{"id":"https://openalex.org/W1985293066","doi":"https://doi.org/10.1111/j.1365-2125.1990.tb03788.x","title":"The effect of oral salbutamol on cation transport measured in vivo in healthy volunteers.","display_name":"The effect of oral salbutamol on cation transport measured in vivo in healthy volunteers.","publication_year":1990,"publication_date":"1990-09-01","ids":{"openalex":"https://openalex.org/W1985293066","doi":"https://doi.org/10.1111/j.1365-2125.1990.tb03788.x","mag":"1985293066","pmid":"https://pubmed.ncbi.nlm.nih.gov/2171617","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1368140"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2125.1990.tb03788.x","doi":"https://doi.org/10.1111/j.1365-2125.1990.tb03788.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2125.1990.tb03788.x","pdf_url":null,"source":{"id":"https://openalex.org/S13842274","display_name":"British Journal of Clinical Pharmacology","issn_l":"0306-5251","issn":["0306-5251","1365-2125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Clinical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1368140","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110090151","display_name":"AJ Wood","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"AJ Wood","raw_affiliation_strings":["University Department of Clinical Pharmacology, Radcliffe Infirmary, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Department of Clinical Pharmacology, Radcliffe Infirmary, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011755628","display_name":"CJ Brearley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"CJ Brearley","raw_affiliation_strings":["University Department of Clinical Pharmacology, Radcliffe Infirmary, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Department of Clinical Pharmacology, Radcliffe Infirmary, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109961014","display_name":"JK Aronson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"JK Aronson","raw_affiliation_strings":["University Department of Clinical Pharmacology, Radcliffe Infirmary, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Department of Clinical Pharmacology, Radcliffe Infirmary, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5105885211","display_name":"DG Grahame\u2010Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"DG Grahame\u2010Smith","raw_affiliation_strings":["University Department of Clinical Pharmacology, Radcliffe Infirmary, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Department of Clinical Pharmacology, Radcliffe Infirmary, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I40120149"],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":0.3588,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.50348685,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"30","issue":"3","first_page":"383","last_page":"390"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.8842999935150146,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.8842999935150146,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.06629999727010727,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.00800000037997961,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/salbutamol","display_name":"salbutamol","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cation-transport","display_name":"cation transport","score":0.8389999866485596},{"id":"https://openalex.org/keywords/na-k-atpase","display_name":"Na+/K+-ATPase","score":0.9330000281333923},{"id":"https://openalex.org/keywords/rubidium-chloride","display_name":"rubidium chloride","score":0.8009999990463257},{"id":"https://openalex.org/keywords/beta2-adrenergic-receptor","display_name":"beta2-adrenergic receptor","score":0.7940000295639038},{"id":"https://openalex.org/keywords/digoxin","display_name":"digoxin","score":0.7419999837875366},{"id":"https://openalex.org/keywords/essential-hypertension","display_name":"essential hypertension","score":0.9089999794960022},{"id":"https://openalex.org/keywords/catecholamines","display_name":"catecholamines","score":0.7760000228881836}],"concepts":[{"id":"https://openalex.org/C526903357","wikidata":"https://www.wikidata.org/wiki/Q895","display_name":"Rubidium","level":3,"score":0.9037452936172485},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.8117777109146118},{"id":"https://openalex.org/C2777394947","wikidata":"https://www.wikidata.org/wiki/Q410358","display_name":"Salbutamol","level":3,"score":0.7392167448997498},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.630824625492096},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.5280131697654724},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.5243011713027954},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5175303816795349},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4593657851219177},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4436458647251129},{"id":"https://openalex.org/C517785266","wikidata":"https://www.wikidata.org/wiki/Q703","display_name":"Potassium","level":2,"score":0.2633991241455078},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24532699584960938},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.23211562633514404},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2023189663887024},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16282585263252258},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000254","descriptor_name":"Sodium-Potassium-Exchanging ATPase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000420","descriptor_name":"Albuterol","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000420","descriptor_name":"Albuterol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002712","descriptor_name":"Chlorides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002712","descriptor_name":"Chlorides","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012413","descriptor_name":"Rubidium","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012413","descriptor_name":"Rubidium","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1111/j.1365-2125.1990.tb03788.x","doi":"https://doi.org/10.1111/j.1365-2125.1990.tb03788.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2125.1990.tb03788.x","pdf_url":null,"source":{"id":"https://openalex.org/S13842274","display_name":"British Journal of Clinical Pharmacology","issn_l":"0306-5251","issn":["0306-5251","1365-2125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Clinical Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1523190","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1368140","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:1368140","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1368140","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Clin Pharmacol","raw_type":"Text"},{"id":"pmid:2171617","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2171617","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of clinical pharmacology","raw_type":"Clinical Trial"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1523190","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1368140","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W600777048","https://openalex.org/W1544485440","https://openalex.org/W1556012018","https://openalex.org/W1965608795","https://openalex.org/W1978813831","https://openalex.org/W2001703458","https://openalex.org/W2006873483","https://openalex.org/W2012400732","https://openalex.org/W2018264703","https://openalex.org/W2029195875","https://openalex.org/W2031109036","https://openalex.org/W2037272627","https://openalex.org/W2072219714","https://openalex.org/W2072301891","https://openalex.org/W2093904586","https://openalex.org/W2130279752","https://openalex.org/W2138714790","https://openalex.org/W2162293702","https://openalex.org/W2165616253","https://openalex.org/W2170057124","https://openalex.org/W2297807256","https://openalex.org/W2309182002","https://openalex.org/W2338626728","https://openalex.org/W2341056698","https://openalex.org/W2394580934","https://openalex.org/W2397264234","https://openalex.org/W2407030480","https://openalex.org/W2418759563","https://openalex.org/W2432728646","https://openalex.org/W2437464446","https://openalex.org/W2437527898","https://openalex.org/W2468518287","https://openalex.org/W2614446243"],"related_works":["https://openalex.org/W2471817677","https://openalex.org/W2468518287","https://openalex.org/W2399717479","https://openalex.org/W2437527898","https://openalex.org/W4385730643","https://openalex.org/W2412327303","https://openalex.org/W4409378111","https://openalex.org/W2282877610","https://openalex.org/W40524529","https://openalex.org/W3184511517"],"abstract_inverted_index":{"1.":[0],"We":[1,185],"have":[2,174,197],"measured":[3],"the":[4,16,36,51,54,64,70,90,115,120,127,130,153,169,189],"effect":[5],"of":[6,18,22,38,53,57,67,105,117,129,158,171,219],"oral":[7,20,55],"salbutamol":[8,39,139,164],"on":[9],"cation":[10,141],"transport":[11,142],"in":[12,25,30,63,77,84,97,109,126,145,160,176,191,200,202],"vivo":[13,98,103,110,146,201],"by":[14,124],"studying":[15],"disposition":[17,162],"an":[19,61],"load":[21,56],"rubidium":[23,46,58,68,87,95,112,118,161,193],"chloride":[24],"healthy":[26],"treated":[27],"volunteers":[28],"and":[29],"untreated":[31],"matched":[32],"controls.":[33],"2.":[34],"During":[35],"administration":[37,52],"there":[40],"was":[41,81,122],"a":[42],"significantly":[43],"lower":[44],"plasma":[45,71,121],"concentration":[47],"5":[48],"h":[49],"after":[50,99,163],"chloride,":[59],"reflecting":[60],"increase":[62],"net":[65],"clearance":[66,116],"from":[69,119,168,214],"into":[72,147,152],"at":[73],"least":[74],"some":[75,148],"tissues":[76,149],"vivo.":[78],"3.":[79],"There":[80],"no":[82],"difference":[83],"either":[85],"intraerythrocytic":[86],"concentrations":[88],"or":[89,181,207],"pseudo-rate":[91],"constant":[92],"for":[93],"erythrocyte":[94,192],"uptake":[96,194],"salbutamol.":[100],"4.":[101],"Ex":[102],"incubation":[104],"whole":[106],"blood":[107],"preloaded":[108],"with":[111,178,204],"showed":[113],"that":[114,138,188],"inhibited":[123],"95%":[125],"presence":[128],"Na+,K(+)-ATPase":[131,144],"inhibitor":[132],"digoxin.":[133],"5.":[134],"These":[135],"data":[136],"suggest":[137,187],"stimulates":[140],"via":[143],"but":[150],"not":[151,212],"erythrocyte.":[154],"6.":[155],"This":[156],"pattern":[157],"change":[159,172],"is":[165],"completely":[166],"different":[167],"patterns":[170],"we":[173,196],"seen":[175],"patients":[177,203],"essential":[179,205],"hypertension":[180,206],"acute":[182,208],"manic":[183,209],"illness.":[184],"therefore":[186],"changes":[190],"which":[195],"previously":[198],"described":[199],"illness":[210],"do":[211],"result":[213],"beta":[215],"2-adrenoceptor-mediated":[216],"catecholamine":[217],"stimulation":[218],"Na+,K(+)-ATPase.":[220]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
