{"id":"https://openalex.org/W1985246512","doi":"https://doi.org/10.1111/j.1365-2141.2011.08905.x","title":"Secondary primary malignancies in patients with multiple myeloma treated with high\u2010dose chemotherapy and autologous blood stem cell transplantation","display_name":"Secondary primary malignancies in patients with multiple myeloma treated with high\u2010dose chemotherapy and autologous blood stem cell transplantation","publication_year":2011,"publication_date":"2011-11-03","ids":{"openalex":"https://openalex.org/W1985246512","doi":"https://doi.org/10.1111/j.1365-2141.2011.08905.x","mag":"1985246512","pmid":"https://pubmed.ncbi.nlm.nih.gov/22050384"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2141.2011.08905.x","doi":"https://doi.org/10.1111/j.1365-2141.2011.08905.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2141.2011.08905.x","pdf_url":null,"source":{"id":"https://openalex.org/S153015021","display_name":"British Journal of Haematology","issn_l":"0007-1048","issn":["0007-1048","1365-2141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Haematology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090048856","display_name":"Roland R. Fenk","orcid":"https://orcid.org/0000-0001-7594-6288","observed_orcids":["https://orcid.org/0000-0001-7594-6288"]},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Roland Fenk","raw_affiliation_strings":["Department of Haematology, Oncology and Clinical Immunology, Heinrich-Heine University Duesseldorf, Duesseldorf, Germany E-mail: [email protected]","Department of Haematology, Oncology and Clinical Immunology, Heinrich\u2010Heine University Duesseldorf, Duesseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, Oncology and Clinical Immunology, Heinrich-Heine University Duesseldorf, Duesseldorf, Germany E-mail: [email protected]","institution_ids":["https://openalex.org/I44260953"]},{"raw_affiliation_string":"Department of Haematology, Oncology and Clinical Immunology, Heinrich\u2010Heine University Duesseldorf, Duesseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053992861","display_name":"Florian Neubauer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Florian Neubauer","raw_affiliation_strings":["Department of Haematology, Oncology and Clinical Immunology, Heinrich-Heine University Duesseldorf, Duesseldorf, Germany E-mail: [email protected]","Department of Haematology, Oncology and Clinical Immunology, Heinrich\u2010Heine University Duesseldorf, Duesseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, Oncology and Clinical Immunology, Heinrich-Heine University Duesseldorf, Duesseldorf, Germany E-mail: [email protected]","institution_ids":["https://openalex.org/I44260953"]},{"raw_affiliation_string":"Department of Haematology, Oncology and Clinical Immunology, Heinrich\u2010Heine University Duesseldorf, Duesseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049125906","display_name":"Ingmar Bruns","orcid":"https://orcid.org/0000-0001-6316-8378","observed_orcids":["https://orcid.org/0000-0001-6316-8378"]},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Ingmar Bruns","raw_affiliation_strings":["Department of Haematology, Oncology and Clinical Immunology, Heinrich-Heine University Duesseldorf, Duesseldorf, Germany E-mail: [email protected]","Department of Haematology, Oncology and Clinical Immunology, Heinrich\u2010Heine University Duesseldorf, Duesseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, Oncology and Clinical Immunology, Heinrich-Heine University Duesseldorf, Duesseldorf, Germany E-mail: [email protected]","institution_ids":["https://openalex.org/I44260953"]},{"raw_affiliation_string":"Department of Haematology, Oncology and Clinical Immunology, Heinrich\u2010Heine University Duesseldorf, Duesseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Thomas Schr\u00f6der","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Thomas Schr\u00f6der","raw_affiliation_strings":["Department of Haematology, Oncology and Clinical Immunology, Heinrich-Heine University Duesseldorf, Duesseldorf, Germany E-mail: [email protected]","Department of Haematology, Oncology and Clinical Immunology, Heinrich\u2010Heine University Duesseldorf, Duesseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, Oncology and Clinical Immunology, Heinrich-Heine University Duesseldorf, Duesseldorf, Germany E-mail: [email protected]","institution_ids":["https://openalex.org/I44260953"]},{"raw_affiliation_string":"Department of Haematology, Oncology and Clinical Immunology, Heinrich\u2010Heine University Duesseldorf, Duesseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113559069","display_name":"Ulrich Germing","orcid":"https://orcid.org/0009-0005-6027-6388","observed_orcids":["https://orcid.org/0009-0005-6027-6388"]},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Ulrich Germing","raw_affiliation_strings":["Department of Haematology, Oncology and Clinical Immunology, Heinrich-Heine University Duesseldorf, Duesseldorf, Germany E-mail: [email protected]","Department of Haematology, Oncology and Clinical Immunology, Heinrich\u2010Heine University Duesseldorf, Duesseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, Oncology and Clinical Immunology, Heinrich-Heine University Duesseldorf, Duesseldorf, Germany E-mail: [email protected]","institution_ids":["https://openalex.org/I44260953"]},{"raw_affiliation_string":"Department of Haematology, Oncology and Clinical Immunology, Heinrich\u2010Heine University Duesseldorf, Duesseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077658794","display_name":"Rainer Haas","orcid":"https://orcid.org/0000-0002-2761-0947","observed_orcids":["https://orcid.org/0000-0002-2761-0947"]},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Rainer Haas","raw_affiliation_strings":["Department of Haematology, Oncology and Clinical Immunology, Heinrich-Heine University Duesseldorf, Duesseldorf, Germany E-mail: [email protected]","Department of Haematology, Oncology and Clinical Immunology, Heinrich\u2010Heine University Duesseldorf, Duesseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, Oncology and Clinical Immunology, Heinrich-Heine University Duesseldorf, Duesseldorf, Germany E-mail: [email protected]","institution_ids":["https://openalex.org/I44260953"]},{"raw_affiliation_string":"Department of Haematology, Oncology and Clinical Immunology, Heinrich\u2010Heine University Duesseldorf, Duesseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111890288","display_name":"Guido Kobbe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Guido Kobbe","raw_affiliation_strings":["Department of Haematology, Oncology and Clinical Immunology, Heinrich-Heine University Duesseldorf, Duesseldorf, Germany E-mail: [email protected]","Department of Haematology, Oncology and Clinical Immunology, Heinrich\u2010Heine University Duesseldorf, Duesseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, Oncology and Clinical Immunology, Heinrich-Heine University Duesseldorf, Duesseldorf, Germany E-mail: [email protected]","institution_ids":["https://openalex.org/I44260953"]},{"raw_affiliation_string":"Department of Haematology, Oncology and Clinical Immunology, Heinrich\u2010Heine University Duesseldorf, Duesseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5049125906","https://openalex.org/A5053992861","https://openalex.org/A5077658794","https://openalex.org/A5090048856","https://openalex.org/A5111890288","https://openalex.org/A5113559069"],"corresponding_institution_ids":["https://openalex.org/I44260953"],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":null,"fwci":1.4583,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.824202,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"156","issue":"5","first_page":"683","last_page":"686"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.6021000146865845,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.6021000146865845,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14078","display_name":"Multiple and Secondary Primary Cancers","score":0.396699994802475,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.8899999856948853},{"id":"https://openalex.org/keywords/secondary-primary-malignancies","display_name":"secondary primary malignancies","score":0.9670000076293945},{"id":"https://openalex.org/keywords/high-dose-chemotherapy","display_name":"high-dose chemotherapy","score":0.9729999899864197},{"id":"https://openalex.org/keywords/autologous-peripheral-blood-stem-cell-transplantation","display_name":"autologous peripheral blood stem cell transplantation","score":0.972000002861023},{"id":"https://openalex.org/keywords/lenalidomide","display_name":"lenalidomide","score":0.890999972820282},{"id":"https://openalex.org/keywords/maintenance-therapy","display_name":"maintenance therapy","score":0.7419999837875366},{"id":"https://openalex.org/keywords/thalidomide","display_name":"thalidomide","score":0.8730000257492065},{"id":"https://openalex.org/keywords/interferon","display_name":"interferon","score":0.8500000238418579},{"id":"https://openalex.org/keywords/melphalan","display_name":"melphalan","score":0.6060000061988831},{"id":"https://openalex.org/keywords/second-malignancy-risk","display_name":"second malignancy risk","score":0.41600000858306885},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.45100000500679016},{"id":"https://openalex.org/keywords/treatment-related-toxicity","display_name":"treatment toxicity","score":0.3109999895095825}],"concepts":[{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.8192706108093262},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7797619104385376},{"id":"https://openalex.org/C2779050716","wikidata":"https://www.wikidata.org/wiki/Q4826373","display_name":"Autologous stem-cell transplantation","level":3,"score":0.7012813091278076},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.6554434895515442},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5857952833175659},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5429262518882751},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5360223650932312},{"id":"https://openalex.org/C194409129","wikidata":"https://www.wikidata.org/wiki/Q103824","display_name":"Hematology","level":2,"score":0.46391645073890686},{"id":"https://openalex.org/C2777408962","wikidata":"https://www.wikidata.org/wiki/Q1128050","display_name":"Hematopoietic stem cell transplantation","level":3,"score":0.42902612686157227},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4155219793319702},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0832878053188324},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016609","descriptor_name":"Neoplasms, Second Primary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018380","descriptor_name":"Hematopoietic Stem Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1365-2141.2011.08905.x","doi":"https://doi.org/10.1111/j.1365-2141.2011.08905.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2141.2011.08905.x","pdf_url":null,"source":{"id":"https://openalex.org/S153015021","display_name":"British Journal of Haematology","issn_l":"0007-1048","issn":["0007-1048","1365-2141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Haematology","raw_type":"journal-article"},{"id":"pmid:22050384","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22050384","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of haematology","raw_type":"Letter"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307105","display_name":"Amgen","ror":"https://ror.org/03g03ge92"},{"id":"https://openalex.org/F4320309086","display_name":"Celgene","ror":"https://ror.org/0527yg379"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W198269578","https://openalex.org/W303557043","https://openalex.org/W2022297754","https://openalex.org/W2059403857","https://openalex.org/W2066800926","https://openalex.org/W2123324449","https://openalex.org/W2170210178","https://openalex.org/W2536796599","https://openalex.org/W2560547378","https://openalex.org/W4247091572"],"related_works":["https://openalex.org/W4401394476","https://openalex.org/W7093123303","https://openalex.org/W2894461821","https://openalex.org/W4321764716","https://openalex.org/W4281645579","https://openalex.org/W4405039738","https://openalex.org/W4389244116","https://openalex.org/W2895334629","https://openalex.org/W4409834776","https://openalex.org/W2581054337"],"abstract_inverted_index":{"High-dose":[0],"therapy":[1,587],"(HDT)":[2],"followed":[3],"by":[4],"autologous":[5,186,589],"peripheral":[6],"blood":[7],"stem":[8,590],"cell":[9,591],"transplantation":[10],"(PBSCT)":[11],"in":[12,34,41,62,91,103,115,143,231,259,277,419,426,486,518,582,640,929,948,978,1163],"combination":[13,260],"with":[14,29,148,178,215,241,261,266,368,377,397,428,438,467,476,488,585,614,620,627,646,658,699,732,765,830,852,960,966,986,1015,1118,1170],"novel":[15,242,853,1119,1134],"agents":[16,1120,1135],"was":[17,89,200,268,275,327,350,392,436,458,541,648,682,688,783,866,964,975,1008,1041,1254,1277],"recently":[18],"reported":[19,511],"to":[20,22,57,113,270,310,387,421,597,611,745,757,761,864,886,950,1069,1099,1157,1176,1256,1279],"lead":[21],"longer":[23,947,1124],"overall":[24],"survival":[25,595,771],"(OS)":[26],"of":[27,38,121,146,173,212,228,233,237,249,272,279,283,292,306,314,325,339,359,385,390,407,414,434,441,465,514,534,539,568,576,579,600,604,608,638,643,654,660,702,730,739,749,753,773,781,794,811,848,858,881,904,924,932,942,970,1033,1062,1082,1108,1113,1131,1141,1149,1152,1168,1181,1184],"patients":[28,43,104,114,147,176,213,238,250,280,284,340,367,427,466,583,626,645,655,691,731,750,860,884,909,980,985,1013,1024,1169],"multiple":[30,580],"myeloma":[31,581],"(MM),":[32],"resulting":[33,1078,1123],"a":[35,134,170,298,343,347,398,411,439,503,685,784,788,806,889,967,987,1102,1111,1114,1129],"10-year":[36],"OS":[37,634],"almost":[39,351],"50%":[40],"young":[42],"(Kumar":[44],"et":[45,49,69,73,77,157,562,1090,1094],"al,":[46,50,70,74,78,158,563,1091,1095],"2008;":[47],"Barlogie":[48],"2010).":[51,79],"Lenalidomide":[52],"maintenance":[53,110,287,612,618,933,958,1017,1030],"treatment":[54,111,226,265,613,619,851,912,934,959,974,1117],"contributed":[55],"greatly":[56],"these":[58],"improvements,":[59],"as":[60,109,127,1110,1128],"shown":[61],"three":[63],"recent":[64],"randomized":[65],"clinical":[66,1166,1179],"trials":[67],"(Attal":[68],"2010;":[71,75],"McCarthy":[72],"Palumbo":[76],"However,":[80,633],"the":[81,116,290,304,311,323,330,352,357,388,463,491,532,537,544,574,598,636,727,737,747,779,792,846,882,907,930,940,951,1011,1022,1059,1070,1074,1080,1106,1122,1139,1142,1150,1164,1178,1182,1195,1204,1214,1230,1234,1240,1246,1250],"Intergroupe":[82],"Francophone":[83],"du":[84],"My\u00e9lome":[85],"trial,":[86],"IFM":[87],"99-02,":[88],"closed":[90],"January":[92,195],"2011":[93],"because":[94],"significantly":[95,650],"more":[96,162,777,1115],"secondary":[97,569],"primary":[98,570],"malignancies":[99,478,571,1045],"(SPM)":[100,572],"were":[101,555,825,862,901,1049],"observed":[102,142,1009,1060],"who":[105,181,341,861,1025],"had":[106,182,629],"received":[107,183,239,251,257,285,1026,1133,1260,1269,1281,1289],"lenalidomide":[108,911],"compared":[112],"placebo":[117],"arm.":[118],"The":[119,197,337,380,431,680,855,922,1039,1172],"issue":[120,166,923],"SPM":[122,140,299,326,391,435,517,535,609,628,647,733,740,795,849,890,905,925,1036,1063,1109,1153,1159],"is":[123,141,734,741,945,1066],"not":[124,319,459,649,742,760,841,976,1127],"entirely":[125],"new,":[126],"sporadic":[128],"data":[129,163,484,1201,1237],"from":[130,383,490,523,573,635,652,778,1079,1263,1272,1284,1292],"patient":[131,376,1191],"registries":[132],"and":[133,180,185,194,207,210,217,222,255,281,373,444,449,457,472,474,481,494,502,543,550,558,588,606,662,696,717,736,759,850,1021,1046,1073,1085,1121,1126,1154,1187,1202,1212,1225,1238,1248,1258,1266,1268,1274,1286,1288,1294],"single":[135],"centre":[136],"experience":[137],"show":[138],"that":[139,322,531,625,653,770,1058],"about":[144],"5%":[145,236],"MM":[149,179,386,519,758],"(Dong":[150,506],"&":[151,507],"Hemminki,":[152,508],"2001;":[153],"Dores,":[154],"2006;":[155],"Hasskarl":[156],"2011).":[159,564],"To":[160],"obtain":[161],"on":[164],"this":[165,766,938,973,991,994,1054],"we":[167,317,364,768,839,955],"retrospectively":[168],"evaluated":[169],"homogeneous":[171],"group":[172,464,642],"313":[174,293],"consecutive":[175,528],"diagnosed":[177],"HDT":[184,963,1065],"PBSCT":[187],"at":[188,205,300,446,536,547,1101],"our":[189,315,641,979],"hospital":[190],"between":[191,462,845,1010],"December":[192],"1994":[193],"2009.":[196],"median":[198,381,412],"age":[199,810],"55":[201],"(range:":[202,395,416,423],"31\u201374)":[203],"years":[204,552,698,775,813,946],"diagnosis":[206,384,454,540,554,578,639,782,989],"3%,":[208],"15%":[209],"81%":[211],"presented":[214],"Durie":[216],"Salmon":[218],"stages":[219],"I,":[220],"II":[221],"III,":[223],"respectively.":[224,725],"Induction":[225],"consisted":[227],"conventional":[229],"chemotherapy":[230,1088],"95%":[232,1002],"patients,":[234,273,294,529],"while":[235,879],"combinations":[240],"agents.":[243,263,854],"As":[244,726,972],"conditioning":[245],"for":[246,516,690,791,834,1105,1190],"HDT,":[247],"71%":[248],"melphalan":[252,258,1084],"200":[253],"mg/m2":[254],"29%":[256],"other":[262,827,1086],"Maintenance":[264],"interferon":[267,1027],"applied":[269],"37%":[271],"thalidomide":[274,615,865,961,1016],"given":[276],"35%":[278],"28%":[282],"no":[286,617,826,1029],"treatment.":[288],"Within":[289],"cohort":[291],"18":[295,644],"(5\u00b78%)":[296],"developed":[297,342,888,1019,1035],"various":[301],"times":[302],"during":[303],"course":[305],"their":[307],"disease.":[308],"Due":[309],"retrospective":[312],"nature":[313],"study":[316,522],"could":[318],"rule":[320],"out":[321],"incidence":[324,331,433,512,567,847,856,969,1061],"under-reported,":[328],"thus":[329],"rates":[332,513,546],"may":[333],"be":[334,1100,1147,1161],"even":[335],"greater.":[336],"number":[338,729],"solid":[344,360,408,468,1047],"neoplasm":[345],"or":[346,616,776,814,1028],"haematological":[348,429,477,1044],"malignancy":[349],"same":[353,681,1040],"(Table":[354],"I).":[355],"Although":[356],"types":[358],"tumour":[361],"varied":[362],"greatly,":[363],"noted":[365],"eight":[366],"myelodysplastic":[369],"syndrome/acute":[370],"myeloid":[371],"leukaemia":[372],"only":[374,983],"one":[375],"Hodgkin":[378],"lymphoma.":[379],"time":[382,413,538,575,637,772,780],"occurrence":[389,406,738],"56":[393],"months":[394,418,425],"14\u2013127)":[396],"trend":[399,807],"(P":[400],"=":[401,667,708,715,723,802,822,869,877,898,920,1006],"0\u00b71)":[402],"towards":[403,808],"an":[404,630,809,831],"earlier":[405],"tumours":[409,469,1048],"after":[410,453,553,693,935,962,990,1064],"51":[415],"14\u201399)":[417],"comparison":[420,949],"61":[422],"23\u2013127)":[424],"malignancies.":[430],"cumulative":[432],"19\u00b77%":[437],"rate":[440,533,857],"0\u00b77%,":[442],"5\u00b78%":[443],"15\u00b77%":[445],"2,":[447,548,694],"5":[448,549,695,774,1032],"10":[450,551],"years,":[451],"respectively,":[452],"(Fig":[455,678,1037],"1A)":[456],"statistically":[460],"different":[461,651],"(0\u00b73%,":[470],"4\u00b74%":[471],"7\u00b75%)":[473],"those":[475,489,984],"(0\u00b74%,":[479],"1\u00b78%":[480],"9\u00b73%).":[482],"These":[483],"are":[485],"line":[487,764],"Surveillance,":[492],"Epidemiology":[493],"End":[495],"Results":[496],"(SEER)":[497],"cancer":[498],"registry":[499,505],"(Dores,":[500],"2006)":[501],"Swedish":[504],"2001),":[509],"which":[510,525],"5\u20136%":[515],"patients.":[520],"Another":[521],"Germany,":[524],"included":[526,1162],"589":[527],"showed":[530,1057],"6\u00b76%":[542],"estimated":[545],"7\u00b78%,":[556],"10\u00b73%":[557],"11\u00b76%,":[559],"respectively":[560,665],"(Hasskarl":[561],"(A)":[565],"Cumulative":[566],"first":[577,988],"treated":[584,1014],"high-dose":[586,1083],"transplantation.":[592],"(B)":[593],"Overall":[594],"according":[596,610],"development":[599,793,1107],"SPM.":[601,762,836,971],"(C)":[602],"Risk":[603],"death":[605],"risk":[607,790,833,1104,1151],"thalidomide.":[621],"One":[622],"would":[623,1174],"assume":[624],"inferior":[631],"OS.":[632],"without":[656],"SPM,":[657],"medians":[659],"70":[661],"83":[663],"months,":[664],"{P":[666],"0\u00b77,":[668],"Hazard":[669],"Ratio":[670],"(HR)":[671],"0\u00b79":[672,703],"[95%":[673],"confidence":[674],"interval":[675],"(CI)":[676],"0\u00b75\u20131\u00b77]}":[677],"1B).":[679],"true":[683,1042],"when":[684,1043],"landmark":[686],"analysis":[687,1056,1211,1224],"performed":[689,1197,1209,1222],"alive":[692],"8":[697],"hazard":[700],"ratios":[701],"(95%":[704,711,719,798,818,873,894,916],"CI":[705,712,720,799,819,874,895,917,1003],"0\u00b75\u20131\u00b77,":[706],"P":[707,714,722,801,821,876,897,919,1005],"0\u00b78),":[709],"0\u00b76":[710],"0\u00b73\u20131\u00b74,":[713],"0\u00b72)":[716],"1\u00b70":[718],"0\u00b72\u20134\u00b73,":[721],"1\u00b70),":[724],"total":[728],"low":[735],"necessarily":[743],"linked":[744],"death,":[746],"majority":[748],"apparently":[751,1067],"die":[752],"fatal":[754],"complications":[755],"related":[756,1068],"In":[763,837,937,1052,1138],"view,":[767],"found":[769],"prognostic":[785],"parameter":[786],"indicating":[787],"greater":[789],"(HR":[796,816,1000],"4\u00b77":[797],"1\u00b71\u201319\u00b78),":[800],"0\u00b704).":[803],"Other":[804],"than":[805],"60":[812],"older":[815],"2\u00b74":[817],"0\u00b79\u20136\u00b73),":[820],"0\u00b707),":[823],"there":[824],"parameters":[828],"associated":[829,965],"increased":[832],"developing":[835],"particular,":[838],"did":[840],"find":[842],"any":[843],"relationship":[844],"206":[859],"exposed":[863,885],"6%":[867],"(n":[868],"13,":[870],"HR":[871,892,914],"1\u00b74":[872],"0\u00b75\u20134\u00b70),":[875],"0\u00b75),":[878],"five":[880],"123":[883],"bortezomib":[887],"(4%,":[891],"0\u00b74":[893,915],"0\u00b71\u20131\u00b71),":[896],"0\u00b71).":[899],"There":[900],"two":[902],"cases":[903],"among":[906],"71":[908],"following":[910],"(3%,":[913],"0\u00b71\u20131\u00b75),":[918],"0\u00b72).":[921],"has":[926],"been":[927],"addressed":[928],"context":[931],"HDT.":[936],"situation":[939],"duration":[941],"drug":[943],"exposure":[944],"relapsed":[952],"setting.":[953],"Therefore,":[954],"analysed":[956],"whether":[957],"higher":[968,1103],"used":[977],"before":[981],"2001,":[982],"date":[992],"entered":[993],"subgroup":[995],"analysis.":[996],"No":[997],"significant":[998],"difference":[999],"1\u00b70,":[1001],"0\u00b73\u20133\u00b72,":[1004],"1\u00b70)":[1007],"96":[1012],"(six":[1018],"SPM)":[1020],"80":[1023],"therapy,":[1031],"whom":[1034],"1C).":[1038],"assessed":[1050],"separately.":[1051],"conclusion,":[1053],"single-institution":[1055],"disease":[1071],"itself":[1072],"additional":[1075],"genotoxic":[1076],"stress":[1077],"application":[1081],"cytotoxic":[1087],"(Bergsagel":[1089],"1979;":[1092],"Cuzick":[1093],"1987).":[1096],"Patients":[1097],"seem":[1098],"consequence":[1112,1130],"effective":[1116],"survival,":[1125],"having":[1132],"per":[1136],"se.":[1137],"light":[1140],"available":[1143],"data,":[1144,1208],"physicians":[1145],"should":[1146,1160],"aware":[1148],"diagnostic":[1155],"measures":[1156],"detect":[1158],"daily":[1165],"workup":[1167],"MM.":[1171],"authors":[1173,1243],"like":[1175],"thank":[1177],"staff":[1180],"Department":[1183],"Haematology,":[1185],"Oncology":[1186],"Clinical":[1188],"Immunology":[1189],"care.":[1192],"RF":[1193,1276],"designed":[1194,1229,1233],"study,":[1196,1235],"statistical":[1198,1210,1223],"analysis,":[1199],"interpreted":[1200,1226,1236],"drafted":[1203,1213,1239],"manuscript.":[1205,1215,1241],"FN":[1206],"collected":[1207,1219],"IB,":[1216],"CS,":[1217],"TS":[1218],"data.":[1220,1227],"UG":[1221],"RH":[1228],"study.":[1231],"GK":[1232,1253],"All":[1242],"critically":[1244],"revised":[1245],"manuscript":[1247],"approved":[1249],"submitted":[1251],"version.":[1252],"consultant":[1255,1278],"Amgen":[1257,1273],"Celgene,":[1259,1280],"lecture":[1261,1282],"fees":[1262,1283],"Amgen,":[1264],"Celgene":[1265,1285],"Janssen-Cilag,":[1267,1287],"research":[1270,1290],"funds":[1271,1291],"Celgene.":[1275,1295],"Novartis":[1293]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
