{"id":"https://openalex.org/W1985306591","doi":"https://doi.org/10.1074/jbc.274.20.14295","title":"Translational Control of Specific Genes during Differentiation of HL-60 Cells","display_name":"Translational Control of Specific Genes during Differentiation of HL-60 Cells","publication_year":1999,"publication_date":"1999-05-01","ids":{"openalex":"https://openalex.org/W1985306591","doi":"https://doi.org/10.1074/jbc.274.20.14295","mag":"1985306591","pmid":"https://pubmed.ncbi.nlm.nih.gov/10318851"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.274.20.14295","doi":"https://doi.org/10.1074/jbc.274.20.14295","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.274.20.14295","pdf_url":"http://www.jbc.org/article/S0021925819733031/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925819733031/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088110750","display_name":"Anna M. Krichevsky","orcid":"https://orcid.org/0000-0002-5080-5507","observed_orcids":["https://orcid.org/0000-0002-5080-5507"]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Anna M. Krichevsky","raw_affiliation_strings":["Department of Molecular Virology, The Faculty of Medicine, Hebrew University of Jerusalem, P. O. Box 12272, Jerusalem 91120, Israel","From the Department of Molecular Virology, The Faculty of Medicine, Hebrew University of Jerusalem, P. O. Box 12272, Jerusalem 91120, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Virology, The Faculty of Medicine, Hebrew University of Jerusalem, P. O. Box 12272, Jerusalem 91120, Israel","institution_ids":["https://openalex.org/I197251160"]},{"raw_affiliation_string":"From the Department of Molecular Virology, The Faculty of Medicine, Hebrew University of Jerusalem, P. O. Box 12272, Jerusalem 91120, Israel","institution_ids":["https://openalex.org/I197251160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012395371","display_name":"Esther Metzer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Esther Metzer","raw_affiliation_strings":["From the Department of Molecular Virology, The Faculty of Medicine, Hebrew University of Jerusalem, P. O. Box 12272, Jerusalem 91120, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Molecular Virology, The Faculty of Medicine, Hebrew University of Jerusalem, P. O. Box 12272, Jerusalem 91120, Israel","institution_ids":["https://openalex.org/I197251160"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110164043","display_name":"Haim Rosen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Haim Rosen","raw_affiliation_strings":["From the Department of Molecular Virology, The Faculty of Medicine, Hebrew University of Jerusalem, P. O. Box 12272, Jerusalem 91120, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Molecular Virology, The Faculty of Medicine, Hebrew University of Jerusalem, P. O. Box 12272, Jerusalem 91120, Israel","institution_ids":["https://openalex.org/I197251160"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5110164043"],"corresponding_institution_ids":["https://openalex.org/I197251160"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.1485,"has_fulltext":true,"cited_by_count":39,"citation_normalized_percentile":{"value":0.75631906,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"274","issue":"20","first_page":"14295","last_page":"14305"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9282000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9282000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.06849999725818634,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/translational-control","display_name":"translational regulation","score":0.9169999957084656},{"id":"https://openalex.org/keywords/hl-60-cells","display_name":"HL-60 cells","score":0.9390000104904175},{"id":"https://openalex.org/keywords/monocyte-differentiation","display_name":"monocyte differentiation","score":0.9860000014305115},{"id":"https://openalex.org/keywords/polysome-association","display_name":"polysome association","score":0.6259999871253967},{"id":"https://openalex.org/keywords/ribosomal-protein-mrnas","display_name":"ribosomal protein mRNAs","score":0.8230000138282776},{"id":"https://openalex.org/keywords/protein-synthesis-regulation","display_name":"protein synthesis regulation","score":0.6729999780654907}],"concepts":[{"id":"https://openalex.org/C65666806","wikidata":"https://www.wikidata.org/wiki/Q970614","display_name":"Polysome","level":5,"score":0.7694507837295532},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7140114903450012},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.6863893270492554},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6141630411148071},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.5257521271705627},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5179561376571655},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5105167627334595},{"id":"https://openalex.org/C185622968","wikidata":"https://www.wikidata.org/wiki/Q4654967","display_name":"AU-rich element","level":5,"score":0.471721351146698},{"id":"https://openalex.org/C89604277","wikidata":"https://www.wikidata.org/wiki/Q424345","display_name":"Untranslated region","level":4,"score":0.43857383728027344},{"id":"https://openalex.org/C39685955","wikidata":"https://www.wikidata.org/wiki/Q3455905","display_name":"Translational regulation","level":5,"score":0.4363917112350464},{"id":"https://openalex.org/C2775992057","wikidata":"https://www.wikidata.org/wiki/Q16956568","display_name":"Translational efficiency","level":5,"score":0.4299168884754181},{"id":"https://openalex.org/C161295673","wikidata":"https://www.wikidata.org/wiki/Q5408696","display_name":"EIF4E","level":5,"score":0.42958712577819824},{"id":"https://openalex.org/C142575336","wikidata":"https://www.wikidata.org/wiki/Q412148","display_name":"Polyadenylation","level":4,"score":0.426510751247406},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4026029109954834},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.4024242162704468},{"id":"https://openalex.org/C88478588","wikidata":"https://www.wikidata.org/wiki/Q42244","display_name":"Ribosome","level":4,"score":0.38719671964645386},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.37050050497055054},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.33769500255584717}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002499","descriptor_name":"Centrifugation, Density Gradient","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011132","descriptor_name":"Polyribosomes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012261","descriptor_name":"Ribonucleoproteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D012261","descriptor_name":"Ribonucleoproteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018922","descriptor_name":"HL-60 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020087","descriptor_name":"Alu Elements","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.274.20.14295","doi":"https://doi.org/10.1074/jbc.274.20.14295","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.274.20.14295","pdf_url":"http://www.jbc.org/article/S0021925819733031/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:10318851","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10318851","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.274.20.14295","doi":"https://doi.org/10.1074/jbc.274.20.14295","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.274.20.14295","pdf_url":"http://www.jbc.org/article/S0021925819733031/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322252","display_name":"Israel Science Foundation","ror":"https://ror.org/04sazxf24"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1985306591.pdf","grobid_xml":"https://content.openalex.org/works/W1985306591.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W155334109","https://openalex.org/W276882634","https://openalex.org/W801295046","https://openalex.org/W1531600133","https://openalex.org/W1536565076","https://openalex.org/W1556724116","https://openalex.org/W1572421367","https://openalex.org/W1607012020","https://openalex.org/W1948232468","https://openalex.org/W1966275499","https://openalex.org/W1978368163","https://openalex.org/W1980123375","https://openalex.org/W1983931221","https://openalex.org/W1989119084","https://openalex.org/W1989873806","https://openalex.org/W1998763890","https://openalex.org/W2000006956","https://openalex.org/W2008219986","https://openalex.org/W2014180493","https://openalex.org/W2027475006","https://openalex.org/W2031321924","https://openalex.org/W2045612031","https://openalex.org/W2048003501","https://openalex.org/W2049661143","https://openalex.org/W2050434777","https://openalex.org/W2060333964","https://openalex.org/W2066743380","https://openalex.org/W2076568433","https://openalex.org/W2080561378","https://openalex.org/W2083877419","https://openalex.org/W2085259673","https://openalex.org/W2093457298","https://openalex.org/W2095887872","https://openalex.org/W2103056147","https://openalex.org/W2105554008","https://openalex.org/W2113031608","https://openalex.org/W2116153438","https://openalex.org/W2116362436","https://openalex.org/W2121855902","https://openalex.org/W2122414439","https://openalex.org/W2127724574","https://openalex.org/W2135339028","https://openalex.org/W2150075316","https://openalex.org/W2155373804","https://openalex.org/W2165055107","https://openalex.org/W2166661434","https://openalex.org/W4254937892"],"related_works":["https://openalex.org/W2011225868","https://openalex.org/W2031321924","https://openalex.org/W2008235906","https://openalex.org/W7034473980","https://openalex.org/W1605400213","https://openalex.org/W2021232778","https://openalex.org/W2013096494","https://openalex.org/W1896196477","https://openalex.org/W1984500802","https://openalex.org/W2004381557"],"abstract_inverted_index":{"Eukaryotic":[0],"gene":[1],"expression":[2],"can":[3],"be":[4],"regulated":[5,44,169],"through":[6],"selective":[7],"translation":[8,28,73],"of":[9,17,23,29,32,54,66,101,109,146,154,172],"specific":[10,30,192],"mRNA":[11,106],"species.":[12],"Nevertheless,":[13],"the":[14,21,52,102,110,143,152,158,163],"limited":[15],"number":[16],"known":[18],"examples":[19],"hampers":[20],"identification":[22],"common":[24],"mechanisms":[25,180],"that":[26,80,165,182],"regulate":[27],"groups":[31],"genes":[33],"in":[34,57,142,157,190],"mammalian":[35],"cells.":[36],"We":[37],"developed":[38],"a":[39,139],"method":[40,47],"to":[41,50],"identify":[42],"translationally":[43],"genes.":[45,115],"This":[46],"was":[48,74,84,123,149],"used":[49],"examine":[51],"regulation":[53],"protein":[55,166],"synthesis":[56,167],"HL-60":[58,173],"cells":[59,174],"undergoing":[60],"monocytic":[61],"differentiation.":[62],"A":[63],"partial":[64],"screening":[65],"cellular":[67],"mRNAs":[68,71,94,148,156,187],"identified":[69,98],"five":[70,78],"whose":[72],"specifically":[75,92],"inhibited":[76,93],"and":[77,178,181],"others":[79],"were":[81],"activated":[82,111],"as":[83,99],"indicated":[85],"by":[86,175],"their":[87],"mobilization":[88],"onto":[89],"polysomes.":[90,159],"The":[91,116],"encoded":[95],"ribosomal":[96],"proteins,":[97],"members":[100],"5'-terminal":[103],"oligopyrimidine":[104],"tract":[105],"family.":[107],"Most":[108],"transcripts":[112],"represented":[113],"uncharacterized":[114],"most":[117],"actively":[118],"mobilized":[119],"transcript":[120],"(termed":[121],"TA-40)":[122],"an":[124],"untranslated":[125],"1.3-kilobase":[126],"polyadenylated":[127],"RNA":[128],"with":[129],"unusual":[130],"structural":[131],"features,":[132],"including":[133],"two":[134],"Alu-like":[135,183],"elements.":[136],"Following":[137],"differentiation,":[138],"significant":[140],"change":[141],"cytoplasmic":[144,186],"distribution":[145],"Alu-containing":[147,155],"observed,":[150],"namely,":[151],"enhancement":[153],"Our":[160],"findings":[161],"support":[162],"notion":[164],"is":[168],"during":[170],"differentiation":[171],"both":[176],"global":[177],"gene-specific":[179],"sequences":[184],"within":[185],"are":[188],"involved":[189],"such":[191],"regulation.":[193]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
