{"id":"https://openalex.org/W1985264665","doi":"https://doi.org/10.1016/s1074-7613(00)80651-2","title":"TdT-Accessible Breaks Are Scattered over the Immunoglobulin V Domain in a Constitutively Hypermutating B Cell Line","display_name":"TdT-Accessible Breaks Are Scattered over the Immunoglobulin V Domain in a Constitutively Hypermutating B Cell Line","publication_year":1998,"publication_date":"1998-12-01","ids":{"openalex":"https://openalex.org/W1985264665","doi":"https://doi.org/10.1016/s1074-7613(00)80651-2","mag":"1985264665","pmid":"https://pubmed.ncbi.nlm.nih.gov/9881976"},"language":"en","primary_location":{"id":"doi:10.1016/s1074-7613(00)80651-2","doi":"https://doi.org/10.1016/s1074-7613(00)80651-2","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1074-7613(00)80651-2","pdf_url":"http://www.cell.com/article/S1074761300806512/pdf","source":{"id":"https://openalex.org/S199671312","display_name":"Immunity","issn_l":"1074-7613","issn":["1074-7613","1097-4180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunity","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1985264665"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.cell.com/article/S1074761300806512/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014144359","display_name":"Julian E. Sale","orcid":"https://orcid.org/0000-0002-5031-3780","observed_orcids":["https://orcid.org/0000-0002-5031-3780"]},"institutions":[{"id":"https://openalex.org/I170203145","display_name":"MRC Laboratory of Molecular Biology","ror":"https://ror.org/00tw3jy02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I170203145","https://openalex.org/I4210087105","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Julian E Sale","raw_affiliation_strings":["Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom","Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I170203145","https://openalex.org/I90344618"]},{"raw_affiliation_string":"Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, United Kingdom","institution_ids":["https://openalex.org/I170203145","https://openalex.org/I90344618"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018578853","display_name":"Michael S. Neuberger","orcid":"https://orcid.org/0000-0001-8453-5325","observed_orcids":["https://orcid.org/0000-0001-8453-5325"]},"institutions":[{"id":"https://openalex.org/I170203145","display_name":"MRC Laboratory of Molecular Biology","ror":"https://ror.org/00tw3jy02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I170203145","https://openalex.org/I4210087105","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Michael S Neuberger","raw_affiliation_strings":["Medical Research Council Laboratory, of Molecular Biology, Hills Road, Cambridge, CB2 2QH, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Council Laboratory, of Molecular Biology, Hills Road, Cambridge, CB2 2QH, United Kingdom","institution_ids":["https://openalex.org/I170203145","https://openalex.org/I90344618"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5018578853"],"corresponding_institution_ids":["https://openalex.org/I170203145","https://openalex.org/I90344618"],"apc_list":{"value":10400,"currency":"USD","value_usd":10400},"apc_paid":null,"fwci":5.6196,"has_fulltext":false,"cited_by_count":259,"citation_normalized_percentile":{"value":0.97163808,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"9","issue":"6","first_page":"859","last_page":"869"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9541000127792358,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9541000127792358,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.02459999918937683,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/somatic-hypermutation","display_name":"somatic hypermutation","score":0.9900000095367432},{"id":"https://openalex.org/keywords/terminal-deoxynucleotidyl-transferase","display_name":"terminal deoxynucleotidyl transferase","score":0.9300000071525574},{"id":"https://openalex.org/keywords/burkitt-lymphoma-cell-lines","display_name":"Burkitt lymphoma cell lines","score":0.8870000243186951},{"id":"https://openalex.org/keywords/nucleotide-substitution-patterns","display_name":"nucleotide substitution patterns","score":0.5860000252723694},{"id":"https://openalex.org/keywords/stop-codon-mutation","display_name":"stop codon mutation","score":0.8069999814033508},{"id":"https://openalex.org/keywords/dna-strand-breaks","display_name":"DNA strand breaks","score":0.9480000138282776},{"id":"https://openalex.org/keywords/antibody-diversification","display_name":"antibody diversification","score":0.6370000243186951}],"concepts":[{"id":"https://openalex.org/C128526571","wikidata":"https://www.wikidata.org/wiki/Q619302","display_name":"Somatic hypermutation","level":4,"score":0.9901731610298157},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8259615302085876},{"id":"https://openalex.org/C154113507","wikidata":"https://www.wikidata.org/wiki/Q411149","display_name":"Terminal deoxynucleotidyl transferase","level":4,"score":0.5119653940200806},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5096683502197266},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5007894039154053},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5007266998291016},{"id":"https://openalex.org/C3020196193","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Immunoglobulin gene","level":3,"score":0.49806952476501465},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.49753621220588684},{"id":"https://openalex.org/C109825262","wikidata":"https://www.wikidata.org/wiki/Q1139164","display_name":"Germline","level":3,"score":0.450035035610199},{"id":"https://openalex.org/C2777563447","wikidata":"https://www.wikidata.org/wiki/Q7243397","display_name":"Primer (cosmetics)","level":2,"score":0.44763267040252686},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.4377537965774536},{"id":"https://openalex.org/C137756551","wikidata":"https://www.wikidata.org/wiki/Q2386881","display_name":"Immunoglobulin class switching","level":4,"score":0.42624953389167786},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.3757999837398529},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.31305766105651855},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.15076470375061035},{"id":"https://openalex.org/C196795494","wikidata":"https://www.wikidata.org/wiki/Q1624817","display_name":"TUNEL assay","level":3,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004253","descriptor_name":"DNA Nucleotidylexotransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007075","descriptor_name":"Immunoglobulin M","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007127","descriptor_name":"Immunoglobulin Constant Regions","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007135","descriptor_name":"Immunoglobulin Variable Region","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007143","descriptor_name":"Immunoglobulin Heavy Chains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007146","descriptor_name":"Immunoglobulin lambda-Chains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007148","descriptor_name":"Immunoglobulin mu-Chains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016254","descriptor_name":"Mutagenesis, Insertional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s1074-7613(00)80651-2","doi":"https://doi.org/10.1016/s1074-7613(00)80651-2","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1074-7613(00)80651-2","pdf_url":"http://www.cell.com/article/S1074761300806512/pdf","source":{"id":"https://openalex.org/S199671312","display_name":"Immunity","issn_l":"1074-7613","issn":["1074-7613","1097-4180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunity","raw_type":"journal-article"},{"id":"pmid:9881976","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9881976","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunity","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s1074-7613(00)80651-2","doi":"https://doi.org/10.1016/s1074-7613(00)80651-2","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1074-7613(00)80651-2","pdf_url":"http://www.cell.com/article/S1074761300806512/pdf","source":{"id":"https://openalex.org/S199671312","display_name":"Immunity","issn_l":"1074-7613","issn":["1074-7613","1097-4180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunity","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W1985264665.pdf"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W272348287","https://openalex.org/W1489478691","https://openalex.org/W1568859377","https://openalex.org/W1591208477","https://openalex.org/W1964508280","https://openalex.org/W1974654770","https://openalex.org/W1976118880","https://openalex.org/W1978573222","https://openalex.org/W1980031804","https://openalex.org/W1986884580","https://openalex.org/W1993187913","https://openalex.org/W1998675277","https://openalex.org/W2008113420","https://openalex.org/W2010776654","https://openalex.org/W2016446495","https://openalex.org/W2016449703","https://openalex.org/W2017942290","https://openalex.org/W2018008391","https://openalex.org/W2021236910","https://openalex.org/W2021690185","https://openalex.org/W2025028594","https://openalex.org/W2028296100","https://openalex.org/W2031549362","https://openalex.org/W2039333182","https://openalex.org/W2042602909","https://openalex.org/W2046230910","https://openalex.org/W2052084059","https://openalex.org/W2066178148","https://openalex.org/W2070341297","https://openalex.org/W2070646447","https://openalex.org/W2072653621","https://openalex.org/W2073497058","https://openalex.org/W2083364374","https://openalex.org/W2085369521","https://openalex.org/W2090092347","https://openalex.org/W2104824773","https://openalex.org/W2120490035","https://openalex.org/W2127933387","https://openalex.org/W2137995685","https://openalex.org/W2138563232","https://openalex.org/W2149674109","https://openalex.org/W2150414930","https://openalex.org/W2153318424","https://openalex.org/W2159866133","https://openalex.org/W2165225696","https://openalex.org/W2169156878","https://openalex.org/W2170343590","https://openalex.org/W2274943243","https://openalex.org/W2396823695","https://openalex.org/W4242524636"],"related_works":["https://openalex.org/W1968950713","https://openalex.org/W2137189278","https://openalex.org/W2154789144","https://openalex.org/W2136960636","https://openalex.org/W1907143774","https://openalex.org/W2017439782","https://openalex.org/W1976229535","https://openalex.org/W2042233605","https://openalex.org/W2013310889","https://openalex.org/W1964549581"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}