{"id":"https://openalex.org/W1985308079","doi":"https://doi.org/10.1097/00042737-199910000-00006","title":"T-cell co-stimulatory molecules are upregulated on intestinal macrophages from inflammatory bowel disease mucosa","display_name":"T-cell co-stimulatory molecules are upregulated on intestinal macrophages from inflammatory bowel disease mucosa","publication_year":1999,"publication_date":"1999-10-01","ids":{"openalex":"https://openalex.org/W1985308079","doi":"https://doi.org/10.1097/00042737-199910000-00006","mag":"1985308079","pmid":"https://pubmed.ncbi.nlm.nih.gov/10524639"},"language":"en","primary_location":{"id":"doi:10.1097/00042737-199910000-00006","doi":"https://doi.org/10.1097/00042737-199910000-00006","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00042737-199910000-00006","pdf_url":null,"source":{"id":"https://openalex.org/S937433771","display_name":"European Journal of Gastroenterology & Hepatology","issn_l":"0954-691X","issn":["0954-691X","0594-691X","1473-5687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Gastroenterology & Hepatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058012401","display_name":"Gerhard Rogler","orcid":"https://orcid.org/0000-0002-1733-9188","observed_orcids":["https://orcid.org/0000-0002-1733-9188"]},"institutions":[{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gerhard Rogler","raw_affiliation_strings":["Department of Internal Medicine I, University of Regensburg, Germany. gerhard.rogler@klinik.uni-regensburg.de","Department of Internal Medicine I, University of Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine I, University of Regensburg, Germany. gerhard.rogler@klinik.uni-regensburg.de","institution_ids":["https://openalex.org/I60668342"]},{"raw_affiliation_string":"Department of Internal Medicine I, University of Regensburg, Germany","institution_ids":["https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065186874","display_name":"Martin Hausmann","orcid":"https://orcid.org/0000-0002-0696-0251","observed_orcids":["https://orcid.org/0000-0002-0696-0251"]},"institutions":[{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martin Hausmann","raw_affiliation_strings":["Department of Internal Medicine I, University of Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine I, University of Regensburg, Germany","institution_ids":["https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031853123","display_name":"Tanja Sp\u00f6ttl","orcid":"https://orcid.org/0000-0001-8780-0227","observed_orcids":["https://orcid.org/0000-0001-8780-0227"]},"institutions":[{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tanja Sp\u00f6ttl","raw_affiliation_strings":["Department of Internal Medicine I, University of Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine I, University of Regensburg, Germany","institution_ids":["https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065334962","display_name":"Daniela Vogl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Daniela Vogl","raw_affiliation_strings":["Department of Internal Medicine I, University of Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine I, University of Regensburg, Germany","institution_ids":["https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055423834","display_name":"E Aschenbrenner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Elisabeth Aschenbrenner","raw_affiliation_strings":["Department of Internal Medicine I, University of Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine I, University of Regensburg, Germany","institution_ids":["https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112165606","display_name":"Tilo Andus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tilo Andus","raw_affiliation_strings":["Department of Internal Medicine I, University of Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine I, University of Regensburg, Germany","institution_ids":["https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051726567","display_name":"Werner Falk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Werner Falk","raw_affiliation_strings":["Department of Internal Medicine I, University of Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine I, University of Regensburg, Germany","institution_ids":["https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110836079","display_name":"J\u00fcrgen Sch\u00f6lmerich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J\u00fcrgen Sch\u00f6lmerich","raw_affiliation_strings":["Department of Internal Medicine I, University of Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine I, University of Regensburg, Germany","institution_ids":["https://openalex.org/I60668342"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010436037","display_name":"Volker Gro\u00df","orcid":"https://orcid.org/0000-0002-0976-8986","observed_orcids":["https://orcid.org/0000-0002-0976-8986"]},"institutions":[{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Volker Gross","raw_affiliation_strings":["Department of Internal Medicine I, University of Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine I, University of Regensburg, Germany","institution_ids":["https://openalex.org/I60668342"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I60668342"],"apc_list":null,"apc_paid":null,"fwci":1.2159,"has_fulltext":false,"cited_by_count":49,"citation_normalized_percentile":{"value":0.77997832,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"11","issue":"10","first_page":"1105","last_page":"1112"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.8140000104904175},{"id":"https://openalex.org/keywords/colonic-macrophages","display_name":"colonic macrophages","score":0.8920000195503235},{"id":"https://openalex.org/keywords/costimulatory-molecules","display_name":"costimulatory molecules","score":0.8629999756813049},{"id":"https://openalex.org/keywords/cd80","display_name":"CD80","score":0.921999990940094},{"id":"https://openalex.org/keywords/cd86","display_name":"CD86","score":0.9990000128746033},{"id":"https://openalex.org/keywords/antigen-presentation","display_name":"antigen presentation","score":0.7269999980926514},{"id":"https://openalex.org/keywords/mucosal-inflammation","display_name":"mucosal inflammation","score":0.8140000104904175},{"id":"https://openalex.org/keywords/crohn-s-disease","display_name":"Crohn's disease","score":0.9670000076293945},{"id":"https://openalex.org/keywords/ulcerative-colitis","display_name":"ulcerative colitis","score":1.0},{"id":"https://openalex.org/keywords/cd14","display_name":"CD14","score":0.9359999895095825},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.6430000066757202}],"concepts":[{"id":"https://openalex.org/C2778297628","wikidata":"https://www.wikidata.org/wiki/Q5009843","display_name":"CD80","level":5,"score":0.854615330696106},{"id":"https://openalex.org/C2781101188","wikidata":"https://www.wikidata.org/wiki/Q5009846","display_name":"CD86","level":4,"score":0.808635950088501},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.7262851595878601},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6206779479980469},{"id":"https://openalex.org/C3019368612","wikidata":"https://www.wikidata.org/wiki/Q17154506","display_name":"Intestinal mucosa","level":2,"score":0.5728067755699158},{"id":"https://openalex.org/C2778513237","wikidata":"https://www.wikidata.org/wiki/Q419553","display_name":"CD14","level":3,"score":0.5312262177467346},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.5141389966011047},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4790678918361664},{"id":"https://openalex.org/C2775862500","wikidata":"https://www.wikidata.org/wiki/Q2453464","display_name":"Colitis","level":2,"score":0.4264284372329712},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.35961073637008667},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2921115458011627},{"id":"https://openalex.org/C39347974","wikidata":"https://www.wikidata.org/wiki/Q21135811","display_name":"CD40","level":4,"score":0.2703434228897095},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23461994528770447},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21942192316055298},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.16639623045921326},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.12998679280281067},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.12088778614997864},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.06654667854309082},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D015212","descriptor_name":"Inflammatory Bowel Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015214","descriptor_name":"Antigens, Differentiation, Myelomonocytic","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D017452","descriptor_name":"Receptors, IgG","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018122","descriptor_name":"B7-1 Antigen","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D018417","descriptor_name":"Th1 Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018418","descriptor_name":"Th2 Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018950","descriptor_name":"Lipopolysaccharide Receptors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D051940","descriptor_name":"B7-2 Antigen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063268","descriptor_name":"Sialic Acid Binding Ig-like Lectin 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00042737-199910000-00006","doi":"https://doi.org/10.1097/00042737-199910000-00006","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00042737-199910000-00006","pdf_url":null,"source":{"id":"https://openalex.org/S937433771","display_name":"European Journal of Gastroenterology & Hepatology","issn_l":"0954-691X","issn":["0954-691X","0594-691X","1473-5687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Gastroenterology & Hepatology","raw_type":"journal-article"},{"id":"pmid:10524639","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10524639","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of gastroenterology & hepatology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2089315976","https://openalex.org/W2003242604","https://openalex.org/W2316810802","https://openalex.org/W2168697127","https://openalex.org/W1970179252","https://openalex.org/W1964875700","https://openalex.org/W2327286908","https://openalex.org/W2158925111","https://openalex.org/W3030936863","https://openalex.org/W3202542272"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1],"AIMS:":[2],"Macrophages":[3],"play":[4,25],"an":[5,26],"important":[6],"role":[7,28],"during":[8],"mucosal":[9],"inflammation":[10],"in":[11,29,138,169,193],"inflammatory":[12],"bowel":[13],"disease":[14,75],"(IBD).":[15],"As":[16],"the":[17,30,41,139,170,201,209,214,229,252],"co-stimulatory":[18,142,230,247],"molecules":[19,143,231,248],"B7-1":[20,45,101],"(CD80)":[21,102],"and":[22,46,53,67,77,106,167,182,233],"B7-2":[23,47,107],"(CD86)":[24,108],"integral":[27],"activation":[31],"of":[32,44,63,100,141,172,200,208,213,246],"T":[33],"cells":[34,37,212],"by":[35,86],"antigen-presenting":[36],"(APC)":[38],"we":[39],"investigated":[40],"surface":[42],"expression":[43,99,140,171,245],"on":[48,114,128],"colonic":[49,115],"macrophages":[50,58,116,129,202,223],"from":[51,61,117,130,224],"normal":[52,118,194,225],"IBD":[54,71,131,236],"mucosa.":[55],"METHODS:":[56],"Intestinal":[57],"were":[59,84,217],"isolated":[60],"biopsies":[62],"13":[64],"control":[65],"persons":[66],"14":[68],"patients":[69],"with":[70,73,79,243],"(seven":[72],"Crohn's":[74],"(CD);":[76],"seven":[78],"ulcerative":[80],"colitis":[81],"(UC)).":[82],"Cells":[83],"characterized":[85],"triple":[87],"fluorescence":[88],"flow":[89],"cytometrical":[90],"analysis":[91],"using":[92],"CD33":[93],"as":[94],"macrophage":[95,239],"marker.":[96],"RESULTS:":[97],"The":[98],"(9.2%":[103],"+/-":[104,110,146,155,176,180,186,190,198],"4.2%)":[105],"(15.1%":[109],"7.3%)":[111],"was":[112,134,161],"low":[113,123],"mucosa,":[119],"indicating":[120],"only":[121,196],"a":[122,135,237],"antigen":[124],"presenting":[125],"potential.":[126],"However,":[127],"colon":[132],"there":[133],"significant":[136,163],"increase":[137],"(CD80,":[144],"33.8%":[145],"8.9%,":[147],"P":[148,157],"=":[149,158],"0.00005":[150],"vs.":[151],"control;":[152],"CD86,":[153],"39.9%":[154],"8.8%,":[156],"0.00002).":[159],"There":[160],"no":[162],"difference":[164],"between":[165],"CD":[166],"UC":[168],"CD80":[173,232],"(CD,":[174,184],"31.3%":[175],"6.7%;":[177],"UC,":[178,188],"34.4%":[179],"13.3%)":[181],"CD86":[183],"41.9%":[185],"3.8%;":[187],"35.6%":[189],"13.8%).":[191],"While":[192],"mucosa":[195,216,226],"10.6%":[197],"4.9%":[199],"expressed":[203],"CD14,":[204],"more":[205],"than":[206],"90%":[207],"CD86/CD80":[210],"positive":[211,218],"inflamed":[215],"for":[219,251],"CD14.":[220],"CONCLUSION:":[221],"Colonic":[222],"rarely":[227],"express":[228],"CD86.":[234],"In":[235],"new":[238],"population":[240],"is":[241],"found":[242],"high":[244],"presumably":[249],"responsible":[250],"perpetuated":[253],"immune":[254],"response.":[255]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}