{"id":"https://openalex.org/W1985260685","doi":"https://doi.org/10.1158/1538-7445.am2014-pl01-02","title":"Abstract PL01-02: The two faces of p53: Tumor suppressor and oncogene","display_name":"Abstract PL01-02: The two faces of p53: Tumor suppressor and oncogene","publication_year":2014,"publication_date":"2014-10-01","ids":{"openalex":"https://openalex.org/W1985260685","doi":"https://doi.org/10.1158/1538-7445.am2014-pl01-02","mag":"1985260685"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2014-pl01-02","doi":"https://doi.org/10.1158/1538-7445.am2014-pl01-02","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2014-pl01-02","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080267048","display_name":"Carol L. Prives","orcid":"https://orcid.org/0000-0003-1846-5562","observed_orcids":["https://orcid.org/0000-0003-1846-5562"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Carol L. Prives","raw_affiliation_strings":["Columbia University, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia University, New York, NY","institution_ids":["https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5080267048"],"corresponding_institution_ids":["https://openalex.org/I78577930"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"74","issue":"19_Supplement","first_page":"PL01","last_page":"02"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.7720000147819519},{"id":"https://openalex.org/keywords/oncogenic-p53","display_name":"oncogenic p53","score":0.7549999952316284},{"id":"https://openalex.org/keywords/mdm2","display_name":"MDM2","score":0.9319999814033508},{"id":"https://openalex.org/keywords/mdmx","display_name":"MDMX","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tab1","display_name":"TAB1","score":0.8479999899864197},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.7699999809265137},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7099999785423279},{"id":"https://openalex.org/keywords/mevalonate-pathway","display_name":"mevalonate pathway","score":0.8889999985694885},{"id":"https://openalex.org/keywords/srebp-2","display_name":"SREBP2","score":0.9769999980926514},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.859000027179718},{"id":"https://openalex.org/keywords/3d-cell-culture","display_name":"3D cell culture","score":0.7699999809265137},{"id":"https://openalex.org/keywords/e3-ubiquitin-ligase","display_name":"E3 ubiquitin ligase","score":0.7239999771118164},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.41200000047683716},{"id":"https://openalex.org/keywords/cell-death","display_name":"cell death","score":0.31700000166893005},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.6039999723434448},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.6430000066757202}],"concepts":[{"id":"https://openalex.org/C2777221213","wikidata":"https://www.wikidata.org/wiki/Q10322346","display_name":"MDMX","level":4,"score":0.8072912693023682},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7527017593383789},{"id":"https://openalex.org/C2776192174","wikidata":"https://www.wikidata.org/wiki/Q18028978","display_name":"Mdm2","level":3,"score":0.6249609589576721},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5722092390060425},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5429103970527649},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.5303885340690613},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.515224039554596},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.4602372646331787},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.45370808243751526},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.44146114587783813},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.43465954065322876},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.43003609776496887},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4294660687446594},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.42785540223121643},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.42454060912132263},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.421478807926178},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3969478905200958},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.36729490756988525},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2758283019065857}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2014-pl01-02","doi":"https://doi.org/10.1158/1538-7445.am2014-pl01-02","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2014-pl01-02","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3157276830","https://openalex.org/W2612972498","https://openalex.org/W7099462791","https://openalex.org/W2804712232","https://openalex.org/W191531438","https://openalex.org/W2471561735","https://openalex.org/W2026367424","https://openalex.org/W2512831568","https://openalex.org/W7097429407","https://openalex.org/W2150144117"],"abstract_inverted_index":{"Abstract":[0],"The":[1,219,592],"p53":[2,49,58,64,88,114,122,148,181,197,223,242,265,281,325,380,481],"protein":[3,217,311],"is":[4,31,65,198,204,296,338,374,442,450,470,541],"a":[5,51,261,399,416,423,439,454,463,476,502,555,564],"sequence-specific":[6],"transcriptional":[7,52,504],"regulator":[8],"of":[9,87,121,138,153,170,179,208,221,229,254,269,279,321,351,379,386,402,446,465,475,479,509,529,557,576,585,595,604,609],"multiple":[10],"genes":[11,173,285,483],"that":[12,43,83,146,203,295,304,336,344,461,506,580],"control":[13],"processes":[14],"associated":[15],"with":[16,246,515],"tumor":[17,71,410,566],"suppression":[18],"such":[19,97],"as":[20,50,98,116,118,210,212,415,449,453,563],"cell":[21,24,156,362,491,537],"cycle":[22],"arrest,":[23],"death,":[25],"senescence,":[26],"and":[27,41,54,69,77,103,123,266,286,315,326,383,422,436,486,553,574,599],"metabolic":[28],"homeostasis.":[29],"It":[30],"held":[32],"in":[33,45,59,90,112,159,185,233,282,347,369,391,398,409,438,488,546,551,554,582],"check":[34],"by":[35,195,298,367,381,431],"two":[36,593],"closely":[37],"related":[38],"proteins,":[39],"Mdm2":[40,322,435],"MdmX,":[42],"work":[44],"concert":[46],"to":[47,56,94,192,224,353,388,532],"repress":[48],"activator":[53],"also":[55,288],"degrade":[57],"unstressed":[60],"cells.":[61,372,393],"While":[62],"wild-type":[63,280],"an":[66,443],"extensively":[67],"studied":[68],"validated":[70],"suppressor,":[72],"epidemiological":[73],"studies,":[74],"mouse":[75],"models":[76],"cell-based":[78],"assays":[79],"support":[80],"the":[81,84,134,150,189,199,226,238,247,277,317,384,429,466,526,572,605,610],"likelihood":[82],"mutant":[85,147,180,196,222,243,264,299],"forms":[86,584],"found":[89,460],"many":[91],"tumors":[92,404,550],"contribute":[93],"oncogenic":[95],"characteristics":[96],"malignant":[99,151,227],"morphology,":[100],"motility,":[101],"invasion":[102],"metastasis.":[104],"Our":[105],"recent":[106],"studies":[107],"have":[108,132,287],"revealed":[109],"novel":[110],"pathways":[111,364],"which":[113,432],"operates":[115],"well":[117,211],"new":[119],"regulators":[120],"Mdm2.":[124],"In":[125],"each":[126],"case":[127],"datasets":[128,259],"from":[129,521],"cancer":[130,155,231,258,292,490],"patients":[131],"supported":[133],"potential":[135,455,565],"clinical":[136],"relevance":[137],"our":[139,447],"basic":[140],"research":[141,448],"findings.":[142],"First,":[143],"we":[144,302,459],"discovered":[145,335],"regulates":[149,434],"phenotype":[152],"breast":[154,230],"lines":[157,492],"grown":[158],"3D":[160,234],"culture":[161],"conditions":[162],"(Freed-Pastor":[163],"et":[164,329,494],"al.,":[165,495],"Cell":[166,497],"2012).":[167,498],"Expression":[168],"levels":[169,178,350,395],"over":[171],"1000":[172],"are":[174,182,274,365,396,569],"significantly":[175,542],"altered":[176],"when":[177],"experimentally":[183],"manipulated":[184],"this":[186],"setting.":[187],"Among":[188],"gene":[190],"sets":[191],"be":[193],"affected":[194],"mevalonate":[200],"(MVA)":[201],"pathway":[202,294],"responsible":[205],"for":[206,216,252,376,472,613],"biosynthesis":[207],"cholesterol":[209],"key":[213,424],"intermediates":[214],"required":[215,251,375,471],"prenylation.":[218],"ability":[220,385],"regulate":[225],"morphology":[228],"cells":[232],"cultures":[235],"likely":[236],"requires":[237],"MVA":[239,255,271,284],"pathway.":[240,427],"A":[241],"can":[244,313],"cooperate":[245],"SREBP2":[248],"transcription":[249,253],"factor":[250],"genes.":[256,272],"Breast":[257],"indicate":[260],"correlation":[262],"between":[263,419],"increased":[267,536],"expression":[268,474,540],"some":[270,583],"We":[273,334,568],"currently":[275,570],"examining":[276,451,571],"role":[278,408,505,562],"regulating":[283],"identified":[289],"another":[290],"highly":[291],"relevant":[293],"regulated":[297,366],"p53.":[300],"Second,":[301],"showed":[303],"TAB":[305],"1":[306,309],"(TGF\u03b2-activated":[307],"kinase":[308],"(TAK1)-binding":[310],"1)":[312],"bind":[314],"inhibit":[316],"E3":[318],"ligase":[319],"activity":[320],"towards":[323],"both":[324,377],"MdmX":[327,387,437],"(Zhu":[328],"al.":[330],"Genes":[331],"Dev":[332],"2013).":[333],"cisplatin":[337,370],"unique":[339],"among":[340],"diverse":[341],"chemotherapeutic":[342],"agents":[343],"were":[345],"tested":[346,480],"requiring":[348],"full":[349],"TAB1":[352,368,373,394,412,433,452],"produce":[354],"p53-dependent":[355],"apoptosis.":[356],"Two":[357],"separate":[358],"but":[359],"possibly":[360],"interrelated":[361],"death":[363],"treated":[371],"phosphorylation":[378],"p38":[382],"facilitate":[389],"apoptosis":[390],"cisplatin-treated":[392],"reduced":[397],"significant":[400],"fraction":[401,556],"ovarian":[403],"indicating":[405],"its":[406,516,561],"possible":[407],"suppression.":[411],"therefore":[413],"serves":[414],"functional":[417],"link":[418],"p53-MDM2":[420],"circuitry":[421],"MAPK":[425],"signaling":[426],"Elucidating":[428],"mechanism":[430],"cisplatin-specific":[440],"manner":[441],"ongoing":[444],"focus":[445],"therapeutic":[456],"target.":[457],"Third,":[458],"Nup98,":[462],"component":[464],"nuclear":[467],"pore":[468],"complex":[469,513],"selective":[473],"small":[477],"subset":[478],"target":[482],"(eg.":[484],"p21":[485,510],"14-3-3-sigma)":[487],"liver":[489],"(Singer":[493],"Mol.":[496],"Interestingly,":[499],"Nup98":[500,530,539,577],"plays":[501],"post":[503],"involves":[507],"stabilization":[508],"mRNA":[511],"via":[512],"formation":[514],"3\u2019UTR,":[517],"thereby":[518],"protecting":[519],"it":[520],"exosomal":[522],"degradation.":[523],"Depending":[524],"on":[525],"setting,":[527],"depletion":[528],"leads":[531],"decreased":[533],"senescence":[534],"or":[535],"death.":[538],"lower":[543],"than":[544],"normal":[545],"hepatocellular":[547],"carcinoma":[548],"(HCC)":[549],"mice":[552],"human":[558],"HCCs,":[559],"suggesting":[560],"suppressor.":[567],"roles":[573],"activities":[575],"fusion":[578],"proteins":[579],"occur":[581],"leukemia.":[586],"Citation":[587],"Format:":[588],"Carol":[589],"L.":[590],"Prives.":[591],"faces":[594],"p53:":[596],"Tumor":[597],"suppressor":[598],"oncogene.":[600],"[abstract].":[601],"In:":[602],"Proceedings":[603],"105th":[606],"Annual":[607],"Meeting":[608],"American":[611],"Association":[612],"Cancer":[614,625],"Research;":[615],"2014":[616],"Apr":[617],"5-9;":[618],"San":[619],"Diego,":[620],"CA.":[621],"Philadelphia":[622],"(PA):":[623],"AACR;":[624],"Res":[626],"2014;74(19":[627],"Suppl):Abstract":[628],"nr":[629],"PL01-02.":[630],"doi:10.1158/1538-7445.AM2014-PL01-02":[631]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}