{"id":"https://openalex.org/W1985247004","doi":"https://doi.org/10.1097/ftd.0b013e318239a41a","title":"An Enzymatic Method to Determine \u03b3-Hydroxybutyric Acid in Serum and Urine","display_name":"An Enzymatic Method to Determine \u03b3-Hydroxybutyric Acid in Serum and Urine","publication_year":2011,"publication_date":"2011-11-19","ids":{"openalex":"https://openalex.org/W1985247004","doi":"https://doi.org/10.1097/ftd.0b013e318239a41a","mag":"1985247004","pmid":"https://pubmed.ncbi.nlm.nih.gov/22105594"},"language":"en","primary_location":{"id":"doi:10.1097/ftd.0b013e318239a41a","doi":"https://doi.org/10.1097/ftd.0b013e318239a41a","is_oa":false,"landing_page_url":"https://doi.org/10.1097/ftd.0b013e318239a41a","pdf_url":null,"source":{"id":"https://openalex.org/S179268941","display_name":"Therapeutic Drug Monitoring","issn_l":"0163-4356","issn":["0163-4356","1536-3694"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic Drug Monitoring","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036951902","display_name":"Lara Hasan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122003","display_name":"B\u00fchlmann (Switzerland)","ror":"https://ror.org/03qhzdc37","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210122003"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Lara Hasan","raw_affiliation_strings":["B\u00fchlmann Laboratories AG, Schoenenbuch, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"B\u00fchlmann Laboratories AG, Schoenenbuch, Switzerland","institution_ids":["https://openalex.org/I4210122003"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009063424","display_name":"Thomas M. Jermann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122003","display_name":"B\u00fchlmann (Switzerland)","ror":"https://ror.org/03qhzdc37","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210122003"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Thomas M Jermann","raw_affiliation_strings":["B\u00fchlmann Laboratories AG, Schoenenbuch, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"B\u00fchlmann Laboratories AG, Schoenenbuch, Switzerland","institution_ids":["https://openalex.org/I4210122003"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110621953","display_name":"Jakob M. Weber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122003","display_name":"B\u00fchlmann (Switzerland)","ror":"https://ror.org/03qhzdc37","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210122003"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Jakob M Weber","raw_affiliation_strings":["B\u00fchlmann Laboratories AG, Schoenenbuch, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"B\u00fchlmann Laboratories AG, Schoenenbuch, Switzerland","institution_ids":["https://openalex.org/I4210122003"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090592689","display_name":"Lars Abrahamsson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148907","display_name":"Norra \u00c4lvsborgs L\u00e4nssjukhus","ror":"https://ror.org/03y7ycy60","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210148907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Lars Abrahamsson","raw_affiliation_strings":["Clinical Chemistry Laboratory, Northern Aelvsborgs Laenssjukhus, Trollhaettan, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Chemistry Laboratory, Northern Aelvsborgs Laenssjukhus, Trollhaettan, Sweden","institution_ids":["https://openalex.org/I4210148907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061636577","display_name":"Michel\u2010Angelo Sciotti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2972652528","display_name":"FHNW University of Applied Sciences and Arts Northwestern Switzerland","ror":"https://ror.org/04mq2g308","country_code":"CH","type":"education","lineage":["https://openalex.org/I2972652528"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Michel-Angelo Sciotti","raw_affiliation_strings":["Department of Life Sciences, University of Applied Sciences Northwestern Switzerland FHNW, Muttenz, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Life Sciences, University of Applied Sciences Northwestern Switzerland FHNW, Muttenz, Switzerland","institution_ids":["https://openalex.org/I2972652528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101554305","display_name":"Michael B\u00f6ttcher","orcid":"https://orcid.org/0000-0002-4143-5612","observed_orcids":["https://orcid.org/0000-0002-4143-5612"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael B\u00f6ttcher","raw_affiliation_strings":["MVZ f\u00fcr Mikrobiologie, Labordiagnostik und Hygiene Dessau, Dessau, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MVZ f\u00fcr Mikrobiologie, Labordiagnostik und Hygiene Dessau, Dessau, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007228182","display_name":"Wolfgang Jochle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Wolfgang J\u00f6chle","raw_affiliation_strings":["Clinical Chemistry Laboratory, University Hospital of Basel, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Chemistry Laboratory, University Hospital of Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043369263","display_name":"Daniel Gygax","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2972652528","display_name":"FHNW University of Applied Sciences and Arts Northwestern Switzerland","ror":"https://ror.org/04mq2g308","country_code":"CH","type":"education","lineage":["https://openalex.org/I2972652528"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Daniel Gygax","raw_affiliation_strings":["Department of Life Sciences, University of Applied Sciences Northwestern Switzerland FHNW, Muttenz, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Life Sciences, University of Applied Sciences Northwestern Switzerland FHNW, Muttenz, Switzerland","institution_ids":["https://openalex.org/I2972652528"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113592728","display_name":"Andr\u00e9 Scholer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andr\u00e9 Scholer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5009063424","https://openalex.org/A5036951902","https://openalex.org/A5110621953"],"corresponding_institution_ids":["https://openalex.org/I4210122003"],"apc_list":null,"apc_paid":null,"fwci":2.0636,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.85139949,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"33","issue":"6","first_page":"757","last_page":"765"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3607","display_name":"Medical Laboratory Technology"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gamma-hydroxybutyric-acid","display_name":"gamma-hydroxybutyric acid","score":0.9980000257492065},{"id":"https://openalex.org/keywords/enzyme-activity-assay","display_name":"enzyme activity assay","score":0.8560000061988831},{"id":"https://openalex.org/keywords/recombinant-enzyme","display_name":"recombinant enzyme","score":0.796999990940094},{"id":"https://openalex.org/keywords/illicit-drug-screening","display_name":"illicit drug screening","score":0.5260000228881836},{"id":"https://openalex.org/keywords/date-rape-drugs","display_name":"date rape drugs","score":0.8619999885559082},{"id":"https://openalex.org/keywords/serum","display_name":"serum","score":0.4869999885559082},{"id":"https://openalex.org/keywords/urine","display_name":"urine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/clinical-chemistry-analyzers","display_name":"clinical chemistry analyzers","score":0.7279999852180481},{"id":"https://openalex.org/keywords/assay-validation","display_name":"assay validation","score":0.6079999804496765},{"id":"https://openalex.org/keywords/drug-overdose","display_name":"drug overdose","score":0.414000004529953}],"concepts":[{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.7988235950469971},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.790674090385437},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7225074768066406},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.5296575427055359},{"id":"https://openalex.org/C64489805","wikidata":"https://www.wikidata.org/wiki/Q873864","display_name":"Liquid chromatography\u2013mass spectrometry","level":3,"score":0.4672394096851349},{"id":"https://openalex.org/C31827203","wikidata":"https://www.wikidata.org/wiki/Q874296","display_name":"Tandem mass spectrometry","level":3,"score":0.44893842935562134},{"id":"https://openalex.org/C205345274","wikidata":"https://www.wikidata.org/wiki/Q873009","display_name":"Gas chromatography\u2013mass spectrometry","level":3,"score":0.4259951114654541},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1509544551372528}],"mesh":[{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002138","descriptor_name":"Calibration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002492","descriptor_name":"Central Nervous System Depressants","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002492","descriptor_name":"Central Nervous System Depressants","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D004355","descriptor_name":"Drug Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006884","descriptor_name":"Hydroxybutyrate Dehydrogenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006884","descriptor_name":"Hydroxybutyrate Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006885","descriptor_name":"Hydroxybutyrates","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006885","descriptor_name":"Hydroxybutyrates","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013287","descriptor_name":"Illicit Drugs","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D013287","descriptor_name":"Illicit Drugs","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015813","descriptor_name":"Substance Abuse Detection","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020118","descriptor_name":"Cupriavidus necator","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D057205","descriptor_name":"Automation, Laboratory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057230","descriptor_name":"Limit of Detection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/ftd.0b013e318239a41a","doi":"https://doi.org/10.1097/ftd.0b013e318239a41a","is_oa":false,"landing_page_url":"https://doi.org/10.1097/ftd.0b013e318239a41a","pdf_url":null,"source":{"id":"https://openalex.org/S179268941","display_name":"Therapeutic Drug Monitoring","issn_l":"0163-4356","issn":["0163-4356","1536-3694"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic Drug Monitoring","raw_type":"journal-article"},{"id":"pmid:22105594","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22105594","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic drug monitoring","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W1602718018","https://openalex.org/W1920931666","https://openalex.org/W1964039772","https://openalex.org/W1964528013","https://openalex.org/W1987116185","https://openalex.org/W1988967272","https://openalex.org/W1990354831","https://openalex.org/W1997246638","https://openalex.org/W2007986922","https://openalex.org/W2015795623","https://openalex.org/W2020210187","https://openalex.org/W2022273366","https://openalex.org/W2024133120","https://openalex.org/W2028381047","https://openalex.org/W2032569168","https://openalex.org/W2032763125","https://openalex.org/W2033061942","https://openalex.org/W2035944257","https://openalex.org/W2037502041","https://openalex.org/W2038504279","https://openalex.org/W2055152090","https://openalex.org/W2060317950","https://openalex.org/W2066260826","https://openalex.org/W2072689274","https://openalex.org/W2075169238","https://openalex.org/W2075700981","https://openalex.org/W2085464875","https://openalex.org/W2085532594","https://openalex.org/W2086382497","https://openalex.org/W2095047245","https://openalex.org/W2095564883","https://openalex.org/W2100748892","https://openalex.org/W2112820102","https://openalex.org/W2122560988","https://openalex.org/W2128635872","https://openalex.org/W2129084804","https://openalex.org/W2129859831","https://openalex.org/W2132410530","https://openalex.org/W2137107830","https://openalex.org/W2150748630","https://openalex.org/W2153362378","https://openalex.org/W2160740810","https://openalex.org/W2160775670","https://openalex.org/W2241739249","https://openalex.org/W2334056680","https://openalex.org/W4297933249"],"related_works":["https://openalex.org/W1987116185","https://openalex.org/W2085532594","https://openalex.org/W2127138637","https://openalex.org/W4251125667","https://openalex.org/W4224298140","https://openalex.org/W1997246638","https://openalex.org/W2963371025","https://openalex.org/W1977567492","https://openalex.org/W2004805804","https://openalex.org/W2090905992"],"abstract_inverted_index":{"BACKGROUND:":[0],"Gamma-hydroxybutyric":[1],"acid":[2],"(GHB)":[3],"has":[4],"become":[5],"one":[6],"of":[7,13,27,77,97,135,152,190,238,256],"the":[8,32,75,98,118,165,235,254],"most":[9],"dangerous":[10],"illicit":[11],"drugs":[12,222],"abuse":[14],"today.":[15],"It":[16,244],"is":[17,46,79,87,230],"used":[18,247],"as":[19,248],"a":[20,51,65,90,103,150,249],"recreational":[21],"and":[22,43,60,126,142,156,175,187,203,220,233,242],"date":[23],"rape":[24],"drug":[25],"because":[26],"its":[28],"depressant":[29],"effect":[30],"on":[31,89,102],"central":[33],"nervous":[34],"system,":[35],"which":[36],"may":[37],"cause":[38],"euphoria,":[39],"amnesia,":[40],"respiratory":[41],"arrest,":[42],"coma.":[44],"There":[45],"an":[47,194],"urgent":[48],"need":[49],"for":[50,55,74,183,212,253],"simple,":[52],"easy-to-use":[53],"assay":[54,68,86,99,161,229,252],"GHB":[56,78,84,92,185,228,239,257],"determination":[57,255],"in":[58,124,129,140,144,154,158,173,177,240,258],"urine":[59],"blood.":[61],"In":[62],"this":[63],"article,":[64],"rapid":[66,250],"enzymatic":[67,85],"adapted":[69],"to":[70,207],"clinical":[71],"chemistry":[72],"analyzers":[73],"detection":[76],"presented.":[80],"METHODS:":[81],"The":[82,94,111,131,146,160],"described":[83],"based":[88],"recombinant":[91],"dehydrogenase.":[93],"full":[95],"validation":[96],"was":[100,114,121,138,162,181,223],"performed":[101],"Konelab":[104],"30":[105],"analyzer":[106],"(Thermo":[107],"Fisher":[108],"Scientific).":[109],"RESULTS:":[110],"analytical":[112],"sensitivity":[113,120],"<1.5":[115],"mg/L,":[116],"whereas":[117],"functional":[119],"4.5":[122],"mg/L":[123,128],"serum":[125,141,155,174,218,241],"2.8":[127],"urine.":[130,145,159,178,243],"total":[132],"imprecision":[133,148],"coefficient":[134],"variation":[136],"(CV)":[137],"<9.8%":[139],"<7.9%":[143],"within-run":[147],"showed":[149,193],"CV":[151],"<3.8%":[153],"<4.6%":[157],"linear":[163],"within":[164],"range":[166],"5-250":[167],"mg/L.":[168],"Mean":[169],"recoveries":[170],"were":[171],"109%":[172],"105%":[176],"No":[179],"cross-reactivity":[180],"observed":[182],"tested":[184],"analogues":[186],"precursors.":[188],"Comparison":[189],"GHB-positive":[191],"samples":[192],"excellent":[195],"correlation":[196],"with":[197],"ion":[198],"chromatography,":[199],"gas":[200],"chromatography-mass":[201],"spectrometry,":[202],"liquid":[204],"chromatography":[205],"associated":[206],"tandem":[208],"mass":[209],"spectrometry.":[210],"Except":[211],"ethanol,":[213],"no":[214],"substantial":[215],"interference":[216],"from":[217],"constituents":[219],"some":[221],"observed.":[224],"CONCLUSIONS:":[225],"This":[226],"automated":[227],"fully":[231],"quantitative":[232],"allows":[234],"accurate":[236],"measurement":[237],"can":[245],"be":[246],"screening":[251],"intoxicated":[259],"or":[260],"overdosed":[261],"patients.":[262]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}