{"id":"https://openalex.org/W1985281044","doi":"https://doi.org/10.1080/07328319108046477","title":"Inhibition of Human Immunodeficiency Virus (HIV) Production by 5\u2032-Hydrogenphosphonates of 3\u2032-Azido-2\u2032,3\u2032- dideoxynucleosides","display_name":"Inhibition of Human Immunodeficiency Virus (HIV) Production by 5\u2032-Hydrogenphosphonates of 3\u2032-Azido-2\u2032,3\u2032- dideoxynucleosides","publication_year":1991,"publication_date":"1991-01-01","ids":{"openalex":"https://openalex.org/W1985281044","doi":"https://doi.org/10.1080/07328319108046477","mag":"1985281044"},"language":"en","primary_location":{"id":"doi:10.1080/07328319108046477","doi":"https://doi.org/10.1080/07328319108046477","is_oa":false,"landing_page_url":"https://doi.org/10.1080/07328319108046477","pdf_url":null,"source":{"id":"https://openalex.org/S4210177795","display_name":"Nucleosides and Nucleotides","issn_l":"0732-8311","issn":["0732-8311","2332-3892"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleosides and Nucleotides","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062420663","display_name":"Natalya B. Tarussqva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100098275","display_name":"Engelhardt Institute of Molecular Biology","ror":"https://ror.org/027hwkg23","country_code":"RU","type":"facility","lineage":["https://openalex.org/I100098275","https://openalex.org/I1313323035","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4405285364","display_name":"Academy of Sciences of the Soviet Union","ror":"https://ror.org/059mhqh10","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4405285364"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Natalya B. Tarussqva","raw_affiliation_strings":["a  V. Engelhardt Institute of Molecular Biology, the USSR Academy of Sciences , Vavilov str.32,  Moscow ,  117984 ,  USSR","V. Engelhardt Institute of Molecular Biology, the USSR Academy of Sciences , Vavilov str.32, Moscow , 117984 , USSR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a  V. Engelhardt Institute of Molecular Biology, the USSR Academy of Sciences , Vavilov str.32,  Moscow ,  117984 ,  USSR","institution_ids":["https://openalex.org/I100098275","https://openalex.org/I4405285364"]},{"raw_affiliation_string":"V. Engelhardt Institute of Molecular Biology, the USSR Academy of Sciences , Vavilov str.32, Moscow , 117984 , USSR","institution_ids":["https://openalex.org/I100098275","https://openalex.org/I4405285364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037409604","display_name":"Marina K. Kukhanova","orcid":"https://orcid.org/0000-0001-8464-437X","observed_orcids":["https://orcid.org/0000-0001-8464-437X"]},"institutions":[{"id":"https://openalex.org/I100098275","display_name":"Engelhardt Institute of Molecular Biology","ror":"https://ror.org/027hwkg23","country_code":"RU","type":"facility","lineage":["https://openalex.org/I100098275","https://openalex.org/I1313323035","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4405285364","display_name":"Academy of Sciences of the Soviet Union","ror":"https://ror.org/059mhqh10","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4405285364"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Marina K. Kukhanova","raw_affiliation_strings":["a  V. Engelhardt Institute of Molecular Biology, the USSR Academy of Sciences , Vavilov str.32,  Moscow ,  117984 ,  USSR","V. Engelhardt Institute of Molecular Biology, the USSR Academy of Sciences , Vavilov str.32, Moscow , 117984 , USSR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a  V. Engelhardt Institute of Molecular Biology, the USSR Academy of Sciences , Vavilov str.32,  Moscow ,  117984 ,  USSR","institution_ids":["https://openalex.org/I100098275","https://openalex.org/I4405285364"]},{"raw_affiliation_string":"V. Engelhardt Institute of Molecular Biology, the USSR Academy of Sciences , Vavilov str.32, Moscow , 117984 , USSR","institution_ids":["https://openalex.org/I100098275","https://openalex.org/I4405285364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110062249","display_name":"Alexander A. Krayevsky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100098275","display_name":"Engelhardt Institute of Molecular Biology","ror":"https://ror.org/027hwkg23","country_code":"RU","type":"facility","lineage":["https://openalex.org/I100098275","https://openalex.org/I1313323035","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4405285364","display_name":"Academy of Sciences of the Soviet Union","ror":"https://ror.org/059mhqh10","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4405285364"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Alexander A. Krayevsky","raw_affiliation_strings":["a  V. Engelhardt Institute of Molecular Biology, the USSR Academy of Sciences , Vavilov str.32,  Moscow ,  117984 ,  USSR","V. Engelhardt Institute of Molecular Biology, the USSR Academy of Sciences , Vavilov str.32, Moscow , 117984 , USSR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a  V. Engelhardt Institute of Molecular Biology, the USSR Academy of Sciences , Vavilov str.32,  Moscow ,  117984 ,  USSR","institution_ids":["https://openalex.org/I100098275","https://openalex.org/I4405285364"]},{"raw_affiliation_string":"V. Engelhardt Institute of Molecular Biology, the USSR Academy of Sciences , Vavilov str.32, Moscow , 117984 , USSR","institution_ids":["https://openalex.org/I100098275","https://openalex.org/I4405285364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015106322","display_name":"Karamov Ev","orcid":"https://orcid.org/0000-0003-1162-118X","observed_orcids":["https://orcid.org/0000-0003-1162-118X"]},"institutions":[{"id":"https://openalex.org/I4210101537","display_name":"D.I. Ivanovsky Institute of Virology Russian Academy of Medical Sciences","ror":"https://ror.org/017pcqs43","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210101537","https://openalex.org/I4210110862"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Edward K. Karamov","raw_affiliation_strings":["b  Ivanovskii Institute of Virology, the USSR Academy of Medical Sciences , Camaleya str.16.,  Moscow ,  123098 ,  USSR","Ivanovskii Institute of Virology, the USSR Academy of Medical Sciences , Camaleya str.16., Moscow , 123098 , USSR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"b  Ivanovskii Institute of Virology, the USSR Academy of Medical Sciences , Camaleya str.16.,  Moscow ,  123098 ,  USSR","institution_ids":["https://openalex.org/I4210101537"]},{"raw_affiliation_string":"Ivanovskii Institute of Virology, the USSR Academy of Medical Sciences , Camaleya str.16., Moscow , 123098 , USSR","institution_ids":["https://openalex.org/I4210101537"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113655903","display_name":"Vladimir V. Lukashov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210101537","display_name":"D.I. Ivanovsky Institute of Virology Russian Academy of Medical Sciences","ror":"https://ror.org/017pcqs43","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210101537","https://openalex.org/I4210110862"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Vladimir V. Lukashov","raw_affiliation_strings":["b  Ivanovskii Institute of Virology, the USSR Academy of Medical Sciences , Camaleya str.16.,  Moscow ,  123098 ,  USSR","Ivanovskii Institute of Virology, the USSR Academy of Medical Sciences , Camaleya str.16., Moscow , 123098 , USSR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"b  Ivanovskii Institute of Virology, the USSR Academy of Medical Sciences , Camaleya str.16.,  Moscow ,  123098 ,  USSR","institution_ids":["https://openalex.org/I4210101537"]},{"raw_affiliation_string":"Ivanovskii Institute of Virology, the USSR Academy of Medical Sciences , Camaleya str.16., Moscow , 123098 , USSR","institution_ids":["https://openalex.org/I4210101537"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031698374","display_name":"Galina B. Kornilayeva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210101537","display_name":"D.I. Ivanovsky Institute of Virology Russian Academy of Medical Sciences","ror":"https://ror.org/017pcqs43","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210101537","https://openalex.org/I4210110862"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Galina B. Kornilayeva","raw_affiliation_strings":["b  Ivanovskii Institute of Virology, the USSR Academy of Medical Sciences , Camaleya str.16.,  Moscow ,  123098 ,  USSR","Ivanovskii Institute of Virology, the USSR Academy of Medical Sciences , Camaleya str.16., Moscow , 123098 , USSR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"b  Ivanovskii Institute of Virology, the USSR Academy of Medical Sciences , Camaleya str.16.,  Moscow ,  123098 ,  USSR","institution_ids":["https://openalex.org/I4210101537"]},{"raw_affiliation_string":"Ivanovskii Institute of Virology, the USSR Academy of Medical Sciences , Camaleya str.16., Moscow , 123098 , USSR","institution_ids":["https://openalex.org/I4210101537"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050458178","display_name":"Mariana A. Rodina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210101537","display_name":"D.I. Ivanovsky Institute of Virology Russian Academy of Medical Sciences","ror":"https://ror.org/017pcqs43","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210101537","https://openalex.org/I4210110862"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Mariana A. Rodina","raw_affiliation_strings":["b  Ivanovskii Institute of Virology, the USSR Academy of Medical Sciences , Camaleya str.16.,  Moscow ,  123098 ,  USSR","Ivanovskii Institute of Virology, the USSR Academy of Medical Sciences , Camaleya str.16., Moscow , 123098 , USSR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"b  Ivanovskii Institute of Virology, the USSR Academy of Medical Sciences , Camaleya str.16.,  Moscow ,  123098 ,  USSR","institution_ids":["https://openalex.org/I4210101537"]},{"raw_affiliation_string":"Ivanovskii Institute of Virology, the USSR Academy of Medical Sciences , Camaleya str.16., Moscow , 123098 , USSR","institution_ids":["https://openalex.org/I4210101537"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070795917","display_name":"Georgii A. Galecov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210101537","display_name":"D.I. Ivanovsky Institute of Virology Russian Academy of Medical Sciences","ror":"https://ror.org/017pcqs43","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210101537","https://openalex.org/I4210110862"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Georgii A. Galecov","raw_affiliation_strings":["b  Ivanovskii Institute of Virology, the USSR Academy of Medical Sciences , Camaleya str.16.,  Moscow ,  123098 ,  USSR","Ivanovskii Institute of Virology, the USSR Academy of Medical Sciences , Camaleya str.16., Moscow , 123098 , USSR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"b  Ivanovskii Institute of Virology, the USSR Academy of Medical Sciences , Camaleya str.16.,  Moscow ,  123098 ,  USSR","institution_ids":["https://openalex.org/I4210101537"]},{"raw_affiliation_string":"Ivanovskii Institute of Virology, the USSR Academy of Medical Sciences , Camaleya str.16., Moscow , 123098 , USSR","institution_ids":["https://openalex.org/I4210101537"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.4517,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.88694097,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"10","issue":"1-3","first_page":"351","last_page":"354"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11748","display_name":"Organophosphorus compounds synthesis","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.7720000147819519},{"id":"https://openalex.org/keywords/hiv-replication-inhibition","display_name":"HIV replication inhibition","score":0.5360000133514404},{"id":"https://openalex.org/keywords/nucleoside-analogs","display_name":"nucleoside analogues","score":0.656000018119812},{"id":"https://openalex.org/keywords/thymidine","display_name":"thymidine","score":0.46700000762939453},{"id":"https://openalex.org/keywords/mt-4-cells","display_name":"MT-4 cells","score":0.6480000019073486},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.6840000152587891},{"id":"https://openalex.org/keywords/antiviral-agents","display_name":"antiviral agents","score":0.593999981880188}],"concepts":[{"id":"https://openalex.org/C2776858809","wikidata":"https://www.wikidata.org/wiki/Q171973","display_name":"Thymine","level":3,"score":0.7929260730743408},{"id":"https://openalex.org/C2776023528","wikidata":"https://www.wikidata.org/wiki/Q178425","display_name":"Cytosine","level":3,"score":0.7584527730941772},{"id":"https://openalex.org/C2778301229","wikidata":"https://www.wikidata.org/wiki/Q169313","display_name":"Guanine","level":4,"score":0.7037423253059387},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.5745546817779541},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4618259072303772},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4577163755893707},{"id":"https://openalex.org/C59659247","wikidata":"https://www.wikidata.org/wiki/Q11990","display_name":"Reproduction","level":2,"score":0.4574519693851471},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4391915202140808},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3235524892807007},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2803686857223511},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.2013832926750183},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16280853748321533},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.13828369975090027},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05243811011314392}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1080/07328319108046477","doi":"https://doi.org/10.1080/07328319108046477","is_oa":false,"landing_page_url":"https://doi.org/10.1080/07328319108046477","pdf_url":null,"source":{"id":"https://openalex.org/S4210177795","display_name":"Nucleosides and Nucleotides","issn_l":"0732-8311","issn":["0732-8311","2332-3892"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleosides and Nucleotides","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W1969043735","https://openalex.org/W1997527001","https://openalex.org/W2027507631","https://openalex.org/W2033686111","https://openalex.org/W2143773220"],"related_works":["https://openalex.org/W2398056123","https://openalex.org/W2044929983","https://openalex.org/W2044338195","https://openalex.org/W6986438814","https://openalex.org/W2000081479","https://openalex.org/W2026457717","https://openalex.org/W1966780168","https://openalex.org/W2080334256","https://openalex.org/W6991941007","https://openalex.org/W2021968908"],"abstract_inverted_index":{"3\u2032-Azido-2\u2032.3\u2032-dideoxynucleoside":[0],"5\u2032-hydrogenphos-phonates":[1],"with":[2,37],"thymine,":[3],"adenine,":[4],"guanine":[5],"and":[6],"cytosine":[7],"bases":[8],"inhibit":[9],"HIV-1":[10],"reproduction":[11],"In":[12],"MT4":[13],"cell":[14],"cultures.":[15],"The":[16],"most":[17],"active":[18],"was":[19],"5\u2032-hydrogenphosphonate":[20],"of":[21,25,39],"3\u2032-azldo-2\u2032,3\u2032-dideoxythymidlne.":[22],"Equi-molar":[23],"mixture":[24],"all":[26],"four":[27],"hydrogenphosphonates":[28],"is":[29],"shorn":[30],"to":[31],"be":[32],"less":[33],"toxic":[34],"in":[35],"comparison":[36],"each":[38],"compounds":[40],"taken":[41],"separately.":[42]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-06-24T00:00:00"}