{"id":"https://openalex.org/W1985255852","doi":"https://doi.org/10.1111/j.1439-0396.2007.00727.x","title":"The effect of dietary l \u2010carnitine supplementation on pulmonary hypertension syndrome mortality in broilers exposed to low temperatures","display_name":"The effect of dietary l \u2010carnitine supplementation on pulmonary hypertension syndrome mortality in broilers exposed to low temperatures","publication_year":2007,"publication_date":"2007-09-14","ids":{"openalex":"https://openalex.org/W1985255852","doi":"https://doi.org/10.1111/j.1439-0396.2007.00727.x","mag":"1985255852","pmid":"https://pubmed.ncbi.nlm.nih.gov/18336417"},"language":"en","primary_location":{"id":"doi:10.1111/j.1439-0396.2007.00727.x","doi":"https://doi.org/10.1111/j.1439-0396.2007.00727.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1439-0396.2007.00727.x","pdf_url":null,"source":{"id":"https://openalex.org/S77728970","display_name":"Journal of Animal Physiology and Animal Nutrition","issn_l":"0931-2439","issn":["0931-2439","1439-0396"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Animal Physiology and Animal Nutrition","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001136827","display_name":"Xun Tan","orcid":"https://orcid.org/0000-0002-0897-9052","observed_orcids":["https://orcid.org/0000-0002-0897-9052"]},"institutions":[{"id":"https://openalex.org/I119454577","display_name":"Nanjing Agricultural University","ror":"https://ror.org/05td3s095","country_code":"CN","type":"education","lineage":["https://openalex.org/I119454577"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"X. Tan","raw_affiliation_strings":["Department of Veterinary Medicine, Zhejiang University, Hangzhou, China, and Institute of Nutritional and Metabolic Disorders in Domestic Animals and Fowls, Nanjing Agricultural University, Nanjing, China. tanxun@zju.edu.cn","Department of Veterinary Medicine, Zhejiang University, Hangzhou, China, and","Institute of Nutritional and Metabolic Disorders in Domestic Animals and Fowls, Nanjing Agricultural University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Medicine, Zhejiang University, Hangzhou, China, and Institute of Nutritional and Metabolic Disorders in Domestic Animals and Fowls, Nanjing Agricultural University, Nanjing, China. tanxun@zju.edu.cn","institution_ids":["https://openalex.org/I119454577","https://openalex.org/I76130692"]},{"raw_affiliation_string":"Department of Veterinary Medicine, Zhejiang University, Hangzhou, China, and","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Institute of Nutritional and Metabolic Disorders in Domestic Animals and Fowls, Nanjing Agricultural University, Nanjing, China","institution_ids":["https://openalex.org/I119454577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047865815","display_name":"Songhua Hu","orcid":"https://orcid.org/0000-0002-8266-6791","observed_orcids":["https://orcid.org/0000-0002-8266-6791"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"S. H. Hu","raw_affiliation_strings":["Department of Veterinary Medicine, Zhejiang University, Hangzhou, China, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Medicine, Zhejiang University, Hangzhou, China, and","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028082594","display_name":"X. L. Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119454577","display_name":"Nanjing Agricultural University","ror":"https://ror.org/05td3s095","country_code":"CN","type":"education","lineage":["https://openalex.org/I119454577"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"X. L. Wang","raw_affiliation_strings":["Institute of Nutritional and Metabolic Disorders in Domestic Animals and Fowls, Nanjing Agricultural University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Nutritional and Metabolic Disorders in Domestic Animals and Fowls, Nanjing Agricultural University, Nanjing, China","institution_ids":["https://openalex.org/I119454577"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5001136827"],"corresponding_institution_ids":["https://openalex.org/I119454577","https://openalex.org/I76130692"],"apc_list":{"value":4650,"currency":"USD","value_usd":4650},"apc_paid":null,"fwci":0.5194,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.67595633,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"92","issue":"2","first_page":"203","last_page":"210"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10152","display_name":"Animal Nutrition and Physiology","score":0.9643999934196472,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10152","display_name":"Animal Nutrition and Physiology","score":0.9643999934196472,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.012000000104308128,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10333","display_name":"Meat and Animal Product Quality","score":0.010200000368058681,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/l-carnitine","display_name":"L-carnitine","score":0.8679999709129333},{"id":"https://openalex.org/keywords/pulmonary-hypertension-syndrome","display_name":"pulmonary hypertension syndrome","score":0.9269999861717224},{"id":"https://openalex.org/keywords/broiler-chickens","display_name":"broiler chickens","score":0.8199999928474426},{"id":"https://openalex.org/keywords/cold-exposure","display_name":"cold exposure","score":0.8989999890327454},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9100000262260437},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":0.8709999918937683},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":1.0},{"id":"https://openalex.org/keywords/pulmonary-vascular-remodeling","display_name":"pulmonary vascular remodeling","score":0.9490000009536743},{"id":"https://openalex.org/keywords/right-ventricle-left-ventricle-ratio","display_name":"right ventricle/left ventricle ratio","score":0.8569999933242798},{"id":"https://openalex.org/keywords/heart-weight","display_name":"heart weight","score":0.8529999852180481},{"id":"https://openalex.org/keywords/dietary-supplementation","display_name":"dietary supplementation","score":0.7080000042915344}],"concepts":[{"id":"https://openalex.org/C2780289900","wikidata":"https://www.wikidata.org/wiki/Q326301","display_name":"Broiler","level":2,"score":0.8505045175552368},{"id":"https://openalex.org/C2778401633","wikidata":"https://www.wikidata.org/wiki/Q418661","display_name":"Malondialdehyde","level":3,"score":0.8401358127593994},{"id":"https://openalex.org/C2778435403","wikidata":"https://www.wikidata.org/wiki/Q243309","display_name":"Carnitine","level":2,"score":0.8290463089942932},{"id":"https://openalex.org/C2778921608","wikidata":"https://www.wikidata.org/wiki/Q2002035","display_name":"Ventricle","level":2,"score":0.7178378105163574},{"id":"https://openalex.org/C140793950","wikidata":"https://www.wikidata.org/wiki/Q168091","display_name":"Animal science","level":1,"score":0.611900269985199},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.5736352205276489},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5321826934814453},{"id":"https://openalex.org/C2780930700","wikidata":"https://www.wikidata.org/wiki/Q1128595","display_name":"Pulmonary hypertension","level":2,"score":0.5140045881271362},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.46111416816711426},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.44909319281578064},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.3936891257762909},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3892871141433716},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37109655141830444},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29233819246292114},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002331","descriptor_name":"Carnitine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002331","descriptor_name":"Carnitine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002645","descriptor_name":"Chickens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003080","descriptor_name":"Cold Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006976","descriptor_name":"Hypertension, Pulmonary","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D006976","descriptor_name":"Hypertension, Pulmonary","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D006976","descriptor_name":"Hypertension, Pulmonary","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008315","descriptor_name":"Malondialdehyde","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011201","descriptor_name":"Poultry Diseases","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D011201","descriptor_name":"Poultry Diseases","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015430","descriptor_name":"Weight Gain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019587","descriptor_name":"Dietary Supplements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1439-0396.2007.00727.x","doi":"https://doi.org/10.1111/j.1439-0396.2007.00727.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1439-0396.2007.00727.x","pdf_url":null,"source":{"id":"https://openalex.org/S77728970","display_name":"Journal of Animal Physiology and Animal Nutrition","issn_l":"0931-2439","issn":["0931-2439","1439-0396"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Animal Physiology and Animal Nutrition","raw_type":"journal-article"},{"id":"pmid:18336417","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18336417","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of animal physiology and animal nutrition","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W48493471","https://openalex.org/W161895620","https://openalex.org/W198227269","https://openalex.org/W1505324034","https://openalex.org/W1510592624","https://openalex.org/W1566835131","https://openalex.org/W1944925433","https://openalex.org/W1976083704","https://openalex.org/W1981916592","https://openalex.org/W1988629484","https://openalex.org/W2000656455","https://openalex.org/W2001899245","https://openalex.org/W2002250342","https://openalex.org/W2014085643","https://openalex.org/W2015265977","https://openalex.org/W2015312259","https://openalex.org/W2017244423","https://openalex.org/W2032402373","https://openalex.org/W2043053568","https://openalex.org/W2056426560","https://openalex.org/W2058746157","https://openalex.org/W2060588008","https://openalex.org/W2063392869","https://openalex.org/W2072322276","https://openalex.org/W2088646648","https://openalex.org/W2102083512","https://openalex.org/W2103607730","https://openalex.org/W2104874461","https://openalex.org/W2116709741","https://openalex.org/W2127370389","https://openalex.org/W2131149472","https://openalex.org/W2134827039","https://openalex.org/W2149700377","https://openalex.org/W2152760161","https://openalex.org/W2155688880","https://openalex.org/W2158802782","https://openalex.org/W2161877652","https://openalex.org/W2162104981","https://openalex.org/W2163447693","https://openalex.org/W2164875096","https://openalex.org/W2232974275","https://openalex.org/W2325861715","https://openalex.org/W2341635912","https://openalex.org/W2404458124","https://openalex.org/W2409227388","https://openalex.org/W3001796133","https://openalex.org/W4301016938"],"related_works":["https://openalex.org/W1981710007","https://openalex.org/W2068006400","https://openalex.org/W4410575868","https://openalex.org/W2372139638","https://openalex.org/W2076953948","https://openalex.org/W4403259642","https://openalex.org/W2143093840","https://openalex.org/W2375928091","https://openalex.org/W4412861554","https://openalex.org/W2072322276"],"abstract_inverted_index":{"Oxidative":[0],"stress":[1],"is":[2],"involved":[3],"in":[4,12,53,72,145,169,222,247,261,271,278],"the":[5,37,47,76,84,87,89,102,120,126,162,178,244,255,262,275],"development":[6],"of":[7,39,42,86,164,258,283],"pulmonary":[8,142,259,279],"hypertension":[9,260],"syndrome":[10],"(PHS)":[11],"broilers.":[13,55],"l-Carnitine":[14],"has":[15,22],"an":[16,40,220],"antiperoxidative":[17],"effect":[18,38],"and":[19,57,131,139,160,188,197],"supplemental":[20,192],"l-carnitine":[21,45,117,152,193,290],"been":[23],"revealed":[24],"to":[25,35,46,64,95,110,119,141,215,274],"increase":[26,221,246,277],"broiler":[27],"heart":[28,249],"weight.":[29,225],"The":[30,67],"present":[31],"study":[32],"was":[33,70,241],"conducted":[34],"evaluate":[36],"addition":[41],"100":[43],"mg/kg":[44],"basal":[48,121],"diets":[49],"on":[50,79,287],"PHS":[51,165,180],"mortality":[52,181],"cold-exposed":[54,170,217],"Two-hundred":[56],"forty":[58],"mixed-sex":[59],"broilers":[60],"were":[61,93,234],"equally":[62],"assigned":[63],"three":[65],"groups.":[66],"control":[68],"group":[69],"reared":[71],"normal":[73],"temperatures":[74],"throughout":[75],"experiment.":[77],"Starting":[78],"day":[80,108,228],"14":[81],"continuing":[82],"until":[83],"end":[85],"experiment,":[88],"other":[90],"two":[91],"groups":[92],"subjected":[94],"a":[96],"step-down":[97],"temperature":[98,103],"programme":[99],"(by":[100],"lowering":[101],"1-2":[104],"degrees":[105,112],"C":[106],"per":[107],"down":[109],"12-14":[111],"C)":[113],"with":[114],"or":[115],"without":[116,147],"added":[118],"diets.":[122],"Cold":[123],"exposure":[124],"increased":[125,156,236],"right/total":[127],"ventricle":[128,224],"ratio":[129],"(RV/TV)":[130],"plasma":[132,154],"malondialdehyde":[133],"(MDA),":[134],"reduced":[135,153],"superoxide":[136],"dismutase":[137],"(SOD)":[138],"led":[140],"vascular":[143],"remodelling":[144,159],"birds":[146,190],"feeding":[148],"additional":[149],"l-carnitine.":[150],"Supplemental":[151],"MDA,":[155],"SOD,":[157],"inhibited":[158],"postponed":[161,256],"occurrence":[163,257],"for":[166,254,295],"1":[167],"week":[168],"broilers;":[171],"nevertheless,":[172],"it":[173],"did":[174],"not":[175],"significantly":[176],"influence":[177],"cumulative":[179],"(p":[182,202,211,237],">":[183,212],"0.05).":[184,239],"On":[185],"days":[186],"24":[187],"32,":[189],"fed":[191],"had":[194],"lower":[195],"RV/TV":[196,232],"higher":[198],"total":[199],"ventricle/body":[200,208],"weight":[201,209,250],"<":[203,238],"0.05)":[204,213],"but":[205],"unchanged":[206],"right":[207],"ratios":[210,233],"compared":[214],"their":[216,231],"counterparts,":[218],"indicating":[219],"left":[223,248],"However,":[226],"from":[227],"39":[229],"on,":[230],"suddenly":[235],"It":[240],"suggested":[242],"that":[243],"l-carnitine-induced":[245],"might":[251],"partially":[252],"account":[253],"early":[263],"stage":[264],"by":[265],"elevating":[266],"cardiac":[267],"output,":[268],"which":[269],"might,":[270],"turn,":[272],"lead":[273],"resulting":[276],"pressure.":[280],"In":[281],"view":[282],"its":[284],"complex":[285],"effects":[286],"cardiopulmonary":[288],"haemodynamics,":[289],"supplementation":[291],"may":[292],"be":[293],"impractical":[294],"reducing":[296],"PHS.":[297]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
