openalex.org/W1985321490","doi":"https://doi.org/10.1172/jci118503","title":"Transfer of granulocyte-macrophage colony-stimulating factor gene to rat lung induces eosinophilia, monocytosis, and fibrotic reactions.","display_name":"Transfer of granulocyte-macrophage colony-stimulating factor gene to rat lung induces eosinophilia, monocytosis, and fibrotic reactions.","publication_year":1996,"publication_date":"1996-02-15","ids":{"openalex":"https://openalex.org/W1985321490","doi":"https://doi.org/10.1172/jci118503","mag":"1985321490","pmid":"https://pubmed.ncbi.nlm.nih.gov/8613534","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/507158"},"language":"en","primary_location":{"id":"doi:10.1172/jci118503","doi":"https://doi.org/10.1172/jci118503","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci118503","pdf_url":"http://www.jci.org/articles/view/118503/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/118503/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Z Xing","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Z Xing","raw_affiliation_strings":["Department of Pathology, Health Sciences Center, McMaster University, Hamilton, Ontario, L8N3Z5, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Health Sciences Center, McMaster University, Hamilton, Ontario, L8N3Z5, Canada","institution_ids":["https://openalex.org/I98251732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055215304","display_name":"Yuichi Ohkawara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Y Ohkawara","raw_affiliation_strings":["Molecular Virology and Immunology Program, Departments of *Pathology and \u2021 Biology, Health Sciences Center, McMaster University, Hamilton, Ontario, L8N 3Z5, Canada","Health Sci-ences Center, Department of Pathology, McMaster University, Hamilton, Ontario L8N 3Z5 Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Virology and Immunology Program, Departments of *Pathology and \u2021 Biology, Health Sciences Center, McMaster University, Hamilton, Ontario, L8N 3Z5, Canada","institution_ids":["https://openalex.org/I98251732"]},{"raw_affiliation_string":"Health Sci-ences Center, Department of Pathology, McMaster University, Hamilton, Ontario L8N 3Z5 Canada","institution_ids":["https://openalex.org/I98251732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065277319","display_name":"Manel Jordana","orcid":"https://orcid.org/0000-0002-5861-5994","observed_orcids":["https://orcid.org/0000-0002-5861-5994"]},"institutions":[{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"M Jordana","raw_affiliation_strings":["Molecular Virology and Immunology Program, Departments of *Pathology and \u2021 Biology, Health Sciences Center, McMaster University, Hamilton, Ontario, L8N 3Z5, Canada","Health Sci-ences Center, Department of Pathology, McMaster University, Hamilton, Ontario L8N 3Z5 Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Virology and Immunology Program, Departments of *Pathology and \u2021 Biology, Health Sciences Center, McMaster University, Hamilton, Ontario, L8N 3Z5, Canada","institution_ids":["https://openalex.org/I98251732"]},{"raw_affiliation_string":"Health Sci-ences Center, Department of Pathology, McMaster University, Hamilton, Ontario L8N 3Z5 Canada","institution_ids":["https://openalex.org/I98251732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108419192","display_name":"Frank L. Graham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"F Graham","raw_affiliation_strings":["Molecular Virology and Immunology Program, Departments of *Pathology and \u2021 Biology, Health Sciences Center, McMaster University, Hamilton, Ontario, L8N 3Z5, Canada","Health Sci-ences Center, Department of Pathology, McMaster University, Hamilton, Ontario L8N 3Z5 Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Virology and Immunology Program, Departments of *Pathology and \u2021 Biology, Health Sciences Center, McMaster University, Hamilton, Ontario, L8N 3Z5, Canada","institution_ids":["https://openalex.org/I98251732"]},{"raw_affiliation_string":"Health Sci-ences Center, Department of Pathology, McMaster University, Hamilton, Ontario L8N 3Z5 Canada","institution_ids":["https://openalex.org/I98251732"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005295653","display_name":"Jack Gauldie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"J Gauldie","raw_affiliation_strings":["Health Sci-ences Center, Department of Pathology, McMaster University, Hamilton, Ontario L8N 3Z5 Canada","Molecular Virology and Immunology Program, Departments of *Pathology and \u2021 Biology, Health Sciences Center, McMaster University, Hamilton, Ontario, L8N 3Z5, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health Sci-ences Center, Department of Pathology, McMaster University, Hamilton, Ontario L8N 3Z5 Canada","institution_ids":["https://openalex.org/I98251732"]},{"raw_affiliation_string":"Molecular Virology and Immunology Program, Departments of *Pathology and \u2021 Biology, Health Sciences Center, McMaster University, Hamilton, Ontario, L8N 3Z5, Canada","institution_ids":["https://openalex.org/I98251732"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I98251732"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":10.7907,"has_fulltext":true,"cited_by_count":212,"citation_normalized_percentile":{"value":0.98751884,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"97","issue":"4","first_page":"1102","last_page":"1110"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12528","display_name":"IL-33, ST2, and ILC Pathways","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gm-csf","display_name":"GM-CSF","score":0.9959999918937683},{"id":"https://openalex.org/keywords/eosinophilia","display_name":"eosinophilia","score":0.7210000157356262},{"id":"https://openalex.org/keywords/monocytosis","display_name":"monocytosis","score":0.9129999876022339},{"id":"https://openalex.org/keywords/pulmonary-fibrosis","display_name":"pulmonary fibrosis","score":0.8600000143051147},{"id":"https://openalex.org/keywords/lung-injury","display_name":"lung injury","score":0.546999990940094},{"id":"https://openalex.org/keywords/adenoviral-gene-transfer","display_name":"adenoviral gene transfer","score":0.8700000047683716},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.5580000281333923},{"id":"https://openalex.org/keywords/granuloma","display_name":"granuloma","score":0.8619999885559082}],"concepts":[{"id":"https://openalex.org/C2777129736","wikidata":"https://www.wikidata.org/wiki/Q505142","display_name":"Eosinophilia","level":2,"score":0.6992762684822083},{"id":"https://openalex.org/C2777478134","wikidata":"https://www.wikidata.org/wiki/Q423660","display_name":"Granulocyte macrophage colony-stimulating factor","level":3,"score":0.6707531809806824},{"id":"https://openalex.org/C2777802486","wikidata":"https://www.wikidata.org/wiki/Q491741","display_name":"Neutrophilia","level":2,"score":0.5898342728614807},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.577495813369751},{"id":"https://openalex.org/C2781087989","wikidata":"https://www.wikidata.org/wiki/Q1682044","display_name":"Monocytosis","level":3,"score":0.4859429597854614},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4858345687389374},{"id":"https://openalex.org/C50442881","wikidata":"https://www.wikidata.org/wiki/Q426626","display_name":"Macrophage colony-stimulating factor","level":4,"score":0.4807117283344269},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.4792047441005707},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4736016094684601},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.47010916471481323},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.45400214195251465},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.4482545554637909},{"id":"https://openalex.org/C2909466502","wikidata":"https://www.wikidata.org/wiki/Q505142","display_name":"Pulmonary Eosinophilia","level":4,"score":0.42104053497314453},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.37414467334747314},{"id":"https://openalex.org/C2777037409","wikidata":"https://www.wikidata.org/wiki/Q107238","display_name":"Eosinophil","level":3,"score":0.37006688117980957},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3517987132072449},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.17836463451385498},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.12664753198623657},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0940929651260376},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.060583531856536865},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001992","descriptor_name":"Bronchoalveolar Lavage Fluid","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004802","descriptor_name":"Eosinophilia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D004802","descriptor_name":"Eosinophilia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006099","descriptor_name":"Granuloma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007958","descriptor_name":"Leukocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011658","descriptor_name":"Pulmonary Fibrosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D011658","descriptor_name":"Pulmonary Fibrosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016178","descriptor_name":"Granulocyte-Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1172/jci118503","doi":"https://doi.org/10.1172/jci118503","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci118503","pdf_url":"http://www.jci.org/articles/view/118503/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:507158","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/507158","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:8613534","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8613534","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1172/jci118503","doi":"https://doi.org/10.1172/jci118503","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci118503","pdf_url":"http://www.jci.org/articles/view/118503/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320324195","display_name":"Medical Research Council Canada","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1985321490.pdf","grobid_xml":"https://content.openalex.org/works/W1985321490.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W75430636","https://openalex.org/W292708302","https://openalex.org/W1043337635","https://openalex.org/W1602937445","https://openalex.org/W1613256162","https://openalex.org/W1670578641","https://openalex.org/W1675276494","https://openalex.org/W1934539591","https://openalex.org/W1968823758","https://openalex.org/W1970097110","https://openalex.org/W1971425598","https://openalex.org/W1980401440","https://openalex.org/W1989669523","https://openalex.org/W1989969353","https://openalex.org/W1990738126","https://openalex.org/W2030904344","https://openalex.org/W2031802924","https://openalex.org/W2037321781","https://openalex.org/W2055037877","https://openalex.org/W2065354528","https://openalex.org/W2069353968","https://openalex.org/W2071020018","https://openalex.org/W2077887480","https://openalex.org/W2087510566","https://openalex.org/W2092657066","https://openalex.org/W2114242966","https://openalex.org/W2119341928","https://openalex.org/W2122582570","https://openalex.org/W2124849447","https://openalex.org/W2129859001","https://openalex.org/W2136902889","https://openalex.org/W2151820072","https://openalex.org/W2216931490","https://openalex.org/W2315876050","https://openalex.org/W2510716823"],"related_works":["https://openalex.org/W7098900284","https://openalex.org/W2340315346","https://openalex.org/W1486248937","https://openalex.org/W2059359470","https://openalex.org/W2402239629","https://openalex.org/W2060970195","https://openalex.org/W2171583706","https://openalex.org/W2172791893","https://openalex.org/W2021178126","https://openalex.org/W2410220490"],"abstract_inverted_index":{"Granulocyte-macrophage":[0],"colony-stimulating":[1],"factor":[2],"(GM-CSF)":[3],"is":[4,10],"a":[5,104],"pleiotropic":[6],"cytokine":[7],"whose":[8],"expression":[9,65],"increased":[11],"in":[12,17,24,30,44,83,95,108,128],"numerous":[13],"respiratory":[14,112],"diseases,":[15],"particularly":[16],"asthma.":[18],"However,":[19],"the":[20,25,37,51,70,84,109,122],"role":[21,107],"of":[22,27,40,50,66,75,90,111],"GM-CSF":[23,41,56,67,102],"pathogenesis":[26],"these":[28,129],"conditions":[29,113],"vivo":[31],"remains":[32],"unclear.":[33],"Here,":[34],"we":[35],"report":[36],"functional":[38],"activities":[39],"highly":[42],"expressed":[43],"rat":[45],"lung":[46,85],"after":[47],"intrapulmonary":[48],"transfer":[49],"gene":[52],"coding":[53],"for":[54,124],"murine":[55],"by":[57,87,115],"using":[58],"an":[59],"adenoviral":[60],"vector.":[61],"This":[62],"high,":[63],"transient":[64],"led":[68],"to":[69],"sustained":[71],"but":[72],"self-limiting":[73],"accumulation":[74],"eosinophils":[76],"and":[77,120],"macrophages":[78],"associated":[79],"with":[80],"tissue":[81],"injury":[82],"followed":[86],"varying":[88],"degrees":[89],"irreversible":[91],"fibrotic":[92],"reactions":[93],"observed":[94],"later":[96],"stages.":[97],"These":[98],"results":[99],"suggest":[100],"that":[101],"plays":[103],"previously":[105],"unrealized":[106],"development":[110],"characterized":[114],"eosinophilia,":[116],"granuloma":[117],"and/or":[118],"fibrosis":[119],"provide":[121],"rationale":[123],"targeting":[125],"this":[126],"molecule":[127],"diseases.":[130]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}