{"id":"https://openalex.org/W1985242446","doi":"https://doi.org/10.1167/iovs.05-0096","title":"Effect of Ruboxistaurin on Blood\u2013Retinal Barrier Permeability in Relation to Severity of Leakage in Diabetic Macular Edema","display_name":"Effect of Ruboxistaurin on Blood\u2013Retinal Barrier Permeability in Relation to Severity of Leakage in Diabetic Macular Edema","publication_year":2005,"publication_date":"2005-09-26","ids":{"openalex":"https://openalex.org/W1985242446","doi":"https://doi.org/10.1167/iovs.05-0096","mag":"1985242446","pmid":"https://pubmed.ncbi.nlm.nih.gov/16186374"},"language":"en","primary_location":{"id":"doi:10.1167/iovs.05-0096","doi":"https://doi.org/10.1167/iovs.05-0096","is_oa":false,"landing_page_url":"https://doi.org/10.1167/iovs.05-0096","pdf_url":null,"source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative Opthalmology &amp; Visual Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:33776266","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111524357","display_name":"Charlotte Str\u00f8m","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I2801827564","display_name":"Herlev Hospital","ror":"https://ror.org/00wys9y90","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801827564","https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Charlotte Str\u00f8m","raw_affiliation_strings":["From the Department of Ophthalmology, Herlev Hospital, University of Copenhagen, Denmark; and the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Ophthalmology, Herlev Hospital, University of Copenhagen, Denmark; and the","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2801827564"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112172468","display_name":"Birgit Sander","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I2801827564","display_name":"Herlev Hospital","ror":"https://ror.org/00wys9y90","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801827564","https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Birgit Sander","raw_affiliation_strings":["From the Department of Ophthalmology, Herlev Hospital, University of Copenhagen, Denmark; and the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Ophthalmology, Herlev Hospital, University of Copenhagen, Denmark; and the","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2801827564"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078593320","display_name":"Kristian Klemp","orcid":"https://orcid.org/0000-0002-9849-0057","observed_orcids":["https://orcid.org/0000-0002-9849-0057"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I2801827564","display_name":"Herlev Hospital","ror":"https://ror.org/00wys9y90","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801827564","https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Kristian Klemp","raw_affiliation_strings":["From the Department of Ophthalmology, Herlev Hospital, University of Copenhagen, Denmark; and the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Ophthalmology, Herlev Hospital, University of Copenhagen, Denmark; and the","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2801827564"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042011351","display_name":"Lloyd Paul Aiello","orcid":"https://orcid.org/0000-0003-2012-3465","observed_orcids":["https://orcid.org/0000-0003-2012-3465"]},"institutions":[{"id":"https://openalex.org/I1293231726","display_name":"Joslin Diabetes Center","ror":"https://ror.org/0280a3n32","country_code":"US","type":"facility","lineage":["https://openalex.org/I1293231726"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lloyd Paul Aiello","raw_affiliation_strings":["Harvard Medical School and3Beetham Eye Institute, Joslin Diabetes Center, Boston, Massachusetts","Harvard Medical School and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School and3Beetham Eye Institute, Joslin Diabetes Center, Boston, Massachusetts","institution_ids":["https://openalex.org/I1293231726","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard Medical School and","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071367797","display_name":"Henrik Lund\u2010Andersen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I2801827564","display_name":"Herlev Hospital","ror":"https://ror.org/00wys9y90","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801827564","https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Henrik Lund-Andersen","raw_affiliation_strings":["From the Department of Ophthalmology, Herlev Hospital, University of Copenhagen, Denmark; and the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Ophthalmology, Herlev Hospital, University of Copenhagen, Denmark; and the","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2801827564"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034221126","display_name":"Michael Larsen","orcid":"https://orcid.org/0000-0002-5172-5891","observed_orcids":["https://orcid.org/0000-0002-5172-5891"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I2801827564","display_name":"Herlev Hospital","ror":"https://ror.org/00wys9y90","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801827564","https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Michael Larsen","raw_affiliation_strings":["From the Department of Ophthalmology, Herlev Hospital, University of Copenhagen, Denmark; and the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Ophthalmology, Herlev Hospital, University of Copenhagen, Denmark; and the","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2801827564"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":null,"fwci":6.7044,"has_fulltext":false,"cited_by_count":58,"citation_normalized_percentile":{"value":0.96781397,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"46","issue":"10","first_page":"3855","last_page":"3855"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11377","display_name":"Retinal and Macular Surgery","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ruboxistaurin","display_name":"ruboxistaurin","score":1.0},{"id":"https://openalex.org/keywords/protein-kinase-c-beta-inhibitor","display_name":"protein kinase C beta inhibitor","score":0.8159999847412109},{"id":"https://openalex.org/keywords/diabetic-macular-edema","display_name":"diabetic macular edema","score":0.9570000171661377},{"id":"https://openalex.org/keywords/blood-retinal-barrier-permeability","display_name":"blood-retinal barrier permeability","score":0.9940000176429749},{"id":"https://openalex.org/keywords/retinal-vascular-leakage","display_name":"retinal vascular leakage","score":0.9950000047683716},{"id":"https://openalex.org/keywords/treatment-response-stratification","display_name":"treatment response stratification","score":0.5740000009536743},{"id":"https://openalex.org/keywords/oral-drug-therapy","display_name":"oral drug therapy","score":0.5379999876022339}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8381417989730835},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.6777234077453613},{"id":"https://openalex.org/C2780886150","wikidata":"https://www.wikidata.org/wiki/Q152234","display_name":"Edema","level":2,"score":0.6334379315376282},{"id":"https://openalex.org/C113045295","wikidata":"https://www.wikidata.org/wiki/Q7916465","display_name":"Vascular permeability","level":2,"score":0.6010281443595886},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5863674283027649},{"id":"https://openalex.org/C2780347916","wikidata":"https://www.wikidata.org/wiki/Q1813737","display_name":"Macular edema","level":3,"score":0.5818185210227966},{"id":"https://openalex.org/C2778371105","wikidata":"https://www.wikidata.org/wiki/Q1622103","display_name":"Blood\u2013retinal barrier","level":4,"score":0.5619065165519714},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.5413309335708618},{"id":"https://openalex.org/C2778257484","wikidata":"https://www.wikidata.org/wiki/Q555066","display_name":"Visual acuity","level":2,"score":0.4404422342777252},{"id":"https://openalex.org/C2985127711","wikidata":"https://www.wikidata.org/wiki/Q631361","display_name":"Diabetic macular edema","level":4,"score":0.4218257963657379},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4137110114097595},{"id":"https://openalex.org/C2779829184","wikidata":"https://www.wikidata.org/wiki/Q631361","display_name":"Diabetic retinopathy","level":3,"score":0.36028414964675903},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.31532466411590576},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24308329820632935},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.08913975954055786},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.08309072256088257},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001813","descriptor_name":"Blood-Retinal Barrier","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002199","descriptor_name":"Capillary Permeability","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006442","descriptor_name":"Glycated Hemoglobin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008269","descriptor_name":"Macular Edema","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008269","descriptor_name":"Macular Edema","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D008269","descriptor_name":"Macular Edema","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008301","descriptor_name":"Maleimides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012171","descriptor_name":"Retinal Vessels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1167/iovs.05-0096","doi":"https://doi.org/10.1167/iovs.05-0096","is_oa":false,"landing_page_url":"https://doi.org/10.1167/iovs.05-0096","pdf_url":null,"source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative Opthalmology &amp; Visual Science","raw_type":"journal-article"},{"id":"pmid:16186374","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16186374","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Clinical Trial"},{"id":"pmh:oai:dash.harvard.edu:1/33776266","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:33776266","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:dash.harvard.edu:1/33776266","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:33776266","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W22189248","https://openalex.org/W184000120","https://openalex.org/W1278427456","https://openalex.org/W1496977463","https://openalex.org/W1519861371","https://openalex.org/W1547438621","https://openalex.org/W1579720892","https://openalex.org/W1591039074","https://openalex.org/W1966419887","https://openalex.org/W1981526907","https://openalex.org/W1988143227","https://openalex.org/W2008428325","https://openalex.org/W2053352120","https://openalex.org/W2073541631","https://openalex.org/W2089964148","https://openalex.org/W2116989611","https://openalex.org/W2119074953","https://openalex.org/W2325938353","https://openalex.org/W2757208104","https://openalex.org/W2769264260","https://openalex.org/W3198570063","https://openalex.org/W4244488104","https://openalex.org/W4251537032"],"related_works":["https://openalex.org/W2307573673","https://openalex.org/W1194240834","https://openalex.org/W4407153471","https://openalex.org/W2591764924","https://openalex.org/W2084823433","https://openalex.org/W1993628563","https://openalex.org/W1995763290","https://openalex.org/W2993944437","https://openalex.org/W2511895956","https://openalex.org/W1578810619"],"abstract_inverted_index":{"PURPOSE:":[0],"The":[1,66],"purpose":[2],"of":[3,11,27,101,104,193],"the":[4,9,25,28,75,102,183],"study":[5,56],"was":[6,85,156,175,188],"to":[7,47,241],"investigate":[8],"effect":[10,103],"orally":[12],"administered":[13],"ruboxistaurin":[14],"(RBX,":[15],"LY333531),":[16],"a":[17,128,159,191],"selective":[18],"protein":[19],"kinase":[20],"C":[21],"beta":[22],"inhibitor,":[23],"on":[24],"permeability":[26,139],"blood-retinal":[29],"barrier":[30],"in":[31,150,163,197,223],"patients":[32,39,71,79,224],"with":[33,40,114,158,171,190,225],"diabetic":[34,41,201],"macular":[35,42,202,227],"edema.":[36],"METHODS:":[37],"Forty-one":[38],"edema":[43,203,228],"were":[44],"randomly":[45],"assigned":[46],"an":[48],"18-month":[49],"randomized,":[50],"placebo-controlled,":[51],"double-masked":[52],"trial":[53],"including":[54],"four":[55],"arms":[57],"(4,":[58],"16,":[59],"or":[60,64,147],"32":[61],"mg/d":[62],"RBX,":[63],"placebo).":[65],"RBX":[67,132,168,186,217],"group":[68,77],"comprised":[69],"30":[70],"(42":[72],"eyes)":[73],"and":[74,92,96,110,118,125,137,179,204,231],"placebo":[76],"11":[78],"(13":[80],"eyes).":[81],"Retinal":[82],"vascular":[83,152,165,195],"leakage":[84,153,166,196,207],"assessed":[86],"using":[87],"vitreous":[88],"fluorometry":[89],"at":[90,134,154,177,208,229],"baseline":[91,115,138,155,178,242],"after":[93,167],"3,":[94],"12,":[95],"18":[97],"months.":[98],"Statistical":[99,123],"analysis":[100,124],"treatment":[105,133,169,187,218],"accounted":[106],"for":[107],"repeated":[108],"measurements":[109],"tested":[111],"potential":[112],"interaction":[113,130],"permeability,":[116],"HbA(1c),":[117],"arterial":[119],"blood":[120],"pressure.":[121],"RESULTS:":[122],"modeling":[126],"demonstrated":[127],"significant":[129,160],"between":[131],"any":[135],"dosage":[136],"(P":[140],"=":[141],"0.032,":[142],"mixed":[143],"models).":[144],"A":[145],"threefold":[146],"higher":[148],"increase":[149],"retinal":[151,164,194],"associated":[157,189],"reduction":[161,192],"(30%)":[162],"compared":[170],"placebo.":[172],"Visual":[173],"acuity":[174],"normal":[176],"remained":[180],"unchanged":[181],"throughout":[182],"study.":[184],"CONCLUSIONS:":[185],"eyes":[198],"that":[199,213],"had":[200],"markedly":[205],"elevated":[206],"baseline.":[209],"These":[210],"data":[211],"suggest":[212],"clinical":[214],"benefit":[215,237],"from":[216,238],"may":[219,236],"be":[220],"most":[221],"prominent":[222],"severe":[226],"baseline,":[230],"trials":[232],"investigating":[233],"this":[234],"therapy":[235],"stratification":[239],"according":[240],"leakage.":[243]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
